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Items: 1 to 20 of 32

1.
circEXOC6B interacting with RRAGB, an mTORC1 activator, inhibits the progression of colorectal cancer by antagonizing the HIF1A-RRAGB-mTORC1 positive feedback loop
Xiaomin Li, Jianjun Wang, Weihao Lin, Qinzi Yuan, Yanxia Lu, Haowei Wang, Yujia Chen, Lixia Chen, Peiling Dai, Huaicheng Long, Xuenong Li
Mol Cancer. 2022; 21: 135. Published online 2022 Jun 23. doi: 10.1186/s12943-022-01600-1
PMCID:
PMC9219196
ArticlePDF–13M
2.
Elevated Ras related GTP binding B (RRAGB) expression predicts poor overall survival and constructs a prognostic nomogram for colon adenocarcinoma
Jianjia Xiao, Qingqing Liu, Weijie Wu, Ying Yuan, Jie Zhou, Jieyu Shi, Shaorong Zhou
Bioengineered. 2021; 12(1): 4620–4632. Published online 2021 Jul 29. doi: 10.1080/21655979.2021.1956402
PMCID:
PMC8806650
ArticlePDF–5.3M
3.
Dynamin-dependent amino acid endocytosis activates mechanistic target of rapamycin complex 1 (mTORC1)
Shusaku Shibutani, Hana Okazaki, Hiroyuki Iwata
J Biol Chem. 2017 Nov 3; 292(44): 18052–18061. Published online 2017 Aug 14. doi: 10.1074/jbc.M117.776443
PMCID:
PMC5672031
ArticlePDF–2.2M
4.
TRIM37 deficiency induces autophagy through deregulating the MTORC1-TFEB axis
Wei Wang, Zhijie Xia, Jean-Claude Farré, Suresh Subramani
Autophagy. 2018; 14(9): 1574–1585. Published online 2018 Aug 21. doi: 10.1080/15548627.2018.1463120
PMCID:
PMC6135569
ArticlePDF–2.3M
5.
mTor Regulates Lysosomal ATP-sensitive Two-Pore Na+ Channel to Adapt to Metabolic State
Chunlei Cang, Yandong Zhou, Betsy Navarro, Young-jun Seo, Kimberly Aranda, Lucy Shi, Shyuefang Battaglia-Hsu, Itzhak Nissim, David E. Clapham, Dejian Ren
Cell. Author manuscript; available in PMC 2014 Feb 14.
Published in final edited form as: Cell. 2013 Feb 14; 152(4): 778–790. Published online 2013 Feb 7. doi: 10.1016/j.cell.2013.01.023
PMCID:
PMC3908667
ArticlePDF–3.6M
6.
SH3BP4 is a negative regulator of amino acid-Rag GTPase-mTORC1 signaling
Young-Mi Kim, Matthew Stone, Tae Hyun Hwang, Yeon-Gil Kim, Jane R. Dunlevy, Timothy J. Griffin, Do-Hyung Kim
Mol Cell. Author manuscript; available in PMC 2013 Jun 29.
Published in final edited form as: Mol Cell. 2012 Jun 29; 46(6): 833–846. Published online 2012 May 9. doi: 10.1016/j.molcel.2012.04.007
PMCID:
PMC3389276
ArticlePDF–8.1M
7.
Regulation of TORC1 in response to amino acid starvation via lysosomal recruitment of TSC2
Constantinos Demetriades, Nikolaos Doumpas, Aurelio A. Teleman
Cell. Author manuscript; available in PMC 2015 Mar 2.
Published in final edited form as: Cell. 2014 Feb 13; 156(4): 786–799. doi: 10.1016/j.cell.2014.01.024
PMCID:
PMC4346203
ArticlePDF–2.7M
8.
Amino Acids Activate Mammalian Target of Rapamycin (mTOR) Complex 1 without Changing Rag GTPase Guanyl Nucleotide Charging
Noriko Oshiro, Joseph Rapley, Joseph Avruch
J Biol Chem. 2014 Jan 31; 289(5): 2658–2674. Published online 2013 Dec 11. doi: 10.1074/jbc.M113.528505
PMCID:
PMC3908400
ArticlePDF–2.6M
9.
Sestrins Function as Guanine Nucleotide Dissociation Inhibitors for Rag GTPases to Control mTORC1 Signaling
Min Peng, Na Yin, Ming O. Li
Cell. Author manuscript; available in PMC 2015 Sep 25.
Published in final edited form as: Cell. 2014 Sep 25; 159(1): 122–133. doi: 10.1016/j.cell.2014.08.038
PMCID:
PMC4181352
ArticlePDF–2.7M
10.
Recruitment of folliculin to lysosomes supports the amino acid–dependent activation of Rag GTPases
Constance S. Petit, Agnes Roczniak-Ferguson, Shawn M. Ferguson
J Cell Biol. 2013 Sep 30; 202(7): 1107–1122. doi: 10.1083/jcb.201307084
PMCID:
PMC3787382
ArticlePDF–4.1M
11.
The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1
Yasemin Sancak, Timothy R. Peterson, Yoav D. Shaul, Robert A. Lindquist, Carson C. Thoreen, Liron Bar-Peled, David M. Sabatini
Science. Author manuscript; available in PMC 2008 Jul 18.
Published in final edited form as: Science. 2008 Jun 13; 320(5882): 1496–1501. Published online 2008 May 22. doi: 10.1126/science.1157535
PMCID:
PMC2475333
ArticlePDF–1.6M
12.
p62 is a key regulator of nutrient sensing in the mTORC1 pathway
Angeles Duran, Ramars Amanchy, Juan F. Linares, Jayashree Joshi, Shadi Abu-Baker, Alexey Porollo, Malene Hansen, Jorge Moscat, Maria T. Diaz-Meco
Mol Cell. Author manuscript; available in PMC 2012 Oct 7.
