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Select item 99500441.

RAGA prevents tumor immune evasion of LUAD by promoting CD47 lysosome degradation

Lian Zhang, Jing Yu, Mingyue Zheng, Hui Zhen, Qingqiang Xie, Chundong Zhang, Zhongjun Zhou, Guoxiang Jin

Commun Biol. 2023; 6: 211. Published online 2023 Feb 23. doi: 10.1038/s42003-023-04581-z

PMCID:: PMC9950044

Abstract Article PDF–2.7M

Select item 49056772.

Mutations of RagA GTPase in mTORC1 Pathway Are Associated with Autosomal Dominant Cataracts

Jian-Huan Chen, Chukai Huang, Bining Zhang, Shengjie Yin, Jiajian Liang, Ciyan Xu, Yuqiang Huang, Ling-Ping Cen, Tsz-Kin Ng, Ce Zheng, Shaobin Zhang, Haoyu Chen, Chi-Pui Pang, Mingzhi Zhang

PLoS Genet. 2016 Jun; 12(6): e1006090. Published online 2016 Jun 13. doi: 10.1371/journal.pgen.1006090

PMCID:: PMC4905677

Abstract Article PDF–4.9M

Select item 82540483.

An interdomain hydrogen bond in the Rag GTPases maintains stable mTORC1 signaling in sensing amino acids

Shawn B. Egri, Kuang Shen

J Biol Chem. 2021 Jul; 297(1): 100861. Published online 2021 Jun 9. doi: 10.1016/j.jbc.2021.100861

PMCID:: PMC8254048

Abstract Article PDF–1.6M

Select item 71899924.

C9orf72 associates with inactive Rag GTPases and regulates mTORC1‐mediated autophagosomal and lysosomal biogenesis

Mingmei Wang, Hongfeng Wang, Zhouteng Tao, Qin Xia, Zongbing Hao, Jochen H. M. Prehn, Xuechu Zhen, Guanghui Wang, Zheng Ying

Aging Cell. 2020 Apr; 19(4): e13126. Published online 2020 Feb 25. doi: 10.1111/acel.13126

PMCID:: PMC7189992

Abstract Article PDF–2.7M

Select item 63936125.

Arg-78 of Nprl2 catalyzes GATOR1-stimulated GTP hydrolysis by the Rag GTPases

Kuang Shen, Max L. Valenstein, Xin Gu, David M. Sabatini

J Biol Chem. 2019 Feb 22; 294(8): 2970–2975. Published online 2019 Jan 16. doi: 10.1074/jbc.AC119.007382

PMCID:: PMC6393612

Abstract Article PDF–1.8M

Select item 57226596.

Hybrid Structure of the RagA/C-Ragulator mTORC1 Activation Complex

Ming-Yuan Su, Kyle L. Morris, Do Jin Kim, Yangxue Fu, Rosalie Lawrence, Goran Stjepanovic, Roberto Zoncu, James H. Hurley

Mol Cell. Author manuscript; available in PMC 2018 Dec 7.

Published in final edited form as: Mol Cell. 2017 Dec 7; 68(5): 835–846.e3. Published online 2017 Nov 5. doi: 10.1016/j.molcel.2017.10.016

PMCID:: PMC5722659

Abstract Article PDF–2.1M

Select item 56748027.

Intersubunit crosstalk in the Rag GTPase heterodimer enables mTORC1 to respond rapidly to amino acid availability

Kuang Shen, Abigail Choe, David M. Sabatini

Mol Cell. Author manuscript; available in PMC 2018 Nov 2.

Published in final edited form as: Mol Cell. 2017 Nov 2; 68(3): 552–565.e8. Published online 2017 Oct 19. doi: 10.1016/j.molcel.2017.09.026

Correction in:: Mol Cell. 2017 Nov 16; 68(4): 821.

PMCID:: PMC5674802

Abstract Article PDF–1.8M

Select item 1912158.

Interaction of an adenovirus 14.7-kilodalton protein inhibitor of tumor necrosis factor alpha cytolysis with a new member of the GTPase superfamily of signal transducers.

Y Li, J Kang, M S Horwitz

J Virol. 1997 Feb; 71(2): 1576–1582. doi: 10.1128/jvi.71.2.1576-1582.1997

PMCID:: PMC191215

Summary PDF–477K

Select item 99315869.

Structure of the lysosomal mTORC1–TFEB–Rag–Ragulator megacomplex

Zhicheng Cui, Gennaro Napolitano, Mariana E. G. de Araujo, Alessandra Esposito, Jlenia Monfregola, Lukas A. Huber, Andrea Ballabio, James H. Hurley

Nature. 2023; 614(7948): 572–579. Published online 2023 Jan 25. doi: 10.1038/s41586-022-05652-7

PMCID:: PMC9931586

Abstract Article PDF–42M

Select item 764464110.

