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Select item 108762061.

Multiomics analysis reveals metabolic subtypes and identifies diacylglycerol kinase α (DGKA) as a potential therapeutic target for intrahepatic cholangiocarcinoma

Weiren Liu, Huqiang Wang, Qianfu Zhao, Chenyang Tao, Weifeng Qu, Yushan Hou, Run Huang, Zimei Sun, Guiqi Zhu, Xifei Jiang, Yuan Fang, Jun Gao, Xiaoling Wu, Zhixiang Yang, Rongyu Ping, Jiafeng Chen, Rui Yang, Tianhao Chu, Jian Zhou, Jia Fan, Zheng Tang, Dong Yang, Yinghong Shi

Cancer Commun (Lond) 2024 Feb; 44(2): 226–250. Published online 2023 Dec 24. doi: 10.1002/cac2.12513

PMCID:: PMC10876206

Abstract Article PDF–7.6M

Select item 73677572.

DGKA provides platinum resistance in ovarian cancer through activation of cJUN-WEE1 signaling

Jie Li, Chaoyun Pan, Austin C. Boese, JiHoon Kang, Anna D. Umano, Kelly R. Magliocca, Wenqing Yang, Yu Zhang, Sagar Lonial, Lingtao Jin, Sumin Kang

Clin Cancer Res. Author manuscript; available in PMC 2021 Jan 15.

Published in final edited form as: Clin Cancer Res. 2020 Jul 15; 26(14): 3843–3855. Published online 2020 Apr 27. doi: 10.1158/1078-0432.CCR-19-3790

PMCID:: PMC7367757

Abstract Article PDF–2.0M

Select item 68877903.

DGKα in Neutrophil Biology and Its Implications for Respiratory Diseases

Gianluca Baldanzi, Mario Malerba

Int J Mol Sci. 2019 Nov; 20(22): 5673. Published online 2019 Nov 13. doi: 10.3390/ijms20225673

PMCID:: PMC6887790

Abstract Article PDF–1.6M

Select item 64237254.

Crystal structure and calcium‐induced conformational changes of diacylglycerol kinase α EF‐hand domains

Daisuke Takahashi, Kano Suzuki, Taiichi Sakamoto, Takeo Iwamoto, Takeshi Murata, Fumio Sakane

Protein Sci. 2019 Apr; 28(4): 694–706. Published online 2019 Feb 4. doi: 10.1002/pro.3572

PMCID:: PMC6423725

Abstract Article PDF–1.2M

Select item 47929585.

Epigenetic regulation of diacylglycerol kinase alpha promotes radiation-induced fibrosis

Christoph Weigel, Marlon R. Veldwijk, Christopher C. Oakes, Petra Seibold, Alla Slynko, David B. Liesenfeld, Mariona Rabionet, Sabrina A. Hanke, Frederik Wenz, Elena Sperk, Axel Benner, Christoph Rösli, Roger Sandhoff, Yassen Assenov, Christoph Plass, Carsten Herskind, Jenny Chang-Claude, Peter Schmezer, Odilia Popanda

Nat Commun. 2016; 7: 10893. Published online 2016 Mar 11. doi: 10.1038/ncomms10893

PMCID:: PMC4792958

Abstract Article PDF–743K

Select item 46446826.

Molecular Pathways: Targeting Diacylglycerol Kinase Alpha in Cancer

Benjamin Purow

Clin Cancer Res. Author manuscript; available in PMC 2016 Nov 15.

Published in final edited form as: Clin Cancer Res. 2015 Nov 15; 21(22): 5008–5012. Published online 2015 Sep 29. doi: 10.1158/1078-0432.CCR-15-0413

PMCID:: PMC4644682

Abstract Article PDF–258K

Select item 43184927.

