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Select item 75073601.

A novel TFG c.793C>G mutation in a Chinese pedigree with Charcot‐Marie‐Tooth disease 2

Ding‐Wen Wu, Yanfang Li, Xinzhen Yin, Baorong Zhang

Brain Behav. 2020 Sep; 10(9): e01724. Published online 2020 Jul 14. doi: 10.1002/brb3.1724

PMCID:: PMC7507360

Abstract Article PDF–580K

Select item 64886422.

Tropomyosin-receptor kinase fused gene (TFG) regulates lipid production in human sebocytes

So-Ra Choi, Yul-Lye Hwang, Soo Jung Kim, Kyung-Cheol Sohn, Chong Won Choi, Kyung Duck Park, Young Lee, Young-Joon Seo, Jeung-Hoon Lee, Seung-Phil Hong, Seong Jun Seo, Seong-Jin Kim, Chang Deok Kim

Sci Rep. 2019; 9: 6587. Published online 2019 Apr 29. doi: 10.1038/s41598-019-43209-3

PMCID:: PMC6488642

Abstract Article PDF–1.3M

Select item 61529363.

Pathogenic TFG Mutations Underlying Hereditary Spastic Paraplegia Impair Secretory Protein Trafficking and Axon Fasciculation

Erin L. Slosarek, Amber L. Schuh, Iryna Pustova, Adam Johnson, Jennifer Bird, Matthew Johnson, E.B. Frankel, Nilakshee Bhattacharya, Michael G. Hanna, Jordan E. Burke, David A. Ruhl, Kyle Quinney, Samuel Block, Jennifer L. Peotter, Edwin R Chapman, Michael D. Sheets, Samuel E. Butcher, Scott M. Stagg, Anjon Audhya

Cell Rep. Author manuscript; available in PMC 2018 Sep 24.

Published in final edited form as: Cell Rep. 2018 Aug 28; 24(9): 2248–2260. doi: 10.1016/j.celrep.2018.07.081

PMCID:: PMC6152936

Abstract Article PDF–3.4M

Select item 48850234.

TFG Promotes Organization of Transitional ER and Efficient Collagen Secretion

Janine McCaughey, Victoria J. Miller, Nicola L. Stevenson, Anna K. Brown, Annika Budnik, Kate J. Heesom, Dominic Alibhai, David J. Stephens

Cell Rep. 2016 May 24; 15(8): 1648–1659. Published online 2016 May 12. doi: 10.1016/j.celrep.2016.04.062

PMCID:: PMC4885023

Abstract Article

Select item 34155345.

The TRK-Fused Gene Is Mutated in Hereditary Motor and Sensory Neuropathy with Proximal Dominant Involvement

Hiroyuki Ishiura, Wataru Sako, Mari Yoshida, Toshitaka Kawarai, Osamu Tanabe, Jun Goto, Yuji Takahashi, Hidetoshi Date, Jun Mitsui, Budrul Ahsan, Yaeko Ichikawa, Atsushi Iwata, Hiide Yoshino, Yuishin Izumi, Koji Fujita, Kouji Maeda, Satoshi Goto, Hidetaka Koizumi, Ryoma Morigaki, Masako Ikemura, Naoko Yamauchi, Shigeo Murayama, Garth A. Nicholson, Hidefumi Ito, Gen Sobue, Masanori Nakagawa, Ryuji Kaji, Shoji Tsuji

Am J Hum Genet. 2012 Aug 10; 91(2): 320–329. doi: 10.1016/j.ajhg.2012.07.014

PMCID:: PMC3415534

Abstract Article PDF–1.6M

Select item 82148596.

Deregulation of CLTC interacts with TFG, facilitating osteosarcoma via the TGF‐beta and AKT/mTOR signaling pathways

Li Shijie, Pan Zhen, Qin Kang, Guo Hua, Yang Qingcheng, Cheng Dongdong

Clin Transl Med. 2021 Jun; 11(6): e377. Published online 2021 Jun 20. doi: 10.1002/ctm2.377

PMCID:: PMC8214859

Abstract Article PDF–9.8M

Select item 76551647.

TFG-maintaining stability of overlooked FANCD2 confers early DNA-damage response

Chi Ma, Kanani Hokutan, Yihang Shen, Manoj Nepal, Jin-Hee Kim, Jun Zhang, Peiwen Fei

Aging (Albany NY) 2020 Oct 31; 12(20): 20268–20284. Published online 2020 Oct 24. doi: 10.18632/aging.103782

PMCID:: PMC7655164

Abstract Article PDF–1.7M

Select item 43693168.

