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Select item 90357061.

Multienzyme interactions of the de novo purine biosynthetic protein PAICS facilitate purinosome formation and metabolic channeling

Jingxuan He, Ling-Nan Zou, Vidhi Pareek, Stephen J. Benkovic

J Biol Chem. 2022 May; 298(5): 101853. Published online 2022 Mar 21. doi: 10.1016/j.jbc.2022.101853

PMCID:: PMC9035706

Abstract Article PDF–1.8M

Select item 89889382.

Evidence Supporting Substrate Channeling between Domains of Human PAICS: A Time-Course Analysis of ¹³C-Bicarbonate Incorporation

Hyungjoo Shon, Elena A. Matveeva, Ella C. Jull, Yijia Hu, Tiffany A. Coupet, Young-Sam Lee

Biochemistry. 2022 Apr 5; 61(7): 575–582. Published online 2022 Mar 14. doi: 10.1021/acs.biochem.1c00803

PMCID:: PMC8988938

Abstract Article PDF–3.5M

Select item 83588643.

Baoshun Du, Zheying Zhang, Wenyu Di, Wenzhong Xu, Lei Yang, Shitao Zhang, Guoyang He, Rui Yang, Maode Wang

J Cell Mol Med. 2021 Aug; 25(16): 7720–7733. Published online 2021 Jun 26. doi: 10.1111/jcmm.16647

PMCID:: PMC8358864

Abstract Article PDF–3.1M

Select item 74501034.

Crystal structures of human PAICS reveal substrate and product binding of an emerging cancer target

Jana Škerlová, Judith Unterlass, Mona Göttmann, Petra Marttila, Evert Homan, Thomas Helleday, Ann-Sofie Jemth, Pål Stenmark

J Biol Chem. 2020 Aug 14; 295(33): 11656–11668. Published online 2020 Jun 22. doi: 10.1074/jbc.RA120.013695

PMCID:: PMC7450103

Abstract Article PDF–4.1M

Select item 60981995.

A Role for De Novo Purine Metabolic Enzyme PAICS in Bladder Cancer Progression

Balabhadrapatruni V.S.K. Chakravarthi, Maria Del Carmen Rodriguez Pena, Sumit Agarwal, Darshan S. Chandrashekar, Sai Akshaya Hodigere Balasubramanya, Fayez J. Jabboure, Andres Matoso, Trinity J. Bivalacqua, Katayoon Rezaei, Alcides Chaux, William E. Grizzle, Guru Sonpavde, Jennifer Gordetsky, George J. Netto, Sooryanarayana Varambally

Neoplasia. 2018 Sep; 20(9): 894–904. Published online 2018 Aug 15. doi: 10.1016/j.neo.2018.07.006

PMCID:: PMC6098199

Abstract Article PDF–885K

Select item 67978106.

Combinatorial targeting of MTHFD2 and PAICS in purine synthesis as a novel therapeutic strategy

Chantal Hoi Yin Cheung, Chia-Lang Hsu, Chao-Yin Tsuei, Tzu-Ting Kuo, Chen-Tsung Huang, Wen-Ming Hsu, Yun-Hsien Chung, Hsin-Yi Wu, Cheng-Chih Hsu, Hsuan-Cheng Huang, Hsueh-Fen Juan

Cell Death Dis. 2019 Nov; 10(11): 786. Published online 2019 Oct 17. doi: 10.1038/s41419-019-2033-z

PMCID:: PMC6797810

Abstract Article PDF–3.0M

Select item 88064507.

Regulating COX10-AS1 / miR-142-5p / PAICS axis inhibits the proliferation of non-small cell lung cancer

Xinyu Tang, YiHe Wu, Jie Yang, Wenyu Zhu

Bioengineered. 2021; 12(1): 4643–4653. Published online 2021 Jul 29. doi: 10.1080/21655979.2021.1957072

PMCID:: PMC8806450

Abstract Article PDF–1.9M

Select item 73383598.

