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Items: 1 to 20 of 25

1.
Risk of chronic pancreatitis in carriers of loss-of-function CTRC variants: A meta-analysis
Amanda Takáts, Gergő Berke, Noémi Gede, Balázs Csaba Németh, Heiko Witt, Stanisław Głuszek, Agnieszka Magdalena Rygiel, Péter Hegyi, Miklós Sahin-Tóth, Eszter Hegyi
PLoS One. 2022; 17(5): e0268859. Published online 2022 May 20. doi: 10.1371/journal.pone.0268859
PMCID:
PMC9122191
ArticlePDF–1.5M
2.
CTRC gene polymorphism (p.G60=; c.180 C > T) in acute pancreatitis
Dorota Koziel, Stanislaw Gluszek, Artur Kowalik, Malgorzata Chlopek
BMC Gastroenterol. 2017; 17: 13. Published online 2017 Jan 17. doi: 10.1186/s12876-016-0566-5
PMCID:
PMC5240263
ArticlePDF–510K
3.
Mesotrypsin Signature Mutation in a Chymotrypsin C (CTRC) Variant Associated with Chronic Pancreatitis
András Szabó, Maren Ludwig, Eszter Hegyi, Renata Szépeová, Heiko Witt, Miklós Sahin-Tóth
J Biol Chem. 2015 Jul 10; 290(28): 17282–17292. Published online 2015 May 26. doi: 10.1074/jbc.M114.618439
PMCID:
PMC4498067
ArticlePDF–1.9M
4.
Comprehensive functional analysis of chymotrypsin C (CTRC) variants reveals distinct loss-of-function mechanisms associated with pancreatitis risk
Sebastian Beer, Jiayi Zhou, András Szabó, Steven Keiles, Giriraj Ratan Chandak, Heiko Witt, Miklós Sahin-Tóth
Gut. Author manuscript; available in PMC 2014 Nov 1.
Published in final edited form as: Gut. 2013 Nov; 62(11): 1616–1624. Published online 2012 Sep 1. doi: 10.1136/gutjnl-2012-303090
PMCID:
PMC3660471
ArticlePDF–1.2M
5.
Long-range Electrostatic Complementarity Governs Substrate Recognition by Human Chymotrypsin C, a Key Regulator of Digestive Enzyme Activation
Jyotica Batra, András Szabó, Thomas R. Caulfield, Alexei S. Soares, Miklós Sahin-Tóth, Evette S. Radisky
J Biol Chem. 2013 Apr 5; 288(14): 9848–9859. Published online 2013 Feb 19. doi: 10.1074/jbc.M113.457382
PMCID:
PMC3617285
ArticlePDF–2.9M
6.
Chymotrypsin C (CTRC) mutations in chronic pancreatitis
Jiayi Zhou, Miklós Sahin-Tóth
J Gastroenterol Hepatol. Author manuscript; available in PMC 2012 Aug 1.
Published in final edited form as: J Gastroenterol Hepatol. 2011 Aug; 26(8): 1238–1246. doi: 10.1111/j.1440-1746.2011.06791.x
PMCID:
PMC3142265
ArticlePDF–1.2M
7.
Chymotrypsin C (CTRC) alterations that diminish activity or secretion are associated with chronic pancreatitis
Jonas Rosendahl, Heiko Witt, Richárd Szmola, Eesh Bhatia, Béla Ózsvári, Olfert Landt, Hans-Ulrich Schulz, Thomas M Gress, Roland Pfützer, Matthias Löhr, Peter Kovacs, Matthias Blüher, Michael Stumvoll, Gourdas Choudhuri, Péter Hegyi, René HM te Morsche, Joost PH Drenth, Kaspar Truninger, Milan Macek, Jr., Gero Puhl, Ulrike Witt, Hartmut Schmidt, Carsten Büning, Johann Ockenga, Andreas Kage, David Alexander Groneberg, Renate Nickel, Thomas Berg, Bertram Wiedenmann, Hans Bödeker, Volker Keim, Joachim Mössner, Niels Teich, Miklós Sahin-Tóth
Nat Genet. Author manuscript; available in PMC 2009 Mar 4.
