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Items: 1 to 20 of 822

1.
Induction of p16Ink4a Gene Expression in Heme Protein–Induced AKI and by Heme: Pathophysiologic Implications
Karl A. Nath, Raman Deep Singh, Anthony J. Croatt, Allan W. Ackerman, Joseph P. Grande, Daniel R. O'Brien, Vesna D. Garovic, Christopher M. Adams, Tamara Tchkonia, James L. Kirkland
Kidney360. 2024 Apr; 5(4): 501–514. Published online 2024 Feb 21. doi: 10.34067/KID.0000000000000395
PMCID:
PMC11093543
AbstractArticlePDF–1.1M
2.
Rejuvenating aged microglia by p16ink4a-siRNA-loaded nanoparticles increases amyloid-β clearance in animal models of Alzheimer’s disease
Hyo Jung Shin, In Soo Kim, Seung Gyu Choi, Kayoung Lee, Hyewon Park, Juhee Shin, Dayoung Kim, Jaewon Beom, Yoon Young Yi, Deepak Prasad Gupta, Gyun Jee Song, Won-Suk Chung, C. Justin Lee, Dong Woon Kim
Mol Neurodegener. 2024; 19: 25. Published online 2024 Mar 16. doi: 10.1186/s13024-024-00715-x
PMCID:
PMC10943801
AbstractArticlePDF–8.9M
3.
Dietary Folate and Cofactors Accelerate Age-dependent p16 Epimutation to Promote Intestinal Tumorigenesis
Li Yang, Robert C. Peery, Leah M. Farmer, Xia Gao, Yiqun Zhang, Chad J. Creighton, Lanjing Zhang, Lanlan Shen
Cancer Res Commun. 2024 Jan; 4(1): 164–169. Published online 2024 Jan 19. doi: 10.1158/2767-9764.CRC-23-0356
PMCID:
PMC10798135
AbstractArticlePDF–2.6M
4.
Transcriptome analysis reveals genes associated with stem cell activation by physical exercise in the dentate gyrus of aged p16Ink4a knockout mice
Laura Micheli, Giorgio D'Andrea, Teresa Maria Creanza, Daniel Volpe, Nicola Ancona, Raffaella Scardigli, Felice Tirone
Front Cell Dev Biol. 2023; 11: 1270892. Published online 2023 Oct 19. doi: 10.3389/fcell.2023.1270892
PMCID:
PMC10621069
AbstractArticlePDF–3.0M
5.
p16 INK4A Drives Non-Alcoholic Fatty Liver Disease Phenotypes in High Fat Diet Fed Mice via Biliary E2F1/FOXO1/IGF-1 Signaling
Debjyoti Kundu, Lindsey Kennedy, Tianhao Zhou, Burcin Ekser, Vik Meadows, Amelia Sybenga, Konstantina Kyritsi, Lixian Chen, Ludovica Ceci, Nan Wu, Chaodong Wu, Shannon Glaser, Guido Carpino, Paolo Onori, Eugenio Gaudio, Gianfranco Alpini, Heather Francis
Hepatology. Author manuscript; available in PMC 2023 Aug 9.
Published in final edited form as: Hepatology. 2023 Jul 1; 78(1): 243–257. Published online 2023 Feb 20. doi: 10.1097/HEP.0000000000000307
PMCID:
PMC10410572
AbstractArticlePDF–4.5M
6.
First-in-class multifunctional TYMS nonclassical antifolate inhibitor with potent in vivo activity that prolongs survival
Maria V. Guijarro, Patrick C. Kellish, Peter E. Dib, Nicholas G. Paciaroni, Akbar Nawab, Jacob Andring, Lidia Kulemina, Nicholas V. Borrero, Carlos Modenutti, Michael Feely, Elham Nasri, Robert P. Seifert, Xiaoping Luo, Richard L. Bennett, Daniil Shabashvili, Jonathan D. Licht, Robert McKenna, Adrian Roitberg, Robert W. Huigens, III, Frederic J. Kaye, Maria Zajac-Kaye
JCI Insight. 2023 May 22; 8(10): e158798. Published online 2023 May 22. doi: 10.1172/jci.insight.158798
PMCID:
PMC10386886
AbstractArticlePDF–2.8M
7.
