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Select item 83516981.

Aberrant expression of WDR4 affects the clinical significance of cancer immunity in pan-cancer

Hanqian Zeng, Shiwen Xu, Erjie Xia, Suzita Hirachan, Adheesh Bhandari, Yanyan Shen

Aging (Albany NY) 2021 Jul 31; 13(14): 18360–18375. Published online 2021 Jul 19. doi: 10.18632/aging.203284

PMCID:: PMC8351698

Abstract Article PDF–5.2M

Select item 62896092.

Mutations in WDR4 as a new cause of Galloway-Mowat syndrome

Daniela A. Braun, Shirlee Shril, Aditi Sinha, Ronen Schneider, Weizhen Tan, Shazia Ashraf, Tobias Hermle, Tilman Jobst-Schwan, Eugen Widmeier, Amar J. Majmundar, Ankana Daga, Jillian K. Warejko, Makiko Nakayama, David Schapiro, Jing Chen, Merlin Airik, Jia Rao, Johanna Magdalena Schmidt, Charlotte A. Hoogstraten, Hannah Hugo, Jitendra Meena, Monkol Lek, Kristen M. Laricchia, Arvind Bagga, Friedhelm Hildebrandt

Am J Med Genet A. Author manuscript; available in PMC 2019 Nov 1.

Published in final edited form as: Am J Med Genet A. 2018 Nov; 176(11): 2460–2465. Published online 2018 Aug 6. doi: 10.1002/ajmg.a.40489

PMCID:: PMC6289609

Abstract Article PDF–566K

Select item 111791473.

Structural basis of regulated m⁷G tRNA modification by METTL1-WDR4

Jiazhi Li, Longfei Wang, Quentin Hahn, Radosław P. Nowak, Thibault Viennet, Esteban Orellana, Shourya S. Roy Burman, Hong Yue, Moritz Hunkeler, Pietro Fontana, Hao Wu, Haribabu Arthanari, Eric Fischer, Richard I. Gregory

Nature. Author manuscript; available in PMC 2024 Jun 15.

Published in final edited form as: Nature. 2023 Jan; 613(7943): 391–397. Published online 2023 Jan 4. doi: 10.1038/s41586-022-05566-4

PMCID:: PMC11179147

Abstract Article PDF–5.7M

Select item 103000024.

Structural insight into how WDR4 promotes the tRNA N7-methylguanosine methyltransferase activity of METTL1

Xiaohuan Jin, Zeyuan Guan, Na Hu, Chunjie He, Ping Yin, Zhou Gong, Delin Zhang

Cell Discov. 2023; 9: 65. Published online 2023 Jun 27. doi: 10.1038/s41421-023-00562-y

PMCID:: PMC10300002

Article PDF–974K

Select item 99306415.

Structures and Mechanisms of tRNA Methylation by METTL1-WDR4

Victor M. Ruiz-Arroyo, Rishi Raj, Kesavan Babu, Otgonbileg Onolbaatar, Paul H. Roberts, Yunsun Nam

Nature. Author manuscript; available in PMC 2023 Jul 4.

Published in final edited form as: Nature. 2023 Jan; 613(7943): 383–390. Published online 2023 Jan 4. doi: 10.1038/s41586-022-05565-5

PMCID:: PMC9930641

Abstract Article PDF–3.4M

Select item 98891426.

Association of RNA m⁷G Modification Gene Polymorphisms with Pediatric Glioma Risk

Jinhong Zhu, Xiaoping Liu, Wei Chen, Yuxiang Liao, Jiabin Liu, Li Yuan, Jichen Ruan, Jing He

Biomed Res Int. 2023; 2023: 3678327. Published online 2023 Jan 24. doi: 10.1155/2023/3678327

PMCID:: PMC9889142

Abstract Article PDF–385K

Select item 86361697.

METTL1/WDR4-mediated m⁷G tRNA modifications and m⁷G codon usage promote mRNA translation and lung cancer progression

Jieyi Ma, Hui Han, Ying Huang, Chunlong Yang, Siyi Zheng, Tiancai Cai, Jiong Bi, Xiaohui Huang, Ruiming Liu, Libin Huang, Yifeng Luo, Wen Li, Shuibin Lin

Mol Ther. 2021 Dec 1; 29(12): 3422–3435. Published online 2021 Aug 8. doi: 10.1016/j.ymthe.2021.08.005

PMCID:: PMC8636169

Abstract Article PDF–4.3M

Select item 82709678.

MYC-targeted WDR4 promotes proliferation, metastasis, and sorafenib resistance by inducing CCNB1 translation in hepatocellular carcinoma

Peng Xia, Hao Zhang, Kequan Xu, Xiang Jiang, Meng Gao, Ganggang Wang, Yingyi Liu, Ye Yao, Xi Chen, Weijie Ma, Zhonglin Zhang, Yufeng Yuan

Cell Death Dis. 2021 Jul; 12(7): 691. Published online 2021 Jul 9. doi: 10.1038/s41419-021-03973-5

PMCID:: PMC8270967

Abstract Article PDF–7.0M

Select item 55314129.

