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Select item 111032531.

GPNMB Promotes Tumor Growth and is a Biomarker for Lymphangioleiomyomatosis

Erin Gibbons, Manisha Taya, Huixing Wu, Samia H Lopa, Joel Moss, Elizabeth P Henske, Francis X McCormack, Stephen R Hammes

Endocr Relat Cancer. Author manuscript; available in PMC 2024 Jun 1.

Published in final edited form as: Endocr Relat Cancer. 2024 Jun 1; 31(6): e230312. Published online 2024 May 9. doi: 10.1530/ERC-23-0312

PMCID:: PMC11103253

Abstract Article PDF–2.0M

Select item 110285542.

The immune inhibitory receptor osteoactivin is upregulated in monocyte-derived dendritic cells by BCR–ABL tyrosine kinase inhibitors

Mark-Alexander Schwarzbich, Michael Gutknecht, Julia Salih, Helmut R. Salih, Peter Brossart, Susanne M. Rittig, Frank Grünebach

Cancer Immunol Immunother. 2012 Feb; 61(2): 193–202. Published online 2011 Aug 27. doi: 10.1007/s00262-011-1096-1

PMCID:: PMC11028554

Abstract Article PDF–589K

Select item 107000203.

Glycoprotein Non-Metastatic Protein B (GPNMB): The Missing Link Between Lysosomes and Obesity

Valentina Bianco, Dagmar Kratky

Exp Clin Endocrinol Diabetes. 2023 Dec; 131(12): 639–645. Published online 2023 Nov 13. doi: 10.1055/a-2192-0101

PMCID:: PMC10700020

Abstract Article PDF–488K

Select item 98700364.

GPNMB confers risk for Parkinson’s disease through interaction with alpha-synuclein

Maria E. Diaz-Ortiz, Yunji Seo, Marijan Posavi, Marc Carceles Cordon, Elisia Clark, Nimansha Jain, Rakshita Charan, Michael D. Gallagher, Travis L. Unger, Noor Amari, R. Tyler Skrinak, Roseanne Davila-Rivera, Eliza M. Brody, Noah Han, Rebecca Zack, Vivianna M. Van Deerlin, Thomas F. Tropea, Kelvin C. Luk, Edward B. Lee, Daniel Weintraub, Alice S. Chen-Plotkin

Science. Author manuscript; available in PMC 2023 Feb 19.

Published in final edited form as: Science. 2022 Aug 19; 377(6608): eabk0637. Published online 2022 Aug 19. doi: 10.1126/science.abk0637

PMCID:: PMC9870036

Abstract Article PDF–2.1M

Select item 94372055.

GPNMB-Positive Cells in Head and Neck Squamous Cell Carcinoma—Their Roles in Cancer Stemness, Therapy Resistance, and Metastasis

Yohei Kawasaki, Hitomi Suzuki, Shinsuke Suzuki, Takechiyo Yamada, Maya Suzuki, Ayumi Ito, Haruka Hatakeyama, Masahito Miura, Yasufumi Omori

Pathol Oncol Res. 2022; 28: 1610450. Published online 2022 Aug 19. doi: 10.3389/pore.2022.1610450

PMCID:: PMC9437205

Abstract Article PDF–3.0M

Select item 93107816.

GPNMB expression identifies TSC1/2/mTOR‐associated and MiT family translocation‐driven renal neoplasms

Daniela C Salles, Kaushal Asrani, Juhyung Woo, Thiago Vidotto, Hans B Liu, Igor Vidal, Andres Matoso, George J Netto, Pedram Argani, Tamara L Lotan

J Pathol. 2022 Jun; 257(2): 158–171. Published online 2022 Mar 29. doi: 10.1002/path.5875

PMCID:: PMC9310781

Abstract Article PDF–40M

Select item 91074557.

Glycoprotein nonmetastatic melanoma protein B (GNMPB) as a novel biomarker for cerebral adrenoleukodystrophy

Leyla A. Taghizadeh, Carina J. King, David R. Nascene, Ashish O. Gupta, Paul J. Orchard, LeeAnn Higgins, Todd W. Markowski, Erin E. Nolan, Justin W. Furcich, Troy C. Lund

Sci Rep. 2022; 12: 7985. Published online 2022 May 14. doi: 10.1038/s41598-022-11552-7

PMCID:: PMC9107455

Abstract Article PDF–1.8M

Select item 81900948.

