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Select item 108168501.

Congenital Hyperinsulinism in Humans and Insulin Secretory Dysfunction in Mice Caused by Biallelic DNAJC3 Variants

Alena Welters, Oliver Nortmann, Laura Wörmeyer, Clemens Freiberg, Daniel Eberhard, Nadine Bachmann, Carsten Bergmann, Ertan Mayatepek, Thomas Meissner, Sebastian Kummer

Int J Mol Sci. 2024 Jan; 25(2): 1270. Published online 2024 Jan 20. doi: 10.3390/ijms25021270

PMCID:: PMC10816850

Abstract Article PDF–979K

Select item 102971872.

Neuronal p58^IPK Protects Retinal Ganglion Cells Independently of Macrophage/Microglia Activation in Ocular Hypertension

Todd McLaughlin, Jinli Wang, Liyun Jia, Fuguo Wu, Yaqin Wang, Joshua J. Wang, Xiuqian Mu, Sarah X. Zhang

Cells. 2023 Jun; 12(12): 1558. Published online 2023 Jun 6. doi: 10.3390/cells12121558

PMCID:: PMC10297187

Abstract Article PDF–4.9M

Select item 61373203.

p58^IPK Is an Endogenous Neuroprotectant for Retinal Ganglion Cells

Todd McLaughlin, Narayan Dhimal, Junhua Li, Joshua Jianxin Wang, Sarah Xin Zhang

Front Aging Neurosci. 2018; 10: 267. Published online 2018 Sep 7. doi: 10.3389/fnagi.2018.00267

PMCID:: PMC6137320

Abstract Article PDF–1.6M

Select item 43404324.

Identification of p58^IPK as a Novel Neuroprotective Factor for Retinal Neurons

Evgenii Boriushkin, Joshua J. Wang, Junhua Li, Guangjun Jing, Gail M. Seigel, Sarah X. Zhang

Invest Ophthalmol Vis Sci. 2015 Feb; 56(2): 1374–1386. Published online 2015 Feb 25. doi: 10.1167/iovs.14-15196

PMCID:: PMC4340432

Abstract Article PDF–2.4M

Select item 42011495.

Deletion of P58^IPK, the Cellular Inhibitor of the Protein Kinases PKR and PERK, Causes Bone Changes and Joint Degeneration in Mice

Sophie J. Gilbert, Lee B. Meakin, Cleo S. Bonnet, Mari A. Nowell, Warren C. Ladiges, John Morton, Victor C. Duance, Deborah J. Mason

Front Endocrinol (Lausanne) 2014; 5: 174. Published online 2014 Oct 17. doi: 10.3389/fendo.2014.00174

PMCID:: PMC4201149

Abstract Article PDF–4.2M

Select item 28470296.

Crystal structure of P58(IPK) TPR fragment reveals the mechanism for its molecular chaperone activity in UPR

Jiahui Tao, Kseniya Petrova, David Ron, Bingdong Sha

J Mol Biol. Author manuscript; available in PMC 2011 Apr 16.

Published in final edited form as: J Mol Biol. 2010 Apr 16; 397(5): 1307–1315. Published online 2010 Feb 22. doi: 10.1016/j.jmb.2010.02.028

PMCID:: PMC2847029

Abstract Article PDF–3.0M

Select item 26774607.

P58^IPK: A Novel “CIHD” Member of the Host Innate Defense Response against Pathogenic Virus Infection

Alan G. Goodman, Jamie L. Fornek, Guruprasad R. Medigeshi, Lucy A. Perrone, Xinxia Peng, Matthew D. Dyer, Sean C. Proll, Sue E. Knoblaugh, Victoria S. Carter, Marcus J. Korth, Jay A. Nelson, Terrence M. Tumpey, Michael G. Katze

PLoS Pathog. 2009 May; 5(5): e1000438. Published online 2009 May 22. doi: 10.1371/journal.ppat.1000438

PMCID:: PMC2677460

Abstract Article PDF–816K

Select item 23741748.

