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Select item 72006261.

Nek7 conformational flexibility and inhibitor binding probed through protein engineering of the R-spine

Matthew J. Byrne, Nazia Nasir, Christine Basmadjian, Chitra Bhatia, Rory F. Cunnison, Katherine H. Carr, Corine Mas-Droux, Sharon Yeoh, Céline Cano, Richard Bayliss

Biochem J. 2020 Apr 30; 477(8): 1525–1539. Prepublished online 2020 Apr 3. Published online 2020 Apr 29. doi: 10.1042/BCJ20200128

PMCID:: PMC7200626

Abstract Article PDF–3.7M

Select item 65476972.

Activation of Aurora A kinase increases YAP stability via blockage of autophagy

Peng Wang, Ying Gong, Tao Guo, Man Li, Lei Fang, Shengchen Yin, Muhammad Kamran, Yang Liu, Jie Xu, Lingzhi Xu, Fei Peng, Xiaoyuan Xue, Mengying Yang, Mie-Chie Hung, Eric W.-F. Lam, Chundong Gu, Chunli Wang, Qimin Zhan, Quentin Liu

Cell Death Dis. 2019 Jun; 10(6): 432. Published online 2019 Jun 3. doi: 10.1038/s41419-019-1664-4

PMCID:: PMC6547697

Abstract Article PDF–2.6M

Select item 55094243.

NEK7 is required for G1 progression and procentriole formation

Akshari Gupta, Yuki Tsuchiya, Midori Ohta, Gen Shiratsuchi, Daiju Kitagawa

Mol Biol Cell. 2017 Jul 15; 28(15): 2123–2134. doi: 10.1091/mbc.E16-09-0643

PMCID:: PMC5509424

Abstract Article PDF–4.7M

Select item 49513144.

Nek7 is overexpressed in hepatocellular carcinoma and promotes hepatocellular carcinoma cell proliferation in vitro and in vivo

Lei Zhou, Zhixin Wang, Xinsen Xu, Yong Wan, Kai Qu, Haining Fan, Qiangpu Chen, Xuejun Sun, Chang Liu

Oncotarget. 2016 Apr 5; 7(14): 18620–18630. Published online 2016 Feb 23. doi: 10.18632/oncotarget.7620

PMCID:: PMC4951314

Abstract Article PDF–4.5M

Select item 20186895.

Mitotic regulation by NIMA-related kinases

Laura O'Regan, Joelle Blot, Andrew M Fry

Cell Div. 2007; 2: 25. Published online 2007 Aug 29. doi: 10.1186/1747-1028-2-25

PMCID:: PMC2018689

Abstract Article PDF–611K

Select item 100918616.

Cryo-EM structures of the active NLRP3 inflammasome disc

Le Xiao, Venkat Giri Magupalli, Hao Wu

Nature. Author manuscript; available in PMC 2024 Jan 1.

Published in final edited form as: Nature. 2023 Jan; 613(7944): 595–600. Published online 2022 Nov 28. doi: 10.1038/s41586-022-05570-8

PMCID:: PMC10091861

Abstract Article PDF–5.8M

Select item 79262337.

Micro‐ribonucleic acid‐23a‐3p prevents the onset of type 2 diabetes mellitus by suppressing the activation of nucleotide‐binding oligomerization‐like receptor family pyrin domain containing 3 inflammatory bodies‐caused pyroptosis through negatively regulating NIMA‐related kinase 7

Hongye Chang, Hongjuan Chang, Tuanjie Cheng, Garrick D Lee, Xiaoping Chen, Kunqing Qi

J Diabetes Investig. 2021 Mar; 12(3): 334–345. Published online 2020 Nov 13. doi: 10.1111/jdi.13396

PMCID:: PMC7926233

Abstract Article PDF–1.8M

Select item 77453158.