Published in final edited form as: Nat Genet. 2008 Jan; 40(1): 78–82. Published online 2007 Dec 2. doi: 10.1038/ng.2007.44
PMCID:
PMC2650829
ArticlePDF–800K
8.
Chymotrypsin C (caldecrin) promotes degradation of human cationic trypsin: Identity with Rinderknecht's enzyme Y
Richárd Szmola, Miklós Sahin-Tóth
Proc Natl Acad Sci U S A. 2007 Jul 3; 104(27): 11227–11232. Published online 2007 Jun 25. doi: 10.1073/pnas.0703714104
PMCID:
PMC2040881
ArticlePDF–1.0M
9.
Inactivation of mesotrypsin by chymotrypsin C prevents trypsin inhibitor degradation
Vanda Toldi, András Szabó, Miklós Sahin-Tóth
J Biol Chem. 2020 Mar 13; 295(11): 3447–3455. Published online 2020 Feb 3. doi: 10.1074/jbc.RA120.012526
PMCID:
PMC7076226
ArticlePDF–1.7M
10.
Early Onset Acute Recurrent and Chronic Pancreatitis is Associated with PRSS1 or CTRC Gene Mutations
Matthew J. Giefer, Mark E. Lowe, Steven L. Werlin, Bridget Zimmerman, Michael Wilschanski, David Troendle, Sarah Jane Schwarzenberg, John F. Pohl, Joseph Palermo, Chee Y. Ooi, Veronique D. Morinville, Tom K. Lin, Sohail Z. Husain, Ryan Himes, Melvin B. Heyman, Tanja Gonska, Cheryl E. Gariepy, Steven D. Freedman, Douglas S. Fishman, Peter R. Durie, Melena D. Bellin, Bradley Barth, Maisam Abu-El-Haija, Aliye Uc
J Pediatr. Author manuscript; available in PMC 2018 Jul 1.
Published in final edited form as: J Pediatr. 2017 Jul; 186: 95–100. Published online 2017 May 10. doi: 10.1016/j.jpeds.2017.03.063
PMCID:
PMC5506853
ArticlePDF–105K
11.
Tighter Control by Chymotrypsin C (CTRC) Explains Lack of Association between Human Anionic Trypsinogen and Hereditary Pancreatitis
Zsanett Jancsó, Miklós Sahin-Tóth
J Biol Chem. 2016 Jun 17; 291(25): 12897–12905. Published online 2016 Apr 18. doi: 10.1074/jbc.M116.725374
PMCID:
PMC4933207
ArticlePDF–2.3M
12.
Increased Activation of Hereditary Pancreatitis-associated Human Cationic Trypsinogen Mutants in Presence of Chymotrypsin C
András Szabó, Miklós Sahin-Tóth
J Biol Chem. 2012 Jun 8; 287(24): 20701–20710. Published online 2012 Apr 26. doi: 10.1074/jbc.M112.360065
PMCID:
PMC3370252
ArticlePDF–1.7M
13.
Genetic mutations in SPINK1, CFTR, CTRC genes in acute pancreatitis
Dorota Koziel, Stanislaw Gluszek, Artur Kowalik, Malgorzata Chlopek, Liliana Pieciak
BMC Gastroenterol. 2015; 15: 70. Published online 2015 Jun 23. doi: 10.1186/s12876-015-0302-6
PMCID:
PMC4476205
ArticlePDF–432K
14.
Chymotrypsin C Is a Co-activator of Human Pancreatic Procarboxypeptidases A1 and A2
Richárd Szmola, Melinda Bence, Andrea Carpentieri, András Szabó, Catherine E. Costello, John Samuelson, Miklós Sahin-Tóth
J Biol Chem. 2011 Jan 21; 286(3): 1819–1827. Published online 2010 Nov 22. doi: 10.1074/jbc.M110.187369
PMCID:
PMC3023477
ArticlePDF–1.3M
15.
PRSS1, SPINK1, CFTR, and CTRC Pathogenic Variants in Korean Patients With Idiopathic Pancreatitis
Sun-Mi Cho, Saeam Shin, Kyung-A Lee
Ann Lab Med. 2016 Nov; 36(6): 555–560. Published online 2016 Aug 24. doi: 10.3343/alm.2016.36.6.555
PMCID:
PMC5011109
ArticlePDF–209K
16.
