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Select item 56502011.

Sickle Cells Produce Functional Immune Modulators and Cytotoxics

Chiao-Wang Sun, Li-Chen Wu, Peter L. Knopick, David S. Bradley, Tim Townes, David S. Terman

Am J Hematol. Author manuscript; available in PMC 2018 Oct 1.

Published in final edited form as: Am J Hematol. 2017 Oct; 92(10): 981–988. Published online 2017 Aug 17. doi: 10.1002/ajh.24836

PMCID:: PMC5650201

Abstract Article PDF–1.7M

Select item 55426362.

Lentiviral Vectors with Cellular Promoters Correct Anemia and Lethal Bone Marrow Failure in a Mouse Model for Diamond-Blackfan Anemia

Shubhranshu Debnath, Pekka Jaako, Kavitha Siva, Michael Rothe, Jun Chen, Maria Dahl, H. Bobby Gaspar, Johan Flygare, Axel Schambach, Stefan Karlsson

Mol Ther. 2017 Aug 2; 25(8): 1805–1814. Published online 2017 Apr 20. doi: 10.1016/j.ymthe.2017.04.002

PMCID:: PMC5542636

Abstract Article PDF–1.6M

Select item 54628603.

CRISPR–Cas9 epigenome editing enables high-throughput screening for functional regulatory elements in the human genome

Tyler S. Klann, Joshua B. Black, Malathi Chellappan, Alexias Safi, Lingyun Song, Isaac B. Hilton, Gregory E. Crawford, Timothy E. Reddy, Charles A. Gersbach

Nat Biotechnol. Author manuscript; available in PMC 2017 Oct 3.

Published in final edited form as: Nat Biotechnol. 2017 Jun; 35(6): 561–568. Published online 2017 Apr 3. doi: 10.1038/nbt.3853

PMCID:: PMC5462860

Abstract Article PDF–1.1M

Select item 50008464.

Forced chromatin looping raises fetal hemoglobin in adult sickle cells to higher levels than pharmacologic inducers

Laura Breda, Irene Motta, Silvia Lourenco, Chiara Gemmo, Wulan Deng, Jeremy W. Rupon, Osheiza Y. Abdulmalik, Deepa Manwani, Gerd A. Blobel, Stefano Rivella

Blood. 2016 Aug 25; 128(8): 1139–1143. Prepublished online 2016 Jul 12. doi: 10.1182/blood-2016-01-691089

PMCID:: PMC5000846

Abstract Article

Select item 48717435.

Original Research: Generation of non-deletional hereditary persistence of fetal hemoglobin β-globin locus yeast artificial chromosome transgenic mouse models: -175 Black HPFH and -195 Brazilian HPFH

Carolina A Braghini, Flavia C Costa, Halyna Fedosyuk, Renee Y Neades, Lesya V Novikova, Matthew P Parker, Robert D Winefield, Kenneth R Peterson

Exp Biol Med (Maywood) 2016 Apr; 241(7): 697–705. Published online 2016 Mar 4. doi: 10.1177/1535370216636724

PMCID:: PMC4871743

Abstract Article PDF–464K

Select item 48701306.

Chromatin looping as a target for altering erythroid gene expression

Ivan Krivega, Ann Dean

Ann N Y Acad Sci. Author manuscript; available in PMC 2017 Mar 1.

Published in final edited form as: Ann N Y Acad Sci. 2016 Mar; 1368(1): 31–39. Published online 2016 Feb 25. doi: 10.1111/nyas.13012

PMCID:: PMC4870130

Abstract Article PDF–910K

Select item 48421487.

Enhancer regulation of transcriptional bursting parameters revealed by forced chromatin looping

Caroline R. Bartman, Sarah C. Hsu, Chris C.-S. Hsiung, Arjun Raj, Gerd A. Blobel

Mol Cell. Author manuscript; available in PMC 2017 Apr 21.

