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Select item 113166931.

17α Hydroxylase/17,20 lyase deficiency: clinical features and genetic insights from a large Turkey cohort

Zeynep Siklar, Emine Camtosun, Semih Bolu, Melek Yildiz, Aysehan Akinci, Firdevs Bas, İsmail Dündar, Asli Bestas, Edip Ünal, Pinar Kocaay, Tulay Guran, Gonul Buyukyilmaz, Aylin Kilinc Ugurlu, Buşra Gurpinar Tosun, Ihsan Turan, Erdal Kurnaz, Bilgin Yuksel, Doga Turkkahraman, Atilla Cayir, Gamze Celmeli, E. Nazli Gonc, Beray Selver Eklioğlu, Semra Cetinkaya, Seniha Kiremitci Yilmaz, Mehmet Emre Atabek, Muammer Buyukinan, Emrullah Arslan, Eda Mengen, Esra Deniz Papatya Cakir, Murat Karaoglan, Nihal Hatipoglu, Zerrin Orbak, Ahmet Ucar, Nesibe Akyurek, Emine Demet Akbas, Emregül Isik, Sare Betul Kaygusuz, Zumrut Kocabey Sutcu, Gulcan Seymen, Merih Berberoglu

Endocrine. 2024; 85(3): 1407–1416. Published online 2024 Jul 17. doi: 10.1007/s12020-024-03962-6

PMCID:: PMC11316693

Abstract Article PDF–658K

Select item 111864552.

Tracking protein–protein interactions by NMR: conformational selection in human steroidogenic cytochrome P450 CYP17A1 induced by cytochrome b₅

Alaina M. Richard, D. Fernando Estrada, Liam Flynn, Susan Sondej Pochapsky, Emily E. Scott, Thomas C. Pochapsky

Phys Chem Chem Phys. 2024 Jun 19; 26(24): 16980–16988. Published online 2024 May 31. doi: 10.1039/d4cp01268b

PMCID:: PMC11186455

Abstract Article

Select item 104407803.

CYP17A1 (rs74357) polymorphism and polycystic ovary syndrome risk: A systemic review and meta-analysis

Mohamed Larbi Rezgoun, Djihan El Khour, Hiba Bendaoud, Djalila Chellat

Acta Biomed. 2023; 94(4): e2023167. Published online 2023 Aug 3. doi: 10.23750/abm.v94i4.14229

PMCID:: PMC10440780

Abstract Article PDF–3.5M

Select item 99728514.

The importance of Asparagine 202 in manipulating active site structure and substrate preference for human CYP17A1

Yilin Liu, Ilia Denisov, Michael Gregory, Stephen G. Sligar, James R. Kincaid

Biochemistry. Author manuscript; available in PMC 2023 Apr 5.

Published in final edited form as: Biochemistry. 2022 Apr 5; 61(7): 583–594. Published online 2022 Mar 15. doi: 10.1021/acs.biochem.2c00023

PMCID:: PMC9972851

Abstract Article PDF–1.5M

Select item 97976735.

Clinical characteristics and molecular etiology of partial 17α-hydroxylase deficiency diagnosed in 46,XX patients

Duoduo Zhang, Fengxia Yao, Min Luo, Yanfang Wang, Tiffany Tian, Shan Deng, Qinjie Tian

Front Endocrinol (Lausanne) 2022; 13: 978026. Published online 2022 Dec 15. doi: 10.3389/fendo.2022.978026

PMCID:: PMC9797673

Abstract Article PDF–5.4M

Select item 96044976.

A Role of DNA Methylation within the CYP17A1 Gene in the Association of Genetic and Environmental Risk Factors with Stress-Related Manifestations of Schizophrenia

Margarita Alfimova, Nikolay Kondratyev, Galina Korovaitseva, Tatyana Lezheiko, Victoria Plakunova, Marina Gabaeva, Vera Golimbet

Int J Mol Sci. 2022 Oct; 23(20): 12629. Published online 2022 Oct 20. doi: 10.3390/ijms232012629

PMCID:: PMC9604497

Abstract Article PDF–1.9M

Select item 88488597.

P450 CYP17A1 Variant with a Disordered Proton Shuttle Assembly Retains Peroxo-Mediated Lyase Efficiency

Yilin Liu, Ilia G. Denisov, Yelena V. Grinkova, Stephen G. Sligar, James R. Kincaid

Chemistry. Author manuscript; available in PMC 2022 Feb 16.

