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Items: 1 to 20 of 84

1.
ALK1 controls hepatic vessel formation, angiodiversity, and angiocrine functions in hereditary hemorrhagic telangiectasia of the liver
Christian David Schmid, Victor Olsavszky, Manuel Reinhart, Vanessa Weyer, Felix A. Trogisch, Carsten Sticht, Manuel Winkler, Sina W. Kürschner, Johannes Hoffmann, Roxana Ola, Theresa Staniczek, Joerg Heineke, Beate K. Straub, Jens Mittler, Kai Schledzewski, Peter ten Dijke, Karsten Richter, Steven Dooley, Cyrill Géraud, Sergij Goerdt, Philipp‐Sebastian Koch
Hepatology. 2023 Apr; 77(4): 1211–1227. Published online 2022 Jul 17. doi: 10.1002/hep.32641
PMCID:
PMC10026949
AbstractArticlePDF–3.8M
2.
Endothelial Activin Receptor-Like Kinase 1 (ALK1) Regulates Myofibroblast Emergence and Peritubular Capillary Stability in the Early Stages of Kidney Fibrosis
Carlos Martínez-Salgado, Fernando Sánchez-Juanes, Francisco J. López-Hernández, José M. Muñoz-Félix
Front Pharmacol. 2022; 13: 843732. Published online 2022 Jun 13. doi: 10.3389/fphar.2022.843732
PMCID:
PMC9234496
AbstractArticlePDF–4.5M
3.
Bone marrow derived Alk1 mutant endothelial cells and clonally expanded somatic Alk1 mutant endothelial cells contribute to the development of brain arteriovenous malformations in mice
Sonali S. Shaligram, Rui Zhang, Wan Zhu, Li Ma, Man Luo, Qiang Li, Miriam Weiss, Thomas Arnold, NG Santander Grez, Rich Liang, Leandro do Prado, Chaoliang Tang, Felix Pan, S. Paul Oh, Peipei Pan, Hua Su
Transl Stroke Res. Author manuscript; available in PMC 2023 Jun 1.
Published in final edited form as: Transl Stroke Res. 2022 Jun; 13(3): 494–504. Published online 2021 Oct 21. doi: 10.1007/s12975-021-00955-9
PMCID:
PMC9021325
AbstractArticlePDF–2.8M
4.
ALK1 signaling is required for the homeostasis of Kupffer cells and prevention of bacterial infection
Dianyuan Zhao, Fengjiao Yang, Yang Wang, Site Li, Yang Li, Fei Hou, Wenting Yang, Di Liu, Yuandong Tao, Qian Li, Jing Wang, Fuchu He, Li Tang
J Clin Invest. 2022 Feb 1; 132(3): e150489. Published online 2022 Feb 1. doi: 10.1172/JCI150489
PMCID:
PMC8803331
AbstractArticlePDF–4.4M
5.
Overexpression of Activin Receptor-Like Kinase 1 in Endothelial Cells Suppresses Development of Arteriovenous Malformations in Mouse Models Of Hereditary Hemorrhagic Telangiectasia
Yong Hwan Kim, Phuong-Nhung Vu, Se-woon Choe, Chang-Jin Jeon, Helen M. Arthur, Calvin P.H. Vary, Young Jae Lee, S. Paul Oh
Circ Res. Author manuscript; available in PMC 2021 Oct 9.
Published in final edited form as: Circ Res. 2020 Oct 9; 127(9): 1122–1137. Published online 2020 Jul 31. doi: 10.1161/CIRCRESAHA.119.316267
PMCID:
PMC7554133
AbstractArticlePDF–2.1M
6.
Alk1 haploinsufficiency causes glomerular dysfunction and microalbuminuria in diabetic mice
Cindy Lora Gil, Nathalie Henley, François A. Leblond, Naoufal Akla, Louis-Philippe Laurin, Virginie Royal, Casimiro Gerarduzzi, Vincent Pichette, Bruno Larrivée
Sci Rep. 2020; 10: 13136. Published online 2020 Aug 4. doi: 10.1038/s41598-020-68515-z
PMCID:
PMC7403732
AbstractArticlePDF–10M
7.
