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Select item 82337861.

Broad Impact of Exchange Protein Directly Activated by cAMP 2 (EPAC2) on Respiratory Viral Infections

Eun-Jin Choi, Wenzhe Wu, Xiaoyan Cong, Ke Zhang, Jiaqi Luo, Sha Ye, Pingyuan Wang, Adarsh Suresh, Uneeb Mohammad Ullah, Jia Zhou, Xiaoyong Bao

Viruses. 2021 Jun; 13(6): 1179. Published online 2021 Jun 21. doi: 10.3390/v13061179

PMCID:: PMC8233786

Abstract Article PDF–2.6M

Select item 66363542.

Structure and functional roles of Epac2 (RAPGEF4)

Kenji Sugawara, Tadao Shibasaki, Harumi Takahashi, Susumu Seino

Gene. Author manuscript; available in PMC 2019 Jul 17.

Published in final edited form as: Gene. 2016 Jan 10; 575(2 Pt 3): 577–583. Published online 2015 Sep 24. doi: 10.1016/j.gene.2015.09.029

PMCID:: PMC6636354

Abstract Article PDF–490K

Select item 30938643.

Mechanism of Intracellular cAMP Sensor Epac2 Activation: cAMP-INDUCED CONFORMATIONAL CHANGES IDENTIFIED BY AMIDE HYDROGEN/DEUTERIUM EXCHANGE MASS SPECTROMETRY (DXMS)

Sheng Li, Tamara Tsalkova, Mark A. White, Fang C. Mei, Tong Liu, Daphne Wang, Virgil L. Woods, Jr, Xiaodong Cheng

J Biol Chem. 2011 May 20; 286(20): 17889–17897. Published online 2011 Mar 17. doi: 10.1074/jbc.M111.224535

PMCID:: PMC3093864

Abstract Article PDF–4.4M

Select item 27491394.

Mechanism of Epac Activation: STRUCTURAL AND FUNCTIONAL ANALYSES OF Epac2 HINGE MUTANTS WITH CONSTITUTIVE AND REDUCED ACTIVITIES

Tamara Tsalkova, Donald K. Blumenthal, Fang C. Mei, Mark A. White, Xiaodong Cheng

J Biol Chem. 2009 Aug 28; 284(35): 23644–23651. Published online 2009 Jun 24. doi: 10.1074/jbc.M109.024950

PMCID:: PMC2749139

Abstract Article PDF–1.6M

Select item 111077445.

The role of Epac in the heart

Takayuki Fujita, Masanari Umemura, Utako Yokoyama, Satoshi Okumura, Yoshihiro Ishikawa

Cell Mol Life Sci. 2017 Feb; 74(4): 591–606. Published online 2016 Aug 22. doi: 10.1007/s00018-016-2336-5

PMCID:: PMC11107744

Abstract Article PDF–1.6M

Select item 95323576.

EPAC Regulates Melanoma Growth by Stimulating mTORC1 Signaling and Loss of EPAC Signaling Dependence Correlates with Melanoma Progression

Aishwarya Krishnan, Aishwarya I. Bhasker, Mithalesh K. Singh, Carlos. I. Rodriguez, Edgardo Castro-Pérez, Sarah Altameemi, Marcos Lares, Hamidullah Khan, Mary Ndiaye, Nihal Ahmad, Stefan M. Schieke, Vijayasaradhi Setaluri

Mol Cancer Res. Author manuscript; available in PMC 2023 Apr 4.

Published in final edited form as: Mol Cancer Res. 2022 Oct 4; 20(10): 1548–1560. doi: 10.1158/1541-7786.MCR-22-0026

PMCID:: PMC9532357

Abstract Article PDF–1.1M

Select item 85349227.

Origin and Isoform Specific Functions of Exchange Proteins Directly Activated by cAMP: A Phylogenetic Analysis

Zhuofu Ni, Xiaodong Cheng

Cells. 2021 Oct; 10(10): 2750. Published online 2021 Oct 14. doi: 10.3390/cells10102750

PMCID:: PMC8534922

Abstract Article PDF–2.8M

Select item 80166578.

Epac: new emerging cAMP-binding protein

Kyungmin Lee

BMB Rep. 2021 Mar 31; 54(3): 149–156. Published online 2021 Mar 31. doi: 10.5483/BMBRep.2021.54.3.233

PMCID:: PMC8016657

Abstract Article PDF–1.7M

Select item 62064719.

Exchange Proteins Directly Activated by cAMP and Their Roles in Respiratory Syncytial Virus Infection

Eun-Jin Choi, Yuping Ren, Yu Chen, Shengxuan Liu, Wenzhe Wu, Junping Ren, Pingyuan Wang, Roberto P. Garofalo, Jia Zhou, Xiaoyong Bao

J Virol. 2018 Nov 15; 92(22): e01200-18. Prepublished online 2018 Sep 5. Published online 2018 Oct 29. doi: 10.1128/JVI.01200-18

PMCID:: PMC6206471

Abstract Article PDF–3.4M

Select item 551067410.

Epac2-Rap1 Signaling Regulates Reactive Oxygen Species Production and Susceptibility to Cardiac Arrhythmias

Zhaokang Yang, Hannah M. Kirton, Moza Al-Owais, Jérôme Thireau, Sylvain Richard, Chris Peers, Derek S. Steele

Antioxid Redox Signal. 2017 Jul 20; 27(3): 117–132. Published online 2017 Jul 20. doi: 10.1089/ars.2015.6485

PMCID:: PMC5510674

Abstract Article PDF–1.6M

Select item 437225511.

