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Select item 84124391.

Cancer-associated point mutations in the DLC1 tumor suppressor and other Rho-GAPs occur frequently and are associated with decreased function

Dunui Wang, Xiaolan Qian, Beatriz Sanchez-Solana, Brajendra K. Tripathi, Marian E. Durkin, Douglas R. Lowy

Cancer Res. Author manuscript; available in PMC 2021 Sep 2.

Published in final edited form as: Cancer Res. 2020 Sep 1; 80(17): 3568–3579. Published online 2020 Jun 30. doi: 10.1158/0008-5472.CAN-19-3984

PMCID:: PMC8412439

Abstract Article PDF–1.1M

Select item 68491122.

Sequencing Analysis at 8p23 Identifies Multiple Rare Variants in DLC1 Associated with Sleep-Related Oxyhemoglobin Saturation Level

Jingjing Liang, Brian E. Cade, Karen Y. He, Heming Wang, Jiwon Lee, Tamar Sofer, Stephanie Williams, Ruitong Li, Han Chen, Daniel J. Gottlieb, Daniel S. Evans, Xiuqing Guo, Sina A. Gharib, Lauren Hale, David R. Hillman, Pamela L. Lutsey, Sutapa Mukherjee, Heather M. Ochs-Balcom, Lyle J. Palmer, Jessica Rhodes, Shaun Purcell, Sanjay R. Patel, Richa Saxena, Katie L. Stone, Weihong Tang, Gregory J. Tranah, Eric Boerwinkle, Xihong Lin, Yongmei Liu, Bruce M. Psaty, Ramachandran S. Vasan, Michael H. Cho, Ani Manichaikul, Edwin K. Silverman, R. Graham Barr, Stephen S. Rich, Jerome I. Rotter, James G. Wilson, NHLBI Trans-Omics for Precision Medicine (TOPMed), TOPMed Sleep Working Group, Susan Redline, Xiaofeng Zhu

Am J Hum Genet. 2019 Nov 7; 105(5): 1057–1068. Published online 2019 Oct 24. doi: 10.1016/j.ajhg.2019.10.002

PMCID:: PMC6849112

Abstract Article PDF–2.1M

Select item 67194423.

SRC and ERK cooperatively phosphorylate DLC1 and attenuate its Rho-GAP and tumor suppressor functions

Brajendra K. Tripathi, Meghan F. Anderman, Xiaolan Qian, Ming Zhou, Dunrui Wang, Alex G. Papageorge, Douglas R. Lowy

J Cell Biol. 2019 Sep 2; 218(9): 3060–3076. Published online 2019 Jul 15. doi: 10.1083/jcb.201810098

PMCID:: PMC6719442

Abstract Article PDF–4.3M

Select item 61681434.

Quantitative phosphoproteomic analysis identifies novel functional pathways of tumor suppressor DLC1 in estrogen receptor positive breast cancer

Yesim Gökmen-Polar, Jason D. True, Edyta Vieth, Yuan Gu, Xiaoping Gu, Guihong D. Qi, Amber L. Mosley, Sunil S. Badve

PLoS One. 2018; 13(10): e0204658. Published online 2018 Oct 2. doi: 10.1371/journal.pone.0204658

PMCID:: PMC6168143

Abstract Article PDF–8.0M

Select item 52167125.

DLC1 is the principal biologically-relevant down-regulated DLC family member in several cancers

Dunrui Wang, Xiaolan Qian, Megha Rajaram, Marian E. Durkin, Douglas R. Lowy

Oncotarget. 2016 Jul 19; 7(29): 45144–45157. Published online 2016 May 10. doi: 10.18632/oncotarget.9266

PMCID:: PMC5216712

Abstract Article PDF–4.5M

Select item 51184006.

Aberrant DNA methylation of alternative promoter of DLC1 isoform 1 in meningiomas

M. Bujko, P. Kober, N. Rusetska, M. Wakuła, K. Goryca, E. Grecka, E. Matyja, J. Neska, T. Mandat, W. Bonicki, J. A. Siedlecki

J Neurooncol. 2016; 130(3): 473–484. Published online 2016 Sep 10. doi: 10.1007/s11060-016-2261-3

PMCID:: PMC5118400

Abstract Article PDF–2.4M

Select item 47433227.

DLC-1 is an independent prognostic marker and potential therapeutic target in hepatocellular cancer

L. J. Song, Q. Liu, X. R. Meng, SH. L Li, L. X. Wang, Q. X. Fan, X. Y. Xuan

Diagn Pathol. 2016; 11: 19. Published online 2016 Feb 4. doi: 10.1186/s13000-016-0470-x

PMCID:: PMC4743322

Abstract Article PDF–1.7M

Select item 45817528.

Low expression of DLC1 is predictive of poor therapeutic efficiency of fluoropyrimidine and oxaliplatin as adjuvant chemotherapy in gastric cancer

YUQI SU, LI LIN, JINGWEN ZHANG, YAQI JIANG, CHANGQIE PAN, LI SUN, JIANGMAN DUAN, WANGJUN LIAO

Mol Med Rep. 2015 Oct; 12(4): 5771–5779. Published online 2015 Aug 3. doi: 10.3892/mmr.2015.4173

PMCID:: PMC4581752

Abstract Article PDF–906K

Select item 45260539.

Significance of genetic variants in DLC1 and their association with hepatocellular carcinoma

CHENG-RONG XIE, HONG-GUANG SUN, YU SUN, WEN-XIU ZHAO, SHENG ZHANG, XIAO-MIN WANG, ZHEN-YU YIN

Mol Med Rep. 2015 Sep; 12(3): 4203–4209. Published online 2015 Jun 22. doi: 10.3892/mmr.2015.3970

PMCID:: PMC4526053

Abstract Article PDF–671K

Select item 440127810.

DLC-1:a Rho GTPase-activating protein and tumour suppressor

Marian E Durkin, Bao-Zhu Yuan, Xiaoling Zhou, Drazen B Zimonjic, Douglas R Lowy, Snorri S Thorgeirsson, Nicholas C Popescu

J Cell Mol Med. 2007 Sep; 11(5): 1185–1207. Published online 2007 Aug 13. doi: 10.1111/j.1582-4934.2007.00098.x

PMCID:: PMC4401278

Abstract Article PDF–656K

Select item 403259511.

Deleted in liver cancer-1 (DLC-1): An emerging metastasis suppressor gene

Nicholas C. Popescu, Steve Goodison

Mol Diagn Ther. Author manuscript; available in PMC 2015 Jun 1.

Published in final edited form as: Mol Diagn Ther. 2014 Jun; 18(3): 293–302. doi: 10.1007/s40291-014-0086-3

PMCID:: PMC4032595

Abstract Article PDF–302K

Select item 393860212.

Uncovering the Rare Variants of DLC1 Isoform 1 and Their Functional Effects in a Chinese Sporadic Congenital Heart Disease Cohort

Bin Lin, Yufeng Wang, Zhen Wang, Huilian Tan, Xianghua Kong, Yang Shu, Yuchao Zhang, Yun Huang, Yufei Zhu, Heng Xu, Zhiqiang Wang, Ping Wang, Guang Ning, Xiangyin Kong, Guohong Hu, Landian Hu

PLoS One. 2014; 9(2): e90215. Published online 2014 Feb 28. doi: 10.1371/journal.pone.0090215