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Volume 6(1);  2022

Reviews

What has preclinical systematic review ever done for us?
Ash Allanna Mark Russell, Brad A Sutherland, Lila M Landowski, Malcolm Macleod, David W Howells
BMJ Open Sci. 2022; 6(1): e100219. Published online 2022 Mar 12. doi: 10.1136/bmjos-2021-100219
PMCID:
PMC8921935
Article PDF–849K
Preregistration of animal research protocols: development and 3-year overview of preclinicaltrials.eu
Mira van der Naald, Steven A J Chamuleau, Julia M L Menon, Wim de Leeuw, Judith de Haan, Dirk J Duncker, Kimberley Elaine Wever
BMJ Open Sci. 2022; 6(1): e100259. Published online 2022 Mar 16. doi: 10.1136/bmjos-2021-100259
PMCID:
PMC8928250
Article PDF–632K

Original Research

Preclinical safety study of nacre powder in an intraosseous sheep model
Donata Iandolo, Norbert Laroche, Dung Kim Nguyen, Miriam Normand, Christophe Met, Ganggang Zhang, Laurence Vico, Didier Mainard, Marthe Rousseau
BMJ Open Sci. 2022; 6(1): e100231. Published online 2022 Sep 15. doi: 10.1136/bmjos-2021-100231
PMCID:
PMC9644736
Article PDF–2.1M
Fibroblasts: the neglected cell type in peripheral sensitisation and chronic pain? A review based on a systematic search of the literature
Naomi Shinotsuka, Franziska Denk
BMJ Open Sci. 2022; 6(1): e100235. Published online 2022 Jan 18. doi: 10.1136/bmjos-2021-100235
PMCID:
PMC8768938
Article PDF–1.4M
Road to FAIR genomes: a gap analysis of NGS data generation and sharing in the Netherlands
Jeroen A M Belien, Anke E Kip, Morris A Swertz
BMJ Open Sci. 2022; 6(1): e100268. Published online 2022 Apr 12. doi: 10.1136/bmjos-2021-100268
PMCID:
PMC9014103
Article PDF–593K
Meta-analysis on reporting practices as a source of heterogeneity in in vitro cancer research
Timo Sander, Joly Ghanawi, Emma Wilson, Sajjad Muhammad, Malcolm Macleod, Ulf Dietrich Kahlert
BMJ Open Sci. 2022; 6(1): e100272. Published online 2022 Jun 1. doi: 10.1136/bmjos-2021-100272
PMCID:
PMC9171230
Article PDF–1.0M
Analysis of rod-cone dystrophy genes reveals unique mutational patterns
Lama Jaffal, Mariam Ibrahim, Said El Shamieh
BMJ Open Sci. 2022; 6(1): e100291. Published online 2022 Dec 13. doi: 10.1136/bmjos-2022-100291
PMCID:
PMC9812813
Article PDF–393K
Effects of cannabinoids in Parkinson’s disease animal models: a systematic review and meta-analysis
Berzenn Urbi, Yunjoo Lee, Ian Hughes, Sarah Thorning, Simon A Broadley, Arman Sabet, Saman Heshmat
BMJ Open Sci. 2022; 6(1): e100302. Published online 2022 Dec 19. doi: 10.1136/bmjos-2022-100302
PMCID:
PMC9812814
Article PDF–2.2M

Protocol

Genome-wide DNA methylation in an animal model and human studies of schizophrenia: a protocol for a meta-analysis
Thabo Magwai, Fredrick Otieno Oginga, Bonginkosi Chiliza, Thabisile Mpofana, Khethelo Richman Xulu
BMJ Open Sci. 2022; 6(1): e100264. Published online 2022 Aug 25. doi: 10.1136/bmjos-2021-100264
PMCID:
PMC9644722
Article PDF–335K
Protocol for a systematic review of the validity of animal models of polydipsia with a basis in schizophrenia aetiology
Brian J Slattery, Sophie Sabherwal, William T O’Connor
BMJ Open Sci. 2022; 6(1): e100276. Published online 2022 Oct 17. doi: 10.1136/bmjos-2022-100276
PMCID:
PMC9644721
Article PDF–295K
Protocol for a systematic review of good surgical practice guidelines for experimental rodent surgery
Felix Gantenbein, Tim Buchholz, Kimberley Elaine Wever, Merel Ritskes Hoitinga, Stephan Zeiter, Petra Seebeck
BMJ Open Sci. 2022; 6(1): e100280. Published online 2022 Sep 5. doi: 10.1136/bmjos-2022-100280
PMCID:
PMC9644723
Article PDF–419K
Articles from BMJ Open Science are provided here courtesy of BMJ Publishing Group