A Molecular Defect in Intracellular Lipid Signaling in Human Neutrophils in Localized Aggressive Periodontal Tissue Damage

Karsten Gronert, Alpdogan Kantarci, Bruce D. Levy, Clary B. Clish, Sabine Odparlik, Hatice Hasturk, John A. Badwey, Sean P. Colgan, Thomas E. Van Dyke, Charles N. Serhan

J Immunol. Author manuscript; available in PMC 2015 Feb 5.

Published in final edited form as: J Immunol. 2004 Feb 1; 172(3): 1856–1861. doi: 10.4049/jimmunol.172.3.1856

PMCID:: PMC4318492

Abstract Article PDF–795K

Select item 31319638.

Diacylglycerol kinase α regulates the formation and polarisation of mature multivesicular bodies involved in the secretion of Fas ligand-containing exosomes in T lymphocytes

R Alonso, C Mazzeo, M C Rodriguez, M Marsh, A Fraile-Ramos, V Calvo, A Avila-Flores, I Merida, M Izquierdo

Cell Death Differ. 2011 Jul; 18(7): 1161–1173. Published online 2011 Jan 21. doi: 10.1038/cdd.2010.184

PMCID:: PMC3131963

Abstract Article PDF–992K

Select item 21855279.

Role of Diacylglycerol Kinase α in the Attenuation of Receptor Signaling

Miguel Angel Sanjuán, David R. Jones, Manuel Izquierdo, Isabel Mérida

J Cell Biol. 2001 Apr 2; 153(1): 207–220. doi: 10.1083/jcb.153.1.207

PMCID:: PMC2185527

Abstract Article PDF–761K

Select item 30207710.

Src-mediated activation of α-diacylglycerol kinase is required for hepatocyte growth factor-induced cell motility

Santina Cutrupi, Gianluca Baldanzi, Daniela Gramaglia, Antonella Maffè, Dick Schaap, Enrico Giraudo, Wim van Blitterswijk, Federico Bussolino, Paolo M. Comoglio, Andrea Graziani

EMBO J. 2000 Sep 1; 19(17): 4614–4622. doi: 10.1093/emboj/19.17.4614

PMCID:: PMC302077

Abstract Article PDF–387K

Select item 1015113911.

Targeting diacylglycerol kinase α impairs lung tumorigenesis by inhibiting cyclin D3

Dong Zhou, Tao Liu, Xinrui Rao, Xiaohua Jie, Yunshang Chen, Zilong Wu, Huilin Deng, Dan Zhang, Jian Wang, Gang Wu

Thorac Cancer. 2023 May; 14(13): 1179–1191. Published online 2023 Mar 25. doi: 10.1111/1759-7714.14851

PMCID:: PMC10151139

Abstract Article PDF–9.3M

Select item 729409512.

Diacylglycerol kinases regulate TRPV1 channel activity

Luyu Liu, Yevgen Yudin, Tibor Rohacs

J Biol Chem. 2020 Jun 12; 295(24): 8174–8185. Published online 2020 Apr 28. doi: 10.1074/jbc.RA119.012505

PMCID:: PMC7294095

Abstract Article PDF–3.9M

Select item 502296013.

Decreased LIPF expression is correlated with DGKA and predicts poor outcome of gastric cancer

Yi Kong, Yan Zheng, Yanfei Jia, Ping Li, Yunshan Wang

Oncol Rep. 2016 Oct; 36(4): 1852–1860. Published online 2016 Aug 1. doi: 10.3892/or.2016.4989

PMCID:: PMC5022960

Abstract Article PDF–630K

Select item 423167014.

Diacylglycerol Kinase α Regulates Tubular Recycling Endosome Biogenesis and Major Histocompatibility Complex Class I Recycling

Shuwei Xie, Naava Naslavsky, Steve Caplan

J Biol Chem. 2014 Nov 14; 289(46): 31914–31926. Published online 2014 Sep 23. doi: 10.1074/jbc.M114.594291

PMCID:: PMC4231670

Abstract Article PDF–4.4M

Select item 382958815.

