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Select item 108000541.

The integration of multidisciplinary approaches revealed PTGES3 as a novel drug target for breast cancer treatment

Qinan Yin, Haodi Ma, Yirui Dong, Shunshun Zhang, Junxiang Wang, Jing Liang, Longfei Mao, Li Zeng, Xin Xiong, Xingang Chen, Jingjing Wang, Xuewei Zheng

J Transl Med. 2024; 22: 84. Published online 2024 Jan 20. doi: 10.1186/s12967-024-04899-0

PMCID:: PMC10800054

Abstract Article PDF–8.7M

Select item 103225802.

Effect of PTGES3 on the Prognosis and Immune Regulation in Lung Adenocarcinoma

Wenyan Jiang, Qiong Wei, Haiqin Xie, Dandan Wu, Haiyan He, Xuedong Lv

Anal Cell Pathol (Amst) 2023; 2023: 4522045. Published online 2023 Jun 28. doi: 10.1155/2023/4522045

PMCID:: PMC10322580

Abstract Article PDF–6.4M

Select item 89945173.

Structure of Hsp90-p23-GR reveals the Hsp90 client-maturation mechanism

Chari M. Noddings, Ray Yu-Ruei Wang, Jill L. Johnson, David A. Agard

Nature. Author manuscript; available in PMC 2022 Apr 9.

Published in final edited form as: Nature. 2022 Jan; 601(7893): 465–469. Published online 2021 Dec 22. doi: 10.1038/s41586-021-04236-1

PMCID:: PMC8994517

Abstract Article PDF–2.9M

Select item 45102064.

The co‐chaperone p23 promotes prostate cancer motility and metastasis

Laia Querol Cano, Derek N. Lavery, Soraya Sin, Emma Spanjaard, Greg N. Brooke, Jessica D. Tilman, Ahmed Abroaf, Luke Gaughan, Craig N. Robson, Rakesh Heer, Francesco Mauri, Johan de Rooij, Keltouma Driouch, Charlotte L. Bevan

Mol Oncol. 2015 Jan; 9(1): 295–308. Published online 2014 Sep 6. doi: 10.1016/j.molonc.2014.08.014

PMCID:: PMC4510206

Abstract Article PDF–2.1M

Select item 38665985.

Dysregulation of glucocorticoid receptor co-factors FKBP5, BAG1 and PTGES3 in prefrontal cortex in psychotic illness

Duncan Sinclair, Stu G. Fillman, Maree J. Webster, Cynthia Shannon Weickert

Sci Rep. 2013; 3: 3539. Published online 2013 Dec 18. doi: 10.1038/srep03539

PMCID:: PMC3866598

Abstract Article PDF–1.9M

Select item 28596886.

Cytosolic Prostaglandin E Synthase: Expression Patterns in Control and Alzheimer's Disease Brains

Uzma A. Chaudhry, Sylvain Dore

Am J Alzheimers Dis Other Demen. 2009 Feb-Mar; 24(1): 46–51. doi: 10.1177/1533317508323655

PMCID:: PMC2859688

Summary PDF–350K

Select item 15927147.

The Cochaperone p23 Differentially Regulates Estrogen Receptor Target Genes and Promotes Tumor Cell Adhesion and Invasion

Ellinor Oxelmark, Jennifer M. Roth, Peter C. Brooks, Steven E. Braunstein, Robert J. Schneider, Michael J. Garabedian

Mol Cell Biol. 2006 Jul; 26(14): 5205–5213. doi: 10.1128/MCB.00009-06

PMCID:: PMC1592714

Abstract Article PDF–278K

Select item 72794168.

Selective Autophagy Maintains the Aryl Hydrocarbon Receptor Levels in HeLa Cells: A Mechanism That Is Dependent on the p23 Co-Chaperone

Yujie Yang, William K. Chan

Int J Mol Sci. 2020 May; 21(10): 3449. Published online 2020 May 13. doi: 10.3390/ijms21103449

PMCID:: PMC7279416

Abstract Article PDF–4.6M

Select item 58113929.

