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Select item 86777661.

Structure-guided bifunctional molecules hit a DEUBAD-lacking hRpn13 species upregulated in multiple myeloma

Xiuxiu Lu, Venkata R. Sabbasani, Vasty Osei-Amponsa, Christine N. Evans, Julianna C. King, Sergey G. Tarasov, Marzena Dyba, Sudipto Das, King C. Chan, Charles D. Schwieters, Sulbha Choudhari, Caroline Fromont, Yongmei Zhao, Bao Tran, Xiang Chen, Hiroshi Matsuo, Thorkell Andresson, Raj Chari, Rolf E. Swenson, Nadya I. Tarasova, Kylie J. Walters

Nat Commun. 2021; 12: 7318. Published online 2021 Dec 16. doi: 10.1038/s41467-021-27570-4

PMCID:: PMC8677766

Article PDF–3.3M

Select item 79886822.

Proteomic analysis identifies mechanism(s) of overcoming bortezomib resistance via targeting ubiquitin receptor Rpn13

Ting Du, Yan Song, Arghya Ray, Dharminder Chauhan, Kenneth C. Anderson

Leukemia. Author manuscript; available in PMC 2021 Aug 1.

Published in final edited form as: Leukemia. 2021 Feb; 35(2): 550–561. Published online 2020 May 18. doi: 10.1038/s41375-020-0865-2

PMCID:: PMC7988682

Article PDF–1.4M

Select item 78067503.

Identification of novel anti-tumor therapeutic target via proteomic characterization of ubiquitin receptor ADRM1/Rpn13

Yan Song, Ting Du, Arghya Ray, Krishan Chauhan, Mehmet Samur, Nikhil Munshi, Dharminder Chauhan, Kenneth C. Anderson

Blood Cancer J. 2021 Jan; 11(1): 13. Published online 2021 Jan 13. doi: 10.1038/s41408-020-00398-9

PMCID:: PMC7806750

Article PDF–1.3M

Select item 55474744.

Early and consistent overexpression of ADRM1 in ovarian high-grade serous carcinoma

Rosie T. Jiang, Anna Yemelyanova, Deyin Xing, Ravi K. Anchoori, Jun Hamazaki, Shigeo Murata, Jeffrey D. Seidman, Tian-Li Wang, Richard B. S. Roden

J Ovarian Res. 2017; 10: 53. Published online 2017 Aug 7. doi: 10.1186/s13048-017-0347-y

PMCID:: PMC5547474

Article PDF–3.2M

Select item 90333015.

A cryptic K48 ubiquitin chain binding site on UCH37 is required for its role in proteasomal degradation

Jiale Du, Sandor Babik, Yanfeng Li, Kirandeep K Deol, Stephen J Eyles, Jasna Fejzo, Marco Tonelli, Eric Strieter

eLife. 2022; 11: e76100. Published online 2022 Apr 22. doi: 10.7554/eLife.76100

PMCID:: PMC9033301

Article PDF–11M

Select item 51014806.

SGTA interacts with the proteasomal ubiquitin receptor Rpn13 via a carboxylate clamp mechanism

Arjun Thapaliya, Yvonne Nyathi, Santiago Martínez-Lumbreras, Ewelina M. Krysztofinska, Nicola J. Evans, Isabelle L. Terry, Stephen High, Rivka L. Isaacson

Sci Rep. 2016; 6: 36622. Published online 2016 Nov 9. doi: 10.1038/srep36622

PMCID:: PMC5101480

Article PDF–2.1M

Select item 48614457.

The Proteasome Ubiquitin Receptor hRpn13 and Its Interacting Deubiquitinating Enzyme Uch37 Are Required for Proper Cell Cycle Progression

Leah Randles, Ravi K. Anchoori, Richard B. S. Roden, Kylie J. Walters

J Biol Chem. 2016 Apr 15; 291(16): 8773–8783. Published online 2016 Feb 23. doi: 10.1074/jbc.M115.694588

PMCID:: PMC4861445

Article PDF–1.9M

Select item 41309248.

Mechanism of the Rpn13-induced activation of Uch37

Lianying Jiao, Songying Ouyang, Neil Shaw, Gaojie Song, Yingang Feng, Fengfeng Niu, Weicheng Qiu, Hongtao Zhu, Li-Wei Hung, Xiaobing Zuo, V. Eleonora Shtykova, Ping Zhu, Yu-Hui Dong, Ruxiang Xu, Zhi-Jie Liu

Protein Cell. 2014 Aug; 5(8): 616–630. Published online 2014 Apr 22. doi: 10.1007/s13238-014-0046-z

PMCID:: PMC4130924

Article PDF–2.2M

Select item 41046839.

SUMOylation of Psmd1 controls Adrm1 Interaction with the Proteasome

Hyunju Ryu, Steven P. Gygi, Yoshiaki Azuma, Alexei Arnaoutov, Mary Dasso

Cell Rep. Author manuscript; available in PMC 2015 Jun 26.

Published in final edited form as: Cell Rep. 2014 Jun 26; 7(6): 1842–1848. Published online 2014 Jun 5. doi: 10.1016/j.celrep.2014.05.009

PMCID:: PMC4104683

Article PDF–1.5M

Select item 355722710.

