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Select item 110397221.

Single-cell transcriptomics in MI identify Slc25a4 as a new modulator of mitochondrial malfunction and apoptosis-associated cardiomyocyte subcluster

Ting Zhou, Jing Pan, Kai Xu, Chenghui Yan, Jing Yuan, Haixu Song, Yaling Han

Sci Rep. 2024; 14: 9274. Published online 2024 Apr 23. doi: 10.1038/s41598-024-59975-8

PMCID:: PMC11039722

Abstract Article PDF–13M

Select item 106436472.

The mitochondrially targeted peptide elamipretide (SS-31) improves ADP sensitivity in aged mitochondria by increasing uptake through the adenine nucleotide translocator (ANT)

Gavin Pharaoh, Varun Kamat, Sricharan Kannan, Rudolph S. Stuppard, Jeremy Whitson, Miguel Martín-Pérez, Wei-Jun Qian, Michael J. MacCoss, Judit Villén, Peter Rabinovitch, Matthew D. Campbell, Ian R. Sweet, David J. Marcinek

GeroScience. 2023 Dec; 45(6): 3529–3548. Published online 2023 Jul 18. doi: 10.1007/s11357-023-00861-y

PMCID:: PMC10643647

Abstract Article PDF–1.8M

Select item 94116823.

Nicotinamide riboside alleviates exercise intolerance in ANT1-deficient mice

Patrick M. Schaefer, Jessica Huang, Arrienne Butic, Caroline Perry, Tal Yardeni, Wendy Tan, Ryan Morrow, Joseph A. Baur, Douglas C. Wallace

Mol Metab. 2022 Oct; 64: 101560. Published online 2022 Aug 6. doi: 10.1016/j.molmet.2022.101560

PMCID:: PMC9411682

Abstract Article PDF–2.7M

Select item 67175134.

Mitochondrial DNA Variation Dictates Expressivity and Progression of Nuclear DNA Mutations Causing Cardiomyopathy

Meagan J. McManus, Martin Picard, Hsiao-Wen Chen, Hans J. De Haas, Prasanth Potluri, Jeremy Leipzig, Atif Towheed, Alessia Angelin, Partho Sengupta, Ryan M. Morrow, Brett A. Kauffman, Marc Vermulst, Jagat Narula, Douglas C. Wallace

Cell Metab. Author manuscript; available in PMC 2019 Aug 31.

Published in final edited form as: Cell Metab. 2019 Jan 8; 29(1): 78–90.e5. Published online 2018 Aug 30. doi: 10.1016/j.cmet.2018.08.002

PMCID:: PMC6717513

Abstract Article PDF–1.3M

Select item 62506785.

Ant1 mutant mice bridge the mitochondrial and serotonergic dysfunctions in bipolar disorder

Tomoaki M. Kato, Mie Kubota-Sakashita, Noriko Fujimori-Tonou, Fumihito Saitow, Satoshi Fuke, Akira Masuda, Shigeyoshi Itohara, Hidenori Suzuki, Tadafumi Kato

Mol Psychiatry. 2018; 23(10): 2039–2049. Published online 2018 Jun 11. doi: 10.1038/s41380-018-0074-9

PMCID:: PMC6250678

Abstract Article PDF–2.2M

Select item 52252896.

Identification of an Epitope from Adenine Nucleotide Translocator 1 That Induces Inflammation in Heart in A/J Mice

Rakesh H. Basavalingappa, Chandirasegaran Massilamany, Bharathi Krishnan, Arunakumar Gangaplara, Guobin Kang, Vahid Khalilzad-Sharghi, Zhongji Han, Shadi Othman, Qingsheng Li, Jean-Jack Riethoven, Raymond A. Sobel, David Steffen, Jay Reddy

Am J Pathol. 2016 Dec; 186(12): 3160–3175. doi: 10.1016/j.ajpath.2016.08.005

PMCID:: PMC5225289

Abstract Article PDF–2.9M

Select item 43913417.

MITOCHIP Assessment of Differential Gene Expression in the Skeletal Muscle of Ant1 Knockout Mice: Coordinate Regulation of OXPHOS, Antioxidant, and Apoptotic Genes

Vaidya Subramaniam, Pawel Golik, Deborah G. Murdock, Shawn Levy, Keith W. Kerstann, Pinar E. Coskun, Goarik A. Melkonian, Douglas C. Wallace

Biochim Biophys Acta. Author manuscript; available in PMC 2015 Apr 9.

Published in final edited form as: Biochim Biophys Acta. 2008 Jul-Aug; 1777(0): 666–675. Published online 2008 Mar 28. doi: 10.1016/j.bbabio.2008.03.015

PMCID:: PMC4391341

Abstract Article PDF–372K

Select item 32710108.

Nitroalkenes Confer Acute Cardioprotection via Adenine Nucleotide Translocase 1

Sergiy M. Nadtochiy, Qiuyu Zhu, William Urciuoli, Ruslan Rafikov, Stephen M. Black, Paul S. Brookes

J Biol Chem. 2012 Jan 27; 287(5): 3573–3580. Published online 2011 Dec 9. doi: 10.1074/jbc.M111.298406

Correction in:: J Biol Chem. 2015 Dec 18; 290(51): 30267.

PMCID:: PMC3271010

Abstract Article PDF–876K

Select item 32457209.