Expression of the NEK7/NLRP3 inflammasome pathway in patients with diabetic lower extremity arterial disease

HuaiQiu Cai, Peng Wang, Bo Zhang, XiaoQiu Dong

BMJ Open Diabetes Res Care. 2020; 8(2): e001808. Published online 2020 Dec 15. doi: 10.1136/bmjdrc-2020-001808

PMCID:: PMC7745315

Abstract Article PDF–1.3M

Select item 67743519.

Structural mechanism for NEK7-licensed NLRP3 inflammasome activation

Humayun Sharif, Li Wang, Wei Li Wang, Venkat Giri Magupalli, Liudmila Andreeva, Qi Qiao, Arthur V. Hauenstein, Zhaolong Wu, Gabriel Nunez, Youdong Mao, Hao Wu

Nature. Author manuscript; available in PMC 2019 Dec 12.

Published in final edited form as: Nature. 2019 Jun; 570(7761): 338–343. Published online 2019 Jun 12. doi: 10.1038/s41586-019-1295-z

PMCID:: PMC6774351

Abstract Article PDF–9.3M

Select item 646253210.

The co-chaperone UNC45A is essential for the expression of mitotic kinase NEK7 and tumorigenesis

Nada H. Eisa, Yasmeen Jilani, Kashish Kainth, Priscilla Redd, Su Lu, Oulia Bougrine, Houssein Abdul Sater, Chaitanya A. Patwardhan, Austin Shull, Huidong Shi, Kebin Liu, Nehal M. Elsherbiny, Laila A. Eissa, Mamdouh M. El-Shishtawy, Anatolij Horuzsko, Roni Bollag, Nita Maihle, Joan Roig, Hasan Korkaya, John K. Cowell, Ahmed Chadli

J Biol Chem. 2019 Apr 5; 294(14): 5246–5260. Published online 2019 Feb 8. doi: 10.1074/jbc.RA118.006597

PMCID:: PMC6462532

Abstract Article PDF–4.5M

Select item 463218511.

Mechanistic basis of Nek7 activation through Nek9 binding and induced dimerization

Tamanna Haq, Mark W. Richards, Selena G. Burgess, Pablo Gallego, Sharon Yeoh, Laura O'Regan, David Reverter, Joan Roig, Andrew M. Fry, Richard Bayliss

Nat Commun. 2015; 6: 8771. Published online 2015 Nov 2. doi: 10.1038/ncomms9771

PMCID:: PMC4632185

Abstract Article PDF–1.6M

Select item 461495012.

Human Nek7-interactor RGS2 is required for mitotic spindle organization

Edmarcia Elisa de Souza, Heidi Hehnly, Arina Marina Perez, Gabriela Vaz Meirelles, Juliana Helena Costa Smetana, Stephen Doxsey, Jörg Kobarg

Cell Cycle. 2015; 14(4): 656–667. Published online 2015 Feb 9. doi: 10.4161/15384101.2014.994988

PMCID:: PMC4614950

Abstract Article PDF–1.3M

Select item 280703413.

An Autoinhibitory Tyrosine Motif in the Cell-Cycle-Regulated Nek7 Kinase Is Released through Binding of Nek9

Mark W. Richards, Laura O'Regan, Corine Mas-Droux, Joelle M.Y. Blot, Jack Cheung, Swen Hoelder, Andrew M. Fry, Richard Bayliss

Mol Cell. 2009 Nov 25; 36(4): 560–570. doi: 10.1016/j.molcel.2009.09.038

PMCID:: PMC2807034

Abstract Article

Select item 270474514.

The Nek6 and Nek7 Protein Kinases Are Required for Robust Mitotic Spindle Formation and Cytokinesis

Laura O'Regan, Andrew M. Fry

Mol Cell Biol. 2009 Jul; 29(14): 3975–3990. Published online 2009 May 4. doi: 10.1128/MCB.01867-08

PMCID:: PMC2704745

Abstract Article PDF–6.8M

Select item 949947715.

