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Items: 1 to 20 of 119

1.
WWP2 ubiquitin ligase and it’s isoforms: new biological insight and promising disease targets
Andrew Chantry
Cell Cycle. Author manuscript; available in PMC 2014 Jun 30.
Published in final edited form as: Cell Cycle. 2011 Aug 1; 10(15): 2437–2439. Published online 2011 Aug 1. doi: 10.4161/cc.10.15.16874
PMCID:
PMC4074766
AbstractArticlePDF–58K
2.
Divergent regulation of α-arrestin ARRDC3 function by ubiquitination
Helen Wedegaertner, Oye Bosompra, Irina Kufareva, JoAnn Trejo
Mol Biol Cell. 2023 Aug 1; 34(9): ar93. Published online 2023 Aug 1. doi: 10.1091/mbc.E23-02-0055
PMCID:
PMC10398895
AbstractArticlePDF–1.9M
3.
Palmitic acid negatively regulates tumor suppressor PTEN through T366 phosphorylation and protein degradation
Dongmei Bai, Yong Wu, Poonamjot Deol, Yumiko Nobumori, Qi Zhou, Frances M. Sladek, Xuan Liu
Cancer Lett. Author manuscript; available in PMC 2023 Jul 6.
Published in final edited form as: Cancer Lett. 2021 Jan 1; 496: 127–133. Published online 2020 Oct 9. doi: 10.1016/j.canlet.2020.10.007
PMCID:
PMC10325098
AbstractArticlePDF–1.2M
4.
Down-regulation of WWP2 aggravates Type 2 diabetes mellitus-induced vascular endothelial injury through modulating ubiquitination and degradation of DDX3X
Shilong You, Jiaqi Xu, Zeyu Yin, Boquan Wu, Pengbo Wang, Mingjun Hao, Cheng Cheng, Mengke Liu, Yuanhui Zhao, Pengyu Jia, Hongkun Jiang, Da Li, Liu Cao, Xingang Zhang, Ying Zhang, Yingxian Sun, Naijin Zhang
Cardiovasc Diabetol. 2023; 22: 107. Published online 2023 May 6. doi: 10.1186/s12933-023-01818-3
PMCID:
PMC10164326
AbstractArticlePDF–12M
5.
WWP2 drives the progression of gastric cancer by facilitating the ubiquitination and degradation of LATS1 protein
Jianping Zou, Ling Zhou, Yi Le, Zhi Fang, Min Zhong, Fengting Nie, Xianpin Wei, Xiaomei Zhang, Zhen Chen, Lingling Cai, Heng Wang, Jianping Xiong, Ziling Fang, Xiaojun Xiang
Cell Commun Signal. 2023; 21: 38. Published online 2023 Feb 17. doi: 10.1186/s12964-023-01050-2
PMCID:
PMC9938551
AbstractArticlePDF–11M
6.
WWP2 ameliorates oxidative stress and inflammation in atherosclerotic mice through regulation of PDCD4/HO-1 pathway: WWP2 interacted with PDCD4 ameliorates AS
Xingye Wang, Lu Ma, Songlin Zhang, Qiang Song, Xumei He, Jun Wang
Acta Biochim Biophys Sin (Shanghai) 2022 Aug; 54(8): 1057–1067. Published online 2022 Aug 16. doi: 10.3724/abbs.2022091
PMCID:
PMC9828489
AbstractArticlePDF–2.7M
7.
The role of E3 ubiquitin ligase WWP2 and the regulation of PARP1 by ubiquitinated degradation in acute lymphoblastic leukemia
Xinxin Lu, Xinyue Huang, Haiqi Xu, Saien Lu, Shilong You, Jiaqi Xu, Qianru Zhan, Chao Dong, Ning Zhang, Ying Zhang, Liu Cao, Xingang Zhang, Naijin Zhang, Lijun Zhang
Cell Death Discov. 2022; 8: 421. Published online 2022 Oct 18. doi: 10.1038/s41420-022-01209-9
PMCID:
PMC9579143
AbstractArticlePDF–4.5M
8.
miR-328-5p Induces Human Intervertebral Disc Degeneration by Targeting WWP2
Jing Yan, Lun-Gang Wu, Ming Zhang, Tao Fang, Wei Pan, Jia-Li Zhao, Quan Zhou
Oxid Med Cell Longev. 2022; 2022: 3511967. Published online 2022 Sep 29. doi: 10.1155/2022/3511967
PMCID:
PMC9537005
AbstractArticlePDF–1.6M
9.
