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Select item 105820871.

Correlation between choline kinase alpha expression and ¹¹C-choline accumulation in breast cancer using positron emission tomography/computed tomography: a retrospective study

Akane Ozawa, Masako Iwasaki, Kota Yokoyama, Junichi Tsuchiya, Ryutaro Kawano, Hiroshi Nishihara, Ukihide Tateishi

Sci Rep. 2023; 13: 17620. Published online 2023 Oct 17. doi: 10.1038/s41598-023-44542-4

PMCID:: PMC10582087

Abstract Article PDF–1.4M

Select item 96308842.

Bi-allelic variants in CHKA cause a neurodevelopmental disorder with epilepsy and microcephaly

Chiara Klöckner, J Pedro Fernández-Murray, Mahtab Tavasoli, Heinrich Sticht, Gisela Stoltenburg-Didinger, Leila Motlagh Scholle, Somayeh Bakhtiari, Michael C Kruer, Hossein Darvish, Saghar Ghasemi Firouzabadi, Alex Pagnozzi, Anju Shukla, Katta Mohan Girisha, Dhanya Lakshmi Narayanan, Parneet Kaur, Reza Maroofian, Maha S Zaki, Mahmoud M Noureldeen, Andreas Merkenschlager, Janina Gburek-Augustat, Elisa Cali, Selina Banu, Kamrun Nahar, Stephanie Efthymiou, Henry Houlden, Rami Abou Jamra, Jason Williams, Christopher R McMaster, Konrad Platzer

Brain. 2022 Jun; 145(6): 1916–1923. Published online 2022 Feb 24. doi: 10.1093/brain/awac074

PMCID:: PMC9630884

Abstract Article PDF–1.6M

Select item 82295653.

DNA Methylation of Human Choline Kinase Alpha Promoter-Associated CpG Islands in MCF-7 Cells

Siti Aisyah Faten Mohamed Sa’dom, Sweta Raikundalia, Shaharum Shamsuddin, Wei Cun See Too, Ling Ling Few

Genes (Basel) 2021 Jun; 12(6): 853. Published online 2021 Jun 1. doi: 10.3390/genes12060853

PMCID:: PMC8229565

Abstract Article PDF–2.1M

Select item 66611124.

Choline Kinase α Mediates Interactions Between the Epidermal Growth Factor Receptor and Mechanistic Target of Rapamycin Complex 2 in Hepatocellular Carcinoma Cells to Promote Drug Resistance and Xenograft Tumor Progression

Xi-Meng Lin, Liang Hu, Jin Gu, Ruo-Yu Wang, Liang Li, Jing Tang, Bao-Hua Zhang, Xing-Zhou Yan, Yan-Jing Zhu, Cong-Li Hu, Wei-Ping Zhou, Shao Li, Jing-Feng Liu, Frank J. Gonzalez, Meng-Chao Wu, Hong-Yang Wang, Lei Chen

Gastroenterology. Author manuscript; available in PMC 2019 Jul 28.

Published in final edited form as: Gastroenterology. 2017 Apr; 152(5): 1187–1202. Published online 2017 Jan 5. doi: 10.1053/j.gastro.2016.12.033

PMCID:: PMC6661112

Abstract Article PDF–3.3M

Select item 53418285.

Overexpression of CHKA contributes to tumor progression and metastasis and predicts poor prognosis in colorectal carcinoma

Liang Hu, Ruo-Yu Wang, Jian Cai, Dan Feng, Guang-Zhen Yang, Qing-Guo Xu, Yan-Xia Zhai, Yu Zhang, Wei-Ping Zhou, Qing-Ping Cai

Oncotarget. 2016 Oct 11; 7(41): 66660–66678. Published online 2016 Aug 20. doi: 10.18632/oncotarget.11433

PMCID:: PMC5341828

Abstract Article PDF–13M

Select item 48498036.

Choline Kinase Alpha as an Androgen Receptor Chaperone and Prostate Cancer Therapeutic Target

Mohammad Asim, Charles E. Massie, Folake Orafidiya, Nelma Pértega-Gomes, Anne Y. Warren, Mohsen Esmaeili, Luke A. Selth, Heather I. Zecchini, Katarina Luko, Arham Qureshi, Ajoeb Baridi, Suraj Menon, Basetti Madhu, Carlos Escriu, Scott Lyons, Sarah L. Vowler, Vincent R. Zecchini, Greg Shaw, Wiebke Hessenkemper, Roslin Russell, Hisham Mohammed, Niki Stefanos, Andy G. Lynch, Elena Grigorenko, Clive D’Santos, Chris Taylor, Alastair Lamb, Rouchelle Sriranjan, Jiali Yang, Rory Stark, Scott M. Dehm, Paul S. Rennie, Jason S. Carroll, John R. Griffiths, Simon Tavaré, Ian G. Mills, Iain J. McEwan, Aria Baniahmad, Wayne D. Tilley, David E. Neal

J Natl Cancer Inst. 2016 May; 108(5): djv371. Published online 2015 Dec 11. doi: 10.1093/jnci/djv371

PMCID:: PMC4849803

Abstract Article PDF–14M

Select item 46197667.

Downregulation of Choline Kinase-Alpha Enhances Autophagy in Tamoxifen-Resistant Breast Cancer Cells

Hoe Suk Kim, Lianji Tian, Minji Jung, Sul Ki Choi, Yujin Sun, Hyeonjin Kim, Woo Kyung Moon

PLoS One. 2015; 10(10): e0141110. Published online 2015 Oct 23. doi: 10.1371/journal.pone.0141110

PMCID:: PMC4619766

Abstract Article PDF–1.8M

Select item 44844518.

