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Select item 111729821.

Loss of CFTR Reverses Senescence Hallmarks in SARS-CoV-2 Infected Bronchial Epithelial Cells

Flavia Merigo, Anna Lagni, Federico Boschi, Paolo Bernardi, Anita Conti, Roberto Plebani, Mario Romano, Claudio Sorio, Virginia Lotti, Andrea Sbarbati

Int J Mol Sci. 2024 Jun; 25(11): 6185. Published online 2024 Jun 4. doi: 10.3390/ijms25116185

PMCID:: PMC11172982

Abstract Article PDF–10M

Select item 111487212.

Prime editing functionally corrects cystic fibrosis-causing CFTR mutations in human organoids and airway epithelial cells

Mattijs Bulcaen, Phéline Kortleven, Ronald B. Liu, Giulia Maule, Elise Dreano, Mairead Kelly, Marjolein M. Ensinck, Sam Thierie, Maxime Smits, Matteo Ciciani, Aurelie Hatton, Benoit Chevalier, Anabela S. Ramalho, Xavier Casadevall i Solvas, Zeger Debyser, François Vermeulen, Rik Gijsbers, Isabelle Sermet-Gaudelus, Anna Cereseto, Marianne S. Carlon

Cell Rep Med. 2024 May 21; 5(5): 101544. Published online 2024 May 1. doi: 10.1016/j.xcrm.2024.101544

PMCID:: PMC11148721

Abstract Article PDF–5.1M

Select item 111475663.

Insights and considerations on CFTR variant reporting in a study of cystic fibrosis patients in Saudi Arabia CFTR 1548del G and 1549del G: Navigating the discovery of novel mutations

Eman A. Al Abdulsalam

Saudi Med J. 2024 May; 45(5): 541. doi: 10.15537/smj.2024.45.5.20240331

PMCID:: PMC11147566

Article PDF–112K

Select item 111391144.

Nucleotide binding domains of human CFTR: a structural classification of critical residues and disease-causing mutations.

R. Eudes, P. Lehn, C. Férec, J. -P. Mornon, I. Callebaut

Cell Mol Life Sci. 2005 Sep; 62(18): 2112–2123. Published online 2005 Aug 26. doi: 10.1007/s00018-005-5224-y

PMCID:: PMC11139114

Abstract Article PDF–742K

Select item 111318605.

Atomic model of human cystic fibrosis transmembrane conductance regulator: Membrane-spanning domains and coupling interfaces

J.-P. Mornon, P. Lehn, I. Callebaut

Cell Mol Life Sci. 2008 Aug; 65(16): 2594–2612. Published online 2008 Jul 4. doi: 10.1007/s00018-008-8249-1

PMCID:: PMC11131860

Abstract Article PDF–5.3M

Select item 111158516.

Molecular models of the open and closed states of the whole human CFTR protein

Jean-Paul Mornon, Pierre Lehn, Isabelle Callebaut

Cell Mol Life Sci. 2009 Nov; 66(21): 3469–3486. Published online 2009 Aug 26. doi: 10.1007/s00018-009-0133-0

PMCID:: PMC11115851

Abstract Article PDF–1.1M

Select item 111139747.

Full-open and closed CFTR channels, with lateral tunnels from the cytoplasm and an alternative position of the F508 region, as revealed by molecular dynamics

Jean-Paul Mornon, Brice Hoffmann, Slavica Jonic, Pierre Lehn, Isabelle Callebaut

Cell Mol Life Sci. 2015 Apr; 72(7): 1377–1403. Published online 2014 Oct 7. doi: 10.1007/s00018-014-1749-2

PMCID:: PMC11113974

Abstract Article PDF–7.6M

Select item 111139068.

Functional and pharmacological induced structural changes of the cystic fibrosis transmembrane conductance regulator in the membrane solved using SAXS

Debora Baroni, Olga Zegarra-Moran, Oscar Moran

Cell Mol Life Sci. 2015 Apr; 72(7): 1363–1375. Published online 2014 Oct 2. doi: 10.1007/s00018-014-1747-4

PMCID:: PMC11113906

Abstract Article PDF–2.0M

Select item 111131469.

A SAXS-based ensemble model of the native and phosphorylated regulatory domain of the CFTR

Carlotta Marasini, Lauretta Galeno, Oscar Moran

Cell Mol Life Sci. 2013 Mar; 70(5): 923–933. Published online 2012 Oct 4. doi: 10.1007/s00018-012-1172-5

PMCID:: PMC11113146

Abstract Article PDF–532K

Select item 1110778210.

From the endoplasmic reticulum to the plasma membrane: mechanisms of CFTR folding and trafficking

Carlos M. Farinha, Sara Canato

Cell Mol Life Sci. 2017 Jan; 74(1): 39–55. Published online 2016 Oct 3. doi: 10.1007/s00018-016-2387-7

PMCID:: PMC11107782

Abstract Article PDF–1.6M

Select item 1110775811.