PAICS contributes to gastric carcinogenesis and participates in DNA damage response by interacting with histone deacetylase 1/2

Nan Huang, Chang Xu, Liang Deng, Xue Li, Zhixuan Bian, Yue Zhang, Shuping Long, Yan Chen, Ni Zhen, Guohui Li, Fenyong Sun

Cell Death Dis. 2020 Jul; 11(7): 507. Published online 2020 Jul 6. doi: 10.1038/s41419-020-2708-5

PMCID:: PMC7338359

Abstract Article PDF–3.6M

Select item 46951299.

Role and regulation of coordinately expressed de novo purine biosynthetic enzymes PPAT and PAICS in lung cancer

Moloy T. Goswami, Guoan Chen, Balabhadrapatruni V.S.K. Chakravarthi, Satya S. Pathi, Sharath K. Anand, Shannon L. Carskadon, Thomas J. Giordano, Arul M. Chinnaiyan, Dafydd G. Thomas, Nallasivam Palanisamy, David G. Beer, Sooryanarayana Varambally

Oncotarget. 2015 Sep 15; 6(27): 23445–23461. Published online 2015 Jun 23. doi: 10.18632/oncotarget.4352

PMCID:: PMC4695129

Abstract Article PDF–7.4M

Select item 14665110.

Role of NRF-1 in bidirectional transcription of the human GPAT-AIRC purine biosynthesis locus.

S Chen, P L Nagy, H Zalkin

Nucleic Acids Res. 1997 May 1; 25(9): 1809–1816. doi: 10.1093/nar/25.9.1809

PMCID:: PMC146651

Summary PDF–172K

Select item 5380411.

Cloning of three human multifunctional de novo purine biosynthetic genes by functional complementation of yeast mutations.

D Schild, A J Brake, M C Kiefer, D Young, P J Barr

Proc Natl Acad Sci U S A. 1990 Apr; 87(8): 2916–2920. doi: 10.1073/pnas.87.8.2916

PMCID:: PMC53804

Summary Page Browse PDF–1.2M

Select item 694490712.

TRIM21‐mediated proteasomal degradation of SAMHD1 regulates its antiviral activity

Zhaolong Li, Chen Huan, Hong Wang, Yue Liu, Xin Liu, Xing Su, Jinghua Yu, Zhilei Zhao, Xiao‐Fang Yu, Baisong Zheng, Wenyan Zhang

EMBO Rep. 2020 Jan 7; 21(1): e47528. Published online 2019 Dec 4. doi: 10.15252/embr.201847528

PMCID:: PMC6944907

Abstract Article PDF–2.4M

Select item 968403013.

ZBTB18 inhibits SREBP-dependent lipid synthesis by halting CTBPs and LSD1 activity in glioblastoma

Roberto Ferrarese, Annalisa Izzo, Geoffroy Andrieux, Simon Lagies, Johanna Paulina Bartmuss, Anie Priscilla Masilamani, Alix Wasilenko, Daniela Osti, Stefania Faletti, Rana Schulzki, Shuai Yuan, Eva Kling, Valentino Ribecco, Dieter Henrik Heiland, Stefan Tholen, Marco Prinz, Giuliana Pelicci, Bernd Kammerer, Melanie Boerries, Maria Stella Carro

Life Sci Alliance. 2023 Jan; 6(1): e202201400. Published online 2022 Nov 22. doi: 10.26508/lsa.202201400

PMCID:: PMC9684030

Abstract Article PDF–3.3M

Select item 975894914.

A novel lncRNA MDHDH suppresses glioblastoma multiforme by acting as a scaffold for MDH2 and PSMA1 to regulate NAD+ metabolism and autophagy

Dong He, Tao Xin, Bo Pang, Jun Sun, Zi Hao Liu, Zhen Qin, Xiao Shuai Ji, Fan Yang, Yan Bang Wei, Zi Xiao Wang, Jia Jia Gao, Qi Pang, Qian Liu

J Exp Clin Cancer Res. 2022; 41: 349. Published online 2022 Dec 17. doi: 10.1186/s13046-022-02543-7

PMCID:: PMC9758949

Abstract Article PDF–18M

Select item 756785315.

