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Select item 69728951.

Investigating Chaperonin-Containing TCP-1 subunit 2 as an essential component of the chaperonin complex for tumorigenesis

Anne E. Showalter, Ana C. Martini, Daniel Nierenberg, Kristen Hosang, Naima Ahmed Fahmi, Priya Gopalan, Amr S. Khaled, Wei Zhang, Annette R. Khaled

Sci Rep. 2020; 10: 798. Published online 2020 Jan 21. doi: 10.1038/s41598-020-57602-w

PMCID:: PMC6972895

Abstract Article PDF–4.3M

Select item 50287372.

CCT2 Mutations Evoke Leber Congenital Amaurosis due to Chaperone Complex Instability

Yuriko Minegishi, XunLun Sheng, Kazutoshi Yoshitake, Yuri Sergeev, Daisuke Iejima, Yoshio Shibagaki, Norikazu Monma, Kazuho Ikeo, Masaaki Furuno, Wenjun Zhuang, Yani Liu, Weining Rong, Seisuke Hattori, Takeshi Iwata

Sci Rep. 2016; 6: 33742. Published online 2016 Sep 20. doi: 10.1038/srep33742

PMCID:: PMC5028737

Abstract Article PDF–2.0M

Select item 29190273.

Association of the Influenza Virus RNA Polymerase Subunit PB2 with the Host Chaperonin CCT

Tatiana Fislová, Benjamin Thomas, Katy M. Graef, Ervin Fodor

J Virol. 2010 Sep; 84(17): 8691–8699. Published online 2010 Jun 23. doi: 10.1128/JVI.00813-10

PMCID:: PMC2919027

Abstract Article PDF–797K

Select item 36915974.

Clinicopathological features and CCT2 and PDIA2 expression in gallbladder squamous/adenosquamous carcinoma and gallbladder adenocarcinoma

Qiong Zou, Zhu-lin Yang, Yuan Yuan, Jing-he Li, Lu-feng Liang, Gui-xiang Zeng, Sen-lin Chen

World J Surg Oncol. 2013; 11: 143. Published online 2013 Jun 19. doi: 10.1186/1477-7819-11-143

PMCID:: PMC3691597

Abstract Article PDF–1.3M

Select item 59741855.

Uncovering the genetic lesions underlying the most severe form of Hirschsprung disease by whole-genome sequencing

Clara SM Tang, Xuehan Zhuang, Wai-Yee Lam, Elly Sau-Wai Ngan, Jacob Shujui Hsu, YU Michelle, SO Man-Ting, Stacey S Cherny, Ngoc Diem Ngo, Pak C Sham, Paul KH Tam, Maria-Mercè Garcia-Barcelo

Eur J Hum Genet. 2018 Jun; 26(6): 818–826. Published online 2018 Feb 26. doi: 10.1038/s41431-018-0129-z

PMCID:: PMC5974185

Abstract Article PDF–764K

Select item 26856766.

p90 Ribosomal S6 Kinase and p70 Ribosomal S6 Kinase Link Phosphorylation of the Eukaryotic Chaperonin Containing TCP-1 to Growth Factor, Insulin, and Nutrient Signaling

Yuki Abe, Sang-Oh Yoon, Kazuishi Kubota, Michelle C. Mendoza, Steven P. Gygi, John Blenis

J Biol Chem. 2009 May 29; 284(22): 14939–14948. doi: 10.1074/jbc.M900097200

PMCID:: PMC2685676

Abstract Article PDF–803K

Select item 1093397.

Maturation of Human Cyclin E Requires the Function of Eukaryotic Chaperonin CCT

Kwang-Ai Won, Robert J. Schumacher, George W. Farr, Arthur L. Horwich, Steven I. Reed

Mol Cell Biol. 1998 Dec; 18(12): 7584–7589. doi: 10.1128/mcb.18.12.7584

PMCID:: PMC109339

Abstract Article PDF–360K

Select item 39243108.

Programmed Cell Death Protein 5 Interacts with the Cytosolic Chaperonin Containing Tailless Complex Polypeptide 1 (CCT) to Regulate β-Tubulin Folding

Christopher M. Tracy, Amy J. Gray, Jorge Cuéllar, Tanner S. Shaw, Alyson C. Howlett, Ryan M. Taylor, John T. Prince, Natalie G. Ahn, José M. Valpuesta, Barry M. Willardson

J Biol Chem. 2014 Feb 14; 289(7): 4490–4502. Published online 2013 Dec 27. doi: 10.1074/jbc.M113.542159

PMCID:: PMC3924310

Abstract Article PDF–2.4M

Select item 39114969.

Sangjune Kim, Do-Young Park, Dohyun Lee, Wanil Kim, Young-Hun Jeong, Juhyun Lee, Sung-Kee Chung, Hyunjung Ha, Bo-Hwa Choi, Kyong-Tai Kim

Mol Cell Biol. 2014 Feb; 34(4): 643–652. doi: 10.1128/MCB.00756-13

PMCID:: PMC3911496

Abstract Article PDF–1.7M

Select item 1001410210.

The ubiquitin ligase TRIM21 regulates mutant p53 accumulation and gain of function in cancer

Juan Liu, Cen Zhang, Dandan Xu, Tianliang Zhang, Chun-Yuan Chang, Jianming Wang, Jie Liu, Lanjing Zhang, Bruce G. Haffty, Wei-Xing Zong, Wenwei Hu, Zhaohui Feng

J Clin Invest. 2023 Mar 15; 133(6): e164354. Published online 2023 Mar 15. doi: 10.1172/JCI164354

PMCID:: PMC10014102

Abstract Article PDF–18M

Select item 424608911.