Selective effects of oral anti-angiogenic tyrosine kinase inhibitors on an animal model of hereditary hemorrhagic telangiectasia
Yong Hwan Kim, Mi-Jung Kim, Se-woon Choe, Dennis Sprecher, Young Jae Lee, S. Paul Oh
J Thromb Haemost. Author manuscript; available in PMC 2018 Jun 1.
Published in final edited form as: J Thromb Haemost. 2017 Jun; 15(6): 1095–1102. Published online 2017 May 3. doi: 10.1111/jth.13683
PMCID:
PMC5902312
AbstractArticlePDF–2.4M
8.
Defective fluid shear stress mechanotransduction mediates hereditary hemorrhagic telangiectasia
Nicolas Baeyens, Bruno Larrivée, Roxana Ola, Brielle Hayward-Piatkowskyi, Alexandre Dubrac, Billy Huang, Tyler D. Ross, Brian G. Coon, Elizabeth Min, Maya Tsarfati, Haibin Tong, Anne Eichmann, Martin A. Schwartz
J Cell Biol. 2016 Sep 26; 214(7): 807–816. doi: 10.1083/jcb.201603106
PMCID:
PMC5037412
AbstractArticlePDF–2.5M
9.
Heterozygous disruption of activin receptor-like kinase 1 is associated with increased arterial pressure in mice
María González-Núñez, Adela S. Riolobos, Orlando Castellano, Isabel Fuentes-Calvo, María de los Ángeles Sevilla, Bárbara Oujo, Miguel Pericacho, Ignacio Cruz-Gonzalez, Fernando Pérez-Barriocanal, Peter ten Dijke, Jose M. López-Novoa
Dis Model Mech. 2015 Nov 1; 8(11): 1427–1439. doi: 10.1242/dmm.019695
PMCID:
PMC4631783
AbstractArticle
10.
De novo cerebrovascular malformation in the adult mouse after endothelial Alk1 deletion and angiogenic stimulation
Wanqiu Chen, Zhengda Sun, Zhenying Han, Kristine Jun, Marine Camus, Mamta Wankhede, Lei Mao, Tom Arnold, William L. Young, Hua Su
Stroke. Author manuscript; available in PMC 2015 Mar 1.
Published in final edited form as: Stroke. 2014 Mar; 45(3): 900–902. Published online 2014 Jan 23. doi: 10.1161/STROKEAHA.113.003655
PMCID:
PMC4117234
AbstractArticlePDF–819K
11.
ALK1 Signaling Inhibits Angiogenesis by Cooperating with the Notch Pathway
Bruno Larrivée, Claudia Prahst, Emma Gordon, Raquel del Toro, Thomas Mathivet, Antonio Duarte, Michael Simons, Anne Eichmann
Dev Cell. Author manuscript; available in PMC 2014 Jun 6.
Published in final edited form as: Dev Cell. 2012 Mar 13; 22(3): 489–500. doi: 10.1016/j.devcel.2012.02.005
PMCID:
PMC4047762
AbstractArticlePDF–2.6M
12.
Endothelial Depletion of Acvrl1 in Mice Leads to Arteriovenous Malformations Associated with Reduced Endoglin Expression
Simon Tual-Chalot, Marwa Mahmoud, Kathleen R. Allinson, Rachael E. Redgrave, Zhenhua Zhai, S. Paul Oh, Marcus Fruttiger, Helen M. Arthur
PLoS One. 2014; 9(6): e98646. Published online 2014 Jun 4. doi: 10.1371/journal.pone.0098646
PMCID:
PMC4045906
AbstractArticlePDF–3.1M
13.
Reduced mural cell coverage and impaired vessel integrity after angiogenic stimulation in the Alk1-deficient brain
Wanqiu Chen, Yi Guo, Espen J. Walker, Fanxia Shen, Kristine Jun, S. Paul Oh, Vincent Degos, Michael T. Lawton, Tarik Tihan, Dimitrios Davalos, Katerina Akassoglou, Jeffrey Nelson, John Pile-Spellman, Hua Su, William L. Young
Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2014 Feb 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2013 Feb; 33(2): 305–310. Published online 2012 Dec 13. doi: 10.1161/ATVBAHA.112.300485
PMCID:
PMC3569037
AbstractArticlePDF–2.7M
14.