MTMDAT-HADDOCK: High-throughput, protein complex structure modeling based on limited proteolysis and mass spectrometry

Janosch Hennig, Sjoerd J de Vries, Klaus DM Hennig, Leah Randles, Kylie J Walters, Maria Sunnerhagen, Alexandre MJJ Bonvin

BMC Struct Biol. 2012; 12: 29. Published online 2012 Nov 15. doi: 10.1186/1472-6807-12-29

PMCID:: PMC3557227

Article PDF–1.1M

Select item 854204111.

Kinectin1 depletion promotes EGFR degradation via the ubiquitin-proteosome system in cutaneous squamous cell carcinoma

Ji Ma, Shudong Ma, Ying Zhang, Yi Shen, Lei Huang, Tianhao Lu, Lu Wang, Yunhan Wen, Zhenhua Ding

Cell Death Dis. 2021 Nov; 12(11): 995. Published online 2021 Oct 23. doi: 10.1038/s41419-021-04276-5

PMCID:: PMC8542041

Article PDF–8.3M

Select item 720557112.

An extended conformation for K48 ubiquitin chains revealed by the hRpn2:Rpn13:K48-diubiquitin structure

Xiuxiu Lu, Danielle L. Ebelle, Hiroshi Matsuo, Kylie J. Walters

Structure. Author manuscript; available in PMC 2021 May 5.

Published in final edited form as: Structure. 2020 May 5; 28(5): 495–506.e3. Published online 2020 Mar 10. doi: 10.1016/j.str.2020.02.007

PMCID:: PMC7205571

Article PDF–2.8M

Select item 685134413.

Acute unfolding of a single protein immediately stimulates recruitment of ubiquitin protein ligase E3C (UBE3C) to 26S proteasomes

Colin D. Gottlieb, Airlia C. S. Thompson, Alban Ordureau, J. Wade Harper, Ron R. Kopito

J Biol Chem. 2019 Nov 8; 294(45): 16511–16524. Published online 2019 Aug 2. doi: 10.1074/jbc.RA119.009654

PMCID:: PMC6851344

Article PDF–1.8M

Select item 530980614.

Ubiquitin C-terminal hydrolase37 regulates Tcf7 DNA binding for the activation of Wnt signalling

Wonhee Han, Hyeyoon Lee, Jin-Kwan Han

Sci Rep. 2017; 7: 42590. Published online 2017 Feb 15. doi: 10.1038/srep42590

PMCID:: PMC5309806

Article PDF–1.5M

Select item 486144815.

Major Histocompatibility Complex (MHC) Class I Processing of the NY-ESO-1 Antigen Is Regulated by Rpn10 and Rpn13 Proteins and Immunoproteasomes following Non-lysine Ubiquitination

Richard Golnik, Andrea Lehmann, Peter-Michael Kloetzel, Frédéric Ebstein

J Biol Chem. 2016 Apr 15; 291(16): 8805–8815. Published online 2016 Feb 22. doi: 10.1074/jbc.M115.705178

PMCID:: PMC4861448

Article PDF–1.6M

Select item 460551716.

A High Affinity hRpn2-Derived Peptide That Displaces Human Rpn13 from Proteasome in 293T Cells

Xiuxiu Lu, Fen Liu, Sarah E. Durham, Sergey G. Tarasov, Kylie J. Walters

PLoS One. 2015; 10(10): e0140518. Published online 2015 Oct 14. doi: 10.1371/journal.pone.0140518

PMCID:: PMC4605517

Article PDF–1.8M

Select item 303418417.

Phospho-ΔNp63α/Rpn13-dependent regulation of LKB1 degradation modulates autophagy in cancer cells

Yiping Huang, Edward A. Ratovitski

Aging (Albany NY) 2010 Dec; 2(12): 959–968. Published online 2010 Dec 20. doi: 10.18632/aging.100249

PMCID:: PMC3034184

Article PDF–2.6M

Select item 300986818.

Phosphorylated TP63 Induces Transcription of RPN13, Leading to NOS2 Protein Degradation

Yiping Huang, Edward A. Ratovitski

J Biol Chem. 2010 Dec 31; 285(53): 41422–41431. Published online 2010 Oct 19. doi: 10.1074/jbc.M110.158642

PMCID:: PMC3009868

Article PDF–2.2M

Select item 288772219.

Structure of Proteasome Ubiquitin Receptor hRpn13 and its Activation by the Scaffolding Protein hRpn2

Xiang Chen, Byung-Hoon Lee, Daniel Finley, Kylie J. Walters

Mol Cell. Author manuscript; available in PMC 2011 May 14.

Published in final edited form as: Mol Cell. 2010 May 14; 38(3): 404–415. doi: 10.1016/j.molcel.2010.04.019

PMCID:: PMC2887722

Article PDF–3.4M

Select item 282515820.

Ubiquitin docking at the proteasome via a novel PH domain interaction

Patrick Schreiner, Xiang Chen, Koraljka Husnjak, Leah Randles, Naixia Zhang, Suzanne Elsasser, Daniel Finley, Ivan Dikic, Kylie Walters, Michael Groll

Nature. Author manuscript; available in PMC 2010 Feb 19.

Published in final edited form as: Nature. 2008 May 22; 453(7194): 548–552. doi: 10.1038/nature06924