Preliminary X-ray crystallographic studies of mouse UPR responsive protein P58(IPK) TPR fragment

Jiahui Tao, Yunkun Wu, David Ron, Bingdong Sha

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Feb 1; 64(Pt 2): 108–110. Published online 2008 Jan 31. doi: 10.1107/S1744309108000833

PMCID:: PMC2374174

Abstract Article PDF–255K

Select item 19517589.

The Role of p58^IPK in Protecting the Stressed Endoplasmic Reticulum

D. Thomas Rutkowski, Sang-Wook Kang, Alan G. Goodman, Jennifer L. Garrison, Jack Taunton, Michael G. Katze, Randal J. Kaufman, Ramanujan S. Hegde

Mol Biol Cell. 2007 Sep; 18(9): 3681–3691. doi: 10.1091/mbc.E07-03-0272

PMCID:: PMC1951758

Abstract Article PDF–1.8M

Select item 186591310.

The Cellular Protein P58^IPK Regulates Influenza Virus mRNA Translation and Replication through a PKR-Mediated Mechanism

Alan G. Goodman, Jennifer A. Smith, Siddharth Balachandran, Olivia Perwitasari, Sean C. Proll, Matthew J. Thomas, Marcus J. Korth, Glen N. Barber, Leslie A. Schiff, Michael G. Katze

J Virol. 2007 Mar; 81(5): 2221–2230. Published online 2006 Dec 13. doi: 10.1128/JVI.02151-06

PMCID:: PMC1865913

Abstract Article PDF–443K

Select item 451221411.

Antioxidants Complement the Requirement for Protein Chaperone Function to Maintain β-Cell Function and Glucose Homeostasis

Jaeseok Han, Benbo Song, Jiun Kim, Vamsi K. Kodali, Anita Pottekat, Miao Wang, Justin Hassler, Shiyu Wang, Subramaniam Pennathur, Sung Hoon Back, Michael G. Katze, Randal J. Kaufman

Diabetes. 2015 Aug; 64(8): 2892–2904. Published online 2015 Mar 20. doi: 10.2337/db14-1357

PMCID:: PMC4512214

Abstract Article PDF–3.1M

Select item 390105012.

Synthetic embryonic lethality upon deletion of the ER cochaperone p58^IPK and the ER stress sensor ATF6α

Javier A. Gomez, Heather M. Tyra, Diane DeZwaan McCabe, Alicia K. Olivier, D. Thomas Rutkowski

Biochem Biophys Res Commun. Author manuscript; available in PMC 2015 Jan 3.

Published in final edited form as: Biochem Biophys Res Commun. 2014 Jan 3; 443(1): 115–119. Published online 2013 Nov 22. doi: 10.1016/j.bbrc.2013.11.060

PMCID:: PMC3901050

Abstract Article PDF–1.6M

Select item 285199713.

Progressive renal injury from transgenic expression of human carbonic anhydrase IV folding mutants is enhanced by deficiency of p58^IPK

Rupak Datta, Gul N. Shah, Timothy S. Rubbelke, Abdul Waheed, Michael Rauchman, Alan G. Goodman, Michael G. Katze, William S. Sly

Proc Natl Acad Sci U S A. 2010 Apr 6; 107(14): 6448–6452. Published online 2010 Mar 22. doi: 10.1073/pnas.1001905107

PMCID:: PMC2851997

Abstract Article PDF–507K

Select item 505032314.

Disruption of Protein Processing in the Endoplasmic Reticulum of DYT1 Knock-in Mice Implicates Novel Pathways in Dystonia Pathogenesis

Genevieve Beauvais, Nicole M. Bode, Jaime L. Watson, Hsiang Wen, Kevin A. Glenn, Hiroyuki Kawano, N. Charles Harata, Michelle E. Ehrlich, Pedro Gonzalez-Alegre

J Neurosci. 2016 Oct 5; 36(40): 10245–10256. doi: 10.1523/JNEUROSCI.0669-16.2016

PMCID:: PMC5050323

Abstract Article PDF–3.1M

Select item 279214715.