Increased tissue perfusion promotes capillary dysplasia in the ALK1-deficient mouse brain following VEGF stimulation
Qi Hao, Hua Su, Douglas A. Marchuk, Radoslaw Rola, Yongqiang Wang, Weizhong Liu, William L. Young, Guo-Yuan Yang
Am J Physiol Heart Circ Physiol. 2008 Dec; 295(6): H2250–H2256. Published online 2008 Oct 3. doi: 10.1152/ajpheart.00083.2008
PMCID:
PMC2614529
AbstractArticle
15.
Blood endothelial ALK1‐BMP4 signaling axis regulates adult hair follicle stem cell activation
Kefei Nina Li, Gopal Chovatiya, Daniel Youngjoo Ko, Sripad Sureshbabu, Tudorita Tumbar
EMBO J. 2023 May; 42(10): e112196. Published online 2023 Mar 30. doi: 10.15252/embj.2022112196
PMCID:
PMC10183823
AbstractArticlePDF–20M
16.
Traffic Patterns of the Migrating Endothelium: How Force Transmission Regulates Vascular Malformation and Functional Shunting During Angiogenic Remodelling
Lowell T. Edgar, Hyojin Park, Jessica R. Crawshaw, James M. Osborne, Anne Eichmann, Miguel O. Bernabeu
Front Cell Dev Biol. 2022; 10: 840066. Published online 2022 May 19. doi: 10.3389/fcell.2022.840066
PMCID:
PMC9160721
AbstractArticlePDF–4.6M
17.
Correcting Smad1/5/8, mTOR, and VEGFR2 treats pathology in hereditary hemorrhagic telangiectasia models
Santiago Ruiz, Haitian Zhao, Pallavi Chandakkar, Julien Papoin, Hyunwoo Choi, Aya Nomura-Kitabayashi, Radhika Patel, Matthew Gillen, Li Diao, Prodyot K. Chatterjee, Mingzhu He, Yousef Al-Abed, Ping Wang, Christine N. Metz, S. Paul Oh, Lionel Blanc, Fabien Campagne, Philippe Marambaud
J Clin Invest. 2020 Feb 3; 130(2): 942–957. Published online 2020 Jan 21. doi: 10.1172/JCI127425
PMCID:
PMC6994128
AbstractArticlePDF–28M
18.
Reduced Activin Receptor Like-Kinase 1 Activity Promotes Cardiac Fibrosis in Heart Failure
Kevin J. Morine, Xiaoying Qiao, Vikram Paruchuri, Mark J. Aronovitz, Emily E. Mackey, Lyanne Buiten, Jonathan Levine, Keshan Ughreja, Prerna Nepali, Robert M. Blanton, S. Paul Oh, Richard H. Karas, Navin K. Kapur
Cardiovasc Pathol. Author manuscript; available in PMC 2018 Nov 1.
Published in final edited form as: Cardiovasc Pathol. 2017 Nov-Dec; 31: 26–33. Published online 2017 Jul 18. doi: 10.1016/j.carpath.2017.07.004
PMCID:
PMC5863230
AbstractArticlePDF–692K
19.
Conditional knockout of activin like kinase-1 (ALK-1) leads to heart failure without maladaptive remodeling
Kevin J. Morine, Vikram Paruchuri, Xiaoying Qiao, Mark J. Aronovitz, Emily E. Mackey, Lyanne Buiten, Jonathan Levine, Keshan Ughreja, Prerna Nepali, Robert M. Blanton, Richard H. Karas, Navin K. Kapur
Heart Vessels. Author manuscript; available in PMC 2018 May 1.
Published in final edited form as: Heart Vessels. 2017 May; 32(5): 628–636. Published online 2017 Feb 17. doi: 10.1007/s00380-017-0955-x
PMCID:
PMC5410196
AbstractArticlePDF–968K
20.
Compound genetically engineered mouse models of cancer reveal dual targeting of ALK1 and endoglin as a synergistic opportunity to impinge on angiogenic TGF-β signaling
Nikolas M. Eleftheriou, Jonas Sjölund, Matteo Bocci, Eliane Cortez, Se-Jin Lee, Sara I. Cunha, Kristian Pietras
Oncotarget. 2016 Dec 20; 7(51): 84314–84325. Published online 2016 Oct 12. doi: 10.18632/oncotarget.12604
PMCID:
PMC5341292
AbstractArticlePDF–6.2M

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