A Conservative Assessment of the Major Genetic Causes of Idiopathic Chronic Pancreatitis: Data from a Comprehensive Analysis of PRSS1, SPINK1, CTRC and CFTR Genes in 253 Young French Patients
Emmanuelle Masson, Jian-Min Chen, Marie-Pierre Audrézet, David N. Cooper, Claude Férec
PLoS One. 2013; 8(8): e73522. Published online 2013 Aug 8. doi: 10.1371/journal.pone.0073522
PMCID:
PMC3738529
ArticlePDF–1.6M
17.
Microsatellite Scan Identifies New Candidate Genes for Susceptibility to Alcoholic Chronic Pancreatitis in Japanese Patients
Kei Kitahara, Shigeyuki Kawa, Yoshihiko Katsuyama, Takeji Umemura, Yayoi Ozaki, Mari Takayama, Norikazu Arakura, Masao Ota
Dis Markers. 2008; 25(3): 175–180. Published online 2008 Dec 16. doi: 10.1155/2008/426764
PMCID:
PMC3827802
SummaryPDF–204K
18.
A proteome-scale map of the human interactome network
Thomas Rolland, Murat Taşan, Benoit Charloteaux, Samuel J. Pevzner, Quan Zhong, Nidhi Sahni, Song Yi, Irma Lemmens, Celia Fontanillo, Roberto Mosca, Atanas Kamburov, Susan D. Ghiassian, Xinping Yang, Lila Ghamsari, Dawit Balcha, Bridget E. Begg, Pascal Braun, Marc Brehme, Martin P. Broly, Anne-Ruxandra Carvunis, Dan Convery-Zupan, Roser Corominas, Jasmin Coulombe-Huntington, Elizabeth Dann, Matija Dreze, Amélie Dricot, Changyu Fan, Eric Franzosa, Fana Gebreab, Bryan J. Gutierrez, Madeleine F. Hardy, Mike Jin, Shuli Kang, Ruth Kiros, Guan Ning Lin, Katja Luck, Andrew MacWilliams, Jörg Menche, Ryan R. Murray, Alexandre Palagi, Matthew M. Poulin, Xavier Rambout, John Rasla, Patrick Reichert, Viviana Romero, Elien Ruyssinck, Julie M. Sahalie, Annemarie Scholz, Akash A. Shah, Amitabh Sharma, Yun Shen, Kerstin Spirohn, Stanley Tam, Alexander O. Tejeda, Shelly A. Wanamaker, Jean-Claude Twizere, Kerwin Vega, Jennifer Walsh, Michael E. Cusick, Yu Xia, Albert-László Barabási, Lilia M. Iakoucheva, Patrick Aloy, Javier De Las Rivas, Jan Tavernier, Michael A. Calderwood, David E. Hill, Tong Hao, Frederick P. Roth, Marc Vidal
Cell. Author manuscript; available in PMC 2015 Nov 20.
Published in final edited form as: Cell. 2014 Nov 20; 159(5): 1212–1226. doi: 10.1016/j.cell.2014.10.050
PMCID:
PMC4266588
ArticlePDF–3.1M
19.
The BioPlex Network: A Systematic Exploration of the Human Interactome
Edward L. Huttlin, Lily Ting, Raphael J. Bruckner, Fana Gebreab, Melanie P. Gygi, John Szpyt, Stanley Tam, Gabriela Zarraga, Greg Colby, Kurt Baltier, Rui Dong, Virginia Guarani, Laura Pontano Vaites, Alban Ordureau, Ramin Rad, Brian K. Erickson, Martin Wühr, Joel Chick, Bo Zhai, Deepak Kolippakkam, Julian Mintseris, Robert A. Obar, Tim Harris, Spyros Artavanis-Tsakonas, Mathew E. Sowa, Pietro DeCamilli, Joao A. Paulo, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2016 Jul 16.
Published in final edited form as: Cell. 2015 Jul 16; 162(2): 425–440. doi: 10.1016/j.cell.2015.06.043
PMCID:
PMC4617211
ArticlePDF–2.2M
20.
A reference map of the human binary protein interactome
Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood
Nature. Author manuscript; available in PMC 2020 Oct 8.
Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x
PMCID:
PMC7169983
ArticlePDF–5.4M

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