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Select item 101757261.

MICU1 occludes the mitochondrial calcium uniporter in divalent-free conditions

Macarena Rodríguez-Prados, Elena Berezhnaya, Maria Teresa Castromonte, Sergio L. Menezes-Filho, Melanie Paillard, György Hajnóczky

Proc Natl Acad Sci U S A. 2023 May 9; 120(19): e2218999120. Published online 2023 May 1. doi: 10.1073/pnas.2218999120

PMCID:: PMC10175726

Abstract Article PDF–1.1M

Select item 101200412.

Evidence supporting the MICU1 occlusion mechanism and against the potentiation model in the mitochondrial calcium uniporter complex

Chen-Wei Tsai, Tsung-Yun Liu, Fan-Yi Chao, Yung-Chi Tu, Madison X. Rodriguez, Anna M. Van Keuren, Zhiwei Ma, John Bankston, Ming-Feng Tsai

Proc Natl Acad Sci U S A. 2023 Apr 18; 120(16): e2217665120. Published online 2023 Apr 10. doi: 10.1073/pnas.2217665120

PMCID:: PMC10120041

Abstract Article PDF–3.5M

Select item 67002023.

MICU1 controls cristae junction and spatially anchors mitochondrial Ca²⁺ uniporter complex

Benjamin Gottschalk, Christiane Klec, Gerd Leitinger, Eva Bernhart, René Rost, Helmut Bischof, Corina T. Madreiter-Sokolowski, Snježana Radulović, Emrah Eroglu, Wolfgang Sattler, Markus Waldeck-Weiermair, Roland Malli, Wolfgang F. Graier

Nat Commun. 2019; 10: 3732. Published online 2019 Aug 19. doi: 10.1038/s41467-019-11692-x

PMCID:: PMC6700202

Abstract Article PDF–5.0M

Select item 54775074.

MICU1 drives glycolysis and chemoresistance in ovarian cancer

Prabir K. Chakraborty, Soumyajit Banerjee Mustafi, Xunhao Xiong, Shailendra Kumar Dhar Dwivedi, Vasyl Nesin, Sounik Saha, Min Zhang, Danny Dhanasekaran, Muralidharan Jayaraman, Robert Mannel, Kathleen Moore, Scott McMeekin, Da Yang, Rosemary Zuna, Kai Ding, Leonidas Tsiokas, Resham Bhattacharya, Priyabrata Mukherjee

Nat Commun. 2017; 8: 14634. Published online 2017 May 22. doi: 10.1038/ncomms14634

PMCID:: PMC5477507

Abstract Article PDF–2.4M

Select item 54248855.

Pathological consequences of MICU1 mutations on mitochondrial calcium signalling and bioenergetics

Gauri Bhosale, Jenny A. Sharpe, Amanda Koh, Antonina Kouli, Gyorgy Szabadkai, Michael R. Duchen

Biochim Biophys Acta. 2017 Jun; 1864(6): 1009–1017. doi: 10.1016/j.bbamcr.2017.01.015

PMCID:: PMC5424885

Abstract Article

Select item 39196286.

MICU1 Motifs Define Mitochondrial Calcium Uniporter Binding and Activity

Nicholas E. Hoffman, Harish C. Chandramoorthy, Santhanam Shamugapriya, Xueqian Zhang, Sudarsan Rajan, Karthik Mallilankaraman, Rajesh Kumar Gandhirajan, Ronald J. Vagnozzi, Lukas M. Ferrer, Krishnalatha Sreekrishnanilayam, Kalimuthusamy Natarajaseenivasan, Sandhya Vallem, Thomas Force, Eric T. Choi, Joseph Y. Cheung, Muniswamy Madesh

Cell Rep. Author manuscript; available in PMC 2014 Dec 26.

Published in final edited form as: Cell Rep. 2013 Dec 26; 5(6): 1576–1588. Published online 2013 Dec 12. doi: 10.1016/j.celrep.2013.11.026

PMCID:: PMC3919628

Abstract Article PDF–6.4M

Select item 36825617.

