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Select item 111415261.

Akt-2 Is a Potential Therapeutic Target for Disseminated Candidiasis

Ling Huang, Yilei Ma, Hui Guo, Na Tang, Song Ouyang, Patrick Nuro-Gyina, Lijian Tao, Yusen Liu, Matthew C. O’Brien, Wallace Y. Langdon, Jian Zhang

J Immunol. Author manuscript; available in PMC 2024 May 31.

Published in final edited form as: J Immunol. 2022 Sep 1; 209(5): 991–1000. Published online 2022 Aug 5. doi: 10.4049/jimmunol.2101003

PMCID:: PMC11141526

Abstract Article PDF–3.0M

Select item 110323182.

Spontaneous Akt2 deficiency in a colony of NOD mice exhibiting early diabetes

Julie Hervé, Karine Haurogné, Marie Allard, Sophie Sourice, Pierre Lindenbaum, Jean-Marie Bach, Blandine Lieubeau

Sci Rep. 2024; 14: 9100. Published online 2024 Apr 20. doi: 10.1038/s41598-024-60021-w

PMCID:: PMC11032318

Abstract Article PDF–1.3M

Select item 93969163.

Methylene-bridge tryptophan fatty acylation regulates PI3K-AKT signaling and glucose uptake

Song-Hua Hu, Xia-Di He, Ji Nie, Jun-Li Hou, Jiang Wu, Xiao-Yan Liu, Yun Wei, Hui-Ru Tang, Wen-Xing Sun, Shu-Xian Zhou, Yi-Yuan Yuan, Yan-Peng An, Guo-Quan Yan, Yan Lin, Peng-Cheng Lin, Jean J. Zhao, Ming-Liang Ye, Jian-Yuan Zhao, Wei Xu, Shi-Min Zhao

Cell Rep. Author manuscript; available in PMC 2022 Aug 23.

Published in final edited form as: Cell Rep. 2022 Mar 15; 38(11): 110509. doi: 10.1016/j.celrep.2022.110509

PMCID:: PMC9396916

Abstract Article PDF–3.1M

Select item 78545134.

PKBβ/AKT2 deficiency impacts brain mTOR signaling, prefrontal cortical physiology, hippocampal plasticity and select murine behaviors.

Sara Palumbo, Clare Paterson, Feng Yang, Veronica L. Hood, Amanda J. Law

Mol Psychiatry. Author manuscript; available in PMC 2021 Aug 1.

Published in final edited form as: Mol Psychiatry. 2021 Feb; 26(2): 411–428. Published online 2020 Dec 16. doi: 10.1038/s41380-020-00964-4

PMCID:: PMC7854513

Abstract Article PDF–1.3M

Select item 71330135.

AKT2 deficiency impairs formation of the BCR signalosome

Zuochen Du, Di Yang, Yongjie Zhang, Xingtian Xuan, Han Li, Leling Hu, Changshun Ruan, Liling Li, Anwei Chen, Liang Deng, Yan Chen, Jingwen Xie, Lisa S. Westerberg, Lu Huang, Chaohong Liu

Cell Commun Signal. 2020; 18: 56. Published online 2020 Apr 6. doi: 10.1186/s12964-020-00534-9

PMCID:: PMC7133013

Abstract Article PDF–4.3M

Select item 69909176.

The Role of Akt2 in the Protective Effect of Fenofibrate against Diabetic Nephropathy

Yanli Cheng, Xiaoyu Zhang, Fuzhe Ma, Weixia Sun, Wanning Wang, Jinyu Yu, Yue Shi, Lu Cai, Zhonggao Xu

Int J Biol Sci. 2020; 16(4): 553–567. Published online 2020 Jan 1. doi: 10.7150/ijbs.40643

PMCID:: PMC6990917

Abstract Article PDF–3.1M

Select item 68513237.

Serine 474 phosphorylation is essential for maximal Akt2 kinase activity in adipocytes

Alison L. Kearney, Kristen C. Cooke, Dougall M. Norris, Armella Zadoorian, James R. Krycer, Daniel J. Fazakerley, James G. Burchfield, David E. James

J Biol Chem. 2019 Nov 8; 294(45): 16729–16739. Published online 2019 Sep 22. doi: 10.1074/jbc.RA119.010036

PMCID:: PMC6851323

Abstract Article PDF–1.9M

Select item 53725818.

