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Select item 92950631.

Lithocholic acid inhibits dendritic cell activation by reducing intracellular glutathione via TGR5 signaling

Jianping Hu, Yiting Zhang, Shenglan Yi, Chaokui Wang, Xinyue Huang, Su Pan, Jinglu Yang, Gangxiang Yuan, Sisi Tan, Hong Li

Int J Biol Sci. 2022; 18(11): 4545–4559. Published online 2022 Jul 11. doi: 10.7150/ijbs.71287

PMCID:: PMC9295063

Abstract Article PDF–2.9M

Select item 80821152.

Circulating Bile Acids in Liver Failure Activate TGR5 and Induce Monocyte Dysfunction

Julia Leonhardt, Raphael S. Haider, Christoph Sponholz, Silke Leonhardt, Julia Drube, Katrin Spengler, Diana Mihaylov, Sophie Neugebauer, Michael Kiehntopf, Nevin A. Lambert, Andreas Kortgen, Tony Bruns, Frank Tacke, Carsten Hoffmann, Michael Bauer, Regine Heller

Cell Mol Gastroenterol Hepatol. 2021; 12(1): 25–40. Published online 2021 Feb 2. doi: 10.1016/j.jcmgh.2021.01.011

PMCID:: PMC8082115

Abstract Article PDF–3.4M

Select item 77603473.

Bile Acids and GPBAR-1: Dynamic Interaction Involving Genes, Environment and Gut Microbiome

Piero Portincasa, Agostino Di Ciaula, Gabriella Garruti, Mirco Vacca, Maria De Angelis, David Q.-H. Wang

Nutrients. 2020 Dec; 12(12): 3709. Published online 2020 Nov 30. doi: 10.3390/nu12123709

PMCID:: PMC7760347

Abstract Article PDF–3.1M

Select item 64034014.

TGR5 activation ameliorates hyperglycemia-induced cardiac hypertrophy in H9c2 cells

Kai-Chun Cheng, Wei-Ting Chang, Feng Yu Kuo, Zhih-Cherng Chen, Yingxiao Li, Juei-Tang Cheng

Sci Rep. 2019; 9: 3633. Published online 2019 Mar 6. doi: 10.1038/s41598-019-40002-0

PMCID:: PMC6403401

Abstract Article PDF–3.0M

Select item 63853585.

Discovery of ((1,2,4-oxadiazol-5-yl)pyrrolidin-3-yl)ureidyl derivatives as selective non-steroidal agonists of the G-protein coupled bile acid receptor-1

Francesco Saverio Di Leva, Carmen Festa, Adriana Carino, Simona De Marino, Silvia Marchianò, Daniele Di Marino, Claudia Finamore, Maria Chiara Monti, Angela Zampella, Stefano Fiorucci, Vittorio Limongelli

Sci Rep. 2019; 9: 2504. Published online 2019 Feb 21. doi: 10.1038/s41598-019-38840-z

PMCID:: PMC6385358

Abstract Article PDF–1.3M

Select item 58800166.

TGR5 expression in normal kidney and renal neoplasms

Chaohui Lisa Zhao, Ali Amin, Yiang Hui, Dongfang Yang, Weibiao Cao

Diagn Pathol. 2018; 13: 22. Published online 2018 Apr 2. doi: 10.1186/s13000-018-0700-5

PMCID:: PMC5880016

Abstract Article PDF–837K

Select item 54646377.

Identification of key amino acid residues in the hTGR5–nomilin interaction and construction of its binding model

Takashi Sasaki, Moeko Mita, Naho Ikari, Ayane Kuboyama, Shuzo Hashimoto, Tatsuya Kaneko, Masaji Ishiguro, Makoto Shimizu, Jun Inoue, Ryuichiro Sato

PLoS One. 2017; 12(6): e0179226. Published online 2017 Jun 8. doi: 10.1371/journal.pone.0179226

PMCID:: PMC5464637

Abstract Article PDF–3.2M

Select item 53308188.

TGR5 expression in benign, preneoplastic and neoplastic lesions of Barrett’s esophagus: Case series and findings

Shivali Marketkar, Dan Li, Dongfang Yang, Weibiao Cao

World J Gastroenterol. 2017 Feb 28; 23(8): 1338–1344. Published online 2017 Feb 28. doi: 10.3748/wjg.v23.i8.1338

PMCID:: PMC5330818

Abstract Article PDF–1.9M

Select item 53086339.

The bile acid receptor GPBAR1 (TGR5) is expressed in human gastric cancers and promotes epithelial-mesenchymal transition in gastric cancer cell lines

Adriana Carino, Luigina Graziosi, Claudio D'Amore, Sabrina Cipriani, Silvia Marchianò, Elisabetta Marino, Angela Zampella, Mario Rende, Paolo Mosci, Eleonora Distrutti, Annibale Donini, Stefano Fiorucci

Oncotarget. 2016 Sep 20; 7(38): 61021–61035. Published online 2016 Jul 7. doi: 10.18632/oncotarget.10477

PMCID:: PMC5308633

Abstract Article PDF–3.4M

Select item 510506910.

Structural assemblies of the di- and oligomeric G-protein coupled receptor TGR5 in live cells: an MFIS-FRET and integrative modelling study

Annemarie Greife, Suren Felekyan, Qijun Ma, Christoph G. W. Gertzen, Lina Spomer, Mykola Dimura, Thomas O. Peulen, Christina Wöhler, Dieter Häussinger, Holger Gohlke, Verena Keitel, Claus A. M. Seidel

Sci Rep. 2016; 6: 36792. Published online 2016 Nov 11. doi: 10.1038/srep36792

PMCID:: PMC5105069

Abstract Article PDF–2.3M

Select item 502287011.

