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Select item 86913961.

In Vivo Metabolic Roles of G Proteins of the G_i Family Studied With Novel Mouse Models

Jürgen Wess

Endocrinology. 2022 Jan; 163(1): bqab245. Published online 2021 Dec 5. doi: 10.1210/endocr/bqab245

PMCID:: PMC8691396

Abstract Article

Select item 79782942.

Requirement of Gαi1 and Gαi3 in interleukin-4-induced signaling, macrophage M2 polarization and allergic asthma response

Jin-yu Bai, Ya Li, Guan-hua Xue, Ke-ran Li, Yu-Fan Zheng, Zhi-qing Zhang, Qin Jiang, Yuan-yuan Liu, Xiao-zhong Zhou, Cong Cao

Theranostics. 2021; 11(10): 4894–4909. Published online 2021 Mar 4. doi: 10.7150/thno.56383

PMCID:: PMC7978294

Abstract Article PDF–3.2M

Select item 75637913.

Allosteric Inhibition of Adenylyl Cyclase Type 5 by G-Protein: A Molecular Dynamics Study

Elisa Frezza, Tina-Méryl Amans, Juliette Martin

Biomolecules. 2020 Sep; 10(9): 1330. Published online 2020 Sep 17. doi: 10.3390/biom10091330

PMCID:: PMC7563791

Abstract Article PDF–18M

Select item 72932674.

Adipocyte G_i signaling is essential for maintaining whole-body glucose homeostasis and insulin sensitivity

Lei Wang, Sai P. Pydi, Lu Zhu, Luiz F. Barella, Yinghong Cui, Oksana Gavrilova, Kendra K. Bence, Cecile Vernochet, Jürgen Wess

Nat Commun. 2020; 11: 2995. Published online 2020 Jun 12. doi: 10.1038/s41467-020-16756-x

PMCID:: PMC7293267

Abstract Article PDF–3.6M

Select item 49898915.

Integrated analysis of omics data using microRNA-target mRNA network and PPI network reveals regulation of Gnai1 function in the spinal cord of Ews/Ewsr1 KO mice

Chai-Jin Lee, Hongryul Ahn, Sean Bong Lee, Jong-Yeon Shin, Woong-Yang Park, Jong-Il Kim, Junghee Lee, Hoon Ryu, Sun Kim

BMC Med Genomics. 2016; 9(Suppl 1): 33. Published online 2016 Aug 12. doi: 10.1186/s12920-016-0195-4

PMCID:: PMC4989891

Abstract Article PDF–2.5M

Select item 36110026.

Leucine Facilitates Insulin Signaling through a Gα_i Protein-dependent Signaling Pathway in Hepatocytes

Xuefeng Yang, Shuang Mei, Xiaolei Wang, Xiang Li, Rui Liu, Yan Ma, Liping Hao, Ping Yao, Liegang Liu, Xiufa Sun, Haihua Gu, Zhenqi Liu, Wenhong Cao

J Biol Chem. 2013 Mar 29; 288(13): 9313–9320. Published online 2013 Feb 12. doi: 10.1074/jbc.M112.409409

PMCID:: PMC3611002

Abstract Article PDF–1.1M

Select item 32893067.

G_o2 G protein mediates galanin inhibitory effects on insulin release from pancreatic β cells

Guanghua Tang, Ying Wang, Sangeun Park, Neil S. Bajpayee, Diana Vi, Yoshiko Nagaoka, Lutz Birnbaumer, Meisheng Jiang

Proc Natl Acad Sci U S A. 2012 Feb 14; 109(7): 2636–2641. Published online 2012 Jan 30. doi: 10.1073/pnas.1200100109

PMCID:: PMC3289306

Abstract Article PDF–1.7M

Select item 66282608.

