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Select item 106123621.

Multi-tissue epigenetic analysis identifies distinct associations underlying insulin resistance and Alzheimer’s disease at CPT1A locus

Chloé Sarnowski, Tianxiao Huan, Yiyi Ma, Roby Joehanes, Alexa Beiser, Charles S. DeCarli, Nancy L. Heard-Costa, Daniel Levy, Honghuang Lin, Ching-Ti Liu, Chunyu Liu, James B. Meigs, Claudia L. Satizabal, Jose C. Florez, Marie-France Hivert, Josée Dupuis, Philip L. De Jager, David A. Bennett, Sudha Seshadri, Alanna C. Morrison

Clin Epigenetics. 2023; 15: 173. Published online 2023 Oct 27. doi: 10.1186/s13148-023-01589-4

PMCID:: PMC10612362

Abstract Article PDF–1.4M

Select item 105234542.

CPT1A-mediated fatty acid oxidation confers cancer cell resistance to immune-mediated cytolytic killing

Zheng Liu, Wenjie Liu, Wei Wang, Yibao Ma, Yufeng Wang, David L. Drum, Jinyang Cai, Hallie Blevins, Eun Lee, Syed Shah, Paul B. Fisher, Xinhui Wang, Xianjun Fang, Chunqing Guo, Xiang-Yang Wang

Proc Natl Acad Sci U S A. 2023 Sep 26; 120(39): e2302878120. Published online 2023 Sep 18. doi: 10.1073/pnas.2302878120

PMCID:: PMC10523454

Abstract Article PDF–1.3M

Select item 103484583.

DNA Methylation Near CPT1A and Changes in Triglyceride-rich Lipoproteins in Response to Weight-loss Diet Interventions

Xiang Li, Xiaojian Shao, Qiaochu Xue, Minghao Kou, Catherine M Champagne, Boryana S Koseva, Yoriko Heianza, Elin Grundberg, Lydia A Bazzano, George A Bray, Frank M Sacks, Lu Qi

J Clin Endocrinol Metab. 2023 Aug; 108(8): e542–e549. Published online 2023 Feb 17. doi: 10.1210/clinem/dgad086

PMCID:: PMC10348458

Abstract Article

Select item 102504694.

Carnitine palmitoyltransferase 1A promotes mitochondrial fission by enhancing MFF succinylation in ovarian cancer

Yaqin Zhu, Yue Wang, Ying Li, Zhongqi Li, Wenhui Kong, Xiaoxuan Zhao, Shuting Chen, Liting Yan, Lenan Wang, Yunli Tong, Huanjie Shao

Commun Biol. 2023; 6: 618. Published online 2023 Jun 8. doi: 10.1038/s42003-023-04993-x

PMCID:: PMC10250469

Abstract Article PDF–1.1M

Select item 99093005.

Overexpression CPT1A reduces lipid accumulation via PPARα/CD36 axis to suppress the cell proliferation in ccRCC: CPT1A inhibits ccRCC cell proliferation via PPARα/CD36 axis

Hui Yang, Hongbo Zhao, Zhongkun Ren, Xiaojia Yi, Qiao Zhang, Zhe Yang, Yingmin Kuang, Yuechun Zhu

Acta Biochim Biophys Sin (Shanghai) 2022 Feb; 54(2): 220–231. Published online 2021 Dec 23. doi: 10.3724/abbs.2021023

PMCID:: PMC9909300

Abstract Article PDF–16M

Select item 98975416.

The impact of variance in carnitine palmitoyltransferase-1 expression on breast cancer prognosis is stratified by clinical and anthropometric factors

Ryan Liu, Shyryn Ospanova, Rachel J. Perry

PLoS One. 2023; 18(2): e0281252. Published online 2023 Feb 3. doi: 10.1371/journal.pone.0281252

PMCID:: PMC9897541

Abstract Article PDF–1.1M

Select item 97479767.

Neutrophil trafficking to the site of infection requires Cpt1a-dependent fatty acid β-oxidation

Ly Pham, Padmini Komalavilas, Alex M. Eddie, Timothy E. Thayer, Dalton L. Greenwood, Ken H. Liu, Jaclyn Weinberg, Andrew Patterson, Joshua P. Fessel, Kelli L. Boyd, Jenny C. Schafer, Jamie L. Kuck, Aaron C. Shaver, David K. Flaherty, Brittany K. Matlock, Christiaan D. M. Wijers, C. Henrique Serezani, Dean P. Jones, Evan L. Brittain, Jeffrey C. Rathmell, Michael J. Noto

Commun Biol. 2022; 5: 1366. Published online 2022 Dec 13. doi: 10.1038/s42003-022-04339-z

PMCID:: PMC9747976

Abstract Article PDF–2.6M

Select item 96920438.