Ubiquitination of tumor suppressor PML regulates prometastatic and immunosuppressive tumor microenvironment

Ya-Ting Wang, Jocelyn Chen, Chou-Wei Chang, Jayu Jen, Tzu-Yu Huang, Chun-Ming Chen, Roger Shen, Suh-Yuen Liang, I-Cheng Cheng, Shuenn-Chen Yang, Wu-Wei Lai, Kuang-Hung Cheng, Tao-Shih Hsieh, Ming-Zong Lai, Hung-Chi Cheng, Yi-Ching Wang, Ruey-Hwa Chen

J Clin Invest. 2017 Aug 1; 127(8): 2982–2997. Published online 2017 Jul 10. doi: 10.1172/JCI89957

PMCID:: PMC5531412

Abstract Article PDF–5.5M

Select item 1056773010.

PTPN23 ubiquitination by WDR4 suppresses EGFR and c-MET degradation to define a lung cancer therapeutic target

Shaifali Singh, Nai Yang Yeat, Ya-Ting Wang, Shu-Yu Lin, I-Ying Kuo, Kuen-Phon Wu, Won-Jing Wang, Wen-Ching Wang, Wu-Chou Su, Yi-Ching Wang, Ruey-Hwa Chen

Cell Death Dis. 2023 Oct; 14(10): 671. Published online 2023 Oct 11. doi: 10.1038/s41419-023-06201-4

Correction in:: Cell Death Dis. 2024 Jul; 15(7): 468.

PMCID:: PMC10567730

Abstract Article PDF–6.4M

Select item 986776111.

Wdr4 promotes cerebellar development and locomotion through Arhgap17-mediated Rac1 activation

Pei-Rung Wu, Shang-Yin Chiang, Robert Midence, Wen-Chao Kao, Chun-Lun Lai, I-Cheng Cheng, Shen-Ju Chou, Chih-Cheng Chen, Chih-Yang Huang, Ruey-Hwa Chen

Cell Death Dis. 2023 Jan; 14(1): 52. Published online 2023 Jan 21. doi: 10.1038/s41419-022-05442-z

PMCID:: PMC9867761

Abstract Article PDF–10M

Select item 114258112.

The tRNA methylase METTL1 is phosphorylated and inactivated by PKB and RSK in vitro and in cells

Robert A Cartlidge, Axel Knebel, Mark Peggie, Andrei Alexandrov, Eric M Phizicky, Philip Cohen

EMBO J. 2005 May 4; 24(9): 1696–1705. Published online 2005 Apr 14. doi: 10.1038/sj.emboj.7600648

PMCID:: PMC1142581

Abstract Article PDF–305K

Select item 470912713.

Wuho Is a New Member in Maintaining Genome Stability through its Interaction with Flap Endonuclease 1

I-Cheng Cheng, Betty Chamay Chen, Hung-Hsun Shuai, Fan-Ching Chien, Peilin Chen, Tao-shih Hsieh

PLoS Biol. 2016 Jan; 14(1): e1002349. Published online 2016 Jan 11. doi: 10.1371/journal.pbio.1002349

PMCID:: PMC4709127

Abstract Article PDF–10M

Select item 458777714.

Mutation in WDR4 impairs tRNA m⁷G₄₆ methylation and causes a distinct form of microcephalic primordial dwarfism

Ranad Shaheen, Ghada M H Abdel-Salam, Michael P. Guy, Rana Alomar, Mohamed S. Abdel-Hamid, Hanan H. Afifi, Samira I. Ismail, Bayoumi A. Emam, Eric M. Phizicky, Fowzan S. Alkuraya

Genome Biol. 2015; 16: 210. Published online 2015 Sep 28. doi: 10.1186/s13059-015-0779-x

PMCID:: PMC4587777

Abstract Article PDF–1.6M

Select item 432144415.

Genome-wide association study of selenium concentrations

Marilyn C. Cornelis, Myriam Fornage, Millennia Foy, Pengcheng Xun, Vadim N. Gladyshev, Steve Morris, Daniel I. Chasman, Frank B. Hu, Eric B. Rimm, Peter Kraft, Joanne M. Jordan, Dariush Mozaffarian, Ka He

Hum Mol Genet. 2015 Mar 1; 24(5): 1469–1477. Published online 2014 Oct 24. doi: 10.1093/hmg/ddu546

PMCID:: PMC4321444

Abstract Article PDF–252K

Select item 152672816.

Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins

Yu-Hui Hu, Hans-Jörg Warnatz, Dominique Vanhecke, Florian Wagner, Andrea Fiebitz, Sabine Thamm, Pascal Kahlem, Hans Lehrach, Marie-Laure Yaspo, Michal Janitz

BMC Genomics. 2006; 7: 155. Published online 2006 Jun 16. doi: 10.1186/1471-2164-7-155