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Select item 73595711.

The Hec1/Ndc80 tail domain is required for force generation at kinetochores, but is dispensable for kinetochore–microtubule attachment formation and Ska complex recruitment

Robert T. Wimbish, Keith F. DeLuca, Jeanne E. Mick, Jack Himes, Ignacio Jiménez-Sánchez, A. Arockia Jeyaprakash, Jennifer G. DeLuca

Mol Biol Cell. 2020 Jul 1; 31(14): 1453–1473. doi: 10.1091/mbc.E20-05-0286

PMCID:: PMC7359571

Article PDF–9.6M

Select item 60896002.

Measuring NDC80 binding reveals the molecular basis of tension-dependent kinetochore-microtubule attachments

Tae Yeon Yoo, Jeong-Mo Choi, William Conway, Che-Hang Yu, Rohit V Pappu, Daniel J Needleman

eLife. 2018; 7: e36392. Published online 2018 Jul 25. doi: 10.7554/eLife.36392

PMCID:: PMC6089600

Article PDF–5.1M

Select item 59262053.

Mechanism of Ska recruitment by Ndc80 complexes to kinetochores

Paweł Ł. Janczyk, Katarzyna A. Skorupka, John Tooley, Daniel R. Matson, Cortney A. Kestner, Thomas West, Owen Pornillos, P. Todd Stukenberg

Dev Cell. Author manuscript; available in PMC 2018 May 22.

Published in final edited form as: Dev Cell. 2017 May 22; 41(4): 438–449.e4. doi: 10.1016/j.devcel.2017.04.020

PMCID:: PMC5926205

Article PDF–2.6M

Select item 58061044.

Nuclear division cycle 80 promotes malignant progression and predicts clinical outcome in colorectal cancer

Xuebing Yan, Linsheng Huang, Liguo Liu, Huanlong Qin, Zhenshun Song

Cancer Med. 2018 Feb; 7(2): 420–432. Published online 2018 Jan 17. doi: 10.1002/cam4.1284

PMCID:: PMC5806104

Article PDF–830K

Select item 55027395.

Hec1 tail phosphorylation differentially regulates mammalian kinetochore coupling to polymerizing and depolymerizing microtubules

Alexandra F. Long, Dylan B. Udy, Sophie Dumont

Curr Biol. Author manuscript; available in PMC 2018 Jun 5.

Published in final edited form as: Curr Biol. 2017 Jun 5; 27(11): 1692–1699.e3. Published online 2017 May 25. doi: 10.1016/j.cub.2017.04.058

PMCID:: PMC5502739

Article PDF–1.4M

Select item 54494246.

Effect of NDC80 in human hepatocellular carcinoma

Lin-Ling Ju, Lin Chen, Jun-Hong Li, Yi-Fan Wang, Ru-Jian Lu, Zhao-Lian Bian, Jian-Guo Shao

World J Gastroenterol. 2017 May 28; 23(20): 3675–3683. Published online 2017 May 28. doi: 10.3748/wjg.v23.i20.3675

PMCID:: PMC5449424

Article PDF–1.6M

Select item 46605817.

The mitotic regulator Hec1 is a critical modulator of prostate cancer through the long non-coding RNA BX647187 in vitro

Haifeng Wang, Xu Gao, Xin Lu, Yan Wang, Chunfei Ma, Zhenkai Shi, Feng Zhu, Biming He, Chuanliang Xu, Yinghao Sun

Biosci Rep. 2015 Dec; 35(6): e00273. Published online 2015 Nov 26. doi: 10.1042/BSR20150003

PMCID:: PMC4660581

Article PDF–1.5M

Select item 44368298.

Multisite phosphorylation of the NDC80 complex gradually tunes its microtubule-binding affinity

Anatoly V. Zaytsev, Jeanne E. Mick, Evgeny Maslennikov, Boris Nikashin, Jennifer G. DeLuca, Ekaterina L. Grishchuk

Mol Biol Cell. 2015 May 15; 26(10): 1829–1844. doi: 10.1091/mbc.E14-11-1539

PMCID:: PMC4436829

Article PDF–6.5M

Select item 43590049.

MAPping the Ndc80 loop in cancer: A possible link between Ndc80/Hec1 overproduction and cancer formation

Ngang Heok Tang, Takashi Toda

Bioessays. 2015 Mar; 37(3): 248–256. Published online 2015 Jan 2. doi: 10.1002/bies.201400175

PMCID:: PMC4359004

Article PDF–1.8M

Select item 400279010.

Inhibition of Hec1 expression enhances the sensitivity of human ovarian cancer cells to paclitaxel

Qing-qing Mo, Ping-bo Chen, Xin Jin, Qian Chen, Lan Tang, Bei-bei Wang, Ke-zhen Li, Peng Wu, Yong Fang, Shi-xuan Wang, Jian-feng Zhou, Ding Ma, Gang Chen

Acta Pharmacol Sin. 2013 Apr; 34(4): 541–548. Published online 2013 Mar 11. doi: 10.1038/aps.2012.197

PMCID:: PMC4002790

Article PDF–3.6M

Select item 349254111.

Multi-modal microtubule binding by the Ndc80 kinetochore complex

Gregory M. Alushin, Vivek Musinipally, Daniel Matson, John Tooley, P. Todd Stukenberg, Eva Nogales

Nat Struct Mol Biol. Author manuscript; available in PMC 2013 May 1.

Published in final edited form as: Nat Struct Mol Biol. 2012 Nov; 19(11): 1161–1167. Published online 2012 Oct 21. doi: 10.1038/nsmb.2411

PMCID:: PMC3492541

Article PDF–1.1M

Select item 347954512.

The Ndc80 kinetochore complex directly modulates microtubule dynamics

Neil T. Umbreit, Daniel R. Gestaut, Jerry F. Tien, Breanna S. Vollmar, Tamir Gonen, Charles L. Asbury, Trisha N. Davis

Proc Natl Acad Sci U S A. 2012 Oct 2; 109(40): 16113–16118. Published online 2012 Aug 20. doi: 10.1073/pnas.1209615109

PMCID:: PMC3479545

Article PDF–1.5M

Select item 307806613.

The Ndc80 complex uses a tripartite attachment point to couple microtubule depolymerization to chromosome movement

John G. Tooley, Stephanie A. Miller, P. Todd Stukenberg

Mol Biol Cell. 2011 Apr 15; 22(8): 1217–1226. doi: 10.1091/mbc.E10-07-0626

PMCID:: PMC3078066

Article PDF–2.1M

Select item 305809914.

Expression analysis of mitotic spindle checkpoint genes in breast carcinoma: role of NDC80/HEC1 in early breast tumorigenicity, and a two-gene signature for aneuploidy

Ivan Bièche, Sophie Vacher, François Lallemand, Sengül Tozlu-Kara, Hind Bennani, Michèle Beuzelin, Keltouma Driouch, Etienne Rouleau, Florence Lerebours, Hugues Ripoche, Géraldine Cizeron-Clairac, Frédérique Spyratos, Rosette Lidereau

Mol Cancer. 2011; 10: 23. Published online 2011 Feb 27. doi: 10.1186/1476-4598-10-23