Characterization of an Hsp90-independent interaction between the co-chaperone p23 and the transcription factor p53

Huiwen Wu, Jashil Hyun, Maria A. Martinez-Yamout, Sung Jean Park, H. Jane Dyson

Biochemistry. Author manuscript; available in PMC 2019 Feb 13.

Published in final edited form as: Biochemistry. 2018 Feb 13; 57(6): 935–944. Published online 2018 Jan 24. doi: 10.1021/acs.biochem.7b01076

PMCID:: PMC5811392

Abstract Article PDF–905K

Select item 541695510.

Role of the HSP90-Associated Cochaperone p23 in Enhancing Activity of the Androgen Receptor and Significance for Prostate Cancer

Vikash Reebye, Laia Querol Cano, Derek N. Lavery, Greg N. Brooke, Sue M. Powell, Deepa Chotai, Marjorie M. Walker, Hayley C. Whitaker, Robin Wait, Helen C. Hurst, Charlotte L. Bevan

Mol Endocrinol. October 1, 2012; 26(10): 1694–1706. Published online 2012 Aug 16. doi: 10.1210/me.2012-1056

PMCID:: PMC5416955

Abstract Article

Select item 414634411.

Molecular Imaging of the Efficacy of Heat Shock Protein 90 Inhibitors in Living Subjects

Carmel T. Chan, Ramasamy Paulmurugan, Olivier S. Gheysens, Joungnam Kim, Gabriela Chiosis, Sanjiv Sam Gambhir

Cancer Res. Author manuscript; available in PMC 2014 Aug 27.

Published in final edited form as: Cancer Res. 2008 Jan 1; 68(1): 216–226. doi: 10.1158/0008-5472.CAN-07-2268

PMCID:: PMC4146344

Abstract Article PDF–1.4M

Select item 347758312.

Ganetespib (STA-9090), a Non-Geldanamycin HSP90 Inhibitor, has Potent Antitumor Activity in In Vitro and In Vivo Models of Non-Small Cell Lung Cancer

Takeshi Shimamura, Samanthi A. Perera, Kevin P. Foley, Jim Sang, Scott J. Rodig, Takayo Inoue, Liang Chen, Danan Li, Julian Carretero, Yu-Chen Li, Papiya Sinha, Christopher D. Carey, Christa L. Borgman, John-Paul Jimenez, Matthew Meyerson, Weiwen Ying, James Barsoum, Kwok-Kin Wong, Geoffrey I. Shapiro

Clin Cancer Res. Author manuscript; available in PMC 2013 Sep 15.

Published in final edited form as: Clin Cancer Res. 2012 Sep 15; 18(18): 4973–4985. Published online 2012 Jul 17. doi: 10.1158/1078-0432.CCR-11-2967

PMCID:: PMC3477583

Abstract Article PDF–6.1M

Select item 324832513.

Research Resource: Enhanced Genome-Wide Occupancy of Estrogen Receptor α by the Cochaperone p23 in Breast Cancer Cells

Natalie E. Simpson, Jason Gertz, Keren Imberg, Richard M. Myers, Michael J. Garabedian

Mol Endocrinol. 2012 Jan; 26(1): 194–202. Published online 2011 Nov 10. doi: 10.1210/me.2011-1068

PMCID:: PMC3248325

Abstract Article

Select item 324604314.

The Small Chaperone Protein p23 and Its Cleaved Product p19 in Cellular Stress

Karen S. Poksay, Surita Banwait, Danielle Crippen, Xiao Mao, Dale E. Bredesen, Rammohan V. Rao

J Mol Neurosci. Author manuscript; available in PMC 2012 Feb 7.

Published in final edited form as: J Mol Neurosci. 2012 Feb; 46(2): 303–314. Published online 2011 Jun 21. doi: 10.1007/s12031-011-9574-7

PMCID:: PMC3246043

Abstract Article PDF–845K

Select item 300712215.

