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FABP3, FABP5, and FABP7 Binding Assay from US Patent US20230365488: "TRUXILLIC ACID MONOESTER-DERIVATIVES AS SELECTIVE FABP5 INHIBITORS AND PHARMACEUTICAL COMPOSITIONS AND USES THEREOF"
Assay data:47 Active, 22 Activity ≤ 1 µM, 47 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Nuclear factor erythroid 2-related factor 2/antioxidant responsive element (Nrf2/ARE) small molecule agonists: luciferase reporter gene qHTS assay in human keratinocytes
Assay data:1099 Active, 1 Activity ≤ 1 nM, 143 Activity ≤ 1 µM, 9667 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Same Project
Inhibition of FAPα In Vitro Enzymatic Activity Assay from US Patent US11504364: "Inhibitors of fibroblast activation protein"
Assay data:3 Active, 3 Activity ≤ 1 µM, 58 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Inhibitory Activity Assay from US Patent US11078214: "Monocyclic thieno, pyrido, and pyrrolo pyrimidine compounds and methods of use and manufacture of same"
Assay data:17 Active, 17 Activity ≤ 1 µM, 17 Tested
Receptor Activity Assay from US Patent US10633388: "Pyrazolopyrimidone derivatives and methods of use thereof"
Assay data:14 Active, 11 Activity ≤ 1 nM, 14 Activity ≤ 1 µM, 14 Tested
Z-LYTE biochemical assay from Article 10.1111/cbdd.12243: "Design, synthesis and biological evaluation of pazopanib derivatives as antitumor agents."
Assay data:12 Active, 11 Activity ≤ 1 µM, 12 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
BP Incorporation Assay from Article 10.1016/j.chembiol.2008.07.015: "Identification of chemical inhibitors to human tissue transglutaminase by screening existing drug libraries."
Assay data:6 Active, 2 Activity ≤ 1 µM, 9 Tested
Tyrosine Kinase Assay from Article 10.1038/nchembio.117: "Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases."
Assay data:3 Active, 2 Activity ≤ 1 µM, 4 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Dose required to inhibit HIV-1 reverse transcriptase activity (K103N mutant) by 50%
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Dose required to inhibit HIV-1 reverse transcriptase activity (Y188L mutant) by 50%
Assay data:1 Active, 1 Activity ≤ 1 µM, 4 Tested
Dose required to inhibit HIV-1 reverse transcriptase activity (Y181I mutant) by 50%
Assay data:2 Active, 1 Activity ≤ 1 µM, 4 Tested
Dose required to inhibit HIV-1 reverse transcriptase activity (V179D mutant) by 50%
Assay data:2 Active, 3 Tested
Concentration that inhibits cellular growth of MT-4 cells acutely infected with HIV-1 RFstrain by 50%
Assay data:15 Active, 15 Activity ≤ 1 µM, 20 Tested
Induction of human wild type STING in PBMC assessed as induced secretion of IFNbeta
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of ABAD (unknown origin) assessed as residual activity using acetoacetyl-CoA in presence of NADH by spectrophotometric assay relative to control
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Inhibition of ABAD (unknown origin) by cell based assay
Agonist activity at human recombinant FPRL2 receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
Assay data:378 Active, 207 Activity ≤ 1 µM, 413 Tested
Inhibition of His-tagged PTPsigma catalytic domain amino acid 1369 to 1948 using DiFMUP as substrate after 20 mins by spectrofluorometric analysis
Assay data:7 Active, 5 Activity ≤ 1 µM, 7 Tested
TP_TRANSPORTER: uptake in membrane vesicle from MRP3-expressing Sf9 cells
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