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Select item 95421621.

Structural and molecular characterization of paraventricular thalamic glucokinase‐expressing neuronal circuits in the mouse

Sevasti Gaspari, Simon Quenneville, Ana Rodriguez Sanchez‐Archidona, Bernard Thorens, Sophie Croizier

J Comp Neurol. 2022 Aug; 530(11): 1773–1949. Published online 2022 Mar 18. doi: 10.1002/cne.25312

PMCID:: PMC9542162

Abstract Article PDF–28M

Select item 87704582.

Differential remodelling of mitochondrial subpopulations and mitochondrial dysfunction are a feature of early stage diabetes

Bodour S. Rajab, Sarah Kassab, Connor D. Stonall, Hussam Daghistani, Stephen Gibbons, Mamas Mamas, David Smith, Aleksandr Mironov, Zainab AlBalawi, Yin Hua Zhang, Florence Baudoin, Min Zi, Sukhpal Prehar, Elizabeth J. Cartwright, Ashraf Kitmitto

Sci Rep. 2022; 12: 978. Published online 2022 Jan 19. doi: 10.1038/s41598-022-04929-1

PMCID:: PMC8770458

Abstract Article PDF–4.0M

Select item 84819773.

Glucokinase neurons of the paraventricular nucleus of the thalamus sense glucose and decrease food consumption

Sébastien Kessler, Gwenaël Labouèbe, Sophie Croizier, Sevasti Gaspari, David Tarussio, Bernard Thorens

iScience. 2021 Oct 22; 24(10): 103122. Published online 2021 Sep 11. doi: 10.1016/j.isci.2021.103122

PMCID:: PMC8481977

Abstract Article PDF–5.5M

Select item 84098094.

Glucokinase is required for high‐starch diet‐induced β‐cell mass expansion in mice

Kazuhisa Tsuchida, Akinobu Nakamura, Hideaki Miyoshi, Kelaier Yang, Yuki Yamauchi, Shinichiro Kawata, Kazuno Omori, Kiyohiko Takahashi, Naoyuki Kitao, Hiroshi Nomoto, Hiraku Kameda, Kyu Yong Cho, Yusuke Seino, Yasuo Terauchi, Tatsuya Atsumi

J Diabetes Investig. 2021 Sep; 12(9): 1545–1554. Published online 2021 Mar 30. doi: 10.1111/jdi.13532

PMCID:: PMC8409809

Abstract Article PDF–1.1M

Select item 83795105.

Ablation of glucokinase-expressing tanycytes impacts energy balance and increases adiposity in mice

Antoine Rohrbach, Emilie Caron, Rafik Dali, Maxime Brunner, Roxane Pasquettaz, Irina Kolotuev, Federico Santoni, Bernard Thorens, Fanny Langlet

Mol Metab. 2021 Nov; 53: 101311. Published online 2021 Jul 26. doi: 10.1016/j.molmet.2021.101311

PMCID:: PMC8379510

Abstract Article PDF–5.3M

Select item 81171856.

Biphasic dynamics of beta cell mass in a mouse model of congenital hyperinsulinism: implications for type 2 diabetes

Sharona Tornovsky-Babeay, Noa Weinberg-Corem, Rachel Schyr Ben Haroush, Dana Avrahami, Judith Lavi, Eseye Feleke, Klaus H. Kaestner, Yuval Dor, Benjamin Glaser

Diabetologia. Author manuscript; available in PMC 2022 May 1.

Published in final edited form as: Diabetologia. 2021 May; 64(5): 1133–1143. Published online 2021 Feb 9. doi: 10.1007/s00125-021-05390-x

PMCID:: PMC8117185

Abstract Article PDF–790K

Select item 65416237.

Berberine alleviates hyperglycemia by targeting hepatic glucokinase in diabetic db/db mice

Meng Li, Yanqi Dang, Qiong Li, Wenjun Zhou, Jianping Zuo, Zemin Yao, Li Zhang, Guang Ji

Sci Rep. 2019; 9: 8003. Published online 2019 May 29. doi: 10.1038/s41598-019-44576-7

PMCID:: PMC6541623

Abstract Article PDF–4.1M

Select item 60313558.