GNAI1 and GNAI3 Reduce Colitis-Associated Tumorigenesis in Mice by Blocking IL6 Signaling and Down-regulating Expression of GNAI2

Zhi-Wei Li, Beicheng Sun, Ting Gong, Sheng Guo, Jianhua Zhang, Junlong Wang, Atsushi Sugawara, Meisheng Jiang, Junjun Yan, Alexandra Gurary, Xin Zheng, Bifeng Gao, Shu-Yuan Xiao, Wenlian Chen, Chi Ma, Christine Farrar, Chenjun Zhu, Owen T. M. Chan, Can Xin, Andrew Winnicki, John Winnicki, Mingxin Tang, Ryan Park, Mary Winnicki, Katrina Diener, Zhanwei Wang, Qicai Liu, Catherine H. Chu, Zhaohui L. Arter, Peibin Yue, Lindsay Alpert, George S. Hui, Peiwen Fei, James Turkson, Wentian Yang, Guangyu Wu, Ailin Tao, Joe W. Ramos, Stefan Moisyadi, Randall F. Holcombe, Wei Jia, Lutz Birnbaumer, Xiqiao Zhou, Wen-Ming Chu

Gastroenterology. Author manuscript; available in PMC 2020 Jun 1.

Published in final edited form as: Gastroenterology. 2019 Jun; 156(8): 2297–2312. Published online 2019 Mar 2. doi: 10.1053/j.gastro.2019.02.040

PMCID:: PMC6628260

Abstract Article PDF–4.3M

Select item 65569819.

Constitutive inhibitory G protein activity upon adenylyl cyclase-dependent cardiac contractility is limited to adenylyl cyclase type 6

Caroline Bull Melsom, Marie-Victoire Cosson, Øivind Ørstavik, Ngai Chin Lai, H. Kirk Hammond, Jan-Bjørn Osnes, Tor Skomedal, Viacheslav Nikolaev, Finn Olav Levy, Kurt Allen Krobert

PLoS One. 2019; 14(6): e0218110. Published online 2019 Jun 7. doi: 10.1371/journal.pone.0218110

PMCID:: PMC6556981

Abstract Article PDF–2.3M

Select item 600807110.

Differential effects of inhibitory G protein isoforms on G protein-gated inwardly rectifying K⁺ currents in adult murine atria

Muriel Nobles, David Montaigne, Sonia Sebastian, Lutz Birnbaumer, Andrew Tinker

Am J Physiol Cell Physiol. 2018 May 1; 314(5): C616–C626. Published online 2018 Jan 17. doi: 10.1152/ajpcell.00271.2016

PMCID:: PMC6008071

Abstract Article

Select item 589948111.

Antidepression action of BDNF requires and is mimicked by Gαi1/3 expression in the hippocampus

John Marshall, Xiao-zhong Zhou, Gang Chen, Su-qing Yang, Ya Li, Yin Wang, Zhi-qing Zhang, Qin Jiang, Lutz Birnbaumer, Cong Cao

Proc Natl Acad Sci U S A. 2018 Apr 10; 115(15): E3549–E3558. Published online 2018 Mar 5. doi: 10.1073/pnas.1722493115

PMCID:: PMC5899481

Abstract Article PDF–1.9M

Select item 473104512.

Gnaq^M1J: An ENU induced mutant allele affecting pigmentation in the mouse

C. Herbert Pratt, Louise Dionne, Heather Fairfield, Soheil S. Dadras, Christopher Potter, John P. Sundberg

J Invest Dermatol. Author manuscript; available in PMC 2016 Jul 1.

Published in final edited form as: J Invest Dermatol. 2016 Jan; 136(1): 334–336. doi: 10.1038/JID.2015.382

PMCID:: PMC4731045

Article PDF–645K

Select item 317935013.

CB2 Cannabinoid Receptor Targets Mitogenic Gi Protein–Cyclin D1 Axis in Osteoblasts

Orr Ofek, Malka Attar-Namdar, Vardit Kram, Mona Dvir-Ginzberg, Raphael Mechoulam, Andreas Zimmer, Baruch Frenkel, Esther Shohami, Itai Bab

J Bone Miner Res. 2011 Feb; 26(2): 308–316. Published online 2010 Aug 27. doi: 10.1002/jbmr.228

PMCID:: PMC3179350

Abstract Article PDF–420K

Select item 306429014.