CPT1A promotes anoikis resistance in esophageal squamous cell carcinoma via redox homeostasis

Tian Tian, Yunxin Lu, Jinfei Lin, Miao Chen, Huijuan Qiu, Wancui Zhu, Haohui Sun, Jinsheng Huang, Han Yang, Wuguo Deng

Redox Biol. 2022 Dec; 58: 102544. Published online 2022 Nov 15. doi: 10.1016/j.redox.2022.102544

PMCID:: PMC9692043

Abstract Article PDF–13M

Select item 95704289.

Augmented CPT1A Expression Is Associated with Proliferation and Colony Formation during Barrett’s Tumorigenesis

Joshua N. Bernard, Vikram Chinnaiyan, Thomas Andl, Gregoire F. Le Bras, M. Nasar Qureshi, Deborah A. Altomare, Claudia D. Andl

Int J Mol Sci. 2022 Oct; 23(19): 11745. Published online 2022 Oct 4. doi: 10.3390/ijms231911745

PMCID:: PMC9570428

Abstract Article PDF–5.2M

Select item 952570910.

The role of CPT1A as a biomarker of breast cancer progression: a bioinformatic approach

Mitali Das, Athina Giannoudis, Vijay Sharma

Sci Rep. 2022; 12: 16441. Published online 2022 Sep 30. doi: 10.1038/s41598-022-20585-x

PMCID:: PMC9525709

Abstract Article PDF–1.4M

Select item 890207911.

CPT1A-Mediated Fatty Acid Oxidation Promotes Precursor Osteoclast Fusion in Rheumatoid Arthritis

Zhaoyang Huang, Rong Luo, Liu Yang, Haiqi Chen, Xinyao Zhang, Jiawen Han, Hongxia Wang, Zhongyang Zhou, Zhao Wang, Lan Shao

Front Immunol. 2022; 13: 838664. Published online 2022 Feb 22. doi: 10.3389/fimmu.2022.838664

PMCID:: PMC8902079

Abstract Article PDF–15M

Select item 871494012.

Multiomic analysis identifies CPT1A as a potential therapeutic target in platinum-refractory, high-grade serous ovarian cancer

Dongqing Huang, Shrabanti Chowdhury, Hong Wang, Sara R. Savage, Richard G. Ivey, Jacob J. Kennedy, Jeffrey R. Whiteaker, Chenwei Lin, Xiaonan Hou, Ann L. Oberg, Melissa C. Larson, Najmeh Eskandari, Davide A. Delisi, Saverio Gentile, Catherine J. Huntoon, Uliana J. Voytovich, Zahra J. Shire, Qing Yu, Steven P. Gygi, Andrew N. Hoofnagle, Zachary T. Herbert, Travis D. Lorentzen, Anna Calinawan, Larry M. Karnitz, S. John Weroha, Scott H. Kaufmann, Bing Zhang, Pei Wang, Michael J. Birrer, Amanda G. Paulovich

Cell Rep Med. 2021 Dec 21; 2(12): 100471. Published online 2021 Dec 21. doi: 10.1016/j.xcrm.2021.100471

PMCID:: PMC8714940

Abstract Article PDF–5.5M

Select item 861857713.

Epigenome-Wide Association Study of Infant Feeding and DNA Methylation in Infancy and Childhood in a Population at Increased Risk for Type 1 Diabetes

Elizabeth Walker-Short, Teresa Buckner, Timothy Vigers, Patrick Carry, Lauren A. Vanderlinden, Fran Dong, Randi K. Johnson, Ivana V. Yang, Katerina Kechris, Marian Rewers, Jill M. Norris

Nutrients. 2021 Nov; 13(11): 4057. Published online 2021 Nov 13. doi: 10.3390/nu13114057

PMCID:: PMC8618577

Abstract Article PDF–1.2M

Select item 832472214.

Association of CPT1A gene polymorphism with the risk of gestational diabetes mellitus: a case-control study

Qingwen Ren, Mengzhu Guo, Feifei Yang, Tianbi Han, Wenqiong Du, Feng Zhao, Jinbo Li, Wangjun Li, Yongliang Feng, Suping Wang, Yawei Zhang, Weiwei Wu

J Assist Reprod Genet. 2021 Jul; 38(7): 1861–1869. Published online 2021 Mar 9. doi: 10.1007/s10815-021-02143-y

PMCID:: PMC8324722

Abstract Article PDF–506K

Select item 765734115.