Expression pattern and prognostic impact of glycoprotein non-metastatic B (GPNMB) in triple-negative breast cancer

Yu-Hsiang Huang, Pei-Yi Chu, Ji-Lin Chen, Chun-Teng Huang, Chi-Cheng Huang, Yi‐Fang Tsai, Yu-Ling Wang, Pei-Ju Lien, Ling-Ming Tseng, Chun-Yu Liu

Sci Rep. 2021; 11: 12171. Published online 2021 Jun 9. doi: 10.1038/s41598-021-91588-3

PMCID:: PMC8190094

Abstract Article PDF–4.7M

Select item 80278149.

The soluble glycoprotein NMB (GPNMB) produced by macrophages induces cancer stemness and metastasis via CD44 and IL-33

M. Liguori, E. Digifico, A. Vacchini, R. Avigni, F. S. Colombo, E. M. Borroni, F. M. Farina, S. Milanesi, A. Castagna, L. Mannarino, I. Craparotta, S. Marchini, E. Erba, N. Panini, M. Tamborini, V. Rimoldi, P. Allavena, C. Belgiovine

Cell Mol Immunol. 2021 Mar; 18(3): 711–722. Published online 2020 Jul 29. doi: 10.1038/s41423-020-0501-0

PMCID:: PMC8027814

Abstract Article PDF–2.7M

Select item 779515110.

Intracerebroventricular Treatment with 2-Hydroxypropyl-β-Cyclodextrin Decreased Cerebellar and Hepatic Glycoprotein Nonmetastatic Melanoma Protein B (GPNMB) Expression in Niemann–Pick Disease Type C Model Mice

Madoka Fukaura, Yoichi Ishitsuka, Seiichi Shirakawa, Naoki Ushihama, Yusei Yamada, Yuki Kondo, Toru Takeo, Naomi Nakagata, Keiichi Motoyama, Taishi Higashi, Hidetoshi Arima, Yuki Kurauchi, Takahiro Seki, Hiroshi Katsuki, Katsumi Higaki, Muneaki Matsuo, Tetsumi Irie

Int J Mol Sci. 2021 Jan; 22(1): 452. Published online 2021 Jan 5. doi: 10.3390/ijms22010452

PMCID:: PMC7795151

Abstract Article PDF–3.2M

Select item 730873511.

GPNMB contributes to a vicious circle for chronic obstructive pulmonary disease

Xi-Juan Zhang, Zhong-Hua Cui, Yan Dong, Xiu-Wen Liang, Yan-Xin Zhao, Ancha Baranova, Hongbao Cao, Ling Wang

Biosci Rep. 2020 Jun 26; 40(6): BSR20194459. Published online 2020 Jun 19. doi: 10.1042/BSR20194459

PMCID:: PMC7308735

Abstract Article PDF–754K

Select item 674803412.

The glycoprotein GPNMB is selectively elevated in the substantia nigra of Parkinson’s disease patients and increases after lysosomal stress

Elizabeth B. Moloney, Alyssa Moskites, Eliza J. Ferrari, Ole Isacson, Penelope J. Hallett

Neurobiol Dis. Author manuscript; available in PMC 2019 Dec 1.

Published in final edited form as: Neurobiol Dis. 2018 Dec; 120: 1–11. Published online 2018 Aug 24. doi: 10.1016/j.nbd.2018.08.013

PMCID:: PMC6748034

Abstract Article PDF–1.5M

Select item 666480913.

A Human Organotypic Microfluidic Tumor Model Permits Investigation Of The Interplay Between Patient-Derived Fibroblasts And Breast Cancer Cells

Danh D. Truong, Alexander Kratz, Jin G. Park, Eric S. Barrientos, Harpinder Saini, Toan Nguyen, Barbara Pockaj, Ghassan Mouneimne, Joshua LaBaer, Mehdi Nikkhah

Cancer Res. Author manuscript; available in PMC 2019 Dec 15.

Published in final edited form as: Cancer Res. 2019 Jun 15; 79(12): 3139–3151. Published online 2019 Apr 16. doi: 10.1158/0008-5472.CAN-18-2293

PMCID:: PMC6664809

Abstract Article PDF–1.2M

Select item 660979714.

Role of the kringle‐like domain in glycoprotein NMB for its tumorigenic potential

Rudy Xie, Yukari Okita, Yumu Ichikawa, Muhammad Ali Fikry, Kim Tuyen Huynh Dam, Sophie Thi PhuongDung Tran, Mitsuyasu Kato

Cancer Sci. 2019 Jul; 110(7): 2237–2246. Published online 2019 Jun 26. doi: 10.1111/cas.14076

PMCID:: PMC6609797

Abstract Article PDF–1.4M

Select item 622257715.