Published in final edited form as: Mol Cell. 2011 Oct 7; 44(1): 134–146. doi: 10.1016/j.molcel.2011.06.038
PMCID:
PMC3190169
ArticlePDF–6.8M
13.
The amino acid transporter SLC38A9 is a key component of a lysosomal membrane complex that signals arginine sufficiency to mTORC1
Shuyu Wang, Zhi-Yang Tsun, Rachel Wolfson, Kuang Shen, Gregory A. Wyant, Molly E. Plovanich, Elizabeth D. Yuan, Tony D. Jones, Lynne Chantranupong, William Comb, Tim Wang, Liron Bar-Peled, Roberto Zoncu, Christoph Straub, Choah Kim, Jiwon Park, Bernardo L. Sabatini, David M. Sabatini
Science. Author manuscript; available in PMC 2015 Jan 15.
Published in final edited form as: Science. 2015 Jan 9; 347(6218): 188–194. Published online 2015 Jan 7. doi: 10.1126/science.1257132
PMCID:
PMC4295826
ArticlePDF–1.6M
14.
SLC38A9 is a component of the lysosomal amino acid-sensing machinery that controls mTORC1
Manuele Rebsamen, Lorena Pochini, Taras Stasyk, Mariana E. G. de Araújo, Michele Galluccio, Richard K. Kandasamy, Berend Snijder, Astrid Fauster, Elena L. Rudashevskaya, Manuela Bruckner, Stefania Scorzoni, Przemyslaw A. Filipek, Kilian V. M. Huber, Johannes Bigenzahn, Leonhard X. Heinz, Claudine Kraft, Keiryn L. Bennett, Cesare Indiveri, Lukas A. Huber, Giulio Superti-Furga
Nature. Author manuscript; available in PMC 2015 Sep 26.
Published in final edited form as: Nature. 2015 Mar 26; 519(7544): 477–481. Published online 2015 Jan 7. doi: 10.1038/nature14107
PMCID:
PMC4376665
ArticlePDF–2.4M
15.
TBK1 Provides Context-Selective Support of the Activated AKT/mTOR Pathway in Lung Cancer
Jonathan M. Cooper, Yi-Hung Ou, Elizabeth A. McMillan, Rachel M. Vaden, Aubhishek Zaman, Brian O. Bodemann, Gurbani Makkar, Bruce A. Posner, Michael A. White
Cancer Res. Author manuscript; available in PMC 2018 Sep 15.
Published in final edited form as: Cancer Res. 2017 Sep 15; 77(18): 5077–5094. Published online 2017 Jul 17. doi: 10.1158/0008-5472.CAN-17-0829
PMCID:
PMC5833933
ArticlePDF–2.9M
16.
SZT2 Dictates GATOR Control of mTORC1 Signaling
Min Peng, Na Yin, Ming O. Li
Nature. Author manuscript; available in PMC 2017 Aug 24.
Published in final edited form as: Nature. 2017 Mar 16; 543(7645): 433–437. Published online 2017 Feb 15. doi: 10.1038/nature21378
Correction in:
Nature. 2018 May 16
PMCID:
PMC5570594
ArticlePDF–2.1M
17.
An expanded Ragulator is a GEF for the Rag GTPases that signal amino acid levels to mTORC1
Liron Bar-Peled, Lawrence D. Schweitzer, Roberto Zoncu, David M. Sabatini
Cell. Author manuscript; available in PMC 2013 Mar 14.
Published in final edited form as: Cell. 2012 Sep 14; 150(6): 1196–1208. doi: 10.1016/j.cell.2012.07.032
PMCID:
PMC3517996
ArticlePDF–4.9M
18.
TRIMs and Galectins globally cooperate and TRIM16 and Galectin-3 co-direct autophagy in endomembrane damage homeostasis
Santosh Chauhan, Suresh Kumar, Ashish Jain, Marisa Ponpuak, Michal H. Mudd, Tomonori Kimura, Seong Won Choi, Ryan Peters, Michael Mandell, Jack-Ansgar Bruun, Terje Johansen, Vojo Deretic
Dev Cell. Author manuscript; available in PMC 2017 Oct 10.
Published in final edited form as: Dev Cell. 2016 Oct 10; 39(1): 13–27. Published online 2016 Sep 29. doi: 10.1016/j.devcel.2016.08.003
PMCID:
PMC5104201
ArticlePDF–2.0M
19.
A tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1
Liron Bar-Peled, Lynne Chantranupong, Andrew D. Cherniack, Walter W. Chen, Kathleen A. Ottina, Brian C. Grabiner, Eric D. Spear, Scott L. Carter, Matthew Meyerson, David M. Sabatini
Science. Author manuscript; available in PMC 2013 Jul 31.
Published in final edited form as: Science. 2013 May 31; 340(6136): 1100–1106. doi: 10.1126/science.1232044
PMCID:
PMC3728654
ArticlePDF–2.5M
20.
Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids
Yasemin Sancak, Liron Bar-Peled, Roberto Zoncu, Andrew L. Markhard, Shigeyuki Nada, David M. Sabatini
Cell. Author manuscript; available in PMC 2011 Jan 21.
Published in final edited form as: Cell. 2010 Apr 16; 141(2): 290–303. Published online 2010 Apr 8. doi: 10.1016/j.cell.2010.02.024
PMCID:
PMC3024592
ArticlePDF–5.5M

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