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Select item 82756201.

Analyses of Gnai3-iresGFP reporter mice reveal unknown Gα_i3 expression sites

Veronika Leiss, Ellen Reisinger, Annika Speidel, Sandra Beer-Hammer, Bernd Nürnberg

Sci Rep. 2021; 11: 14271. Published online 2021 Jul 12. doi: 10.1038/s41598-021-93591-0

PMCID:: PMC8275620

Abstract Article PDF–2.9M

Select item 62578342.

Guanine and nucleotide binding protein 3 promotes odonto/osteogenic differentiation of apical papilla stem cells via JNK and ERK signaling pathways

Yang Zhang, Lichan Yuan, Li Meng, Mengru Fang, Shuyu Guo, Dongyue Wang, Junqing Ma, Lin Wang

Int J Mol Med. 2019 Jan; 43(1): 382–392. Published online 2018 Nov 7. doi: 10.3892/ijmm.2018.3984

PMCID:: PMC6257834

Abstract Article PDF–1.2M

Select item 39772613.

Dual regulation of G proteins and the G-protein–activated K⁺ channels by lithium

Isabella Farhy Tselnicker, Vladimir Tsemakhovich, Ida Rishal, Uri Kahanovitch, Carmen W. Dessauer, Nathan Dascal

Proc Natl Acad Sci U S A. 2014 Apr 1; 111(13): 5018–5023. Published online 2014 Mar 17. doi: 10.1073/pnas.1316425111

PMCID:: PMC3977261

Abstract Article PDF–1.1M

Select item 109331814.

Protective effects of Gα_i3 deficiency in a murine heart-failure model of β₁-adrenoceptor overexpression

Tobias Schröper, Dennis Mehrkens, Veronika Leiss, Frederik Tellkamp, Stefan Engelhardt, Stefan Herzig, Lutz Birnbaumer, Bernd Nürnberg, Jan Matthes

Naunyn Schmiedebergs Arch Pharmacol. 2024; 397(4): 2401–2420. Published online 2023 Oct 16. doi: 10.1007/s00210-023-02751-8

PMCID:: PMC10933181

Abstract Article PDF–5.5M

Select item 79782945.

Requirement of Gαi1 and Gαi3 in interleukin-4-induced signaling, macrophage M2 polarization and allergic asthma response

Jin-yu Bai, Ya Li, Guan-hua Xue, Ke-ran Li, Yu-Fan Zheng, Zhi-qing Zhang, Qin Jiang, Yuan-yuan Liu, Xiao-zhong Zhou, Cong Cao

Theranostics. 2021; 11(10): 4894–4909. Published online 2021 Mar 4. doi: 10.7150/thno.56383

PMCID:: PMC7978294

Abstract Article PDF–3.2M

Select item 60844006.

Gα_i3 signaling is associated with sexual dimorphic expression of the clock-controlled output gene Dbp in murine liver

Madhurendra Singh, Laura Bergmann, Alexander Lang, Katja Pexa, Fabian Kuck, Dennis Stibane, Linda Janke, Hakima Ezzahoini, Antje Lindecke, Constanze Wiek, Helmut Hanenberg, Karl Köhrer, Charlotte von Gall, Hans Reinke, Roland P. Piekorz

Oncotarget. 2018 Jul 13; 9(54): 30213–30224. Published online 2018 Jul 13. doi: 10.18632/oncotarget.25727

PMCID:: PMC6084400

Abstract Article PDF–2.7M

Select item 48686577.

Gαi2 and Gαi3 differentially regulate arrest from flow and chemotaxis in mouse neutrophils

Yoshihiro Kuwano, Micha Adler, Hong Zhang, Alex Groisman, Klaus Ley

J Immunol. Author manuscript; available in PMC 2017 May 1.

Published in final edited form as: J Immunol. 2016 May 1; 196(9): 3828–3833. Published online 2016 Mar 14. doi: 10.4049/jimmunol.1500532

PMCID:: PMC4868657

Abstract Article PDF–1.1M

Select item 44433328.