A miR-297/hypoxia/DGK-α axis regulating glioblastoma survival

Benjamin Kefas, Desiree H. Floyd, Laurey Comeau, Alyse Frisbee, Charli Dominguez, Charles G. diPierro, Fadila Guessous, Roger Abounader, Benjamin Purow

Neuro Oncol. 2013 Dec; 15(12): 1652–1663. Published online 2013 Oct 24. doi: 10.1093/neuonc/not118

PMCID:: PMC3829588

Abstract Article PDF–679K

Select item 322189016.

SAP-MEDIATED INHIBITION OF DIACYLGLYCEROL KINASE ALPHA REGULATES TCR-INDUCED DIACYLGLYCEROL SIGNALING

Gianluca Baldanzi, Andrea Pighini, Valentina Bettio, Elena Rainero, Sara Traini, Federica Chianale, Paolo Porporato, Nicoletta Filigheddu, Riccardo Mesturini, Shuping Song, Tamas Schweighoffer, Laura Patrussi, Cosima Tatiana Baldari, Xiao-Ping Zhong, Wim J. van Blitterswijk, Fabiola Sinigaglia, Kim E. Nichols, Ignacio Rubio, Ornella Parolini, Andrea Graziani

J Immunol. Author manuscript; available in PMC 2012 Dec 1.

Published in final edited form as: J Immunol. 2011 Dec 1; 187(11): 5941–5951. Published online 2011 Nov 2. doi: 10.4049/jimmunol.1002476

PMCID:: PMC3221890

Abstract Article PDF–1.7M

Select item 312753817.

Diacylglycerol Lipase-α and -β Control Neurite Outgrowth in Neuro-2a Cells through Distinct Molecular Mechanisms

Kwang-Mook Jung, Giuseppe Astarita, Dean Thongkham, Daniele Piomelli

Mol Pharmacol. 2011 Jul; 80(1): 60–67. doi: 10.1124/mol.110.070458

PMCID:: PMC3127538

Abstract Article PDF–1.3M

Select item 284012318.

Diacylglycerol kinase α mediates HGF-induced Rac activation and membrane ruffling by regulating atypical PKC and RhoGDI

Federica Chianale, Elena Rainero, Cristina Cianflone, Valentina Bettio, Andrea Pighini, Paolo E. Porporato, Nicoletta Filigheddu, Guido Serini, Fabiola Sinigaglia, Gianluca Baldanzi, Andrea Graziani

Proc Natl Acad Sci U S A. 2010 Mar 2; 107(9): 4182–4187. Published online 2010 Feb 16. doi: 10.1073/pnas.0908326107

PMCID:: PMC2840123

Abstract Article PDF–1.3M

Select item 209659719.

Diacylglycerol Kinase-α Mediates Hepatocyte Growth Factor-induced Epithelial Cell Scatter by Regulating Rac Activation and Membrane Ruffling

Federica Chianale, Santina Cutrupi, Elena Rainero, Gianluca Baldanzi, Paolo E. Porporato, Sara Traini, Nicoletta Filigheddu, Viola F. Gnocchi, Massimo M. Santoro, Ornella Parolini, Wim J. van Blitterswijk, Fabiola Sinigaglia, Andrea Graziani

Mol Biol Cell. 2007 Dec; 18(12): 4859–4871. doi: 10.1091/mbc.E07-02-0177

PMCID:: PMC2096597

Abstract Article PDF–1.7M

Select item 864180420.

Diacylglycerol Kinase Inhibition Reduces Airway Contraction by Negative Feedback Regulation of Gq-Signaling

Pawan Sharma, Santosh K. Yadav, Sushrut D. Shah, Elham Javed, John M. Lim, Shi Pan, Ajay P. Nayak, Reynold A. Panettieri, Jr., Raymond B. Penn, Taku Kambayashi, Deepak A. Deshpande

Am J Respir Cell Mol Biol. 2021 Dec; 65(6): 658–671. Published online 2021 Mar 30. doi: 10.1165/rcmb.2021-0106OC

PMCID:: PMC8641804

Abstract Article PDF–1.5M

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