Probing Novel Roles of the Mitochondrial Uniporter in Ovarian Cancer Cells Using Nanoparticles

Rochelle R. Arvizo, Daniel F. Moyano, Sounik Saha, Michael A. Thompson, Resham Bhattacharya, Vincent M. Rotello, Y. S. Prakash, Priyabrata Mukherjee

J Biol Chem. 2013 Jun 14; 288(24): 17610–17618. Published online 2013 Apr 24. doi: 10.1074/jbc.M112.435206

PMCID:: PMC3682561

Abstract Article PDF–2.4M

Select item 36485558.

CBARA1 Plays a Role in Stemness and Proliferation of Human Embryonic Stem Cells

Kevin Chen, Lih-Tao Hsu, Cheng-Yi Wu, Shiun-Yin Chang, Hui-Ting Huang, Wannhsin Chen

PLoS One. 2013; 8(5): e63653. Published online 2013 May 8. doi: 10.1371/journal.pone.0063653

PMCID:: PMC3648555

Abstract Article PDF–1.7M

Select item 103883959.

MICU1 regulates mitochondrial cristae structure and function independently of the mitochondrial Ca²⁺ uniporter channel

Dhanendra Tomar, Manfred Thomas, Joanne F. Garbincius, Devin W. Kolmetzky, Oniel Salik, Pooja Jadiya, Suresh K. Joseph, April C. Carpenter, György Hajnóczky, John W. Elrod

Sci Signal. Author manuscript; available in PMC 2023 Oct 25.

Published in final edited form as: Sci Signal. 2023 Apr 25; 16(782): eabi8948. Published online 2023 Apr 25. doi: 10.1126/scisignal.abi8948

PMCID:: PMC10388395

Abstract Article PDF–3.3M

Select item 752792210.

The structure of the MICU1‐MICU2 complex unveils the regulation of the mitochondrial calcium uniporter

Wenping Wu, Qingya Shen, Ruiling Zhang, Zhiyu Qiu, Youjun Wang, Jimin Zheng, Zongchao Jia

EMBO J. 2020 Oct 1; 39(19): e104285. Published online 2020 Aug 13. doi: 10.15252/embj.2019104285

PMCID:: PMC7527922

Abstract Article PDF–4.0M

Select item 705537011.

Structure of the MICU1–MICU2 heterodimer provides insights into the gatekeeping threshold shift

Jongseo Park, Youngjin Lee, Taein Park, Jung Youn Kang, Sang A Mun, Minwoo Jin, Jihyeong Yang, Soo Hyun Eom

IUCrJ. 2020 Mar 1; 7(Pt 2): 355–365. Published online 2020 Feb 27. doi: 10.1107/S2052252520001840

PMCID:: PMC7055370

Abstract Article PDF–1.8M

Select item 700769112.

Dysregulation of Mitochondrial Ca²⁺ Uptake and Sarcolemma Repair Underlie Muscle Weakness and Wasting in Patients and Mice Lacking MICU1

Valentina Debattisti, Adam Horn, Raghavendra Singh, Erin L. Seifert, Marshall W. Hogarth, Davi A. Mazala, Kai Ting Huang, Rita Horvath, Jyoti K. Jaiswal, György Hajnóczky

Cell Rep. Author manuscript; available in PMC 2020 Feb 8.

Published in final edited form as: Cell Rep. 2019 Oct 29; 29(5): 1274–1286.e6. doi: 10.1016/j.celrep.2019.09.063

PMCID:: PMC7007691

Abstract Article PDF–1.4M

Select item 672690613.

The crystal structure of MICU2 provides insight into Ca²⁺ binding and MICU1‐MICU2 heterodimer formation

Wenping Wu, Qingya Shen, Zhen Lei, Zhiyu Qiu, Dan Li, Hairun Pei, Jimin Zheng, Zongchao Jia

EMBO Rep. 2019 Sep; 20(9): e47488. Published online 2019 Aug 9. doi: 10.15252/embr.201847488

PMCID:: PMC6726906

Abstract Article PDF–4.1M

Select item 633172114.