Platelet G_i protein Gα_i2 is an essential mediator of thrombo-inflammatory organ damage in mice

Vasudharani Devanathan, Ina Hagedorn, David Köhler, Katja Pexa, Deya Cherpokova, Peter Kraft, Madhurendra Singh, Peter Rosenberger, Guido Stoll, Lutz Birnbaumer, Roland P. Piekorz, Sandra Beer-Hammer, Bernhard Nieswandt, Bernd Nürnberg

Proc Natl Acad Sci U S A. 2015 May 19; 112(20): 6491–6496. Published online 2015 May 5. doi: 10.1073/pnas.1505887112

PMCID:: PMC4443332

Abstract Article PDF–1.0M

Select item 42487179.

Canonical and Noncanonical G-Protein Signaling Helps Coordinate Actin Dynamics To Promote Macrophage Phagocytosis of Zymosan

Ning-Na Huang, Steven Becker, Cedric Boularan, Olena Kamenyeva, Ali Vural, Il-Young Hwang, Chong-Shan Shi, John H. Kehrl

Mol Cell Biol. 2014 Nov; 34(22): 4186–4199. doi: 10.1128/MCB.00325-14

PMCID:: PMC4248717

Abstract Article PDF–7.7M

Select item 403228010.

Gα_i2- and Gα_i3-Deficient Mice Display Opposite Severity of Myocardial Ischemia Reperfusion Injury

David Köhler, Vasudharani Devanathan, Claudia Bernardo de Oliveira Franz, Therese Eldh, Ana Novakovic, Judith M. Roth, Tiago Granja, Lutz Birnbaumer, Peter Rosenberger, Sandra Beer-Hammer, Bernd Nürnberg

PLoS One. 2014; 9(5): e98325. Published online 2014 May 23. doi: 10.1371/journal.pone.0098325

Correction in:: PLoS One. 2015; 10(3): e0119092.

PMCID:: PMC4032280

Abstract Article PDF–1.7M

Select item 399400611.

Regulator of G-Protein Signaling 19 (RGS19) and Its Partner Gα-Inhibiting Activity Polypeptide 3 (GNAI3) Are Required for zVAD-Induced Autophagy and Cell Death in L929 Cells

Ting Wu, Yuanyue Li, Deli Huang, Felicia Han, Ying-Ying Zhang, Duan-Wu Zhang, Jiahuai Han

PLoS One. 2014; 9(4): e94634. Published online 2014 Apr 21. doi: 10.1371/journal.pone.0094634

PMCID:: PMC3994006

Abstract Article PDF–2.1M

Select item 378702612.

A Constitutively Active Gαi3 Protein Corrects the Abnormal Retinal Pigment Epithelium Phenotype of Oa1−/− mice

Alejandra Young, Ying Wang, Novruz B. Ahmedli, Meisheng Jiang, Debora B. Farber

PLoS One. 2013; 8(9): e76240. Published online 2013 Sep 30. doi: 10.1371/journal.pone.0076240

PMCID:: PMC3787026

Abstract Article PDF–6.1M

Select item 318027913.

Gα_i2- and Gα_i3-Specific Regulation of Voltage-Dependent L-Type Calcium Channels in Cardiomyocytes

Sara Dizayee, Sonja Kaestner, Fabian Kuck, Peter Hein, Christoph Klein, Roland P. Piekorz, Janos Meszaros, Jan Matthes, Bernd Nürnberg, Stefan Herzig

PLoS One. 2011; 6(9): e24979. Published online 2011 Sep 26. doi: 10.1371/journal.pone.0024979

Correction in:: PLoS One. 2013; 8(8): 10.1371/annotation/7be097c0-9075-41ae-91e9-d2209de952cc.

PMCID:: PMC3180279

Abstract Article PDF–585K

Select item 316747914.

FTY720 blocks egress of T cells in part by abrogation of their adhesion on the lymph node sinus

Liang Zhi, Pilhan Kim, Brian D. Thompson, Costas Pitsillides, Alexander J. Bankovich, Seok-Hyun Yun, Charles P. Lin, Jason G. Cyster, Mei X. Wu

J Immunol. Author manuscript; available in PMC 2012 Mar 1.

Published in final edited form as: J Immunol. 2011 Sep 1; 187(5): 2244–2251. Published online 2011 Jul 25. doi: 10.4049/jimmunol.1100670

PMCID:: PMC3167479

Abstract Article PDF–1.5M

Select item 258696815.

Reciprocal function of Gαi2 and Gαi3 in graft-versus-host disease

Yong Zhu Jin, Brian D. Thompson, Zho Yan Zhou, Yineng Fu, Lutz Birnbaumer, Mei X. Wu

Eur J Immunol. Author manuscript; available in PMC 2008 Nov 25.

