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Select item 62192931.

Muscarinic acetylcholine receptor M1 mediates prostate cancer cell migration and invasion through hedgehog signaling

Qing-Qing Yin, Lin-Hui Xu, Mi Zhang, Chen Xu

Asian J Androl. 2018 Nov-Dec; 20(6): 608–614. Published online 2018 Jul 13. doi: 10.4103/aja.aja_55_18

PMCID:: PMC6219293

Article PDF–2.9M

Select item 42461202.

Mechanistic Insights into Allosteric Structure-Function Relationships at the M₁ Muscarinic Acetylcholine Receptor

Alaa Abdul-Ridha, J. Robert Lane, Shailesh N. Mistry, Laura López, Patrick M. Sexton, Peter J. Scammells, Arthur Christopoulos, Meritxell Canals

J Biol Chem. 2014 Nov 28; 289(48): 33701–33711. Published online 2014 Oct 17. doi: 10.1074/jbc.M114.604967

PMCID:: PMC4246120

Article PDF–1.6M

Select item 41409393.

Allosteric Modulation of M₁ Muscarinic Acetylcholine Receptor Internalization and Subcellular Trafficking

Holly R. Yeatman, J. Robert Lane, Kwok Ho Christopher Choy, Nevin A. Lambert, Patrick M. Sexton, Arthur Christopoulos, Meritxell Canals

J Biol Chem. 2014 May 30; 289(22): 15856–15866. Published online 2014 Apr 21. doi: 10.1074/jbc.M113.536672

PMCID:: PMC4140939

Article PDF–1.3M

Select item 39376734.

Molecular Determinants of Allosteric Modulation at the M₁ Muscarinic Acetylcholine Receptor

Alaa Abdul-Ridha, Laura López, Peter Keov, David M. Thal, Shailesh N. Mistry, Patrick M. Sexton, J. Robert Lane, Meritxell Canals, Arthur Christopoulos

J Biol Chem. 2014 Feb 28; 289(9): 6067–6079. Published online 2014 Jan 17. doi: 10.1074/jbc.M113.539080

PMCID:: PMC3937673

Article PDF–2.1M

Select item 36337175.

Epigenetic regulation of cholinergic receptor M1 (CHRM1) by histone H3K9me3 impairs Ca2+ signaling in Huntington’s disease

Junghee Lee, Yu Jin Hwang, Jong-Yeon Shin, Won-Chul Lee, Jinhong Wie, Ki Yoon Kim, Min Young Lee, Daehee Hwang, Rajiv R. Ratan, Ae Nim Pae, Neil W. Kowall, Insuk So, Jong-Il Kim, Hoon Ryu

Acta Neuropathol. Author manuscript; available in PMC 2014 May 1.

Published in final edited form as: Acta Neuropathol. 2013 May; 125(5): 727–739. Published online 2013 Mar 2. doi: 10.1007/s00401-013-1103-z

PMCID:: PMC3633717

Article PDF–4.1M

Select item 35838306.

Autoantibodies against Muscarinic Receptors in Breast Cancer: Their Role in Tumor Angiogenesis

María Gabriela Lombardi, María Pía Negroni, Laura Tatiana Pelegrina, María Ester Castro, Gabriel L. Fiszman, María Eugenia Azar, Carlos Cresta Morgado, María Elena Sales

PLoS One. 2013; 8(2): e57572. Published online 2013 Feb 27. doi: 10.1371/journal.pone.0057572

PMCID:: PMC3583830

Article PDF–625K

Select item 31731277.

Structural Model of Ligand-G Protein-coupled Receptor (GPCR) Complex Based on Experimental Double Mutant Cycle Data: MT7 SNAKE TOXIN BOUND TO DIMERIC hM1 MUSCARINIC RECEPTOR

Catherine Marquer, Carole Fruchart-Gaillard, Guillaume Letellier, Elodie Marcon, Gilles Mourier, Sophie Zinn-Justin, André Ménez, Denis Servent, Bernard Gilquin

J Biol Chem. 2011 Sep 9; 286(36): 31661–31675. Published online 2011 Jun 17. doi: 10.1074/jbc.M111.261404

PMCID:: PMC3173127

Article PDF–4.1M

Select item 30097408.

Pharmacological Evaluation of the Long-Term Effects of Xanomeline on the M₁ Muscarinic Acetylcholine Receptor

Marianne K. O. Grant, Meredith J. Noetzel, Kayla C. De Lorme, Jan Jakubík, Vladimír Doležal, Esam E. El-Fakahany

PLoS One. 2010; 5(12): e15722. Published online 2010 Dec 23. doi: 10.1371/journal.pone.0015722

PMCID:: PMC3009740

Article PDF–701K

Select item 28238959.

Formation and dissociation of M₁ muscarinic receptor dimers seen by total internal reflection fluorescence imaging of single molecules

Jonathan A. Hern, Asma H. Baig, Gregory I. Mashanov, Berry Birdsall, John E. T. Corrie, Sebastian Lazareno, Justin E. Molloy, Nigel J. M. Birdsall

Proc Natl Acad Sci U S A. 2010 Feb 9; 107(6): 2693–2698. Published online 2010 Jan 20. doi: 10.1073/pnas.0907915107

PMCID:: PMC2823895

Article PDF–1.3M

Select item 275122010.

