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Fold shift mGlu8 using GIRK assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Modulation of the Metabotropic Glutamate Receptors mGlu7 and mGlu8: Potency at rat mGlu8/calcium
Assay data:21 Active, 2 Activity ≤ 1 µM, 23 Tested
Modulation of the Metabotropic Glutamate Receptors mGlu7and mGlu8:Potency at rat mGlu8/GIRK (Confirmatory)
Assay data:1 Active, 1 Tested
SummaryCompounds, ActiveRelated BioAssays by DepositorRelated BioAssays by Target
Identifying inhibitors with PLD2 specific Cellular Isoenzyme Activity
Assay data:23 Active, 80 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Discovery of novel antagonists of the dopamine 4 (D4) human receptor
Assay data:11 Active, 50 Tested
Discovery of Novel Antagonists of Muscarinic Receptor M5: CRC Assay
Assay data:5 Active, 1 Activity ≤ 1 µM, 11 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Summary of Broad Institute MLPCN Serine Threonine Kinase 33 Inhibitor Project
Assay data:2 Active, 2 Tested
Discovery of inhibitors for Menin-MLL in MLL related Leukemias
Assay data:19 Active, 19 Activity ≤ 1 µM, 20 Tested
Modulation of the Metabotropic Glutamate Receptors mGlu7 and mGlu8: # Fold shift at rat mGlu8/calcium
Discovery of novel antagonists of the dopamine 4 (D4) human receptor, Confirmatory Assay
Assay data:11 Active, 7 Activity ≤ 1 µM, 11 Tested
Discovery and structure-activity relationship of a novel choline transporter inhibitor, Selectivity Studies
Assay data:29 Active, 72 Tested
Discovery of Novel Positive Allosteric Modulators (PAMs) of Muscarinic Receptor M5: Confirmatory Assay
Assay data:46 Active, 15 Activity ≤ 1 µM, 79 Tested
Discovery of Novel Positive Allosteric Modulators (PAMs) of Muscarinic Receptor M5: Single Point Assay
Assay data:53 Active, 130 Tested
Broad Institute Inhibitors of PDI Inhibitor Probe Project
SummaryCompounds, ActiveRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Discovery of Novel Negative Allosteric Modulators (NAM) of Muscarinic Receptor M5: CRC Assay
Assay data:32 Active, 3 Activity ≤ 1 µM, 42 Tested
Identification of compounds that allosterically activate MrgX1 receptor signaling
Assay data:15 Active, 6 Activity ≤ 1 µM, 15 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions via Bim (BCL2-like 11)
Broad Institute HTS fluorescence polarization assay for inhibitors of Keap1-Nrf2 interaction Inhibitor Probe Project
Discovery of Novel Positive Allosteric Modulators (PAM) of the Muscarinic Receptor M5: CRC Assay
Assay data:9 Active, 3 Activity ≤ 1 µM, 12 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
ML326 M5 PAM Competition in Radioligand Binding assays (Eurofins PanLabs)
SummaryCompounds, ActiveRelated BioAssays by Target
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