The Inflammasome Activity of NLRP3 Is Independent of NEK7 in HEK293 Cells Co-Expressing ASC

Dominik Alexander Machtens, Ian Philipp Bresch, Jan Eberhage, Thomas Frank Reubold, Susanne Eschenburg

Int J Mol Sci. 2022 Sep; 23(18): 10269. Published online 2022 Sep 7. doi: 10.3390/ijms231810269

PMCID:: PMC9499477

Abstract Article PDF–1.7M

Select item 1123420516.

P2X7R Modulates NEK7-NLRP3 Interaction to Exacerbate Experimental Autoimmune Prostatitis via GSDMD-mediated Prostate Epithelial Cell Pyroptosis

Lei Chen, Yi Liu, Shaoyu Yue, Hui Wang, Jia Chen, Wenming Ma, Wenlong Xu, Muyang Xu, Ziqi Chen, Xianguo Chen, Li Zhang, Chaozhao Liang

Int J Biol Sci. 2024; 20(9): 3393–3411. Published online 2024 Jun 11. doi: 10.7150/ijbs.94704

PMCID:: PMC11234205

Abstract Article PDF–15M

Select item 876258017.

SARS-CoV-2 viroporin encoded by ORF3a triggers the NLRP3 inflammatory pathway

Huanzhou Xu, Ibukun A. Akinyemi, Siddhi A. Chitre, Julia C. Loeb, John A. Lednicky, Michael T. McIntosh, Sumita Bhaduri-McIntosh

Virology. 2022 Mar; 568: 13–22. Published online 2022 Jan 17. doi: 10.1016/j.virol.2022.01.003

PMCID:: PMC8762580

Abstract Article PDF–6.4M

Select item 724030018.

EML4–ALK V3 oncogenic fusion proteins promote microtubule stabilization and accelerated migration through NEK9 and NEK7

Laura O'Regan, Giancarlo Barone, Rozita Adib, Chang Gok Woo, Hui Jeong Jeong, Emily L. Richardson, Mark W. Richards, Patricia A. J. Muller, Spencer J. Collis, Dean A. Fennell, Jene Choi, Richard Bayliss, Andrew M. Fry

J Cell Sci. 2020 May 1; 133(9): jcs241505. Published online 2020 May 11. doi: 10.1242/jcs.241505

PMCID:: PMC7240300

Abstract Article

Select item 688551719.

NEK7 interacts with NLRP3 to modulate the pyroptosis in inflammatory bowel disease via NF-κB signaling

Xueliang Chen, Ganglei Liu, Yuanyuan Yuan, Guotao Wu, Shalong Wang, Lianwen Yuan

Cell Death Dis. 2019 Dec; 10(12): 906. Published online 2019 Dec 2. doi: 10.1038/s41419-019-2157-1

PMCID:: PMC6885517

Abstract Article PDF–2.1M

Select item 592469820.

Nek7 Protects Telomeres from Oxidative DNA Damage by Phosphorylation and Stabilization of TRF1

Rong Tan, Satoshi Nakajima, Qun Wang, Hongxiang Sun, Jing Xue, Jian Wu, Sabine Hellwig, Xuemei Zeng, Nathan A. Yates, Thomas E. Smithgall, Ming Lei, Yu Jiang, Arthur S. Levine, Bing Su, Li Lan

Mol Cell. Author manuscript; available in PMC 2018 Apr 29.

Published in final edited form as: Mol Cell. 2017 Mar 2; 65(5): 818–831.e5. Published online 2017 Feb 16. doi: 10.1016/j.molcel.2017.01.015

PMCID:: PMC5924698

Abstract Article PDF–1.2M

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PMC Links for Gene (Select 140609) (58)
PMC
serine/threonine-protein kinase Nek7 isoform X2 [Homo sapiens]
serine/threonine-protein kinase Nek7 isoform X2 [Homo sapiens]
gi|2462504076|ref|XP_054190474.1|

Protein
serine/threonine-protein kinase Nek7 isoform X7 [Homo sapiens]
serine/threonine-protein kinase Nek7 isoform X7 [Homo sapiens]
gi|767908452|ref|XP_011507511.1|

Protein

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