AKT2 Blocks Nucleus Translocation of Apoptosis-Inducing Factor (AIF) and Endonuclease G (EndoG) While Promoting Caspase Activation during Cardiac Ischemia

Shuai Yang, Xinmei Zhao, Hui Xu, Fan Chen, Yitao Xu, Zhe Li, Daniel Sanchis, Liang Jin, Yubin Zhang, Junmei Ye

Int J Mol Sci. 2017 Mar; 18(3): 565. Published online 2017 Mar 6. doi: 10.3390/ijms18030565

PMCID:: PMC5372581

Abstract Article PDF–5.0M

Select item 43937899.

The role of mouse Akt2 in insulin-dependent suppression of adipocyte lipolysis in vivo

Shlomit Koren, Lisa M. DiPilato, Matthew J. Emmett, Abigail L. Shearin, Qingwei Chu, Bob Monks, Morris J. Birnbaum

Diabetologia. Author manuscript; available in PMC 2016 May 1.

Published in final edited form as: Diabetologia. 2015 May; 58(5): 1063–1070. Published online 2015 Mar 5. doi: 10.1007/s00125-015-3532-9

PMCID:: PMC4393789

Abstract Article PDF–1.0M

Select item 414179710.

Akt2 Is Involved in Loss of Epithelial Cells and Renal Fibrosis following Unilateral Ureteral Obstruction

Aiping Lan, Jing Zhang, Zhicheng Xiao, Xiaogang Peng, Yongfen Qi, Jie Du

PLoS One. 2014; 9(8): e105451. Published online 2014 Aug 22. doi: 10.1371/journal.pone.0105451

PMCID:: PMC4141797

Abstract Article PDF–4.5M

Select item 411639411.

Regulation of renal tubular glucose reabsorption by Akt2/PKBβ

Daniela S. Kempe, Gulab Siraskar, Henning Fröhlich, Anja T. Umbach, Michael Stübs, Florian Weiss, Teresa F. Ackermann, Harald Völkl, Morris J. Birnbaum, David Pearce, Michael Föller, Florian Lang

Am J Physiol Renal Physiol. 2010 May; 298(5): F1113–F1117. Published online 2010 Feb 17. doi: 10.1152/ajprenal.00592.2009

PMCID:: PMC4116394

Abstract Article

Select item 402506512.

Hydrogen sulfide alleviates cardiac contractile dysfunction in an Akt2-knockout murine model of insulin resistance: role of mitochondrial injury and apoptosis

Nan Hu, Maolong Dong, Jun Ren

Am J Physiol Regul Integr Comp Physiol. 2014 May 15; 306(10): R761–R771. Published online 2014 Mar 12. doi: 10.1152/ajpregu.00327.2013

PMCID:: PMC4025065

Abstract Article

Select item 380676113.

Characterization of the Akt2 Domain Essential for Binding Nuclear p21cip1 to Promote Cell Cycle Arrest during Myogenic Differentiation

Lisa Heron-Milhavet, Celine Franckhauser, Anne Fernandez, Ned J. Lamb

PLoS One. 2013; 8(10): e76987. Published online 2013 Oct 23. doi: 10.1371/journal.pone.0076987

PMCID:: PMC3806761

Abstract Article PDF–1.5M

Select item 370919214.

Regulation of Gastric Acid Secretion by PKB/Akt2

Anand Rotte, Venkanna Pasham, Madhuri Bhandaru, Melanie Eichenmüller, Wenting Yang, Syed M. Qadri, Daniela S. Kempe, Goverdhan Puchchakayala, David Pearce, Morris J. Birnbaum, Florian Lang

Cell Physiol Biochem. 2010 May; 25(6): 695–704. doi: 10.1159/000315089

PMCID:: PMC3709192

Abstract Article PDF–507K

Select item 321395715.

Myocardial injury after ischemia-reperfusion in mice deficient in Akt2 is associated with increased cardiac macrophage density

Xue Li, Deana Mikhalkova, Erhe Gao, Jin Zhang, Valerie Myers, Carmen Zincarelli, Yonghong Lei, Jianliang Song, Walter J. Koch, Karsten Peppel, Joseph Y. Cheung, Arthur M. Feldman, Tung O. Chan

Am J Physiol Heart Circ Physiol. 2011 Nov; 301(5): H1932–H1940. Published online 2011 Sep 2. doi: 10.1152/ajpheart.00755.2010