Systems Genetics Approach to Biomarker Discovery: GPNMB and Heart Failure in Mice and Humans

Liang-Yu Lin, Sunny Chun Chang, Jim O’Hearn, Simon T. Hui, Marcus Seldin, Pritha Gupta, Galyna Bondar, Mario Deng, Raimo Jauhiainen, Johanna Kuusisto, Markku Laakso, Janet S. Sinsheimer, Arjun Deb, Christoph Rau, Shuxun Ren, Yibin Wang, Aldons J. Lusis, Jessica J. Wang, Adriana Huertas-Vazquez

G3 (Bethesda) 2018 Nov; 8(11): 3499–3506. Published online 2018 Sep 10. doi: 10.1534/g3.118.200655

PMCID:: PMC6222577

Abstract Article PDF–851K

Select item 621921216.

GPNMB methylation: a new marker of potentially carcinogenic colon lesions

Hassan Ashktorab, Hamed Rahi, Mehdi Nouraie, Babak Shokrani, Edward Lee, Tahmineh Haydari, Adeyinka O. Laiyemo, Peter Siegel, Hassan Brim

BMC Cancer. 2018; 18: 1068. Published online 2018 Nov 6. doi: 10.1186/s12885-018-4903-7

PMCID:: PMC6219212

Abstract Article PDF–2.2M

Select item 619468717.

Glycoprotein NMB: a novel Alzheimer’s disease associated marker expressed in a subset of activated microglia

Melanie Hüttenrauch, Isabella Ogorek, Hans Klafki, Markus Otto, Christine Stadelmann, Sascha Weggen, Jens Wiltfang, Oliver Wirths

Acta Neuropathol Commun. 2018; 6: 108. Published online 2018 Oct 19. doi: 10.1186/s40478-018-0612-3

PMCID:: PMC6194687

Abstract Article PDF–5.7M

Select item 616894118.

MAPK Pathway Inhibitors Sensitize BRAF Mutant Melanoma to an Antibody-Drug Conjugate Targeting GPNMB

April A. N. Rose, Matthew G. Annis, Dennie T. Frederick, Marco Biondini, Zhifeng Dong, Lawrence Kwong, Lynda Chin, Tibor Keler, Thomas Hawthorne, Ian R. Watson, Keith T. Flaherty, Peter M. Siegel

Clin Cancer Res. Author manuscript; available in PMC 2018 Oct 3.

Published in final edited form as: Clin Cancer Res. 2016 Dec 15; 22(24): 6088–6098. Published online 2016 Aug 11. doi: 10.1158/1078-0432.CCR-16-1192

PMCID:: PMC6168941

Abstract Article PDF–1.1M

Select item 598553619.

Loss of GPNMB Causes Autosomal-Recessive Amyloidosis Cutis Dyschromica in Humans

Chi-Fan Yang, Shuan-Pei Lin, Chien-Ping Chiang, Yu-Hung Wu, Weng Siong H’ng, Chun-Ping Chang, Yuan-Tsong Chen, Jer-Yuarn Wu

Am J Hum Genet. 2018 Feb 1; 102(2): 219–232. Published online 2018 Jan 11. doi: 10.1016/j.ajhg.2017.12.012

PMCID:: PMC5985536

Abstract Article PDF–3.9M

Select item 559212820.

OSTEOACTIVIN REGULATES HEAD AND NECK SQUAMOUS CELL CARCINOMA INVASION BY MODULATING MATRIX METALLOPROTEASES

Oneida A. Arosarena, Eric W. Barr, Ryan Thorpe, Hilary Yankey, Joseph T. Tarr, Fayez F. Safadi

J Cell Physiol. Author manuscript; available in PMC 2019 Jan 1.

Published in final edited form as: J Cell Physiol. 2018 Jan; 233(1): 409–421. Published online 2017 Apr 25. doi: 10.1002/jcp.25900

PMCID:: PMC5592128

Abstract Article PDF–794K

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PMC Links for Gene (Select 10457) (77)
PMC
Homo sapiens frizzled class receptor 4 (FZD4), mRNA
Homo sapiens frizzled class receptor 4 (FZD4), mRNA
gi|1519314218|ref|NM_012193.4|

Nucleotide
tu67a04.x1 NCI_CGAP_Gas4 Homo sapiens cDNA clone IMAGE:2256078 3', mRNA sequence
tu67a04.x1 NCI_CGAP_Gas4 Homo sapiens cDNA clone IMAGE:2256078 3', mRNA sequence
gi|4890065|gnl|dbEST|2579663|gb|AI6 .1|

Nucleotide
acid ceramidase isoform X1 [Homo sapiens]
acid ceramidase isoform X1 [Homo sapiens]
gi|530387776|ref|XP_005273561.1|

Protein

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