Paradoxical attenuation of β₂-AR function in airway smooth muscle by G_i-mediated counterregulation in transgenic mice overexpressing type 5 adenylyl cyclase

Wayne C. H. Wang, Rachel M. Schillinger, Molly M. Malone, Stephen B. Liggett

Am J Physiol Lung Cell Mol Physiol. 2011 Mar; 300(3): L472–L478. Published online 2010 Dec 3. doi: 10.1152/ajplung.00273.2010

PMCID:: PMC3064290

Abstract Article

Select item 302974315.

Augmented glucose-induced insulin release in mice lacking G_o2, but not G_o1 or G_i proteins

Ying Wang, Sangeun Park, Neil S. Bajpayee, Yoshiko Nagaoka, Guylain Boulay, Lutz Birnbaumer, Meisheng Jiang

Proc Natl Acad Sci U S A. 2011 Jan 25; 108(4): 1693–1698. Published online 2011 Jan 10. doi: 10.1073/pnas.1018903108

PMCID:: PMC3029743

Abstract Article PDF–1.2M

Select item 226597916.

Differential regulation of lipopolysaccharide and Gram-positive bacteria induced cytokine and chemokine production in macrophages by Gα_i proteins

Hongkuan Fan, David L Williams, Basilia Zingarelli, Kevin F Breuel, Giuseppe Teti, George E Tempel, Karsten Spicher, Guylain Boulay, Lutz Birnbaumer, Perry V Halushka, James A Cook

Immunology. 2007 Sep; 122(1): 116–123. doi: 10.1111/j.1365-2567.2007.02619.x

PMCID:: PMC2265979

Abstract Article PDF–580K

Select item 441677617.

Acidosis Mediates the Switching of G_s-PKA and G_i-PKC_ε Dependence in Prolonged Hyperalgesia Induced by Inflammation

Wei-Yu Huang, Shih-Ping Dai, Yan-Ching Chang, Wei-Hsin Sun

PLoS One. 2015; 10(5): e0125022. Published online 2015 May 1. doi: 10.1371/journal.pone.0125022

PMCID:: PMC4416776

Abstract Article PDF–3.0M

Select item 440318818.

Gα_i1 and Gα_i3 regulate macrophage polarization by forming a complex containing CD14 and Gab1

Xianjing Li, Duowei Wang, Zhen Chen, Ermei Lu, Zhuo Wang, Jingjing Duan, Wei Tian, Yun Wang, Linjun You, Yulian Zou, Yan Cheng, Qingyi Zhu, Xiaojian Wan, Tao Xi, Meisheng Jiang, Yuyuan Han, Cong Cao, Lutz Birnbaumer, Wen-Ming Chu, Yong Yang

Proc Natl Acad Sci U S A. 2015 Apr 14; 112(15): 4731–4736. Published online 2015 Mar 30. doi: 10.1073/pnas.1503779112

Correction in:: Proc Natl Acad Sci U S A. 2018 May 29; 115(22): E5252.

PMCID:: PMC4403188

Abstract Article PDF–1.2M

Select item 339534719.

The role of inhibitory heterotrimeric G proteins in the control of in vivo heart rate dynamics

Zia Zuberi, Lutz Birnbaumer, Andrew Tinker

Am J Physiol Regul Integr Comp Physiol. 2008 Dec; 295(6): R1822–R1830. doi: 10.1152/ajpregu.90625.2008

PMCID:: PMC3395347

Abstract Article

Select item 336521720.

G-protein–mediated inhibition of the Trp channel TRPM1 requires the Gβγ dimer

Yin Shen, Melissa Ann F. Rampino, Reed C. Carroll, Scott Nawy

Proc Natl Acad Sci U S A. 2012 May 29; 109(22): 8752–8757. Published online 2012 May 14. doi: 10.1073/pnas.1117433109

PMCID:: PMC3365217

Abstract Article PDF–466K

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