Impaired β-cell glucokinase as an underlying mechanism in diet-induced diabetes

Brian Lu, Kiran Kurmi, Miguel Munoz-Gomez, Egon J. Jacobus Ambuludi, Jason M. Tonne, Kuntol Rakshit, Taro Hitosugi, Yogish C. Kudva, Aleksey V. Matveyenko, Yasuhiro Ikeda

Dis Model Mech. 2018 Jun 1; 11(6): dmm033316. Published online 2018 Jun 13. doi: 10.1242/dmm.033316

PMCID:: PMC6031355

Abstract Article

Select item 47427619.

Regulation of Glucokinase by Intracellular Calcium Levels in Pancreatic β Cells

Michele L. Markwardt, Kendra M. Seckinger, Mark A. Rizzo

J Biol Chem. 2016 Feb 5; 291(6): 3000–3009. Published online 2015 Dec 23. doi: 10.1074/jbc.M115.692160

PMCID:: PMC4742761

Abstract Article PDF–815K

Select item 416485810.

3-Dimensional histological reconstruction and imaging of the murine pancreas

Steven L. Ciciotte, Mark Lessard, Ellen C. Akeson, Elizabeth Cameron, Timothy M. Stearns, James M. Denegre, Jesus Ruberte, Karen L. Svenson

Mamm Genome. 2014; 25(9): 539–548. Published online 2014 May 18. doi: 10.1007/s00335-014-9522-2

PMCID:: PMC4164858

Abstract Article PDF–3.8M

Select item 396674411.

Characterization of the heterozygous glucokinase knockout mouse as a translational disease model for glucose control in type 2 diabetes

D J Baker, A M Atkinson, G P Wilkinson, G J Coope, A D Charles, B Leighton

Br J Pharmacol. 2014 Apr; 171(7): 1629–1641. Published online 2014 Mar 18. doi: 10.1111/bph.12498

PMCID:: PMC3966744

Abstract Article PDF–1.7M

Select item 323477912.

Generation of N-Ethyl-N-nitrosourea (ENU) Diabetes Models in Mice Demonstrates Genotype-specific Action of Glucokinase Activators

Deborah Fenner, Stella Odili, Hee-Kyung Hong, Yumiko Kobayashi, Akira Kohsaka, Sandra M. Siepka, Martha H. Vitaterna, Pan Chen, Bogumil Zelent, Joseph Grimsby, Joseph S. Takahashi, Franz M. Matschinsky, Joseph Bass

J Biol Chem. 2011 Nov 11; 286(45): 39560–39572. Published online 2011 Sep 15. doi: 10.1074/jbc.M111.269100

PMCID:: PMC3234779

Abstract Article PDF–2.2M

Select item 313831313.

Protective Effects of Dipeptidyl Peptidase-4 (DPP-4) Inhibitor against Increased β Cell Apoptosis Induced by Dietary Sucrose and Linoleic Acid in Mice with Diabetes

Jun Shirakawa, Kikuko Amo, Hirokazu Ohminami, Kazuki Orime, Yu Togashi, Yuzuru Ito, Kazuki Tajima, Megumi Koganei, Hajime Sasaki, Eiji Takeda, Yasuo Terauchi

J Biol Chem. 2011 Jul 22; 286(29): 25467–25476. Published online 2011 May 25. doi: 10.1074/jbc.M110.217216

PMCID:: PMC3138313

Abstract Article PDF–3.8M

Select item 306409814.

Diet-Induced Adipose Tissue Inflammation and Liver Steatosis Are Prevented by DPP-4 Inhibition in Diabetic Mice

Jun Shirakawa, Hideki Fujii, Kei Ohnuma, Koichiro Sato, Yuzuru Ito, Mitsuyo Kaji, Eri Sakamoto, Megumi Koganei, Hajime Sasaki, Yoji Nagashima, Kikuko Amo, Kazutaka Aoki, Chikao Morimoto, Eiji Takeda, Yasuo Terauchi

Diabetes. 2011 Apr; 60(4): 1246–1257. Published online 2011 Mar 22. doi: 10.2337/db10-1338

PMCID:: PMC3064098

Abstract Article PDF–2.3M

Select item 298833115.

