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Volume 15(3);  2024 Mar 14

Articles from this journal are generally available in PMC after a 12-month delay (embargo); however, the delay may vary at the discretion of the publisher.

Editorials

Forging a Future Free from Neglected Tropical Diseases
Flavio da Silva Emery, Kelly Chibale
ACS Med Chem Lett. 2024 Mar 14; 15(3): 314–315. Published online 2024 Feb 26. doi: 10.1021/acsmedchemlett.4c00060
PMCID:
PMC10945539
Tips for Getting Your Manuscript Accepted into ACS Medicinal Chemistry Letters
John G. Woodland, Kelly Chibale
ACS Med Chem Lett. 2024 Mar 14; 15(3): 316–317. Published online 2024 Feb 27. doi: 10.1021/acsmedchemlett.4c00059
PMCID:
PMC10945533

Expression of Concern

Expression of Concern for “Molecular Biology Clues Portray SARS-CoV-2 as a Gain-of-Function Laboratory Manipulation of Bat CoV RaTG13”
Dennis Liotta
ACS Med Chem Lett. 2024 Mar 14; 15(3): 423. Published online 2021 Oct 12. doi: 10.1021/acsmedchemlett.1c00525
PMCID:
PMC10950065

Featured Letter

64Cu-Labeled Boron-Containing Cyclic RGD Peptides for BNCT and PET Imaging
Soyeon Kim, Sajid Mushtaq, Kyo Chul Lee, Ji Ae Park, Jung Young Kim
ACS Med Chem Lett. 2024 Mar 14; 15(3): 344–348. Published online 2024 Feb 21. doi: 10.1021/acsmedchemlett.4c00007
PMCID:
PMC10945535

Letters

Rose Campbell, Nicklas W. Buchbinder, Connor Szwetkowski, Yumeng Zhu, Karla Piedl, Mindy Truong, John B. Matson, Webster L. Santos, Emily Mevers
ACS Med Chem Lett. 2024 Mar 14; 15(3): 349–354. Published online 2024 Feb 22. doi: 10.1021/acsmedchemlett.3c00463
PMCID:
PMC10945556
Discovery and Characterization of Active CBP/EP300 Degraders Targeting the HAT Domain
Iván Cheng-Sánchez, Katherine A. Gosselé, Leonardo Palaferri, Mariia S. Kirillova, Cristina Nevado
ACS Med Chem Lett. 2024 Mar 14; 15(3): 355–361. Published online 2024 Jan 26. doi: 10.1021/acsmedchemlett.3c00490
PMCID:
PMC10945562
Cole Gannett, Kateland Tiller, Anthony J. Briganti, Anne M. Brown, James Weger-Lucarelli, Andrew N. Lowell
ACS Med Chem Lett. 2024 Mar 14; 15(3): 362–368. Published online 2024 Feb 23. doi: 10.1021/acsmedchemlett.3c00527
PMCID:
PMC10945559
Vittorio Canale, Iwona Skiba-Kurek, Karolina Klesiewicz, Monika Papież, Marlena Ropek, Bartosz Pomierny, Kamil Piska, Paulina Koczurkiewicz-Adamczyk, Joanna Empel, Elżbieta Karczewska, Paweł Zajdel
ACS Med Chem Lett. 2024 Mar 14; 15(3): 369–375. Published online 2024 Feb 5. doi: 10.1021/acsmedchemlett.3c00536
PMCID:
PMC10945555
Suppressive Effects of Neuromedin U Receptor 2-Selective Peptide Agonists on Appetite and Prolactin Secretion in Mice
Asuka Nomoto, Yui Suzuki, Katsuya Morito, Kazuki Nagasawa, Kentaro Takayama
ACS Med Chem Lett. 2024 Mar 14; 15(3): 376–380. Published online 2024 Feb 14. doi: 10.1021/acsmedchemlett.3c00541
PMCID:
PMC10945547
Discovery of Alternative Binding Poses through Fragment-Based Identification of DHODH Inhibitors
Lindsey G. DeRatt, E. Christine Pietsch, Justin S. Cisar, Edgar Jacoby, Faraz Kazmi, Rosalie Matico, Paul Shaffer, Alexandra Tanner, Weixue Wang, Ricardo Attar, James P. Edwards, Scott D. Kuduk
ACS Med Chem Lett. 2024 Mar 14; 15(3): 381–387. Published online 2024 Feb 7. doi: 10.1021/acsmedchemlett.3c00543
PMCID:
PMC10945543
Selective Recognition of c-KIT 1 G-Quadruplex by Structural Tuning of Heteroaromatic Scaffolds and Side Chains
Khushnood Fatma, Prasanth Thumpati, Deepanjan Panda, Ravichandiran Velayutham, Jyotirmayee Dash
ACS Med Chem Lett. 2024 Mar 14; 15(3): 388–395. Published online 2024 Feb 12. doi: 10.1021/acsmedchemlett.3c00537
PMCID:
PMC10945540
Novel-Type GABAB PAMs: Structure–Activity Relationship in Light of the Protein Structure
Balázs Krámos, Zsuzsa Hadady, Attila Makó, Gábor Szántó, Nóra Felföldi, Ildikó Magdó, Amrita Ágnes Bobok, Imre Bata, Viktor Román, András Visegrády, György M. Keserű, István Greiner, János Éles
ACS Med Chem Lett. 2024 Mar 14; 15(3): 396–405. Published online 2024 Mar 1. doi: 10.1021/acsmedchemlett.3c00560
PMCID:
PMC10945541
ZX703: A Small-Molecule Degrader of GPX4 Inducing Ferroptosis in Human Cancer Cells
Mengdie Hu, Xiaomei Li, Lin Wang, Yanping Zhang, Yujie Sun, Hui Hua, Huina Liu, Ting Cai, Dongsheng Zhu, Qiuping Xiang
ACS Med Chem Lett. 2024 Mar 14; 15(3): 406–412. Published online 2024 Feb 15. doi: 10.1021/acsmedchemlett.3c00571
PMCID:
PMC10945796

