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Select item 84690111.

Extended Phenotyping and Functional Validation Facilitate Diagnosis of a Complex Patient Harboring Genetic Variants in MCCC1 and GNB5 Causing Overlapping Phenotypes

Zhuo Shao, Ikuo Masuho, Anupreet Tumber, Jason T. Maynes, Erika Tavares, Asim Ali, Stacy Hewson, Andreas Schulze, Peter Kannu, Kirill A. Martemyanov, Ajoy Vincent

Genes (Basel) 2021 Sep; 12(9): 1352. Published online 2021 Aug 29. doi: 10.3390/genes12091352

PMCID:: PMC8469011

Abstract Article PDF–4.0M

Select item 86399302.

Inhibition of G-protein signalling in cardiac dysfunction of intellectual developmental disorder with cardiac arrhythmia (IDDCA) syndrome

Pasquelena De Nittis, Stephanie Efthymiou, Alexandre Sarre, Nicolas Guex, Jacqueline Chrast, Audrey Putoux, Tipu Sultan, Javeria Raza Alvi, Zia ur Rahman, Faisal Zafar, Nuzhat Rana, Fatima Rahman, Najwa Anwar, Shazia Maqbool, Maha S Zaki, Joseph G Gleeson, David Murphy, Hamid Galehdari, Gholamreza Shariati, Neda Mazaheri, Alireza Sedaghat, SYNAPS Study Group, Gaetan Lesca, Nicolas Chatron, Vincenzo Salpietro, Marilena Christoforou, Henry Houlden, William F Simonds, Thierry Pedrazzini, Reza Maroofian, Alexandre Reymond

J Med Genet. 2021 Dec; 58(12): 815–831. Published online 2020 Nov 10. doi: 10.1136/jmedgenet-2020-107015

PMCID:: PMC8639930

Abstract Article PDF–6.3M

Select item 67727743.

Selective Regulation of N-Type Ca Channels by Different Combinations of G-Protein β/γ Subunits and RGS Proteins

Janice Y. Zhou, David P. Siderovski, Richard J. Miller

J Neurosci. 2000 Oct 1; 20(19): 7143–7148. doi: 10.1523/JNEUROSCI.20-19-07143.2000

PMCID:: PMC6772774

Abstract Article PDF–285K

Select item 50376134.

GNB5 mutation causes a novel neuropsychiatric disorder featuring attention deficit hyperactivity disorder, severely impaired language development and normal cognition

Hanan E. Shamseldin, Ikuo Masuho, Ahmed Alenizi, Suad Alyamani, Dipak N. Patil, Niema Ibrahim, Kirill A. Martemyanov, Fowzan S. Alkuraya

Genome Biol. 2016; 17: 195. Published online 2016 Sep 27. doi: 10.1186/s13059-016-1061-6

PMCID:: PMC5037613

Abstract Article PDF–1.5M

Select item 12155295.

Hepatitis B virus X protein interacts with β5 subunit of heterotrimeric guanine nucleotide binding protein

Siew Hui Lwa, Wei Ning Chen

Virol J. 2005; 2: 76. Published online 2005 Aug 31. doi: 10.1186/1743-422X-2-76

PMCID:: PMC1215529

Abstract Article PDF–379K

Select item 268146.

Gβ5 prevents the RGS7-Gαo interaction through binding to a distinct Gγ-like domain found in RGS7 and other RGS proteins

Konstantin Levay, Jorge L. Cabrera, Daulet K. Satpaev, Vladlen Z. Slepak

Proc Natl Acad Sci U S A. 1999 Mar 2; 96(5): 2503–2507. doi: 10.1073/pnas.96.5.2503

PMCID:: PMC26814

Abstract Article PDF–203K

Select item 89261517.

Cryo-EM structure of human GPR158 receptor coupled to the RGS7-Gβ5 signaling complex

Dipak N. Patil, Shikha Singh, Thibaut Laboute, Timothy S. Strutzenberg, Xingyu Qiu, Di Wu, Scott J. Novick, Carol V. Robinson, Patrick R. Griffin, John F. Hunt, Tina Izard, Appu K. Singh, Kirill A. Martemyanov

Science. Author manuscript; available in PMC 2023 Jan 7.