Membrane bile acid receptor TGR5 predicts good prognosis in ampullary adenocarcinoma patients with hyperbilirubinemia

Min-Chan Chen, Yi-Ling Chen, Tzu-Wen Wang, Hui-Ping Hsu, Ming-Derg Lai

Oncol Rep. 2016 Oct; 36(4): 1997–2008. Published online 2016 Aug 10. doi: 10.3892/or.2016.5011

PMCID:: PMC5022870

Abstract Article PDF–963K

Select item 474146112.

The G-protein-coupled bile acid receptor Gpbar1 (TGR5) suppresses gastric cancer cell proliferation and migration through antagonizing STAT3 signaling pathway

Cong Guo, Jia Su, Zhijun Li, Rui Xiao, Jianxun Wen, Yanyan Li, Meng Zhang, Xueting Zhang, Donna Yu, Wendong Huang, Wei-Dong Chen, Yan-Dong Wang

Oncotarget. 2015 Oct 27; 6(33): 34402–34413. Published online 2015 Sep 21. doi: 10.18632/oncotarget.5353

PMCID:: PMC4741461

Abstract Article PDF–3.5M

Select item 452313913.

TGR5 in the Cholangiociliopathies

Tatyana V. Masyuk, Anatoliy I. Masyuk, Nicholas F. LaRusso

Dig Dis. Author manuscript; available in PMC 2015 Aug 27.

Published in final edited form as: Dig Dis. 2015; 33(3): 420–425. Published online 2015 May 27. doi: 10.1159/000371696

PMCID:: PMC4523139

Abstract Article PDF–478K

Select item 422008214.

Highly lipophilic 3-epi-betulinic acid derivatives as potent and selective TGR5 agonists with improved cellular efficacy

Xiao-yin Wang, Shu-yong Zhang, Jing Li, Hua-nan Liu, Xin Xie, Fa-jun Nan

Acta Pharmacol Sin. 2014 Nov; 35(11): 1463–1472. Published online 2014 Oct 6. doi: 10.1038/aps.2014.97

PMCID:: PMC4220082

Abstract Article PDF–698K

Select item 391656715.

A Membrane-proximal, C-terminal α-Helix Is Required for Plasma Membrane Localization and Function of the G Protein-coupled Receptor (GPCR) TGR5

Lina Spomer, Christoph G. W. Gertzen, Birte Schmitz, Dieter Häussinger, Holger Gohlke, Verena Keitel

J Biol Chem. 2014 Feb 7; 289(6): 3689–3702. Published online 2013 Dec 13. doi: 10.1074/jbc.M113.502344

PMCID:: PMC3916567

Abstract Article PDF–3.6M

Select item 389440116.

Aberrant DNA Methylation of G-protein-coupled Bile Acid Receptor Gpbar1 (TGR5) is a Potential Biomarker for Hepatitis B Virus Associated Hepatocellular Carcinoma

Li-Yan Han, Yu-Chen Fan, Nan-Nan Mu, Shuai Gao, Feng Li, Xiang-Fen Ji, Cheng-Yun Dou, Kai Wang

Int J Med Sci. 2014; 11(2): 164–171. Published online 2014 Jan 7. doi: 10.7150/ijms.6745

PMCID:: PMC3894401

Abstract Article PDF–486K

Select item 363936717.

The TGR5 gene is expressed in human subcutaneous adipose tissue and is associated with obesity, weight loss and resting metabolic rate

Per-Arne Svensson, Maja Olsson, Johanna C Andersson-Assarsson, Magdalena Taube, Maria J. Pereira, Philippe Froguel, Peter Jacobson

Biochem Biophys Res Commun. 2013 Apr 19; 433(4): 563–566. doi: 10.1016/j.bbrc.2013.03.031

PMCID:: PMC3639367

Abstract Article PDF–371K

Select item 363453618.

TGR5 signalling inhibits the production of pro-inflammatory cytokines by in vitro differentiated inflammatory and intestinal macrophages in Crohn's disease

Kazuaki Yoneno, Tadakazu Hisamatsu, Katsuyoshi Shimamura, Nobuhiko Kamada, Riko Ichikawa, Mina T Kitazume, Maiko Mori, Michihide Uo, Yuka Namikawa, Katsuyoshi Matsuoka, Toshiro Sato, Kazutaka Koganei, Akira Sugita, Takanori Kanai, Toshifumi Hibi

Immunology. 2013 May; 139(1): 19–29. Published online 2013 Apr 8. doi: 10.1111/imm.12045

PMCID:: PMC3634536

Abstract Article PDF–478K

Select item 356661419.

Expression of bile acid receptor TGR5 in gastric adenocarcinoma

Weibiao Cao, Wei Tian, Jie Hong, Dan Li, Rosemarie Tavares, Lelia Noble, Steven F. Moss, Murray B. Resnick

Am J Physiol Gastrointest Liver Physiol. 2013 Feb 15; 304(4): G322–G327. Published online 2012 Dec 13. doi: 10.1152/ajpgi.00263.2012

PMCID:: PMC3566614

Abstract Article

Select item 340326120.

Bile acids induce monocyte differentiation toward interleukin-12 hypo-producing dendritic cells via a TGR5-dependent pathway

Riko Ichikawa, Tetsuro Takayama, Kazuaki Yoneno, Nobuhiko Kamada, Mina T Kitazume, Hajime Higuchi, Katsuyoshi Matsuoka, Mitsuhiro Watanabe, Hiroshi Itoh, Takanori Kanai, Tadakazu Hisamatsu, Toshifumi Hibi

Immunology. 2012 Jun; 136(2): 153–162. doi: 10.1111/j.1365-2567.2012.03554.x