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Select item 101938771.

ACKnowledging the role of the Activated-Cdc42 associated kinase (ACK) in regulating protein stability in cancer

Samantha Hodder, Millie Fox, Ana Masara Binti Ahmad Mokhtar, Helen R. Mott, Darerca Owen

Small GTPases. 2023; 14(1): 14–25. Published online 2023 May 16. doi: 10.1080/21541248.2023.2212573

PMCID:: PMC10193877

Abstract Article PDF–2.6M

Select item 100474192.

Domain Architecture of the Nonreceptor Tyrosine Kinase Ack1

Yagmur Kan, YiTing Paung, Markus A. Seeliger, W. Todd Miller

Cells. 2023 Mar; 12(6): 900. Published online 2023 Mar 15. doi: 10.3390/cells12060900

PMCID:: PMC10047419

Abstract Article PDF–8.4M

Select item 79580053.

TNK2 promoted esophageal cancer progression via activating egfr‐akt signaling

Anqing Zhang, Rongxin Zhang, Zhiming Yang, Rui Tian

J Clin Lab Anal. 2021 Mar; 35(3): e23700. Published online 2021 Jan 23. doi: 10.1002/jcla.23700

PMCID:: PMC7958005

Abstract Article PDF–404K

Select item 79061484.

Identification of downstream signaling cascades of ACK1 and prognostic classifiers in non-small cell lung cancer

Jinhong Zhu, Yang Liu, Meng Zhao, Kui Cao, Jianqun Ma, Shiyun Peng

Aging (Albany NY) 2021 Feb 15; 13(3): 4482–4502. Published online 2021 Jan 20. doi: 10.18632/aging.202408

PMCID:: PMC7906148

Abstract Article PDF–4.9M

Select item 68542355.

Research Progress of the Functional Role of ACK1 in Breast Cancer

Xia Liu, Xuan Wang, Lifang Li, Baolin Han

Biomed Res Int. 2019; 2019: 1018034. Published online 2019 Oct 20. doi: 10.1155/2019/1018034

PMCID:: PMC6854235

Abstract Article PDF–1.0M

Select item 57925466.

Blockade of ACK1/TNK2 To Squelch the Survival of Prostate Cancer Stem-like Cells

Nupam P. Mahajan, Domenico Coppola, Jongphil Kim, Harshani R. Lawrence, Nicholas J. Lawrence, Kiran Mahajan

Sci Rep. 2018; 8: 1954. Published online 2018 Jan 31. doi: 10.1038/s41598-018-20172-z

PMCID:: PMC5792546

Abstract Article PDF–1.7M

Select item 53550477.

Amplification of ACK1 promotes gastric tumorigenesis via ECD-dependent p53 ubiquitination degradation

Song-Hui Xu, Jin-Zhou Huang, Min Chen, Ming Zeng, Fei-Yan Zou, De Chen, Guang-Rong Yan

Oncotarget. 2017 Feb 21; 8(8): 12705–12716. Published online 2015 Oct 20. doi: 10.18632/oncotarget.6194

PMCID:: PMC5355047

Abstract Article PDF–5.6M

Select item 51581298.

Involvement of Activated Cdc42 Kinase1 in Colitis and Colorectal Neoplasms

Chaolan Lv, Hongxiang Gu, Xinmei Zhao, Liyun Huang, Sanxi Zhou, Fachao Zhi

Med Sci Monit. 2016; 22: 4794–4802. Published online 2016 Dec 7. doi: 10.12659/MSM.902274

PMCID:: PMC5158129

Abstract Article PDF–673K

Select item 47473579.

Ack1 overexpression promotes metastasis and indicates poor prognosis of hepatocellular carcinoma

Xiong Lei, Yun-feng Li, Guo-dong Chen, Di-peng Ou, Xiao-xin Qiu, Chao-hui Zuo, Lian-Yue Yang

Oncotarget. 2015 Dec 1; 6(38): 40622–40641. Published online 2015 Oct 20. doi: 10.18632/oncotarget.5872

PMCID:: PMC4747357

Abstract Article PDF–12M

Select item 470354910.

Identification and characterization of Tyrosine Kinase Non-receptor 2 mutations in leukemia through integration of kinase inhibitor screening and genomic analysis

Julia E. Maxson, Melissa L. Abel, Jinhua Wang, Xianming Deng, Sina Reckel, Samuel B. Luty, Huahang Sun, Julie Gorenstein, Seamus Hughes, Daniel Bottomly, Beth Wilmot, Shannon K. McWeeney, Jerald Radich, Oliver Hantschel, Richard E Middleton, Nathanael S. Gray, Brian J. Druker, Jeffrey W. Tyner

Cancer Res. Author manuscript; available in PMC 2017 Jan 1.

Published in final edited form as: Cancer Res. 2016 Jan 1; 76(1): 127–138. Published online 2015 Dec 17. doi: 10.1158/0008-5472.CAN-15-0817

PMCID:: PMC4703549

Abstract Article PDF–1.3M

Select item 285626911.

Cancer-associated Mutations Activate the Nonreceptor Tyrosine Kinase Ack1

Victoria Prieto-Echagüe, Azad Gucwa, Barbara P. Craddock, Deborah A. Brown, W. Todd Miller

J Biol Chem. 2010 Apr 2; 285(14): 10605–10615. Published online 2010 Jan 28. doi: 10.1074/jbc.M109.060459

PMCID:: PMC2856269

Abstract Article PDF–1.7M

Select item 127610012.