The biophysics, biochemistry and physiology of CFTR

Oscar Moran

Cell Mol Life Sci. 2017 Jan; 74(1): 1–2. Published online 2016 Oct 4. doi: 10.1007/s00018-016-2384-x

PMCID:: PMC11107758

Article PDF–302K

Select item 1110774212.

The gating of the CFTR channel

Oscar Moran

Cell Mol Life Sci. 2017 Jan; 74(1): 85–92. Published online 2016 Oct 1. doi: 10.1007/s00018-016-2390-z

PMCID:: PMC11107742

Abstract Article PDF–968K

Select item 1110770213.

Molecular modelling and molecular dynamics of CFTR

Isabelle Callebaut, Brice Hoffmann, Pierre Lehn, Jean-Paul Mornon

Cell Mol Life Sci. 2017 Jan; 74(1): 3–22. Published online 2016 Oct 7. doi: 10.1007/s00018-016-2385-9

PMCID:: PMC11107702

Abstract Article PDF–3.9M

Select item 1110766214.

Architecture and functional properties of the CFTR channel pore

Paul Linsdell

Cell Mol Life Sci. 2017 Jan; 74(1): 67–83. Published online 2016 Oct 3. doi: 10.1007/s00018-016-2389-5

PMCID:: PMC11107662

Abstract Article PDF–4.5M

Select item 1110574515.

Conformational change of the extracellular parts of the CFTR protein during channel gating

Alexander Negoda, Elizabeth A. Cowley, Yassine El Hiani, Paul Linsdell

Cell Mol Life Sci. 2018 Aug; 75(16): 3027–3038. Published online 2018 Feb 14. doi: 10.1007/s00018-018-2777-0

PMCID:: PMC11105745

Abstract Article PDF–1.7M

Select item 1110559816.

Cystic fibrosis transmembrane conductance regulator—emerging regulator of cancer

Jieting Zhang, Yan Wang, Xiaohua Jiang, Hsiao Chang Chan

Cell Mol Life Sci. 2018 May; 75(10): 1737–1756. Published online 2018 Feb 6. doi: 10.1007/s00018-018-2755-6

PMCID:: PMC11105598

Abstract Article PDF–1.3M

Select item 1110553617.

Impairment of CFTR activity in cultured epithelial cells upregulates the expression and activity of LDH resulting in lactic acid hypersecretion

Ángel G. Valdivieso, Mariángeles Clauzure, María M. Massip-Copiz, Carla E. Cancio, Cristian J. A. Asensio, Consuelo Mori, Tomás A. Santa-Coloma

Cell Mol Life Sci. 2019 Apr; 76(8): 1579–1593. Published online 2019 Jan 1. doi: 10.1007/s00018-018-3001-y

PMCID:: PMC11105536

Abstract Article PDF–3.4M

Select item 1110540518.

Contribution of the eighth transmembrane segment to the function of the CFTR chloride channel pore

Alexander Negoda, Mairin S. Hogan, Elizabeth A. Cowley, Paul Linsdell

Cell Mol Life Sci. 2019 Jun; 76(12): 2411–2423. Published online 2019 Feb 13. doi: 10.1007/s00018-019-03043-2

PMCID:: PMC11105405

Abstract Article PDF–2.4M

Select item 1097064019.

Functional Consequences of CFTR Interactions in Cystic Fibrosis

Yashaswini Ramananda, Anjaparavanda P. Naren, Kavisha Arora

Int J Mol Sci. 2024 Mar; 25(6): 3384. Published online 2024 Mar 16. doi: 10.3390/ijms25063384

PMCID:: PMC10970640

Abstract Article PDF–3.6M

Select item 1087597620.

The impact of genomic distance on enhancer‐promoter interactions at the CFTR locus

Jenny L. Kerschner, Frederick Meckler, Giuliana C. Coatti, Nirbhayaditya Vaghela, Alekh Paranjapye, Ann Harris

J Cell Mol Med. 2024 Feb; 28(4): e18142. Published online 2024 Feb 19. doi: 10.1111/jcmm.18142

PMCID:: PMC10875976

Abstract Article PDF–5.1M

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PMC Links for Gene (Select 1080) (814)
PMC
fp18d03.x1 zebrafish gridded kidney Danio rerio cDNA clone IMAGE:4729781 3', mRN...
fp18d03.x1 zebrafish gridded kidney Danio rerio cDNA clone IMAGE:4729781 3', mRNA sequence
gi|14260314|gnl|dbEST|8647564|gb|BG 2.1|

Nucleotide
zyg11l zyg-11 family member, cell cycle regulator, like [Danio rerio]
zyg11l zyg-11 family member, cell cycle regulator, like [Danio rerio]
Gene ID:567429

Gene
krt18a.1 keratin 18a, tandem duplicate 1 [Danio rerio]
krt18a.1 keratin 18a, tandem duplicate 1 [Danio rerio]
Gene ID:352912

Gene

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