Notes

Laszlo Kondacs, Priyanka Parijat, Alexander J. A. Cobb, Thomas Kampourakis
ACS Med Chem Lett. 2024 Mar 14; 15(3): 413–417. Published online 2024 Feb 7. doi: 10.1021/acsmedchemlett.3c00511
PMCID:
PMC10945792
Probing the Use of Triphenyl Phosphonium Cation for Mitochondrial Nucleoside Delivery
Mathis Guiraud, Lamiaa M. A. Ali, Emma Gabrieli-Magot, Laure Lichon, Morgane Daurat, David Egron, Magali Gary-Bobo, Suzanne Peyrottes
ACS Med Chem Lett. 2024 Mar 14; 15(3): 418–422. Published online 2024 Feb 15. doi: 10.1021/acsmedchemlett.3c00568
PMCID:
PMC10945795

Patent Highlight

Novel Tetrahydropyrido[3,4-d]pyrimidines as HPK1 Inhibitors for Treating Cancer, Inflammatory, and Autoimmune Diseases
Ram W. Sabnis
ACS Med Chem Lett. 2024 Mar 14; 15(3): 318–319. Published online 2024 Jan 31. doi: 10.1021/acsmedchemlett.4c00023
PMCID:
PMC10945532
TYK2 Inhibitors for Treating Autoimmune and Inflammatory Diseases
Ram W. Sabnis
ACS Med Chem Lett. 2024 Mar 14; 15(3): 320–321. Published online 2024 Feb 6. doi: 10.1021/acsmedchemlett.4c00024
PMCID:
PMC10945538
Pyrrolidinone Derivatives as NIK Inhibitors for Treating Inflammatory and Autoimmune Diseases
Ram W. Sabnis
ACS Med Chem Lett. 2024 Mar 14; 15(3): 322–323. Published online 2024 Feb 14. doi: 10.1021/acsmedchemlett.4c00044
PMCID:
PMC10945552
Novel Heterocyclic Compounds for Treating Huntington’s Disease
Ram W. Sabnis, Anika R. Sabnis
ACS Med Chem Lett. 2024 Mar 14; 15(3): 324–325. Published online 2024 Feb 13. doi: 10.1021/acsmedchemlett.4c00045
PMCID:
PMC10945529
Novel AT2R Antagonists for Treating Chronic Pain
Ram W. Sabnis
ACS Med Chem Lett. 2024 Mar 14; 15(3): 326–327. Published online 2024 Feb 13. doi: 10.1021/acsmedchemlett.4c00046
PMCID:
PMC10945537
Innovations in Pharmacology: Enhancing Bioavailability and Efficacy through Novel Compositions
Robert B. Kargbo
ACS Med Chem Lett. 2024 Mar 14; 15(3): 328–330. Published online 2024 Feb 13. doi: 10.1021/acsmedchemlett.4c00055
PMCID:
PMC10945534
Advancements in Predictive Medicine: NLRP3 Inflammasome Inhibitors and AI-Driven Predictive Health Analytics
Robert B. Kargbo
ACS Med Chem Lett. 2024 Mar 14; 15(3): 331–333. Published online 2024 Feb 13. doi: 10.1021/acsmedchemlett.4c00056
PMCID:
PMC10945530
AI in Pharma: Transforming Drug Discovery and Strategic Management with MYC-Modulating Compounds and BET Protein Inhibitors
Robert B. Kargbo
ACS Med Chem Lett. 2024 Mar 14; 15(3): 334–336. Published online 2024 Feb 13. doi: 10.1021/acsmedchemlett.4c00057
PMCID:
PMC10945536
Pioneering Methods in Brain Optimization and Mental Health Treatment
Robert B. Kargbo
ACS Med Chem Lett. 2024 Mar 14; 15(3): 337–339. Published online 2024 Feb 13. doi: 10.1021/acsmedchemlett.4c00058
PMCID:
PMC10945793
Novel Heterocyclic PAD4 Inhibitors for Treating Diseases
Ram W. Sabnis
ACS Med Chem Lett. 2024 Mar 14; 15(3): 340–341. Published online 2024 Feb 27. doi: 10.1021/acsmedchemlett.4c00075
PMCID:
PMC10945553
Combination of Allosteric and Orthosteric EGFR Inhibitors for Treating Non-Small-Cell Lung Cancer
Ram W. Sabnis
ACS Med Chem Lett. 2024 Mar 14; 15(3): 342–343. Published online 2024 Feb 27. doi: 10.1021/acsmedchemlett.4c00076
PMCID:
PMC10945531

Articles from ACS Medicinal Chemistry Letters are provided here courtesy of American Chemical Society