Developmental Expression of the Cell Cycle Regulator p16INK4a in Retinal Glial Cells: A Novel Marker for Immature Ocular Astrocytes?
Cristina Martinez-Fernandez de la Camara, Tina Storm, Ahmed Salman, Thomas Burgoyne, Martin Qvist Rasmussen, Harry O. Orlans, Angela J. Russell, Stephen G. Davies, Alun R. Barnard, Robert E. MacLaren
J Histochem Cytochem. 2023 Jun; 71(6): 301–320. Published online 2023 Jun 23. doi: 10.1369/00221554231184286
PMCID:
PMC10315990
AbstractArticlePDF–11M
8.
Oxylipin-PPARγ-initiated Adipocyte Senescence Propagates Secondary Senescence in the Bone Marrow
Xiaonan Liu, Yiru Gu, Surendra Kumar, Sahran Amin, Qiaoyue Guo, Jiekang Wang, Ching-Lien Fang, Xu Cao, Mei Wan
Cell Metab. Author manuscript; available in PMC 2024 Apr 4.
Published in final edited form as: Cell Metab. 2023 Apr 4; 35(4): 667–684.e6. doi: 10.1016/j.cmet.2023.03.005
PMCID:
PMC10127143
AbstractArticlePDF–3.9M
9.
ARF suppression by MYC but not MYCN confers increased malignancy of aggressive pediatric brain tumors
Oliver J. Mainwaring, Holger Weishaupt, Miao Zhao, Gabriela Rosén, Anna Borgenvik, Laura Breinschmid, Annemieke D. Verbaan, Stacey Richardson, Dean Thompson, Steven C. Clifford, Rebecca M. Hill, Karl Annusver, Anders Sundström, Karl O. Holmberg, Maria Kasper, Sonja Hutter, Fredrik J. Swartling
Nat Commun. 2023; 14: 1221. Published online 2023 Mar 3. doi: 10.1038/s41467-023-36847-9
PMCID:
PMC9984535
AbstractArticlePDF–4.7M
10.
Clearance of p16Ink4a-positive cells in a mouse transgenic model does not change β-cell mass and has limited effects on their proliferative capacity
Nadine Bahour, Lucia Bleichmar, Cristian Abarca, Emeline Wilmann, Stephanie Sanjines, Cristina Aguayo-Mazzucato
Aging (Albany NY) 2023 Jan 31; 15(2): 441–458. Published online 2023 Jan 12. doi: 10.18632/aging.204483
PMCID:
PMC9925693
AbstractArticlePDF–1.8M
11.
Immortalized murine tenocyte cells: a novel and innovative tool for tendon research
Gil Lola Oreff, Barbara Maurer, Ahmed N. ELKhamary, Iris Gerner, Veronika Sexl, Florien Jenner
Sci Rep. 2023; 13: 1566. Published online 2023 Jan 28. doi: 10.1038/s41598-023-28318-4
PMCID:
PMC9884217
AbstractArticlePDF–3.0M
12.
Endothelial senescence mediates hypoxia-induced vascular remodeling by modulating PDGFB expression
Priscilla Kyi, Kathryn Hendee, Tendai Hunyenyiwa, Kienna Matus, Tadanori Mammoto, Akiko Mammoto
Front Med (Lausanne) 2022; 9: 908639. Published online 2022 Sep 20. doi: 10.3389/fmed.2022.908639
PMCID:
PMC9530050
AbstractArticlePDF–5.3M
13.
Modulation of fracture healing by the transient accumulation of senescent cells
Dominik Saul, David G Monroe, Jennifer L Rowsey, Robyn Laura Kosinsky, Stephanie J Vos, Madison L Doolittle, Joshua N Farr, Sundeep Khosla
eLife. 2021; 10: e69958. Published online 2021 Oct 7. doi: 10.7554/eLife.69958
PMCID:
PMC8526061
AbstractArticlePDF–9.1M
14.
p16-3MR: A Novel Model to Study Cellular Senescence in Cigarette Smoke-Induced Lung Injuries
Gagandeep Kaur, Isaac K. Sundar, Irfan Rahman
Int J Mol Sci. 2021 May; 22(9): 4834. Published online 2021 May 3. doi: 10.3390/ijms22094834
PMCID:
PMC8125702
AbstractArticlePDF–4.7M
15.