Metastatic properties and genomic amplification of the tyrosine kinase gene ACK1

Edward Htun van der Horst, Yan Y. Degenhardt, Astrid Strelow, Anthony Slavin, Lawrence Chinn, Jessica Orf, Minqing Rong, Shyun Li, Lei-Hoon See, Ken Q. C. Nguyen, Timothy Hoey, Holger Wesche, Scott Powers

Proc Natl Acad Sci U S A. 2005 Nov 1; 102(44): 15901–15906. Published online 2005 Oct 24. doi: 10.1073/pnas.0508014102

PMCID:: PMC1276100

Abstract Article PDF–524K

Select item 1103435513.

ZNF692 promotes osteosarcoma cell proliferation, migration, and invasion through TNK2-mediated activation of the MEK/ERK pathway

Di Zheng, Zhun Wei, Chong Zhang, Wenda Liu, Changtian Gong, Fei Wu, Weichun Guo

Biol Direct. 2024; 19: 28. Published online 2024 Apr 22. doi: 10.1186/s13062-024-00472-3

PMCID:: PMC11034355

Abstract Article PDF–15M

Select item 1005283814.

Biochemical Studies of Systemic Lupus Erythematosus-Associated Mutations in Nonreceptor Tyrosine Kinases Ack1 and Brk

Yagmur Kan, YiTing Paung, Yunyoung Kim, Markus A. Seeliger, W. Todd Miller

Biochemistry. Author manuscript; available in PMC 2023 Mar 29.

Published in final edited form as: Biochemistry. 2023 Mar 21; 62(6): 1124–1137. Published online 2023 Feb 28. doi: 10.1021/acs.biochem.2c00685

PMCID:: PMC10052838

Abstract Article PDF–1.1M

Select item 552791315.

Somatic mutation in the ACK1 ubiquitin association domain enhances oncogenic signaling through EGFR regulation in renal cancer derived cells

Boon Tin Chua, Shu Jing Lim, Su Chin Tham, Wei Jie Poh, Axel Ullrich

Mol Oncol. 2010 Aug; 4(4): 323–334. Published online 2010 Mar 19. doi: 10.1016/j.molonc.2010.03.001

PMCID:: PMC5527913

Abstract Article PDF–1.0M

Select item 494664716.

Whole-Exome Sequencing in Familial Parkinson Disease

Janice L. Farlow, Laurie A. Robak, Kurt Hetrick, Kevin Bowling, Eric Boerwinkle, Zeynep H. Coban-Akdemir, Tomasz Gambin, Richard A. Gibbs, Shen Gu, Preti Jain, Joseph Jankovic, Shalini Jhangiani, Kaveeta Kaw, Dongbing Lai, Hai Lin, Hua Ling, Yunlong Liu, James R. Lupski, Donna Muzny, Paula Porter, Elizabeth Pugh, Janson White, Kimberly Doheny, Richard M. Myers, Joshua M. Shulman, Tatiana Foroud

JAMA Neurol. Author manuscript; available in PMC 2017 Jan 1.

Published in final edited form as: JAMA Neurol. 2016 Jan; 73(1): 68–75. doi: 10.1001/jamaneurol.2015.3266

PMCID:: PMC4946647

Abstract Article PDF–720K

Select item 425895517.

Mutational analysis of the tyrosine kinome in serous and clear cell endometrial cancer uncovers rare somatic mutations in TNK2 and DDR1

Meghan L Rudd, Hassan Mohamed, Jessica C Price, Andrea J O’Hara, Matthieu Le Gallo, Mary Ellen Urick, NISC Comparative Sequencing Program, Pedro Cruz, Suiyuan Zhang, Nancy F Hansen, Andrew K Godwin, Dennis C Sgroi, Tyra G Wolfsberg, James C Mullikin, Maria J Merino, Daphne W Bell

BMC Cancer. 2014; 14: 884. Published online 2014 Nov 26. doi: 10.1186/1471-2407-14-884

PMCID:: PMC4258955

Abstract Article PDF–502K

Select item 393089718.

Bosutinib inhibits migration and invasion via ack1 in kras mutant non-small cell lung cancer

Daniel SW Tan, Benjamin Haaland, Jia Min Gan, Su Chin Tham, Indrajit Sinha, Eng Huat Tan, Kiat Hon Lim, Angela Takano, Sai Sakktee Krisna, Minn Minn Myint Thu, Hoe Peng Liew, Axel Ullrich, Wan-Teck Lim, Boon Tin Chua

Mol Cancer. 2014; 13: 13. Published online 2014 Jan 24. doi: 10.1186/1476-4598-13-13

PMCID:: PMC3930897

Abstract Article PDF–2.9M

Select item 338116919.

Ack1-mediated Androgen Receptor Phosphorylation Modulates Radiation Resistance in Castration-resistant Prostate Cancer

Kiran Mahajan, Domenico Coppola, Bhupendra Rawal, Y. Ann Chen, Harshani R. Lawrence, Robert W. Engelman, Nicholas J. Lawrence, Nupam P. Mahajan

J Biol Chem. 2012 Jun 22; 287(26): 22112–22122. Published online 2012 May 7. doi: 10.1074/jbc.M112.357384

PMCID:: PMC3381169

Abstract Article PDF–2.6M

Select item 334989520.

Ack1 Tyrosine Kinase Activation Correlates with Pancreatic Cancer Progression

Kiran Mahajan, Domenico Coppola, Y. Ann Chen, Weiwei Zhu, Harshani R. Lawrence, Nicholas J. Lawrence, Nupam P. Mahajan

Am J Pathol. 2012 Apr; 180(4): 1386–1393. doi: 10.1016/j.ajpath.2011.12.028

PMCID:: PMC3349895

Abstract Article PDF–1.3M

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