High levels of Hsp90 co-chaperone p23 promotes tumor progression and poor prognosis in breast cancer by increasing lymph node metastases and drug resistance

Natalie E. Simpson, W. Marcus Lambert, Renecia Watkins, Shah Giashuddin, S. Joseph Huang, Ellinor Oxelmark, Rezina Arju, Tsivia Hochman, Judith D. Goldberg, Robert J. Schneider, Luiz Fernando Lima Reiz, Fernando Augusto Soares, Susan K. Logan, Michael J. Garabedian

Cancer Res. Author manuscript; available in PMC 2011 Nov 1.

Published in final edited form as: Cancer Res. 2010 Nov 1; 70(21): 8446–8456. Published online 2010 Sep 16. doi: 10.1158/0008-5472.CAN-10-1590

PMCID:: PMC3007122

Abstract Article PDF–661K

Select item 596060916.

p23 protects the human aryl hydrocarbon receptor from degradation via a heat shock protein 90-independent mechanism

Beverly Pappas, Yujie Yang, Yu Wang, Kyung Kim, Hee Jae Chung, Michael Cheung, Katie Ngo, Annie Shinn, William K. Chan

Biochem Pharmacol. Author manuscript; available in PMC 2019 Jun 1.

Published in final edited form as: Biochem Pharmacol. 2018 Jun; 152: 34–44. Published online 2018 Mar 17. doi: 10.1016/j.bcp.2018.03.015

PMCID:: PMC5960609

Abstract Article PDF–1.6M

Select item 1111587017.

The enhancement of antiproliferative and proapoptotic activity of HDAC inhibitors by curcumin is mediated by Hsp90 inhibition

Chiara Giommarelli, Valentina Zuco, Enrica Favini, Claudio Pisano, Fabrizio Dal Piaz, Nunziatina De Tommasi, Franco Zunino

Cell Mol Life Sci. 2010 Mar; 67(6): 995–1004. Published online 2009 Dec 29. doi: 10.1007/s00018-009-0233-x

PMCID:: PMC11115870

Abstract Article PDF–432K

Select item 391010118.

Oxidative inhibition of Hsp90 disrupts the super-chaperone complex and attenuates pancreatic adenocarcinoma in vitro and in vivo

Sayantani Sarkar, Devawati Dutta, Suman Kumar Samanta, Kaushik Bhattacharya, Bikas Chandra Pal, Jinping Li, Kaustubh Datta, Chhabinath Mandal, Chitra Mandal

Int J Cancer. Author manuscript; available in PMC 2014 Feb 3.

Published in final edited form as: Int J Cancer. 2013 Feb 1; 132(3): 695–706. Published online 2012 Jul 9. doi: 10.1002/ijc.27687

PMCID:: PMC3910101

Abstract Article PDF–4.1M

Select item 372792319.

Hsp90 cochaperones p23 and FKBP4 physically interact with hAgo2 and activate RNA interference–mediated silencing in mammalian cells

Justin M. Pare, Paul LaPointe, Tom C. Hobman

Mol Biol Cell. 2013 Aug 1; 24(15): 2303–2310. doi: 10.1091/mbc.E12-12-0892

PMCID:: PMC3727923

Abstract Article PDF–1.2M

Select item 341838320.

p23 co-chaperone protects the aryl hydrocarbon receptor from degradation in mouse and human cell lines

Phuong Minh Nguyen, Depeng Wang, Yu Wang, Yanjie Li, James A. Uchizono, William K. Chan

Biochem Pharmacol. Author manuscript; available in PMC 2013 Sep 15.

Published in final edited form as: Biochem Pharmacol. 2012 Sep 15; 84(6): 838–850. Published online 2012 Jul 1. doi: 10.1016/j.bcp.2012.06.018

PMCID:: PMC3418383

Abstract Article PDF–2.0M

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PMC Links for Gene (Select 10728) (148)
PMC
Homo sapiens prostaglandin E synthase 3 (PTGES3), transcript variant 3, mRNA
Homo sapiens prostaglandin E synthase 3 (PTGES3), transcript variant 3, mRNA
gi|1676317303|ref|NM_001282602.2|

Nucleotide
Autoimmune hypoparathyroidism
Autoimmune hypoparathyroidism

MedGen
SRX10457008 (1)
SRA

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