BioID-based proteomic analysis of the Bid interactome identifies novel proteins involved in cell-cycle-dependent apoptotic priming

Robert Pedley, Louise E. King, Venkatesh Mallikarjun, Pengbo Wang, Joe Swift, Keith Brennan, Andrew P. Gilmore

Cell Death Dis. 2020 Oct; 11(10): 872. Published online 2020 Oct 16. doi: 10.1038/s41419-020-03091-8

PMCID:: PMC7567853

Abstract Article PDF–2.9M

Select item 413128416.

CHK2 kinase promotes pre-mRNA splicing via phosphorylating CDK11^p110

Hee-Hyun Choi, Hyun-Kyung Choi, Sung Yun Jung, Judith Hyle, Beom-Jun Kim, Keejung Yoon, Eun-Jung Cho, Hong-Duk Youn, Jill M. Lahti, Jun Qin, Seong-Tae Kim

Oncogene. Author manuscript; available in PMC 2014 Aug 13.

Published in final edited form as: Oncogene. 2014 Jan 2; 33(1): 108–115. Published online 2012 Nov 26. doi: 10.1038/onc.2012.535

PMCID:: PMC4131284

Abstract Article PDF–1.0M

Select item 263802117.

Regulation of PKD by the MAPK p38δ in Insulin Secretion and Glucose Homeostasis

Grzegorz Sumara, Ivan Formentini, Stephan Collins, Izabela Sumara, Renata Windak, Bernd Bodenmiller, Reshma Ramracheya, Dorothée Caille, Huiping Jiang, Kenneth A. Platt, Paolo Meda, Rudolf Aebersold, Patrik Rorsman, Romeo Ricci

Cell. 2009 Jan 23; 136(2): 235–248. doi: 10.1016/j.cell.2008.11.018

PMCID:: PMC2638021

Abstract Article

Select item 929241318.

Proteomic analysis of ubiquitination substrates reveals a CTLH E3 ligase complex‐dependent regulation of glycolysis

Matthew E. R. Maitland, Miljan Kuljanin, Xu Wang, Gilles A. Lajoie, Caroline Schild‐Poulter

FASEB J. 2021 Sep; 35(9): e21825. Published online 2021 Aug 12. doi: 10.1096/fj.202100664R

PMCID:: PMC9292413

Abstract Article PDF–1.5M

Select item 448120519.

Bruno D. Fonseca, Chadi Zakaria, Jian-Jun Jia, Tyson E. Graber, Yuri Svitkin, Soroush Tahmasebi, Danielle Healy, Huy-Dung Hoang, Jacob M. Jensen, Ilo T. Diao, Alexandre Lussier, Christopher Dajadian, Niranjan Padmanabhan, Walter Wang, Edna Matta-Camacho, Jaclyn Hearnden, Ewan M. Smith, Yoshinori Tsukumo, Akiko Yanagiya, Masahiro Morita, Emmanuel Petroulakis, Jose L. González, Greco Hernández, Tommy Alain, Christian K. Damgaard

J Biol Chem. 2015 Jun 26; 290(26): 15996–16020. Published online 2015 May 4. doi: 10.1074/jbc.M114.621730

PMCID:: PMC4481205

Abstract Article PDF–5.8M

Select item 486077420.

A genome-wide IR-induced RAD51 foci RNAi screen identifies CDC73 involved in chromatin remodeling for DNA repair

Patrick Herr, Cecilia Lundin, Bastiaan Evers, Daniel Ebner, Christina Bauerschmidt, Guy Kingham, Timea Palmai-Pallag, Oliver Mortusewicz, Oliver Frings, Erik Sonnhammer, Thomas Helleday

Cell Discov. 2015; 1: 15034. Published online 2015 Dec 1. doi: 10.1038/celldisc.2015.34

PMCID:: PMC4860774

Abstract Article PDF–4.1M

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