Published in final edited form as: Eur J Immunol. 2008 Jul; 38(7): 1988–1998. doi: 10.1002/eji.200737738

PMCID:: PMC2586968

Abstract Article PDF–1.4M

Select item 236681316.

Inhibition of Gαwi2 activation by Gαi3 in CXCR3-mediated signaling

Brian D. Thompzson, Yongzhu Jin, Kevin H. Wu, Richard A. Colvin, Andrew D. Luster, Lutz Birnbaumer, Mei X. Wu

J Biol Chem. Author manuscript; available in PMC 2008 May 5.

Published in final edited form as: J Biol Chem. 2007 Mar 30; 282(13): 9547–9555. Published online 2007 Feb 8. doi: 10.1074/jbc.M610931200

PMCID:: PMC2366813

Abstract Article PDF–1.8M

Select item 183860917.

Gα_i2-mediated signaling events in the endothelium are involved in controlling leukocyte extravasation

Ralph S. Pero, Michael T. Borchers, Karsten Spicher, Sergei I. Ochkur, Lyudmila Sikora, Savita P. Rao, Hiam Abdala-Valencia, Katie R. O'Neill, Huahao Shen, Michael P. McGarry, Nancy A. Lee, Joan M. Cook-Mills, P. Sriramarao, Melvin I. Simon, Lutz Birnbaumer, James J. Lee

Proc Natl Acad Sci U S A. 2007 Mar 13; 104(11): 4371–4376. Published online 2007 Mar 7. doi: 10.1073/pnas.0700185104

PMCID:: PMC1838609

Abstract Article PDF–878K

Select item 181529618.

An obligatory requirement for the heterotrimeric G protein G_i3 in the antiautophagic action of insulin in the liver

Antje Gohla, Karinna Klement, Roland P. Piekorz, Katja Pexa, Stephan vom Dahl, Karsten Spicher, Vladyslav Dreval, Dieter Häussinger, Lutz Birnbaumer, Bernd Nrnberg

Proc Natl Acad Sci U S A. 2007 Feb 20; 104(8): 3003–3008. Published online 2007 Feb 12. doi: 10.1073/pnas.0611434104

PMCID:: PMC1815296

Abstract Article PDF–1.6M

Select item 662826019.

GNAI1 and GNAI3 Reduce Colitis-Associated Tumorigenesis in Mice by Blocking IL6 Signaling and Down-regulating Expression of GNAI2

Zhi-Wei Li, Beicheng Sun, Ting Gong, Sheng Guo, Jianhua Zhang, Junlong Wang, Atsushi Sugawara, Meisheng Jiang, Junjun Yan, Alexandra Gurary, Xin Zheng, Bifeng Gao, Shu-Yuan Xiao, Wenlian Chen, Chi Ma, Christine Farrar, Chenjun Zhu, Owen T. M. Chan, Can Xin, Andrew Winnicki, John Winnicki, Mingxin Tang, Ryan Park, Mary Winnicki, Katrina Diener, Zhanwei Wang, Qicai Liu, Catherine H. Chu, Zhaohui L. Arter, Peibin Yue, Lindsay Alpert, George S. Hui, Peiwen Fei, James Turkson, Wentian Yang, Guangyu Wu, Ailin Tao, Joe W. Ramos, Stefan Moisyadi, Randall F. Holcombe, Wei Jia, Lutz Birnbaumer, Xiqiao Zhou, Wen-Ming Chu

Gastroenterology. Author manuscript; available in PMC 2020 Jun 1.

Published in final edited form as: Gastroenterology. 2019 Jun; 156(8): 2297–2312. Published online 2019 Mar 2. doi: 10.1053/j.gastro.2019.02.040

PMCID:: PMC6628260

Abstract Article PDF–4.3M

Select item 613167420.

RXFP1 Receptor Activation by Relaxin-2 Induces Vascular Relaxation in Mice via a Gα_i2-Protein/PI3Kß/γ/Nitric Oxide-Coupled Pathway

Xiaoming Lian, Sandra Beer-Hammer, Gabriele M. König, Evi Kostenis, Bernd Nürnberg, Maik Gollasch

Front Physiol. 2018; 9: 1234. Published online 2018 Sep 4. doi: 10.3389/fphys.2018.01234

PMCID:: PMC6131674

Abstract Article PDF–2.8M

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