N-terminal protein labeling with N-hydroxysuccinimide esters and microscale thermophoresis measurements of protein-protein interactions using labeled protein
Hanjie Jiang, Philip A. Cole
Curr Protoc. Author manuscript; available in PMC 2022 Jan 1.
Published in final edited form as: Curr Protoc. 2021 Jan; 1(1): e14. doi: 10.1002/cpz1.14
Correction in:
Curr Protoc. 2022 Aug; 2(8): e552.
PMCID:
PMC7839251
AbstractArticlePDF–1.1M
10.
Smad7 Binds Differently to Individual and Tandem WW3 and WW4 Domains of WWP2 Ubiquitin Ligase Isoforms
Lloyd C. Wahl, Jessica E. Watt, Hiu T. T. Yim, Danielle De Bourcier, James Tolchard, Surinder M. Soond, Tharin M. A. Blumenschein, Andrew Chantry
Int J Mol Sci. 2019 Oct; 20(19): 4682. Published online 2019 Sep 21. doi: 10.3390/ijms20194682
PMCID:
PMC6801763
AbstractArticlePDF–1.7M
11.
Wwp2 maintains cartilage homeostasis through regulation of Adamts5
Sho Mokuda, Ryo Nakamichi, Tokio Matsuzaki, Yoshiaki Ito, Tempei Sato, Kohei Miyata, Masafumi Inui, Merissa Olmer, Eiji Sugiyama, Martin Lotz, Hiroshi Asahara
Nat Commun. 2019; 10: 2429. Published online 2019 Jun 3. doi: 10.1038/s41467-019-10177-1
PMCID:
PMC6546747
AbstractArticlePDF–2.8M
12.
Site-specific Protein Labeling with NHS-Esters and the Analysis of Ubiquitin Ligase Mechanisms
Daniel R. Dempsey, Hanjie Jiang, Jay H. Kalin, Zan Chen, Philip A. Cole
J Am Chem Soc. Author manuscript; available in PMC 2019 Aug 1.
Published in final edited form as: J Am Chem Soc. 2018 Aug 1; 140(30): 9374–9378. Published online 2018 Jul 23. doi: 10.1021/jacs.8b05098
PMCID:
PMC6093203
AbstractArticlePDF–850K
13.
Gamabufotalin triggers c-Myc degradation via induction of WWP2 in multiple myeloma cells
Zhenlong Yu, Tao Li, Chao Wang, Sa Deng, Baojing Zhang, Xiaokui Huo, Bo Zhang, Xiaobo Wang, Yuping Zhong, Xiaochi Ma
Oncotarget. 2016 Mar 29; 7(13): 15725–15737. Published online 2016 Feb 15. doi: 10.18632/oncotarget.7398
PMCID:
PMC4941272
AbstractArticlePDF–10M
14.
lncRNA BREA2 promotes metastasis by disrupting the WWP2-mediated ubiquitination of Notch1
Zhen Zhang, Yun-xin Lu, Fangzhou Liu, Lingjie Sang, Chengyu Shi, Shaofang Xie, Weixiang Bian, Jie-cheng Yang, Zuozhen Yang, Lei Qu, Shi-yi Chen, Jun Li, Lu Yang, Qingfeng Yan, Wenqi Wang, Peifen Fu, Jianzhong Shao, Xu Li, Aifu Lin
Proc Natl Acad Sci U S A. 2023 Feb 21; 120(8): e2206694120. Published online 2023 Feb 16. doi: 10.1073/pnas.2206694120
PMCID:
PMC9974429
AbstractArticlePDF–9.9M
15.