Adenine Nucleotide Translocator 1 Deficiency Increases Resistance of Mouse Brain and Neurons to Excitotoxic Insults

Jaewon Lee, Samuel E. Schriner, Douglas C. Wallace

Biochim Biophys Acta. Author manuscript; available in PMC 2011 Dec 23.

Published in final edited form as: Biochim Biophys Acta. 2009 May; 1787(5): 364–370. Published online 2009 Jan 30. doi: 10.1016/j.bbabio.2009.01.014

PMCID:: PMC3245720

Abstract Article PDF–1.6M

Select item 305577510.

Retinal Function and Structure in Ant1-Deficient Mice

M. Joseph Phillips, Sarah Webb-Wood, Amanda E. Faulkner, Seema B. Jabbar, Valerie Biousse, Nancy J. Newman, Vi T. Do, Jeffrey H. Boatright, Douglas C. Wallace, Machelle T. Pardue

Invest Ophthalmol Vis Sci. 2010 Dec; 51(12): 6744–6752. doi: 10.1167/iovs.10-5421

PMCID:: PMC3055775

Abstract Article PDF–2.5M

Select item 276842811.

ADENINE NUCLEOTIDE TRANSLOCASE-1 INDUCES CARDIOMYOCYTE DEATH THROUGH UPREGULATION OF THE PRO-APOPTOTIC PROTEIN BAX

Christopher P. Baines, Jeffery D. Molkentin

J Mol Cell Cardiol. Author manuscript; available in PMC 2010 Jun 1.

Published in final edited form as: J Mol Cell Cardiol. 2009 Jun; 46(6): 969–977. doi: 10.1016/j.yjmcc.2009.01.016

PMCID:: PMC2768428

Abstract Article PDF–2.5M

Select item 265116212.

Inhibition of mitochondrial permeability transition by cyclosporin A prevents pyrazole plus lipopolysaccharide-induced liver injury in mice

Jian Zhuge, Arthur I. Cederbaum

Free Radic Biol Med. Author manuscript; available in PMC 2010 Feb 1.

Published in final edited form as: Free Radic Biol Med. 2009 Feb 1; 46(3): 406–413. Published online 2008 Oct 31. doi: 10.1016/j.freeradbiomed.2008.10.037

PMCID:: PMC2651162

Abstract Article PDF–1.1M

Select item 964667513.

Mitochondrial uncouplers induce proton leak by activating AAC and UCP1

Ambre M. Bertholet, Andrew M. Natale, Paola Bisignano, Junji Suzuki, Andriy Fedorenko, James Hamilton, Tatiana Brustovetsky, Lawrence Kazak, Ryan Garrity, Edward T. Chouchani, Nickolay Brustovetsky, Michael Grabe, Yuriy Kirichok

Nature. Author manuscript; available in PMC 2022 Dec 1.

Published in final edited form as: Nature. 2022 Jun; 606(7912): 180–187. Published online 2022 May 25. doi: 10.1038/s41586-022-04747-5

PMCID:: PMC9646675

Abstract Article PDF–2.9M

Select item 510001214.

Deficiency in the Mouse Mitochondrial Adenine Nucleotide Translocator Isoform 2 Gene is Associated with Cardiac Noncompaction

Jason E. Kokoszka, Katrina G. Waymire, Adrian Flierl, Katelyn M. Sweeney, Alessia Angelin, Grant R. MacGregor, Douglas C. Wallace

Biochim Biophys Acta. Author manuscript; available in PMC 2017 Aug 1.

Published in final edited form as: Biochim Biophys Acta. 2016 Aug; 1857(8): 1203–1212. Published online 2016 Apr 24. doi: 10.1016/j.bbabio.2016.03.026

PMCID:: PMC5100012

Abstract Article PDF–3.6M

Select item 434966315.

Increased frequency of follicular helper T cells in mice viral myocarditis is relevant with anti-ANT antoantibody

Fan Yang, Wen-hong Mo, Bao-ping Tan, Xiao-mou Wei, Hong Wang

Virol J. 2015; 12: 20. Published online 2015 Feb 11. doi: 10.1186/s12985-015-0257-9

PMCID:: PMC4349663

Abstract Article PDF–1015K

Select item 428167616.

Downregulation of adenine nucleotide translocator 1 exacerbates tumor necrosis factor-α-mediated cardiac inflammatory responses

Shi Pan, Nadan Wang, Sara Bisetto, Bing Yi, Shey-Shing Sheu

Am J Physiol Heart Circ Physiol. 2015 Jan 1; 308(1): H39–H48. Published online 2014 Nov 7. doi: 10.1152/ajpheart.00330.2014

PMCID:: PMC4281676

Abstract Article

Select item 358719617.

Severity of cardiomyopathy associated with adenine nucleotide translocator-1 deficiency correlates with mtDNA haplogroup

Kevin A. Strauss, Lauren DuBiner, Mariella Simon, Michael Zaragoza, Partho P. Sengupta, Peng Li, Navneet Narula, Sandra Dreike, Julia Platt, Vincent Procaccio, Xilma R. Ortiz-González, Erik G. Puffenberger, Richard I. Kelley, D. Holmes Morton, Jagat Narula, Douglas C. Wallace

Proc Natl Acad Sci U S A. 2013 Feb 26; 110(9): 3453–3458. Published online 2013 Feb 11. doi: 10.1073/pnas.1300690110