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Items: 1 to 20 of 27

1.
RASGRP2 is a potential immune-related biomarker and regulates mitochondrial-dependent apoptosis in lung adenocarcinoma
Yongting Liu, Yanhong Ouyang, Ziyang Feng, Zhaohui Jiang, Jiayao Ma, Xin Zhou, Changjing Cai, Ying Han, Shan Zeng, Shanshan Liu, Hong Shen
Front Immunol. 2023; 14: 1100231. Published online 2023 Feb 3. doi: 10.3389/fimmu.2023.1100231
PMCID:
PMC9936229
AbstractArticlePDF–8.6M
2.
CalDAG-GEFI Deficiency in a Family with Symptomatic Heterozygous and Homozygous Carriers of a Likely Pathogenic Variant in RASGRP2
Sara Morais, Mónica Pereira, Catarina Lau, Ana Gonçalves, Catarina Monteiro, Marta Gonçalves, Jorge Oliveira, Lurdes Moreira, Eugénia Cruz, Rosário Santos, Margarida Lima
Int J Mol Sci. 2021 Nov; 22(22): 12423. Published online 2021 Nov 17. doi: 10.3390/ijms222212423
PMCID:
PMC8618213
AbstractArticlePDF–400K
3.
The Role of RASGRP2 in Vascular Endothelial Cells—A Mini Review
Jun-ichi Takino, Shouhei Miyazaki, Kentaro Nagamine, Takamitsu Hori
Int J Mol Sci. 2021 Oct; 22(20): 11129. Published online 2021 Oct 15. doi: 10.3390/ijms222011129
PMCID:
PMC8537898
AbstractArticlePDF–1.3M
4.
RasGRP2 inhibits glyceraldehyde-derived toxic advanced glycation end-products from inducing permeability in vascular endothelial cells
Jun-ichi Takino, Takuma Sato, Takumi Kanetaka, Kasumi Okihara, Kentaro Nagamine, Masayoshi Takeuchi, Takamitsu Hori
Sci Rep. 2021; 11: 2959. Published online 2021 Feb 3. doi: 10.1038/s41598-021-82619-0
PMCID:
PMC7859393
AbstractArticlePDF–1.7M
5.
RasGRP2 Structure, Function and Genetic Variants in Platelet Pathophysiology
Matthias Canault, Marie-Christine Alessi
Int J Mol Sci. 2020 Feb; 21(3): 1075. Published online 2020 Feb 6. doi: 10.3390/ijms21031075
PMCID:
PMC7037602
AbstractArticlePDF–1.4M
6.
Marked bleeding diathesis in patients with platelet dysfunction due to a novel mutation in RASGRP2, encoding CalDAG-GEFI (p.Gly305Asp)
Emilse Bermejo, Maria F Alberto, David S Paul, Aaron A Cook, Paquita Nurden, Analia Sanchez Luceros, Alan Nurden, Wolfgang Bergmeier
Platelets. Author manuscript; available in PMC 2019 May 1.
Published in final edited form as: Platelets. 2018 Jan; 29(1): 84–86. Published online 2017 Jul 20. doi: 10.1080/09537104.2017.1332759
PMCID:
PMC6492242
AbstractArticlePDF–395K
7.
Expanded repertoire of RASGRP2 variants responsible for platelet dysfunction and severe bleeding
Sarah K. Westbury, Matthias Canault, Daniel Greene, Emilse Bermejo, Katharine Hanlon, Michele P. Lambert, Carolyn M. Millar, Paquita Nurden, Samya G. Obaji, Shoshana Revel-Vilk, Chris Van Geet, Kate Downes, Sofia Papadia, Salih Tuna, Christopher Watt, NIHR BioResource–Rare Diseases Consortium, Kathleen Freson, Michael A. Laffan, Willem H. Ouwehand, Marie-Christine Alessi, Ernest Turro, Andrew D. Mumford
Blood. 2017 Aug 24; 130(8): 1026–1030. Prepublished online 2017 Jun 21. doi: 10.1182/blood-2017-03-776773
PMCID:
PMC5785798
AbstractArticle
8.