Structural mechanism for amino acid-dependent Rag GTPase nucleotide state switching by SLC38A9

Simon A. Fromm, Rosalie E. Lawrence, James H. Hurley

Nat Struct Mol Biol. Author manuscript; available in PMC 2021 Feb 28.

Published in final edited form as: Nat Struct Mol Biol. 2020 Nov; 27(11): 1017–1023. Published online 2020 Aug 31. doi: 10.1038/s41594-020-0490-9

PMCID:: PMC7644641

Abstract Article PDF–3.9M

Select item 447637211.

Skp2-mediated RagA ubiquitination elicits a negative feedback to prevent amino acid-dependent mTORC1 hyperactivation by recruiting GATOR1

Guoxiang Jin, Szu-Wei Lee, Xian Zhang, Zhen Cai, Yuan Gao, Ping-Chieh Chou, Abdol Hossein Rezaeian, Fei Han, Chi-Yun Wang, Juo-Chin Yao, Zhaohui Gong, Chia-Hsin Chan, Shih-Hsin Tu, Chih-Hsiung Wu, Dos D. Sarbassov, Yuan-Soon Ho, Hui-Kuan Lin

Mol Cell. Author manuscript; available in PMC 2016 Jun 18.

Published in final edited form as: Mol Cell. 2015 Jun 18; 58(6): 989–1000. Published online 2015 Jun 4. doi: 10.1016/j.molcel.2015.05.010

PMCID:: PMC4476372

Abstract Article PDF–1.4M

Select item 833705412.

A conserved ubiquitin- and ESCRT-dependent pathway internalizes human lysosomal membrane proteins for degradation

Weichao Zhang, Xi Yang, Liang Chen, Yun-Yu Liu, Varsha Venkatarangan, Lucas Reist, Phyllis Hanson, Haoxing Xu, Yanzhuang Wang, Ming Li

PLoS Biol. 2021 Jul; 19(7): e3001361. Published online 2021 Jul 23. doi: 10.1371/journal.pbio.3001361

PMCID:: PMC8337054

Abstract Article PDF–4.9M

Select item 597596413.

Architecture of the human GATOR1 and GATOR1-Rag complexes

Kuang Shen, Rick K. Huang, Edward J. Brignole, Kendall J. Condon, Max L. Valenstein, Lynne Chantranupong, Aimaiti Bomaliyamu, Abigail Choe, Chuan Hong, Zhiheng Yu, David M. Sabatini

Nature. Author manuscript; available in PMC 2018 Oct 5.

Published in final edited form as: Nature. 2018 Apr 5; 556(7699): 64–69. Published online 2018 Mar 28. doi: 10.1038/nature26158

PMCID:: PMC5975964

Abstract Article PDF–2.4M

Select item 761094414.

TASL is the SLC15A4-associated adaptor for IRF5 activation by TLR7-9

Leonhard X. Heinz, JangEun Lee, Utkarsh Kapoor, Felix Kartnig, Vitaly Sedlyarov, Konstantinos Papakostas, Adrian César-Razquin, Patrick Essletzbichler, Ulrich Goldmann, Adrijana Stefanovic, Johannes W. Bigenzahn, Stefania Scorzoni, Mattia D. Pizzagalli, Ariel Bensimon, André C. Müller, F. James King, Jun Li, Enrico Girardi, M. Lamine Mbow, Charles E. Whitehurst, Manuele Rebsamen, Giulio Superti-Furga

Nature. Author manuscript; available in PMC 2021 Jun 9.

Published in final edited form as: Nature. 2020 May 1; 581(7808): 316–322. Published online 2020 May 13. doi: 10.1038/s41586-020-2282-0

PMCID:: PMC7610944

Abstract Article PDF–6.7M

Select item 582361115.

Lysosomal Cholesterol Activates mTORC1 via an SLC38A9-Niemann Pick C1 Signaling Complex

Brian M. Castellano, Ashley M. Thelen, Ofer Moldavski, McKenna Feltes, Reini E. N. van der Welle, Laurel Mydock-McGrane, Xuntian Jiang, Robert J van Eijkeren, Oliver B. Davis, Sharon M. Louie, Rushika M. Perera, Douglas Covey, Daniel K. Nomura, Daniel S. Ory, Roberto Zoncu

Science. Author manuscript; available in PMC 2018 Feb 22.

Published in final edited form as: Science. 2017 Mar 24; 355(6331): 1306–1311. doi: 10.1126/science.aag1417

PMCID:: PMC5823611

Abstract Article PDF–698K

Select item 679553616.

Architecture of human Rag GTPase heterodimers and their complex with mTORC1

Madhanagopal Anandapadamanaban, Glenn R. Masson, Olga Perisic, Alex Berndt, Jonathan Kaufman, Chris M. Johnson, Balaji Santhanam, Kacper B. Rogala, David M. Sabatini, Roger L. Williams

Science. Author manuscript; available in PMC 2020 Apr 11.

Published in final edited form as: Science. 2019 Oct 11; 366(6462): 203–210. doi: 10.1126/science.aax3939