Alteration of the unfolded protein response modifies neurodegeneration in a mouse model of Marinesco–Sjögren syndrome

Lihong Zhao, Christine Rosales, Kevin Seburn, David Ron, Susan L. Ackerman

Hum Mol Genet. 2010 Jan 1; 19(1): 25–35. Published online 2009 Oct 3. doi: 10.1093/hmg/ddp464

PMCID:: PMC2792147

Abstract Article PDF–564K

Select item 258078116.

Regulated association of misfolded endoplasmic reticulum lumenal proteins with P58/DNAJc3

Kseniya Petrova, Seiichi Oyadomari, Linda M Hendershot, David Ron

EMBO J. 2008 Nov 5; 27(21): 2862–2872. Published online 2008 Oct 16. doi: 10.1038/emboj.2008.199

PMCID:: PMC2580781

Abstract Article PDF–305K

Select item 13854017.

Control of PERK eIF2α kinase activity by the endoplasmic reticulum stress-induced molecular chaperone P58^IPK

Wei Yan, Christopher L. Frank, Marcus J. Korth, Bryce L. Sopher, Isabel Novoa, David Ron, Michael G. Katze

Proc Natl Acad Sci U S A. 2002 Dec 10; 99(25): 15920–15925. Published online 2002 Nov 22. doi: 10.1073/pnas.252341799

PMCID:: PMC138540

Abstract Article PDF–622K

Select item 506892518.

Hepatocyte DACH1 is Increased in Obesity Via Nuclear Exclusion of HDAC4 and Promotes Hepatic Insulin Resistance

Lale Ozcan, Devram S. Ghorpade, Ze Zheng, Jane Cristina de Souza, Ke Chen, Marc Bessler, Melissa Bagloo, Beth Schrope, Richard Pestell, Ira Tabas

Cell Rep. Author manuscript; available in PMC 2016 Oct 18.

Published in final edited form as: Cell Rep. 2016 Jun 7; 15(10): 2214–2225. Published online 2016 May 26. doi: 10.1016/j.celrep.2016.05.006

Correction in:: Cell Rep. 2022 Jun 21; 39(12): 111015.

PMCID:: PMC5068925

Abstract Article PDF–1.7M

Select item 291899919.

Coxsackievirus B3 Infection Activates the Unfolded Protein Response and Induces Apoptosis through Downregulation of p58^IPK and Activation of CHOP and SREBP1

Huifang M. Zhang, Xin Ye, Yue Su, Ji Yuan, Zhen Liu, David A. Stein, Decheng Yang

J Virol. 2010 Sep; 84(17): 8446–8459. Published online 2010 Jun 16. doi: 10.1128/JVI.01416-09

PMCID:: PMC2918999

Abstract Article PDF–2.0M

Select item 285953220.

Deficiency of Suppressor Enhancer Lin12 1 Like (SEL1L) in Mice Leads to Systemic Endoplasmic Reticulum Stress and Embryonic Lethality

Adam B. Francisco, Rajni Singh, Shuai Li, Anish K. Vani, Liu Yang, Robert J. Munroe, Giuseppe Diaferia, Marina Cardano, Ida Biunno, Ling Qi, John C. Schimenti, Qiaoming Long

J Biol Chem. 2010 Apr 30; 285(18): 13694–13703. Published online 2010 Mar 2. doi: 10.1074/jbc.M109.085340

PMCID:: PMC2859532

Abstract Article PDF–2.5M

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PMC Links for Gene (Select 100037258) (38)
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pyruvate dehydrogenase (acetyl-transferring) subunit E1 alpha [Saccharomyces cer...
pyruvate dehydrogenase (acetyl-transferring) subunit E1 alpha [Saccharomyces cerevisiae S288C]
gi|398365125|ref|NP_011105.4|

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