Structural Basis for the Failure of the C1 Domain of Ras Guanine Nucleotide Releasing Protein 2 (RasGRP2) to Bind Phorbol Ester with High Affinity
Agnes Czikora, Daniel J. Lundberg, Adelle Abramovitz, Nancy E. Lewin, Noemi Kedei, Megan L. Peach, Xiaoling Zhou, Raymond C. Merritt, Jr., Elizabeth A. Craft, Derek C. Braun, Peter M. Blumberg
J Biol Chem. 2016 May 20; 291(21): 11133–11147. Published online 2016 Mar 28. doi: 10.1074/jbc.M116.725333
PMCID:
PMC4900263
AbstractArticlePDF–3.0M
9.
Ras guanyl nucleotide releasing protein 2 affects cell viability and cell–matrix adhesion in ECV304 endothelial cells
Junichi Takino, Kentaro Nagamine, Takamitsu Hori
Cell Adh Migr. 2013 May 1; 7(3): 262–266. Published online 2013 Apr 5. doi: 10.4161/cam.24082
PMCID:
PMC3711991
AbstractArticlePDF–1.1M
10.
Novel mutations in RASGRP2, which encodes CalDAG-GEFI, abrogate Rap1 activation, causing platelet dysfunction
María Luisa Lozano, Aaron Cook, José María Bastida, David S. Paul, Gemma Iruin, Ana Rosa Cid, Rosa Adan-Pedroso, José Ramón González-Porras, Jesús María Hernández-Rivas, Sarah J. Fletcher, Ben Johnson, Neil Morgan, Francisca Ferrer-Marin, Vicente Vicente, John Sondek, Steve P. Watson, Wolfgang Bergmeier, José Rivera
Blood. 2016 Sep 1; 128(9): 1282–1289. Prepublished online 2016 May 27. doi: 10.1182/blood-2015-11-683102
PMCID:
PMC5009515
AbstractArticle
11.
Human CalDAG-GEFI gene (RASGRP2) mutation affects platelet function and causes severe bleeding
Matthias Canault, Dorsaf Ghalloussi, Charlotte Grosdidier, Marie Guinier, Claire Perret, Nadjim Chelghoum, Marine Germain, Hana Raslova, Franck Peiretti, Pierre E. Morange, Noemie Saut, Xavier Pillois, Alan T. Nurden, François Cambien, Anne Pierres, Timo K. van den Berg, Taco W. Kuijpers, Marie-Christine Alessi, David-Alexandre Tregouet
J Exp Med. 2014 Jun 30; 211(7): 1349–1362. doi: 10.1084/jem.20130477
PMCID:
PMC4076591
AbstractArticlePDF–3.1M
12.
Megakaryocytes derived from embryonic stem cells implicate CalDAG-GEFI in integrin signaling
Koji Eto, Ronan Murphy, Steve W. Kerrigan, Alessandra Bertoni, Heidi Stuhlmann, Toru Nakano, Andrew D. Leavitt, Sanford J. Shattil
Proc Natl Acad Sci U S A. 2002 Oct 1; 99(20): 12819–12824. Published online 2002 Sep 18. doi: 10.1073/pnas.202380099
PMCID:
PMC130543
AbstractArticlePDF–402K
13.
Calcium-RasGRP2-Rap1 signaling mediates CD38-induced migration of chronic lymphocytic leukemia cells
Silvia Mele, Stephen Devereux, Andrea G. Pepper, Elvira Infante, Anne J. Ridley
Blood Adv. 2018 Jul 10; 2(13): 1551–1561. Published online 2018 Jul 3. doi: 10.1182/bloodadvances.2017014506
PMCID:
PMC6039665
AbstractArticlePDF–1.6M
14.
A negative-feedback loop regulating ERK1/2 activation and mediated by RasGPR2 phosphorylation
Jinqi Ren, Aaron A. Cook, Wolfgang Bergmeier, John Sondek
Biochem Biophys Res Commun. Author manuscript; available in PMC 2017 May 20.