Published in final edited form as: Science. 2022 Jan 7; 375(6576): 86–91. Published online 2021 Nov 18. doi: 10.1126/science.abl4732

PMCID:: PMC8926151

Abstract Article PDF–1.0M

Select item 86110648.

Structure of the class C orphan GPCR GPR158 in complex with RGS7-Gβ5

Eunyoung Jeong, Yoojoong Kim, Jihong Jeong, Yunje Cho

Nat Commun. 2021; 12: 6805. Published online 2021 Nov 23. doi: 10.1038/s41467-021-27147-1

PMCID:: PMC8611064

Abstract Article PDF–2.7M

Select item 66793739.

Genetic variation in GNB5 causes bradycardia by augmenting the cholinergic response via increased acetylcholine-activated potassium current (I_K,ACh)

Christiaan C. Veerman, Isabella Mengarelli, Charlotte D. Koopman, Ronald Wilders, Shirley C. van Amersfoorth, Diane Bakker, Rianne Wolswinkel, Mariam Hababa, Teun P. de Boer, Kaomei Guan, James Milnes, Elisabeth M. Lodder, Jeroen Bakkers, Arie O. Verkerk, Connie R. Bezzina

Dis Model Mech. 2019 Jul 1; 12(7): dmm037994. Published online 2019 Jul 9. doi: 10.1242/dmm.037994

PMCID:: PMC6679373

Abstract Article

Select item 667352610.

Gβ5 Is Required for Normal Light Responses and Morphology of Retinal ON-Bipolar Cells

Anjali Rao, Rebecca Dallman, Scott Henderson, Ching-Kang Chen

J Neurosci. 2007 Dec 19; 27(51): 14199–14204. doi: 10.1523/JNEUROSCI.4934-07.2007

PMCID:: PMC6673526

Abstract Article PDF–404K

Select item 631046111.

Structural organization of a major neuronal G protein regulator, the RGS7-Gβ5-R7BP complex

Dipak N Patil, Erumbi S Rangarajan, Scott J Novick, Bruce D Pascal, Douglas J Kojetin, Patrick R Griffin, Tina Izard, Kirill A Martemyanov

eLife. 2018; 7: e42150. Published online 2018 Dec 12. doi: 10.7554/eLife.42150

PMCID:: PMC6310461

Abstract Article PDF–6.0M

Select item 501064212.

GNB5 Mutations Cause an Autosomal-Recessive Multisystem Syndrome with Sinus Bradycardia and Cognitive Disability

Elisabeth M. Lodder, Pasquelena De Nittis, Charlotte D. Koopman, Wojciech Wiszniewski, Carolina Fischinger Moura de Souza, Najim Lahrouchi, Nicolas Guex, Valerio Napolioni, Federico Tessadori, Leander Beekman, Eline A. Nannenberg, Lamiae Boualla, Nico A. Blom, Wim de Graaff, Maarten Kamermans, Dario Cocciadiferro, Natascia Malerba, Barbara Mandriani, Zeynep Hande Coban Akdemir, Richard J. Fish, Mohammad K. Eldomery, Ilham Ratbi, Arthur A.M. Wilde, Teun de Boer, William F. Simonds, Marguerite Neerman-Arbez, V. Reid Sutton, Fernando Kok, James R. Lupski, Alexandre Reymond, Connie R. Bezzina, Jeroen Bakkers, Giuseppe Merla

Am J Hum Genet. 2016 Sep 1; 99(3): 704–710. Published online 2016 Aug 11. doi: 10.1016/j.ajhg.2016.06.025

Correction in:: Am J Hum Genet. 2016 Sep 1; 99(3): 786.

PMCID:: PMC5010642

Abstract Article PDF–1.0M

Select item 414651613.