TFG clusters COPII-coated transport carriers and promotes early secretory pathway organization

Adam Johnson, Nilakshee Bhattacharya, Michael Hanna, Janice G Pennington, Amber L Schuh, Lei Wang, Marisa S Otegui, Scott M Stagg, Anjon Audhya

EMBO J. 2015 Mar 12; 34(6): 811–827. Published online 2015 Jan 16. doi: 10.15252/embj.201489032

PMCID:: PMC4369316

Abstract Article PDF–2.8M

Select item 36126789.

Inhibition of TFG function causes hereditary axon degeneration by impairing endoplasmic reticulum structure

Christian Beetz, Adam Johnson, Amber L. Schuh, Seema Thakur, Rita-Eva Varga, Thomas Fothergill, Nicole Hertel, Ewa Bomba-Warczak, Holger Thiele, Gudrun Nürnberg, Janine Altmüller, Renu Saxena, Edwin R. Chapman, Erik W. Dent, Peter Nürnberg, Anjon Audhya

Proc Natl Acad Sci U S A. 2013 Mar 26; 110(13): 5091–5096. Published online 2013 Mar 11. doi: 10.1073/pnas.1217197110

PMCID:: PMC3612678

Abstract Article PDF–933K

Select item 280573010.

TFG, a target of chromosome translocations in lymphoma and soft tissue tumors, fuses to GPR128 in healthy individuals

Andrew Chase, Thomas Ernst, Andreas Fiebig, Andrew Collins, Francis Grand, Philipp Erben, Andreas Reiter, Stefan Schreiber, Nicholas C.P. Cross

Haematologica. 2010 Jan; 95(1): 20–26. Published online 2009 Oct 1. doi: 10.3324/haematol.2009.011536

PMCID:: PMC2805730

Abstract Article PDF–362K

Select item 186721011.

Diversity of Genomic Breakpoints in TFG-ALK Translocations in Anaplastic Large Cell Lymphomas : Identification of a New TFG-ALK_XL Chimeric Gene with Transforming Activity

Luis Hernández, Sílvia Beà, Beatriz Bellosillo, Magda Pinyol, Brunangelo Falini, Antonino Carbone, German Ott, Andreas Rosenwald, Alberto Fernández, Karen Pulford, David Mason, Stephan W. Morris, Eugenio Santos, Elias Campo

Am J Pathol. 2002 Apr; 160(4): 1487–1494. doi: 10.1016/S0002-9440(10)62574-6

PMCID:: PMC1867210

Abstract Article PDF–219K

Select item 23086312.

The DNA rearrangement that generates the TRK-T3 oncogene involves a novel gene on chromosome 3 whose product has a potential coiled-coil domain.

A Greco, C Mariani, C Miranda, A Lupas, S Pagliardini, M Pomati, M A Pierotti

Mol Cell Biol. 1995 Nov; 15(11): 6118–6127. doi: 10.1128/mcb.15.11.6118

PMCID:: PMC230863

Summary PDF–732K

Select item 879572913.

TRK-fused gene (TFG) regulates ULK1 stability via TRAF3-mediated ubiquitination and protects macrophages from LPS-induced pyroptosis

Jian-Hong Shi, Chen Ling, Ting-Ting Wang, Li-Nuo Zhang, Wen-Wen Liu, Yan Qin, Ying-Hui Tan, Nai-Peng Cui, Zhi-Yu Ni

Cell Death Dis. 2022 Jan; 13(1): 93. Published online 2022 Jan 28. doi: 10.1038/s41419-022-04539-9

PMCID:: PMC8795729

Abstract Article PDF–5.3M

Select item 812691014.

TFG binds LC3C to regulate ULK1 localization and autophagosome formation

Marianna Carinci, Beatrice Testa, Matteo Bordi, Giacomo Milletti, Massimo Bonora, Laura Antonucci, Caterina Ferraina, Marta Carro, Mukesh Kumar, Donatella Ceglie, Franziska Eck, Roberta Nardacci, Francois le Guerroué, Stefania Petrini, Maria E Soriano, Ignazio Caruana, Valentina Doria, Maria Manifava, Camille Peron, Matteo Lambrughi, Valeria Tiranti, Christian Behrends, Elena Papaleo, Paolo Pinton, Carlotta Giorgi, Nicholas T Ktistakis, Franco Locatelli, Francesca Nazio, Francesco Cecconi

EMBO J. 2021 May 17; 40(10): e103563. Published online 2021 May 1. doi: 10.15252/embj.2019103563

PMCID:: PMC8126910

Abstract Article PDF–2.4M

Select item 515975615.