Role of Cdkn2a in the Emery–Dreifuss Muscular Dystrophy Cardiac Phenotype
Gloria Pegoli, Marika Milan, Pierluigi Giuseppe Manti, Andrea Bianchi, Federica Lucini, Philina Santarelli, Claudia Bearzi, Roberto Rizzi, Chiara Lanzuolo
Biomolecules. 2021 Apr; 11(4): 538. Published online 2021 Apr 6. doi: 10.3390/biom11040538
PMCID:
PMC8103514
AbstractArticlePDF–51M
16.
CDKN2A/p16INK4a suppresses hepatic fatty acid oxidation through the AMPKα2-SIRT1-PPARα signaling pathway
Yann Deleye, Alexia Karen Cotte, Sarah Anissa Hannou, Nathalie Hennuyer, Lucie Bernard, Bruno Derudas, Sandrine Caron, Vanessa Legry, Emmanuelle Vallez, Emilie Dorchies, Nathalie Martin, Steve Lancel, Jean Sébastien Annicotte, Kadiombo Bantubungi, Albin Pourtier, Violeta Raverdy, François Pattou, Philippe Lefebvre, Corinne Abbadie, Bart Staels, Joel T. Haas, Réjane Paumelle
J Biol Chem. 2020 Dec 11; 295(50): 17310–17322. Published online 2020 Oct 9. doi: 10.1074/jbc.RA120.012543
PMCID:
PMC7863903
AbstractArticlePDF–3.0M
17.
Unique Transcriptome Changes in Peripheral B Cells Revealed by Comparing Age Groups From Naive or Vaccinated Mice, Including snoRNA and Cdkn2a
Robin L Baudier, Kevin J Zwezdaryk, Malwina Czarny-Ratajczak, Lauren H Kodroff, Deborah E Sullivan, Elizabeth B Norton
J Gerontol A Biol Sci Med Sci. 2020 Dec; 75(12): 2326–2332. Published online 2020 Aug 1. doi: 10.1093/gerona/glaa165
PMCID:
PMC7759738
AbstractArticlePDF–8.6M
18.
Downregulation of p16 Decreases Biliary Damage and Liver Fibrosis in the Mdr2−/− Mouse Model of Primary Sclerosing Cholangitis
Konstantina Kyritsi, Heather Francis, Tianhao Zhou, Ludovica Ceci, Nan Wu, Zhihong Yang, Fanyin Meng, Lixian Chen, Leonardo Baiocchi, Debjyoti Kundu, Lindsey Kennedy, Suthat Liangpunsakul, Chaodong Wu, Shannon Glaser, Gianfranco Alpini
Gene Expr. 2020; 20(2): 89–103. Published online 2020 Nov 11. doi: 10.3727/105221620X15889714507961
PMCID:
PMC7650011
AbstractArticlePDF–34M
19.
CDKN2A/B homozygous deletion is associated with early recurrence in meningiomas
Philipp Sievers, Thomas Hielscher, Daniel Schrimpf, Damian Stichel, David E. Reuss, Anna S. Berghoff, Marian C. Neidert, Hans-Georg Wirsching, Christian Mawrin, Ralf Ketter, Werner Paulus, Guido Reifenberger, Katrin Lamszus, Manfred Westphal, Nima Etminan, Miriam Ratliff, Christel Herold-Mende, Stefan M. Pfister, David T. W. Jones, Michael Weller, Patrick N. Harter, Wolfgang Wick, Matthias Preusser, Andreas von Deimling, Felix Sahm
Acta Neuropathol. 2020; 140(3): 409–413. Published online 2020 Jul 8. doi: 10.1007/s00401-020-02188-w
PMCID:
PMC7423850
ArticlePDF–987K
20.
Loss of ARF/INK4A Promotes Liver Progenitor Cell Transformation Toward Tumorigenicity Supporting Their Role in Hepatocarcinogenesis
Robyn P. Strauss, Katherine M. Audsley, Adam M. Passman, Joanne H. van Vuuren, Megan L. Finch-Edmondson, Bernard A. Callus, George C. Yeoh
Gene Expr. 2020; 20(1): 39–52. Published online 2020 Jun 12. doi: 10.3727/105221620X15874935364268
PMCID:
PMC7284103
AbstractArticlePDF–31M

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