G Protein Beta 5 Is Targeted to D2-Dopamine Receptor-Containing Biochemical Compartments and Blocks Dopamine-Dependent Receptor Internalization

J. Christopher Octeau, Joseph M. Schrader, Ikuo Masuho, Meenakshi Sharma, Christopher Aiudi, Ching-Kang Chen, Abraham Kovoor, Jeremy Celver

PLoS One. 2014; 9(8): e105791. Published online 2014 Aug 27. doi: 10.1371/journal.pone.0105791

PMCID:: PMC4146516

Abstract Article PDF–2.7M

Select item 643869114.

Intramolecular domain dynamics regulate synaptic MAGUK protein interactions

Nils Rademacher, Benno Kuropka, Stella-Amrei Kunde, Markus C Wahl, Christian Freund, Sarah A Shoichet

eLife. 2019; 8: e41299. Published online 2019 Mar 13. doi: 10.7554/eLife.41299

PMCID:: PMC6438691

Abstract Article PDF–11M

Select item 312223515.

Type 5 G Protein β Subunit (Gβ5) Controls the Interaction of Regulator of G Protein Signaling 9 (RGS9) with Membrane Anchors

Ikuo Masuho, Hideko Wakasugi-Masuho, Ekaterina N. Posokhova, Joseph R. Patton, Kirill A. Martemyanov

J Biol Chem. 2011 Jun 17; 286(24): 21806–21813. Published online 2011 Apr 21. doi: 10.1074/jbc.M111.241513

PMCID:: PMC3122235

Abstract Article PDF–2.2M

Select item 679390316.

Regulators of G-Protein Signaling (RGS) Proteins: Region-Specific Expression of Nine Subtypes in Rat Brain

Stephen J. Gold, Yan G. Ni, Henrik G. Dohlman, Eric J. Nestler

J Neurosci. 1997 Oct 15; 17(20): 8024–8037. doi: 10.1523/JNEUROSCI.17-20-08024.1997

PMCID:: PMC6793903

Abstract Article PDF–2.9M

Select item 276642917.

Gβ₅-RGS7 selectively inhibits muscarinic M3 receptor signaling via the interaction between the third intracellular loop of the receptor and the DEP domain of RGS7

Simone L. Sandiford, Vladlen Z. Slepak

Biochemistry. Author manuscript; available in PMC 2010 Mar 17.

Published in final edited form as: Biochemistry. 2009 Mar 17; 48(10): 2282–2289. doi: 10.1021/bi801989c

PMCID:: PMC2766429

Abstract Article PDF–843K

Select item 12500418.

R9AP, a membrane anchor for the photoreceptor GTPase accelerating protein, RGS9-1

Guang Hu, Theodore G. Wensel

Proc Natl Acad Sci U S A. 2002 Jul 23; 99(15): 9755–9760. Published online 2002 Jul 15. doi: 10.1073/pnas.152094799

PMCID:: PMC125004

Abstract Article PDF–289K

Select item 2379319.

A G protein γ subunit-like domain shared between RGS11 and other RGS proteins specifies binding to G_β5 subunits

Bryan E. Snow, Andrejs M. Krumins, Greg M. Brothers, Sheu-Fen Lee, Mark A. Wall, Stephen Chung, Joan Mangion, Sudha Arya, Alfred G. Gilman, David P. Siderovski

Proc Natl Acad Sci U S A. 1998 Oct 27; 95(22): 13307–13312. doi: 10.1073/pnas.95.22.13307

PMCID:: PMC23793

Abstract Article PDF–542K

Select item 2690920.

Fidelity of G protein β-subunit association by the G protein γ-subunit-like domains of RGS6, RGS7, and RGS11

Bryan E. Snow, Laurie Betts, Joan Mangion, John Sondek, David P. Siderovski

Proc Natl Acad Sci U S A. 1999 May 25; 96(11): 6489–6494. doi: 10.1073/pnas.96.11.6489

PMCID:: PMC26909

Abstract Article PDF–545K

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