Global metabolic profile identifies choline kinase alpha as a key regulator of glutathione-dependent antioxidant cell defense in ovarian carcinoma

Anna Granata, Roberta Nicoletti, Paola Perego, Egidio Iorio, Balaji Krishnamachary, Fabio Benigni, Alessandro Ricci, Franca Podo, Zaver M. Bhujwalla, Silvana Canevari, Marina Bagnoli, Delia Mezzanzanica

Oncotarget. 2015 May 10; 6(13): 11216–11230. Published online 2015 Mar 14. doi: 10.18632/oncotarget.3589

PMCID:: PMC4484451

Abstract Article PDF–1.8M

Select item 43826539.

Dysregulated choline metabolism in T-cell lymphoma: role of choline kinase-α and therapeutic targeting

J Xiong, J Bian, L Wang, J-Y Zhou, Y Wang, Y Zhao, L-L Wu, J-J Hu, B Li, S-J Chen, C Yan, W-L Zhao

Blood Cancer J. 2015 Mar; 5(3): 287. Published online 2015 Mar 13. doi: 10.1038/bcj.2015.10

PMCID:: PMC4382653

Abstract Article PDF–4.7M

Select item 420991710.

Direct Inhibition of Choline Kinase by a Near-Infrared Fluorescent Carbocyanine

Sean P. Arlauckas, Anatoliy V. Popov, Edward J. Delikatny

Mol Cancer Ther. Author manuscript; available in PMC 2015 Sep 1.

Published in final edited form as: Mol Cancer Ther. 2014 Sep; 13(9): 2149–2158. Published online 2014 Jul 15. doi: 10.1158/1535-7163.MCT-14-0085

PMCID:: PMC4209917

Abstract Article PDF–1.1M

Select item 389976511.

Choline kinase-alpha by regulating cell aggressiveness and drug sensitivity is a potential druggable target for ovarian cancer

A Granata, R Nicoletti, V Tinaglia, L De Cecco, M E Pisanu, A Ricci, F Podo, S Canevari, E Iorio, M Bagnoli, D Mezzanzanica

Br J Cancer. 2014 Jan 21; 110(2): 330–340. Published online 2013 Nov 26. doi: 10.1038/bjc.2013.729

PMCID:: PMC3899765

Abstract Article PDF–1.4M

Select item 380048012.

Characterizing choline kinase in human endothelial cells

Noriko Mori, Mayur Gadiya, Flonne Wildes, Balaji Krishnamachary, Kristine Glunde, Zaver M. Bhujwalla

NMR Biomed. Author manuscript; available in PMC 2014 Nov 1.

Published in final edited form as: NMR Biomed. 2013 Nov; 26(11): 1501–1507. Published online 2013 Jun 18. doi: 10.1002/nbm.2983

PMCID:: PMC3800480

Abstract Article PDF–2.5M

Select item 367792113.

Combined 5-FU and ChoKα Inhibitors as a New Alternative Therapy of Colorectal Cancer: Evidence in Human Tumor-Derived Cell Lines and Mouse Xenografts

Ana de la Cueva, Ana Ramírez de Molina, Néstor Álvarez-Ayerza, Ma Angeles Ramos, Arancha Cebrián, Teresa Gómez del Pulgar, Juan Carlos Lacal

PLoS One. 2013; 8(6): e64961. Published online 2013 Jun 10. doi: 10.1371/journal.pone.0064961

PMCID:: PMC3677921

Abstract Article PDF–2.6M

Select item 364135514.

A non-catalytic role of choline kinase alpha is important in promoting cancer cell survival

S C Falcon, C S Hudson, Y Huang, M Mortimore, J M Golec, P A Charlton, P Weber, H Sundaram

Oncogenesis. 2013 Mar; 2(3): e38. Published online 2013 Mar 25. doi: 10.1038/oncsis.2013.2

PMCID:: PMC3641355

Abstract Article PDF–605K

Select item 321332815.

Functional interactions between Choline kinase a, epidermal growth factor receptor (EGFR), and c-Src in breast cancer cell proliferations

Tsuyoshi Miyake, Sarah J. Parsons

Oncogene. Author manuscript; available in PMC 2012 Sep 15.

Published in final edited form as: Oncogene. 2012 Mar 15; 31(11): 1431–1441. Published online 2011 Aug 8. doi: 10.1038/onc.2011.332

PMCID:: PMC3213328

Abstract Article PDF–2.0M

Select item 290823716.

A critical role for Choline Kinase alpha in the aggressiveness of bladder carcinomas

Eva Hernando, Jacinto Sarmentero-Estrada, Theresa Koppie, Cristóbal Belda-Iniesta, Victor Ramírez de Molina, Paloma Cejas, Choichiro Ozu, Carl Le, Jose Javier Sánchez, Manuel González-Barón, Jason Koutcher, Carlos Cordón-Cardó, Bernard H. Bochner, Juan Carlos Lacal, Ana Ramírez de Molina

Oncogene. Author manuscript; available in PMC 2010 Jul 22.

Published in final edited form as: Oncogene. 2009 Jul 2; 28(26): 2425–2435. Published online 2009 May 18. doi: 10.1038/onc.2009.91