The E3 ubiquitin ligase WWP2 regulates pro-fibrogenic monocyte infiltration and activity in heart fibrosis
Huimei Chen, Gabriel Chew, Nithya Devapragash, Jui Zhi Loh, Kevin Y. Huang, Jing Guo, Shiyang Liu, Elisabeth Li Sa Tan, Shuang Chen, Nicole Gui Zhen Tee, Masum M. Mia, Manvendra K. Singh, Aihua Zhang, Jacques Behmoaras, Enrico Petretto
Nat Commun. 2022; 13: 7375. Published online 2022 Nov 30. doi: 10.1038/s41467-022-34971-6
PMCID:
PMC9712659
AbstractArticlePDF–4.6M
16.
The Tumour Suppressor TMEM127 Is a Nedd4-Family E3 Ligase Adaptor Required by Salmonella SteD to Ubiquitinate and Degrade MHC Class II Molecules
Eric Alix, Camilla Godlee, Ondrej Cerny, Samkeliso Blundell, Romina Tocci, Sophie Matthews, Mei Liu, Jonathan N. Pruneda, Kirby N. Swatek, David Komander, Tabitha Sleap, David W. Holden
Cell Host Microbe. 2020 Jul 8; 28(1): 54–68.e7. doi: 10.1016/j.chom.2020.04.024
PMCID:
PMC7342019
AbstractArticle
17.
Role of WW domain E3 ubiquitin protein ligase 2 in modulating ubiquitination and Degradation of Septin4 in oxidative stress endothelial injury
Naijin Zhang, Ying Zhang, Boquan Wu, Shilong You, Yingxian Sun
Redox Biol. 2020 Feb; 30: 101419. Published online 2020 Jan 2. doi: 10.1016/j.redox.2019.101419
PMCID:
PMC6951091
AbstractArticlePDF–4.2M
18.
Long noncoding RNA lnc-DILC stabilizes PTEN and suppresses clear cell renal cell carcinoma progression
Han Zhang, Pengtao Wei, Wenwei Lv, Xingtao Han, Jinhui Yang, Shuaifeng Qin
Cell Biosci. 2019; 9: 81. Published online 2019 Oct 2. doi: 10.1186/s13578-019-0345-4
PMCID:
PMC6775667
AbstractArticlePDF–6.3M
19.
WWP2 regulates pathological cardiac fibrosis by modulating SMAD2 signaling
Huimei Chen, Aida Moreno-Moral, Francesco Pesce, Nithya Devapragash, Massimiliano Mancini, Ee Ling Heng, Maxime Rotival, Prashant K. Srivastava, Nathan Harmston, Kirill Shkura, Owen J. L. Rackham, Wei-Ping Yu, Xi-Ming Sun, Nicole Gui Zhen Tee, Elisabeth Li Sa Tan, Paul J. R. Barton, Leanne E. Felkin, Enrique Lara-Pezzi, Gianni Angelini, Cristina Beltrami, Michal Pravenec, Sebastian Schafer, Leonardo Bottolo, Norbert Hubner, Costanza Emanueli, Stuart A. Cook, Enrico Petretto
Nat Commun. 2019; 10: 3616. Published online 2019 Aug 9. doi: 10.1038/s41467-019-11551-9
Correction in:
Nat Commun. 2019; 10: 4085.
PMCID:
PMC6689010
AbstractArticlePDF–4.1M
20.
MicroRNA-32 silences WWP2 expression to maintain the pluripotency of human amniotic epithelial stem cells and β islet-like cell differentiation
Gang Zou, Te Liu, Lihe Guo, Yongyi Huang, Ya Feng, Tao Duan
Int J Mol Med. 2018 Apr; 41(4): 1983–1991. Published online 2018 Jan 29. doi: 10.3892/ijmm.2018.3436
PMCID:
PMC5810217
AbstractArticlePDF–986K

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