The Molecular Chaperone TRiC/CCT Binds to the Trp-Asp 40 (WD40) Repeat Protein WDR68 and Promotes Its Folding, Protein Kinase DYRK1A Binding, and Nuclear Accumulation

Yoshihiko Miyata, Takeshi Shibata, Masato Aoshima, Takuichi Tsubata, Eisuke Nishida

J Biol Chem. 2014 Nov 28; 289(48): 33320–33332. Published online 2014 Oct 22. doi: 10.1074/jbc.M114.586115

PMCID:: PMC4246089

Abstract Article PDF–2.6M

Select item 764229512.

Dlec1 is required for spermatogenesis and male fertility in mice

Yu Okitsu, Mamoru Nagano, Takahiro Yamagata, Chizuru Ito, Kiyotaka Toshimori, Hideo Dohra, Wataru Fujii, Keiichiro Yogo

Sci Rep. 2020; 10: 18883. Published online 2020 Nov 3. doi: 10.1038/s41598-020-75957-y

PMCID:: PMC7642295

Abstract Article PDF–2.3M

Select item 187711913.

Functional Interaction between Phosducin-like Protein 2 and Cytosolic Chaperonin Is Essential for Cytoskeletal Protein Function and Cell Cycle Progression

Peter C. Stirling, Martin Srayko, Karam S. Takhar, Andrei Pozniakovsky, Anthony A. Hyman, Michel R. Leroux

Mol Biol Cell. 2007 Jun; 18(6): 2336–2345. doi: 10.1091/mbc.E07-01-0069

PMCID:: PMC1877119

Abstract Article PDF–1.0M

Select item 662958214.

The chaperonin TRiC/CCT associates with Prefoldin through a conserved electrostatic interface essential for cellular proteostasis

Daniel Gestaut, Soung Hun Roh, Boxue Ma, Grigore Pintilie, Lukasz A. Joachimiak, Alexander Leitner, Thomas Walzthoeni, Ruedi Aebersold, Wah Chiu, Judith Frydman

Cell. Author manuscript; available in PMC 2020 Apr 18.

Published in final edited form as: Cell. 2019 Apr 18; 177(3): 751–765.e15. Published online 2019 Apr 4. doi: 10.1016/j.cell.2019.03.012

PMCID:: PMC6629582

Abstract Article PDF–4.1M

Select item 358162315.

Human TRiC complex purified from HeLa cells contains all eight CCT subunits and is active in vitro

Kelly M. Knee, Oksana A. Sergeeva, Jonathan A. King

Cell Stress Chaperones. 2013 Mar; 18(2): 137–144. Published online 2012 Aug 13. doi: 10.1007/s12192-012-0357-z

PMCID:: PMC3581623

Abstract Article PDF–377K

Select item 354260816.

Targeting β-tubulin:CCT-β complexes incurs Hsp90- and VCP-related protein degradation and induces ER stress-associated apoptosis by triggering capacitative Ca²⁺ entry, mitochondrial perturbation and caspase overactivation

Y-F Lin, Y-F Lee, P-H Liang

Cell Death Dis. 2012 Nov; 3(11): e434. Published online 2012 Nov 29. doi: 10.1038/cddis.2012.173

PMCID:: PMC3542608

Abstract Article PDF–3.5M

Select item 766091117.

The prefoldin complex stabilizes the von Hippel-Lindau protein against aggregation and degradation

Franck Chesnel, Anne Couturier, Adrien Alusse, Jean-Philippe Gagné, Guy G. Poirier, Dominique Jean, François-Michel Boisvert, Pauline Hascoet, Luc Paillard, Yannick Arlot-Bonnemains, Xavier Le Goff

PLoS Genet. 2020 Nov; 16(11): e1009183. Published online 2020 Nov 2. doi: 10.1371/journal.pgen.1009183

PMCID:: PMC7660911

Abstract Article PDF–3.5M

Select item 662306618.

Parkin Interacts with Ambra1 to Induce Mitophagy

Cindy Van Humbeeck, Tom Cornelissen, Hilde Hofkens, Wim Mandemakers, Kris Gevaert, Bart De Strooper, Wim Vandenberghe

J Neurosci. 2011 Jul 13; 31(28): 10249–10261. doi: 10.1523/JNEUROSCI.1917-11.2011

PMCID:: PMC6623066

Abstract Article PDF–3.5M

Select item 266201719.

PP4R4/KIAA1622 Forms a Novel Stable Cytosolic Complex with Phosphoprotein Phosphatase 4

Ginny I. Chen, Sally Tisayakorn, Claus Jorgensen, Lisa M. D'Ambrosio, Marilyn Goudreault, Anne-Claude Gingras

J Biol Chem. 2008 Oct 24; 283(43): 29273–29284. doi: 10.1074/jbc.M803443200

PMCID:: PMC2662017

Abstract Article PDF–759K

Select item 493134420.

The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding

Mark R. Woodford, Diana M. Dunn, Adam R. Blanden, Dante Capriotti, David Loiselle, Chrisostomos Prodromou, Barry Panaretou, Philip F. Hughes, Aaron Smith, Wendi Ackerman, Timothy A. Haystead, Stewart N. Loh, Dimitra Bourboulia, Laura S. Schmidt, W. Marston Linehan, Gennady Bratslavsky, Mehdi Mollapour

Nat Commun. 2016; 7: 12037. Published online 2016 Jun 29. doi: 10.1038/ncomms12037