The cAMP sensors, EPAC1 and EPAC2, display distinct subcellular distributions despite sharing a common nuclear pore localisation signal

Euan Parnell, Brian O. Smith, Stephen J. Yarwood

Cell Signal. 2015 May; 27(5): 989–996. doi: 10.1016/j.cellsig.2015.02.009

PMCID:: PMC4372255

Abstract Article

Select item 841673112.

Pancreatic cancer-derived exosomal microRNA-19a induces β-cell dysfunction by targeting ADCY1 and EPAC2

Wenjing Pang, Weiyan Yao, Xin Dai, Aisen Zhang, Lidan Hou, Lei Wang, Yu Wang, Xin Huang, Xiangjun Meng, Lei Li

Int J Biol Sci. 2021; 17(13): 3622–3633. Published online 2021 Aug 21. doi: 10.7150/ijbs.56271

PMCID:: PMC8416731

Abstract Article PDF–2.0M

Select item 655762613.

Fusion pore regulation by cAMP/Epac2 controls cargo release during insulin exocytosis

Alenka Guček, Nikhil R Gandasi, Muhmmad Omar-Hmeadi, Marit Bakke, Stein O Døskeland, Anders Tengholm, Sebastian Barg

eLife. 2019; 8: e41711. Published online 2019 May 20. doi: 10.7554/eLife.41711

PMCID:: PMC6557626

Abstract Article PDF–2.1M

Select item 328366614.

Anti-Inflammatory Role of the cAMP Effectors Epac and PKA: Implications in Chronic Obstructive Pulmonary Disease

Anouk Oldenburger, Sara S. Roscioni, Esther Jansen, Mark H. Menzen, Andrew J. Halayko, Wim Timens, Herman Meurs, Harm Maarsingh, Martina Schmidt

PLoS One. 2012; 7(2): e31574. Published online 2012 Feb 21. doi: 10.1371/journal.pone.0031574

PMCID:: PMC3283666

Abstract Article PDF–1.5M

Select item 189291015.

Exchange protein activated by cAMP (Epac) mediates cAMP activation of p38 MAPK and modulation of Ca²⁺-dependent K⁺ channels in cerebellar neurons

Jeanne Ster, Frédéric De Bock, Nathalie C. Guérineau, Andrea Janossy, Stéphanie Barrère-Lemaire, Johannes L. Bos, Joël Bockaert, Laurent Fagni

Proc Natl Acad Sci U S A. 2007 Feb 13; 104(7): 2519–2524. Published online 2007 Feb 6. doi: 10.1073/pnas.0611031104

PMCID:: PMC1892910

Abstract Article PDF–1.4M

Select item 504819416.

Anxiety and depression with neurogenesis defects in exchange protein directly activated by cAMP 2-deficient mice are ameliorated by a selective serotonin reuptake inhibitor, Prozac

L Zhou, S L Ma, P K K Yeung, Y H Wong, K W K Tsim, K F So, L C W Lam, S K Chung

Transl Psychiatry. 2016 Sep; 6(9): e881. Published online 2016 Sep 6. doi: 10.1038/tp.2016.129

PMCID:: PMC5048194

Abstract Article PDF–2.0M

Select item 388813217.

Deficiency of the purine metabolic gene HPRT dysregulates microRNA-17 family cluster and guanine-based cellular functions: a role for EPAC in Lesch-Nyhan syndrome

Ghiabe-Henri Guibinga, Fiona Murray, Nikki Barron, William Pandori, Gorjan Hrustanovic

Hum Mol Genet. 2013 Nov 15; 22(22): 4502–4515. Published online 2013 Jun 25. doi: 10.1093/hmg/ddt298

PMCID:: PMC3888132

Abstract Article PDF–791K

Select item 113395518.

Exchange protein directly activated by cAMP (EPAC) interacts with the light chain (LC) 2 of MAP1A

Maria M. Magiera, Mona Gupta, Catherine J. Rundell, Nilima Satish, Isabelle Ernens, Stephen J. Yarwood

Biochem J. 2004 Sep 15; 382(Pt 3): 803–810. Prepublished online 2004 Jun 18. Published online 2004 Sep 7. doi: 10.1042/BJ20040122

PMCID:: PMC1133955

Abstract Article PDF–604K

Select item 420033019.

Activation of EPAC1/2 is essential for osteoclast formation by modulating NFκB nuclear translocation and actin cytoskeleton rearrangements

Aránzazu Mediero, Miguel Perez-Aso, Bruce N. Cronstein

FASEB J. 2014 Nov; 28(11): 4901–4913. doi: 10.1096/fj.14-255703

PMCID:: PMC4200330

Abstract Article

Select item 2378220.

A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia

Hiroaki Kawasaki, Gregory M. Springett, Shinichiro Toki, Juan J. Canales, Patricia Harlan, Justin P. Blumenstiel, Emy J. Chen, I. Amy Bany, Naoki Mochizuki, Amy Ashbacher, Michiyuki Matsuda, David E. Housman, Ann M. Graybiel

Proc Natl Acad Sci U S A. 1998 Oct 27; 95(22): 13278–13283. doi: 10.1073/pnas.95.22.13278