Carbohydrate and fat intake associated with risk of metabolic diseases through epigenetics of CPT1A

Chao-Qiang Lai, Laurence D Parnell, Caren E Smith, Tao Guo, Sergi Sayols-Baixeras, Stella Aslibekyan, Hemant K Tiwari, Marguerite R Irvin, Carl Bender, David Fei, Bertha Hidalgo, Paul N Hopkins, Devin M Absher, Michael A Province, Roberto Elosua, Donna K Arnett, Jose M Ordovas

Am J Clin Nutr. 2020 Nov; 112(5): 1200–1211. Published online 2020 Sep 15. doi: 10.1093/ajcn/nqaa233

PMCID:: PMC7657341

Abstract Article PDF–570K

Select item 757658516.

Genetic study of the Arctic CPT1A variant suggests that its effect on fatty acid levels is modulated by traditional Inuit diet

Ninna Senftleber, Marit Eika Jørgensen, Emil Jørsboe, Fumiaki Imamura, Nita Gandhi Forouhi, Christina Lytken Larsen, Peter Bjerregaard, Torben Hansen, Anders Albrechtsen

Eur J Hum Genet. 2020 Nov; 28(11): 1592–1601. Published online 2020 Jun 19. doi: 10.1038/s41431-020-0674-0

PMCID:: PMC7576585

Abstract Article PDF–1.1M

Select item 733532117.

Targeting fatty acid oxidation to promote anoikis and inhibit ovarian cancer progression

Brandon T. Sawyer, Lubna Qamar, Tomomi M. Yamamoto, Alexandra McMellen, Zachary L. Watson, Jennifer K. Richer, Kian Behbakht, Isabel R. Schlaepfer, Benjamin G. Bitler

Mol Cancer Res. Author manuscript; available in PMC 2021 Jan 1.

Published in final edited form as: Mol Cancer Res. 2020 Jul; 18(7): 1088–1098. Published online 2020 Mar 20. doi: 10.1158/1541-7786.MCR-19-1057

PMCID:: PMC7335321

Abstract Article PDF–1.7M

Select item 694125418.

Alteration of fatty acid oxidation by increased CPT1A on replicative senescence of placenta-derived mesenchymal stem cells

Jin Seok, Hyun Sook Jung, Sohae Park, Jung Ok Lee, Chong Jai Kim, Gi Jin Kim

Stem Cell Res Ther. 2020; 11: 1. Published online 2020 Jan 3. doi: 10.1186/s13287-019-1471-y

PMCID:: PMC6941254

Abstract Article PDF–1.8M

Select item 683034719.

CPT1A Supports Castration-Resistant Prostate Cancer in Androgen-Deprived Conditions

Molishree Joshi, Gergana E. Stoykova, Maren Salzmann-Sullivan, Monika Dzieciatkowska, Lauren N. Liebman, Gagan Deep, Isabel R. Schlaepfer

Cells. 2019 Oct; 8(10): 1115. Published online 2019 Sep 20. doi: 10.3390/cells8101115

PMCID:: PMC6830347

Abstract Article PDF–3.0M

Select item 627898220.

A reversible carnitine palmitoyltransferase (CPT1) inhibitor offsets the proliferation of chronic lymphocytic leukemia cells

Elena Gugiatti, Claudya Tenca, Silvia Ravera, Marina Fabbi, Fabio Ghiotto, Andrea N. Mazzarello, Davide Bagnara, Daniele Reverberi, Daniela Zarcone, Giovanna Cutrona, Adalberto Ibatici, Ermanno Ciccone, Zbigniew Darzynkiewicz, Franco Fais, Silvia Bruno

Haematologica. 2018 Nov; 103(11): e531–e536. doi: 10.3324/haematol.2017.175414

PMCID:: PMC6278982

Article PDF–938K

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PMC Links for Gene (Select 1374) (131)
PMC
Homo sapiens gem (nuclear organelle) associated protein 8, mRNA (cDNA clone MGC:...
Homo sapiens gem (nuclear organelle) associated protein 8, mRNA (cDNA clone MGC:1030 IMAGE:2987964), complete cds
gi|33869273|gb|BC003607.2|

Nucleotide
Lactobacillus brevis asp. otakiensis ATCC 27306
Lactobacillus brevis asp. otakiensis ATCC 27306

biosample
Increased level of L-pyroglutamic acid in urine
Increased level of L-pyroglutamic acid in urine

MedGen
595512[uid] (1)
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