Single nucleotide polymorphisms of the human M1 muscarinic acetylcholine receptor gene

Julie L. Lucas, Wolfgang Sadee, Joseph A. DeYoung

AAPS PharmSci. 2001 Dec; 3(4): 57–61. Published online 2001 Nov 28. doi: 10.1208/ps030431

PMCID:: PMC2751220

Article PDF–320K

Select item 274263811.

Muscarinic acetylcholine receptor 1 gene polymorphisms associated with high myopia

Hui-Ju Lin, Lei Wan, Yuhsin Tsai, Wen-Chi Chen, Shih-Wei Tsai, Fuu-Jen Tsai

Mol Vis. 2009; 15: 1774–1780. Published online 2009 Sep 4.

PMCID:: PMC2742638

Article PDF–1.2M

Select item 274057912.

Pirenzepine Promotes the Dimerization of Muscarinic M1 Receptors through a Three-step Binding Process

Brigitte Ilien, Nicole Glasser, Jean-Pierre Clamme, Pascal Didier, Etienne Piemont, Raja Chinnappan, Sandrine B. Daval, Jean-Luc Galzi, Yves Mely

J Biol Chem. 2009 Jul 17; 284(29): 19533–19543. Published online 2009 May 18. doi: 10.1074/jbc.M109.017145

PMCID:: PMC2740579

Article PDF–1.4M

Select item 266201813.

A Novel Mechanism of G Protein-coupled Receptor Functional Selectivity: MUSCARINIC PARTIAL AGONIST McN-A-343 AS A BITOPIC ORTHOSTERIC/ALLOSTERIC LIGAND

Celine Valant, Karen J. Gregory, Nathan E. Hall, Peter J. Scammells, Michael J. Lew, Patrick M. Sexton, Arthur Christopoulos

J Biol Chem. 2008 Oct 24; 283(43): 29312–29321. doi: 10.1074/jbc.M803801200

PMCID:: PMC2662018

Article PDF–611K

Select item 33998414.

Sequence of the gene encoding the human M1 muscarinic acetylcholine receptor.

W J Allard, I S Sigal, R A Dixon

Nucleic Acids Res. 1987 Dec 23; 15(24): 10604. doi: 10.1093/nar/15.24.10604

PMCID:: PMC339984

Summary Page Browse PDF–131K

Select item 33071715.

Isolation of the human ml (Hml) muscarinic acetylcholine receptor gene by PCR amplification.

C G Chapman, M J Browne

Nucleic Acids Res. 1990 Apr 25; 18(8): 2191. doi: 10.1093/nar/18.8.2191

PMCID:: PMC330717

Summary Page Browse PDF–90K

Select item 491538716.

Crystal Structures of the M₁ and M₄ Muscarinic Acetylcholine Receptors

David M. Thal, Bingfa Sun, Dan Feng, Vindhya Nawaratne, Katie Leach, Christian C. Felder, Mark G. Bures, David A. Evans, William I. Weis, Priti Bachhawat, Tong Sun Kobilka, Patrick M. Sexton, Brian K. Kobilka, Arthur Christopoulos

Nature. Author manuscript; available in PMC 2016 Sep 17.

Published in final edited form as: Nature. 2016 Mar 17; 531(7594): 335–340. Published online 2016 Mar 9. doi: 10.1038/nature17188

PMCID:: PMC4915387

Article PDF–1.9M

Select item 463025317.

Changes in Membrane Cholesterol Differentially Influence Preferential and Non-preferential Signaling of the M1 and M3 Muscarinic Acetylcholine Receptors

Pavel Michal, Esam E. El-Fakahany, Vladimír Doležal

Neurochem Res. 2015; 40(10): 2068–2077. Published online 2014 May 13. doi: 10.1007/s11064-014-1325-z

PMCID:: PMC4630253

Article PDF–765K

Select item 359473118.

Decreased cortical muscarinic M1 receptors in schizophrenia are associated with changes in gene promoter methylation, mRNA and gene targeting microRNA

E Scarr, J M Craig, M J Cairns, M S Seo, J C Galati, N J Beveridge, A Gibbons, S Juzva, B Weinrich, M Parkinson-Bates, A P Carroll, R Saffery, B Dean

Transl Psychiatry. 2013 Feb; 3(2): e230. Published online 2013 Feb 19. doi: 10.1038/tp.2013.3

PMCID:: PMC3594731

Article PDF–900K

Select item 245103919.

Characterization of a CNS penetrant, selective M₁ muscarinic receptor agonist, 77-LH-28-1

C J Langmead, N E Austin, C L Branch, J T Brown, K A Buchanan, C H Davies, I T Forbes, V A H Fry, J J Hagan, H J Herdon, G A Jones, R Jeggo, J N C Kew, A Mazzali, R Melarange, N Patel, J Pardoe, A D Randall, C Roberts, A Roopun, K R Starr, A Teriakidis, M D Wood, M Whittington, Z Wu, J Watson

Br J Pharmacol. 2008 Jul; 154(5): 1104–1115. Published online 2008 May 5. doi: 10.1038/bjp.2008.152