Published in final edited form as: Mol Cell. 2016 Apr 21; 62(2): 237–247. Published online 2016 Apr 7. doi: 10.1016/j.molcel.2016.03.007

PMCID:: PMC4842148

Abstract Article PDF–1.2M

Select item 47336838.

Fetal Hemoglobin in Tunisian Sickle Cell Disease Patient: Relationship with Polymorphic Sequences Cis to the β-Globin Gene

Imen Moumni, Maha Ben Mustapha, Ikbel Ben Mansour, Amine Zoraï, Kaïs Douzi, Sarah Sassi, Dorra Chaouachi, Fethi Mellouli, Mohamed Bejaoui, Salem Abbes

Indian J Hematol Blood Transfus. 2016 Mar; 32(1): 114–119. Published online 2015 Jan 23. doi: 10.1007/s12288-015-0504-7

PMCID:: PMC4733683

Abstract Article PDF–453K

Select item 46946999.

Novel Inducers of Fetal Globin Identified through High Throughput Screening (HTS) Are Active In Vivo in Anemic Baboons and Transgenic Mice

Michael S. Boosalis, Jose I. Sangerman, Gary L. White, Roman F. Wolf, Ling Shen, Yan Dai, Emily White, Levi H. Makala, Biaoru Li, Betty S. Pace, Mehdi Nouraie, Douglas V. Faller, Susan P. Perrine

PLoS One. 2015; 10(12): e0144660. Published online 2015 Dec 29. doi: 10.1371/journal.pone.0144660

PMCID:: PMC4694699

Abstract Article PDF–2.3M

Select item 466677810.

Highly Specific Epigenome Editing by CRISPR/Cas9 Repressors for Silencing of Distal Regulatory Elements

Pratiksha I. Thakore, Anthony M D’Ippolito, Lingyun Song, Alexias Safi, Nishkala K. Shivakumar, Ami M. Kabadi, Timothy E. Reddy, Gregory E. Crawford, Charles A. Gersbach

Nat Methods. Author manuscript; available in PMC 2016 May 18.

Published in final edited form as: Nat Methods. 2015 Dec; 12(12): 1143–1149. Published online 2015 Oct 26. doi: 10.1038/nmeth.3630

PMCID:: PMC4666778

Abstract Article PDF–1.7M

Select item 461482511.

Keeping fetal hemoglobin in the loop

Jeremy D Grevet, Gerd A Blobel

Cell Cycle. 2014; 13(20): 3153–3154. Published online 2014 Oct 29. doi: 10.4161/15384101.2014.969995

PMCID:: PMC4614825

Article PDF–44K

Select item 452088112.

Inhibition of G9a methyltransferase stimulates fetal hemoglobin production by facilitating LCR/γ-globin looping

Ivan Krivega, Colleen Byrnes, Jaira F. de Vasconcellos, Y. Terry Lee, Megha Kaushal, Ann Dean, Jeffery L. Miller

Blood. 2015 Jul 30; 126(5): 665–672. Prepublished online 2015 May 15. doi: 10.1182/blood-2015-02-629972

PMCID:: PMC4520881

Abstract Article

Select item 442022213.

Hb S/β⁺-thalassemia due to Hb sickle and a novel deletion of DNase I hypersensitive sites HS3 and HS4 of the β locus control region

Ali Amid, Melina Cheong, Barry Eng, Meredith Hanna, Betty-Ann Hohenadel, Lisa M. Nakamura, Lynda Walker, Isaac Odame, Melanie Kirby-Allen, John S. Waye

Haematologica. 2015 May; 100(5): e166–e168. doi: 10.3324/haematol.2014.117408

PMCID:: PMC4420222

Article PDF–527K

Select item 426336914.

Short-chain fatty acid derivatives stimulate cell proliferation and induce STAT-5 activation

Michael S. Boosalis, Ram Bandyopadhyay, Emery H. Bresnick, Betty S. Pace, Karyn Van DeMark, Baohua Zhang, Douglas V. Faller, Susan P. Perrine

Blood. Author manuscript; available in PMC 2014 Dec 11.