Published in final edited form as: Biochem Biophys Res Commun. 2016 May 20; 474(1): 193–198. Published online 2016 Apr 21. doi: 10.1016/j.bbrc.2016.04.100
PMCID:
PMC4872870
AbstractArticlePDF–1.1M
15.
A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia
Hiroaki Kawasaki, Gregory M. Springett, Shinichiro Toki, Juan J. Canales, Patricia Harlan, Justin P. Blumenstiel, Emy J. Chen, I. Amy Bany, Naoki Mochizuki, Amy Ashbacher, Michiyuki Matsuda, David E. Housman, Ann M. Graybiel
Proc Natl Acad Sci U S A. 1998 Oct 27; 95(22): 13278–13283. doi: 10.1073/pnas.95.22.13278
Correction in:
Proc Natl Acad Sci U S A. 1999 Jan 5; 96(1): 318.
PMCID:
PMC23782
AbstractArticlePDF–572K
16.
Genome-wide association study for serum urate concentrations and gout among African Americans identifies genomic risk loci and a novel URAT1 loss-of-function allele
Adrienne Tin, Owen M. Woodward, Wen Hong Linda Kao, Ching-Ti Liu, Xiaoning Lu, Michael A. Nalls, Daniel Shriner, Mariam Semmo, Ermeg L. Akylbekova, Sharon B. Wyatt, Shih-Jen Hwang, Qiong Yang, Alan B. Zonderman, Adebowale A. Adeyemo, Cameron Palmer, Yan Meng, Muredach Reilly, Michael G. Shlipak, David Siscovick, Michele K. Evans, Charles N. Rotimi, Michael F. Flessner, Michael Köttgen, L. Adrienne Cupples, Caroline S. Fox, Anna Köttgen
Hum Mol Genet. 2011 Oct 15; 20(20): 4056–4068. Published online 2011 Jul 18. doi: 10.1093/hmg/ddr307
PMCID:
PMC3177647
AbstractArticlePDF–256K
17.
Multiple roles of Rap1 in hematopoietic cells: complementary versus antagonistic functions
Philip J. S. Stork, Tara J. Dillon
Blood. 2005 Nov 1; 106(9): 2952–2961. Prepublished online 2005 Aug 2. doi: 10.1182/blood-2005-03-1062
PMCID:
PMC1895320
AbstractArticle
18.
A Genome-Wide Knockout Screen in Human Macrophages Identified Host Factors Modulating Salmonella Infection
Amy T. Y. Yeung, Yoon Ha Choi, Amy H. Y. Lee, Christine Hale, Hannes Ponstingl, Derek Pickard, David Goulding, Mark Thomas, Erin Gill, Jong Kyoung Kim, Allan Bradley, Robert E. W. Hancock, Gordon Dougan
mBio. 2019 Sep-Oct; 10(5): e02169-19. Published online 2019 Oct 8. doi: 10.1128/mBio.02169-19
PMCID:
PMC6786873
AbstractArticlePDF–2.2M
19.
Comparative Protein Interaction Network Analysis Identifies Shared and Distinct Functions for the Human ROCO Proteins
James E. Tomkins, Sybille Dihanich, Alexandra Beilina, Raffaele Ferrari, Nicolò Ilacqua, Mark R. Cookson, Patrick A. Lewis, Claudia Manzoni
Proteomics. 2018 May; 18(10): 1700444. Published online 2018 Apr 17. doi: 10.1002/pmic.201700444
PMCID:
PMC5992104
AbstractArticlePDF–1.2M
20.
PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα
Evelyn Ramberger, Valeria Sapozhnikova, Elisabeth Kowenz-Leutz, Karin Zimmermann, Nathalie Nicot, Petr V. Nazarov, Daniel Perez-Hernandez, Ulf Reimer, Philipp Mertins, Gunnar Dittmar, Achim Leutz
iScience. 2021 Jun 25; 24(6): 102686. Published online 2021 Jun 4. doi: 10.1016/j.isci.2021.102686
PMCID:
PMC8220391
AbstractArticlePDF–4.4M

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