Chronic Ethanol Consumption-induced Pancreatic β-Cell Dysfunction and Apoptosis through Glucokinase Nitration and Its Down-regulation

Ji Yeon Kim, Eun Hyun Song, Hyun Jung Lee, Yeo Kyoung Oh, Yoon Shin Park, Joo-Won Park, Bong Jo Kim, Dae Jin Kim, Inkyu Lee, Jihyun Song, Won-Ho Kim

J Biol Chem. 2010 Nov 26; 285(48): 37251–37262. Published online 2010 Sep 20. doi: 10.1074/jbc.M110.142315

PMCID:: PMC2988331

Abstract Article PDF–2.7M

Select item 217292216.

Regulation of β cell glucokinase by S-nitrosylation and association with nitric oxide synthase

Megan A. Rizzo, David W. Piston

J Cell Biol. 2003 Apr 28; 161(2): 243–248. doi: 10.1083/jcb.200301063

PMCID:: PMC2172922

Abstract Article PDF–182K

Select item 937382217.

MAP4K3/GLK inhibits Treg differentiation by direct phosphorylating IKKβ and inducing IKKβ-mediated FoxO1 nuclear export and Foxp3 downregulation

Jyun-Ni Chi, Jhih-Yu Yang, Chia-Hsin Hsueh, Ching-Yi Tsai, Huai-Chia Chuang, Tse-Hua Tan

Theranostics. 2022; 12(13): 5744–5760. Published online 2022 Jul 18. doi: 10.7150/thno.72148

PMCID:: PMC9373822

Abstract Article PDF–3.2M

Select item 797324918.

Genetic activation of α-cell glucokinase in mice causes enhanced glucose-suppression of glucagon secretion during normal and diabetic states

Varun Bahl, Catherine Lee May, Alanis Perez, Benjamin Glaser, Klaus H. Kaestner

Mol Metab. 2021 Jul; 49: 101193. Published online 2021 Feb 19. doi: 10.1016/j.molmet.2021.101193

PMCID:: PMC7973249

Abstract Article PDF–1.6M

Select item 642533819.

The APOE^∗3-Leiden Heterozygous Glucokinase Knockout Mouse as Novel Translational Disease Model for Type 2 Diabetes, Dyslipidemia, and Diabetic Atherosclerosis

Marianne G. Pouwer, Suvi E. Heinonen, Margareta Behrendt, Anne-Christine Andréasson, Arianne van Koppen, Aswin L. Menke, Elsbet J. Pieterman, Anita M. van den Hoek, J. Wouter Jukema, Brendan Leighton, Ann-Cathrine Jönsson-Rylander, Hans M. G. Princen

J Diabetes Res. 2019; 2019: 9727952. Published online 2019 Feb 21. doi: 10.1155/2019/9727952

PMCID:: PMC6425338

Abstract Article PDF–5.4M

Select item 619772320.

Molecular reductions in glucokinase activity increase counter-regulatory responses to hypoglycemia in mice and humans with diabetes

Ali J. Chakera, Paul S. Hurst, Gill Spyer, Emmanuel O. Ogunnowo-Bada, William J. Marsh, Christine H. Riches, Chen-Yu Yueh, S. Pauliina Markkula, Jeffrey W. Dalley, Roger D. Cox, Ian A. Macdonald, Stephanie A. Amiel, Kenneth M. MacLeod, Lora K. Heisler, Andrew T. Hattersley, Mark L. Evans

Mol Metab. 2018 Nov; 17: 17–27. Published online 2018 Aug 13. doi: 10.1016/j.molmet.2018.08.001

PMCID:: PMC6197723

Abstract Article PDF–1.3M

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PMC Links for Gene (Select 103988) (89)
PMC
PREDICTED: Mus musculus glucokinase (Gck), transcript variant X1, mRNA
PREDICTED: Mus musculus glucokinase (Gck), transcript variant X1, mRNA
gi|1907079481|ref|XM_006514443.5|

Nucleotide
PREDICTED: Mus musculus glucokinase (Gck), transcript variant X4, misc_RNA
PREDICTED: Mus musculus glucokinase (Gck), transcript variant X4, misc_RNA
gi|1907079484|ref|XR_004936676.1|

Nucleotide

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