Hereditary spastic paraplegias: identification of a novel SPG57 variant affecting TFG oligomerization and description of HSP subtypes in Sudan

Liena E O Elsayed, Inaam N Mohammed, Ahlam A A Hamed, Maha A Elseed, Adam Johnson, Mathilde Mairey, Hassab Elrasoul S A Mohamed, Mohamed N Idris, Mustafa A M Salih, Sarah M El-sadig, Mahmoud E Koko, Ashraf Y O Mohamed, Laure Raymond, Marie Coutelier, Frédéric Darios, Rayan A Siddig, Ahmed K M A Ahmed, Arwa M A Babai, Hiba M O Malik, Zulfa M B M Omer, Eman O E Mohamed, Hanan B Eltahir, Nasr Aldin A Magboul, Elfatih E Bushara, Abdelrahman Elnour, Salah M Abdel Rahim, Abdelmoneim Alattaya, Mustafa I Elbashir, Muntaser E Ibrahim, Alexandra Durr, Anjon Audhya, Alexis Brice, Ammar E Ahmed, Giovanni Stevanin

Eur J Hum Genet. 2017 Jan; 25(1): 100–110. Published online 2016 Sep 7. doi: 10.1038/ejhg.2016.108

PMCID:: PMC5159756

Abstract Article PDF–2.2M

Select item 779022816.

TRK-Fused Gene (TFG), a protein involved in protein secretion pathways, is an essential component of the antiviral innate immune response

Kashif Aziz Khan, Alexandre Marineau, Priscilla Doyon, Mariana Acevedo, Étienne Durette, Anne-Claude Gingras, Marc J. Servant

PLoS Pathog. 2021 Jan; 17(1): e1009111. Published online 2021 Jan 7. doi: 10.1371/journal.ppat.1009111

PMCID:: PMC7790228

Abstract Article PDF–5.8M

Select item 236423717.

Biological activity of the thyroid TRK-T3 oncogene requires signalling through Shc

E Roccato, C Miranda, V Ranzi, M Gishizki, M A Pierotti, A Greco

Br J Cancer. 2002 Sep 9; 87(6): 645–653. Published online 2002 Sep 4. doi: 10.1038/sj.bjc.6600544

Correction in:: Br J Cancer. 2016 Jun 14; 114(12): e19.

PMCID:: PMC2364237

Abstract Article PDF–260K

Select item 408488018.

TRIM68 Negatively Regulates IFN-β Production by Degrading TRK Fused Gene, a Novel Driver of IFN-β Downstream of Anti-Viral Detection Systems

Claire Wynne, Elisa Lazzari, Siobhán Smith, Eoghan M. McCarthy, Joan Ní Gabhann, Lara E. Kallal, Rowan Higgs, Sally Ann Cryan, Christine A. Biron, Caroline A. Jefferies

PLoS One. 2014; 9(7): e101503. Published online 2014 Jul 7. doi: 10.1371/journal.pone.0101503

Correction in:: PLoS One. 2015; 10(2): e0117957.

PMCID:: PMC4084880

Abstract Article PDF–1.2M

Select item 962739119.

TFG mutation induces haploinsufficiency and drives axonal Charcot–Marie–Tooth disease by causing neurite degeneration

Xihui Chen, Fangfang Liu, Kun Chen, Yufeng Wang, Anan Yin, Xiaowei Kang, Shanming Yang, Hanwen Zhao, Songqi Dong, Yunqing Li, Jing Chen, Yuanming Wu

CNS Neurosci Ther. 2022 Dec; 28(12): 2076–2089. Published online 2022 Aug 19. doi: 10.1111/cns.13943

PMCID:: PMC9627391

Abstract Article PDF–8.2M

Select item 331122120.

Mechanisms by which TFG functions in protein secretion and oncogenesis

Kristen Witte, Amber L. Schuh, Jan Hegermann, Ali Sarkeshik, Jonathan R. Mayers, Katrin Schwarze, John R. Yates, III, Stefan Eimer, Anjon Audhya

Nat Cell Biol. Author manuscript; available in PMC 2012 Mar 23.

Published in final edited form as: Nat Cell Biol. 2011 May; 13(5): 550–558. Published online 2011 Apr 10. doi: 10.1038/ncb2225

PMCID:: PMC3311221

Abstract Article PDF–2.0M

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