txid9606[orgn] AND "type 11"[All Fields] - PubChem BioAssay - NCBI

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Select item 6023671.

Dose Response selectivity of inhibitors of Striatal-Enriched Phosphatase (STEP) in a SHP2 (PTPN11) Inhibition Assay

Source:: Burnham Center for Chemical Genomics

Protein Target:: tyrosine-protein phosphatase non-receptor type 11 isoform 1

Assay data:160 Active, 27 Activity ≤ 1 µM, 166 Tested

AID:: 602367

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Depositor Related BioAssays by Same Project Related BioAssays by Target

Select item 15299792.

Binding affinity to phosphorylated TTBK1 (unknown origin) assessed as association rate constant by SPR analysis

Source:: ChEMBL

Protein Target:: Tau-tubulin kinase 1

Assay data:2 Tested

AID:: 1529979

Summary PubMed Citation Related BioAssays by Target

Select item 16775303.

Growth inhibition of human MDA-MB-468 cells after 48 hrs by SRB assay

Source:: ChEMBL

Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested

AID:: 1677530

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 16775294.

Growth inhibition of human HCC1806 cells after 48 hrs by SRB assay

Source:: ChEMBL

Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1677529

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 16775285.

Growth inhibition of human BT-549 cells after 48 hrs by SRB assay

Source:: ChEMBL

Assay data:9 Active, 2 Activity ≤ 1 µM, 12 Tested

AID:: 1677528

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 16775276.

Growth inhibition of human MDA-MB-157 cells after 48 hrs by SRB assay

Source:: ChEMBL

Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1677527

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 16775267.

Growth inhibition of human MDA-MB-231 cells after 48 hrs by SRB assay

Source:: ChEMBL

Assay data:11 Active, 5 Activity ≤ 1 µM, 12 Tested

AID:: 1677526

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 15299848.

Inhibition of FTK (unknown origin)

Source:: ChEMBL

Assay data:1 Tested

AID:: 1529984

Summary PubMed Citation

Select item 15299839.

Inhibition of KDR (unknown origin)

Source:: ChEMBL

Protein Target:: Vascular endothelial growth factor receptor 2

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1529983

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 152998210.

Inhibition of FLT (unknown origin)

Source:: ChEMBL

Protein Target:: Vascular endothelial growth factor receptor 1

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1529982

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 152998111.

Inhibition of TTBK2 (unknown origin)

Source:: ChEMBL

Protein Target:: Tau-tubulin kinase 2

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1529981

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 152998012.

Inhibition of TTBK1 (unknown origin)

Source:: ChEMBL

Protein Target:: Tau-tubulin kinase 1

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1529980

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 148357213.

Inhibition of NIK in human HeLa cells assessed as decrease in antilymphotoxin-beta receptor antibody-stimulated p52 translocation from cytoplasm to nucleus after 5 hrs

Source:: ChEMBL

Protein Target:: Mitogen-activated protein kinase kinase kinase 14

Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested

AID:: 1483572

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 148357114.

Cytotoxicity against HEK293 cells assessed as effect on cell viability after 24 hrs by HSV-TK reporter assay

Source:: ChEMBL

Assay data:3 Tested

AID:: 1483571

Summary PubMed Citation

Select item 148357015.

Inhibition of NIK (unknown origin) expressed in HEK293 cells assessed as decrease in NFkappaB signal after 24 hrs by dual glo luciferase reporter gene assay

Source:: ChEMBL

Protein Target:: Mitogen-activated protein kinase kinase kinase 14

Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested

AID:: 1483570

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 140202516.

Inhibition of human 11beta-HSD1 expressed in HEK293 cell lysates at 50 uM using [1,2-3H]-cortisone as substrate preincubated for 10 mins followed by substrate addition in presence of NADPH by scintillation counting relative to control

Source:: ChEMBL

Protein Target:: Corticosteroid 11-beta-dehydrogenase isozyme 1

Assay data:1 Tested

AID:: 1402025

Summary PubMed Citation Related BioAssays by Target

Select item 167755617.

Antiproliferative activity against human RDES cells assessed as reduction in cell viability after 48 hrs by SRB assay

Source:: ChEMBL

Assay data:1 Active, 1 Tested

AID:: 1677556

Summary Compounds, Active PubMed Citation

Select item 167752518.

Antiproliferative activity against human SK-ES1 cells assessed as reduction in cell viability after 48 hrs by SRB assay

Source:: ChEMBL

Assay data:1 Active, 1 Tested

AID:: 1677525

Summary Compounds, Active PubMed Citation

Select item 34831019.

Growth inhibition of human LS180 cells assessed as BrdU incorporation after 72 hrs by spectrophotometry

Source:: ChEMBL

Assay data:3 Tested

AID:: 348310

Summary PubMed Citation

Select item 148357520.

Selectivity ratio of Ki for N-terminal His6-tagged recombinant full-length human p110delta/untagged recombinant full length human p85alpha to Ki for NIK (unknown origin)

Source:: ChEMBL

Assay data:1 Tested

AID:: 1483575

Summary PubMed Citation

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Activity (IC50, etc) ≤ 1 nM (20)
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