Akt‐mediated phosphorylation of MICU1 regulates mitochondrial Ca²⁺ levels and tumor growth

Saverio Marchi, Mariangela Corricelli, Alessio Branchini, Veronica Angela Maria Vitto, Sonia Missiroli, Giampaolo Morciano, Mariasole Perrone, Mattia Ferrarese, Carlotta Giorgi, Mirko Pinotti, Lorenzo Galluzzi, Guido Kroemer, Paolo Pinton

EMBO J. 2019 Jan 15; 38(2): e99435. Published online 2018 Nov 30. doi: 10.15252/embj.201899435

PMCID:: PMC6331721

Abstract Article PDF–2.2M

Select item 615510915.

Parkin-dependent regulation of the MCU complex component MICU1

Alessandra Matteucci, Maria Patron, Denis Vecellio Reane, Stefano Gastaldello, Salvatore Amoroso, Rosario Rizzuto, Marisa Brini, Anna Raffaello, Tito Calì

Sci Rep. 2018; 8: 14199. Published online 2018 Sep 21. doi: 10.1038/s41598-018-32551-7

Correction in:: Sci Rep. 2019; 9: 4665.

PMCID:: PMC6155109

Abstract Article PDF–2.2M

Select item 611274616.

MICU1 imparts the mitochondrial uniporter with the ability to discriminate between Ca²⁺ and Mn²⁺

Kimberli J. Kamer, Yasemin Sancak, Yevgenia Fomina, Joshua D. Meisel, Dipayan Chaudhuri, Zenon Grabarek, Vamsi K. Mootha

Proc Natl Acad Sci U S A. 2018 Aug 21; 115(34): E7960–E7969. Published online 2018 Aug 6. doi: 10.1073/pnas.1807811115

PMCID:: PMC6112746

Abstract Article PDF–1.0M

Select item 553842617.

High‐affinity cooperative Ca²⁺ binding by MICU1–MICU2 serves as an on–off switch for the uniporter

Kimberli J Kamer, Zenon Grabarek, Vamsi K Mootha

EMBO Rep. 2017 Aug; 18(8): 1397–1411. Published online 2017 Jun 14. doi: 10.15252/embr.201643748

PMCID:: PMC5538426

Abstract Article PDF–804K

Select item 474575018.

RPS3 regulates melanoma cell growth and apoptosis by targeting Cyto C/Ca²⁺/MICU1 dependent mitochondrial signaling

Yun Tian, Lijun Qin, Huijuan Qiu, Dingbo Shi, Rui Sun, Wenbing Li, Tianze Liu, Jingshu Wang, Tingting Xu, Wei Guo, Tiebang Kang, Wenlin Huang, Guowen Wang, Wuguo Deng

Oncotarget. 2015 Oct 6; 6(30): 29614–29625. Published online 2015 Aug 22. doi: 10.18632/oncotarget.4868

PMCID:: PMC4745750

Abstract Article PDF–7.6M

Select item 398969619.

MICU1 and MICU2 play nonredundant roles in the regulation of the mitochondrial calcium uniporter

Kimberli J Kamer, Vamsi K Mootha

EMBO Rep. 2014 Mar; 15(3): 299–307. Published online 2014 Feb 6. doi: 10.1002/embr.201337946

PMCID:: PMC3989696

Abstract Article PDF–1.2M

Select item 372206720.

MICU1 controls both the threshold and cooperative activation of the mitochondrial Ca²⁺ uniporter

György Csordás, Tünde Golenár, Erin L. Seifert, Kimberli J. Kamer, Yasemin Sancak, Fabiana Perocchi, Cynthia Moffat, David Weaver, Sergio de la Fuente Perez, Roman Bogorad, Victor Koteliansky, Jeffrey Adijanto, Vamsi K. Mootha, György Hajnóczky

Cell Metab. Author manuscript; available in PMC 2014 Jun 4.

Published in final edited form as: Cell Metab. 2013 Jun 4; 17(6): 976–987. doi: 10.1016/j.cmet.2013.04.020

PMCID:: PMC3722067

Abstract Article PDF–2.8M

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