Published in final edited form as: Blood. 2001 May 15; 97(10): 3259–3267. doi: 10.1182/blood.v97.10.3259

PMCID:: PMC4263369

Abstract Article PDF–4.1M

Select item 425177615.

High-Density SNP Genotyping to Define β-Globin Locus Haplotypes

Li Liu, Shalini Muralidhar, Manisha Singh, Caprice Sylvan, Inderdeep S. Kalra, Charles T. Quinn, Onyinye C. Onyekwere, Betty S. Pace

Blood Cells Mol Dis. Author manuscript; available in PMC 2014 Dec 2.

Published in final edited form as: Blood Cells Mol Dis. 2009 Jan-Feb; 42(1): 16–24. Published online 2008 Oct 1. doi: 10.1016/j.bcmd.2008.07.002

PMCID:: PMC4251776

Abstract Article PDF–931K

Select item 414779016.

Haplotype Map of Sickle Cell Anemia in Tunisia

Imen Moumni, Maha Ben Mustapha, Sarra Sassi, Amine Zorai, Ikbel Ben Mansour, Kais Douzi, Dorra Chouachi, Fethi Mellouli, Mohamed Bejaoui, Salem Abbes

Dis Markers. 2014; 2014: 938301. Published online 2014 Jul 2. doi: 10.1155/2014/938301

PMCID:: PMC4147790

Abstract Article PDF–1.0M

Select item 374483317.

Cell-cycle specific association of transcription factors and RNA polymerase II with the human β-globin gene locus

Michael Rosenberg, Alex Xiucheng Fan, I-Ju Lin, Shermi Y Liang, Jörg Bungert

J Cell Biochem. Author manuscript; available in PMC 2014 Sep 1.

Published in final edited form as: J Cell Biochem. 2013 Sep; 114(9): 10.1002/jcb.24542. doi: 10.1002/jcb.24542

PMCID:: PMC3744833

Abstract Article PDF–1.1M

Select item 363973618.

Transient Expression Assay of ^Aγ-588 (A/G) Mutations in the K562 Cell Line

Mohammad Hamid, Frouzandeh Mahjoubi, Mohammad Taghi Akbari, Hossein Khanahmad, Fatemeh Jamshidi, Sirous Zeinali, Morteza Karimipoor

Iran Biomed J. 2011 Jan-Apr; 15(1-2): 15–21.

PMCID:: PMC3639736

Abstract Article PDF–241K

Select item 359759219.

High-Efficiency Transduction of Primary Human Hematopoietic Stem Cells and Erythroid Lineage-Restricted Expression by Optimized AAV6 Serotype Vectors In Vitro and in a Murine Xenograft Model In Vivo

Liujiang Song, Xiaomiao Li, Giridhara R. Jayandharan, Yuan Wang, George V. Aslanidi, Chen Ling, Li Zhong, Guangping Gao, Mervin C. Yoder, Changquan Ling, Mengqun Tan, Arun Srivastava

PLoS One. 2013; 8(3): e58757. Published online 2013 Mar 14. doi: 10.1371/journal.pone.0058757

PMCID:: PMC3597592

Abstract Article PDF–5.7M

Select item 358299420.

Development of K562 cell clones expressing β-globin mRNA carrying the β⁰39 thalassaemia mutation for the screening of correctors of stop-codon mutations

Francesca Salvatori, Vera Cantale, Giulia Breveglieri, Cristina Zuccato, Alessia Finotti, Nicoletta Bianchi, Monica Borgatti, Giordana Feriotto, Federica Destro, Alessandro Canella, Laura Breda, Stefano Rivella, Roberto Gambari

Biotechnol Appl Biochem. Author manuscript; available in PMC 2013 Feb 27.

Published in final edited form as: Biotechnol Appl Biochem. 2009 Jul 9; 54(1): 41–52. Published online 2009 Jul 9. doi: 10.1042/BA20080266

PMCID:: PMC3582994

Abstract Article PDF–2.1M

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