Published in final edited form as: Chemistry. 2020 Dec 15; 26(70): 16846–16852. Published online 2020 Nov 9. doi: 10.1002/chem.202003181

PMCID:: PMC8848859

Abstract Article PDF–849K

Select item 88229028.

Mechanism of the Clinically Relevant E305G Mutation in Human P450 CYP17A1

Yilin Liu, Yelena Grinkova, Michael C. Gregory, Ilia G. Denisov, James R. Kincaid, Stephen G. Sligar

Biochemistry. Author manuscript; available in PMC 2022 Nov 2.

Published in final edited form as: Biochemistry. 2021 Nov 2; 60(43): 3262–3271. Published online 2021 Oct 18. doi: 10.1021/acs.biochem.1c00282

PMCID:: PMC8822902

Abstract Article PDF–1.5M

Select item 83500209.

Stepwise binding of inhibitors to human cytochrome P450 17A1 and rapid kinetics of inhibition of androgen biosynthesis

F. Peter Guengerich, Kevin D. McCarty, Jesse G. Chapman, Yasuhiro Tateishi

J Biol Chem. 2021 Aug; 297(2): 100969. Published online 2021 Jul 15. doi: 10.1016/j.jbc.2021.100969

PMCID:: PMC8350020

Abstract Article PDF–1.2M

Select item 808765510.

Steroidogenic Cytochrome P450 17A1 Structure and Function

Sarah D. Burris-Hiday, Emily E. Scott

Mol Cell Endocrinol. Author manuscript; available in PMC 2022 May 15.

Published in final edited form as: Mol Cell Endocrinol. 2021 May 15; 528: 111261. Published online 2021 Mar 26. doi: 10.1016/j.mce.2021.111261

PMCID:: PMC8087655

Abstract Article PDF–1.6M

Select item 751800311.

Polymorphism in the Androgen Biosynthesis Gene (CYP17), a Risk for Prostate Cancer: A Meta-Analysis

Clement Yaw Effah, Ling Wang, Clement Agboyibor, Emmanuel Kwateng Drokow, Songcheng Yu, Wei Wang, Yongjun Wu

Am J Mens Health. 2020 Sep-Oct; 14(5): 1557988320959984. Published online 2020 Sep 23. doi: 10.1177/1557988320959984

PMCID:: PMC7518003

Abstract Article PDF–1.0M

Select item 746925212.

Slow-, Tight-Binding Inhibition of CYP17A1 by Abiraterone Redefines Its Kinetic Selectivity and Dosing Regimen

Eleanor Jing Yi Cheong, Pramod C. Nair, Rebecca Wan Yi Neo, Ho Thanh Tu, Fu Lin, Edmund Chiong, Kesavan Esuvaranathan, Hao Fan, Russell Z. Szmulewitz, Cody J. Peer, William D. Figg, Christina Li Lin Chai, John O. Miners, Eric Chun Yong Chan

J Pharmacol Exp Ther. 2020 Sep; 374(3): 438–451. Published online 2020 Sep. doi: 10.1124/jpet.120.265868

PMCID:: PMC7469252

Abstract Article PDF–1.2M

Select item 740235213.

Discovery of Novel Non-Steroidal Cytochrome P450 17A1 Inhibitors as Potential Prostate Cancer Agents

Tomasz M. Wróbel, Oksana Rogova, Kasper L. Andersen, Rahul Yadav, Simone Brixius-Anderko, Emily E. Scott, Lars Olsen, Flemming Steen Jørgensen, Fredrik Björkling

Int J Mol Sci. 2020 Jul; 21(14): 4868. Published online 2020 Jul 9. doi: 10.3390/ijms21144868

PMCID:: PMC7402352

Abstract Article PDF–1.6M

Select item 608347514.

A Rare Cause of Congenital Adrenal Hyperplasia: Clinical and Genetic Findings and Follow-up Characteristics of Six Patients with 17-Hydroxylase Deficiency Including Two Novel Mutations

Aslı Derya Kardelen, Güven Toksoy, Firdevs Baş, Zehra Yavaş Abalı, Genco Gençay, Şükran Poyrazoğlu, Rüveyde Bundak, Umut Altunoğlu, Şahin Avcı, Adam Najaflı, Oya Uyguner, Birsen Karaman, Seher Başaran, Feyza Darendeliler

J Clin Res Pediatr Endocrinol. 2018 Sep; 10(3): 206–215. Published online 2018 Jul 31. doi: 10.4274/jcrpe.0032