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Select item 99690901.

IL-12α deficiency attenuates pressure overload-induced cardiac inflammation, hypertrophy, dysfunction, and heart failure progression

Umesh Bhattarai, Xiaochen He, Rui Xu, Xiaoguang Liu, Lihong Pan, Yuxiang Sun, Jian-Xiong Chen, Yingjie Chen

Front Immunol. 2023; 14: 1105664. Published online 2023 Feb 13. doi: 10.3389/fimmu.2023.1105664

PMCID:: PMC9969090

Abstract Article PDF–13M

Select item 90097362.

A tumor-specific pro-IL-12 activates preexisting cytotoxic T cells to control established tumors

Diyuan Xue, Benjamin Moon, Jing Liao, Jingya Guo, Zhuangzhi Zou, Yanfei Han, Shuaishuai Cao, Yang Wang, Yang-Xin Fu, Hua Peng

Sci Immunol. Author manuscript; available in PMC 2022 Jul 7.

Published in final edited form as: Sci Immunol. 2022 Jan 7; 7(67): eabi6899. Published online 2022 Jan 7. doi: 10.1126/sciimmunol.abi6899

PMCID:: PMC9009736

Abstract Article PDF–1.4M

Select item 85255923.

IL-35 promotes CD4⁺Foxp3⁺ Tregs and inhibits atherosclerosis via maintaining CCR5-amplified Treg-suppressive mechanisms

Ying Shao, William Y. Yang, Fatma Saaoud, Charles Drummer, IV, Yu Sun, Keman Xu, Yifan Lu, Huimin Shan, Ethan M. Shevach, Xiaohua Jiang, Hong Wang, Xiaofeng Yang

JCI Insight. 2021 Oct 8; 6(19): e152511. Published online 2021 Oct 8. doi: 10.1172/jci.insight.152511

PMCID:: PMC8525592

Abstract Article PDF–2.6M

Select item 83108874.

Targeted cytokine delivery: cell therapy to remodel the pre-metastatic niche

Michael A. Morgan, Lucas Lange, Axel Schambach

Signal Transduct Target Ther. 2021; 6: 282. Published online 2021 Jul 25. doi: 10.1038/s41392-021-00694-1

PMCID:: PMC8310887

Article PDF–545K

Select item 61547735.

Interleukin-12p35 Knock Out Aggravates Doxorubicin-Induced Cardiac Injury and Dysfunction by Aggravating the Inflammatory Response, Oxidative Stress, Apoptosis and Autophagy in Mice

Jing Ye, Ying Huang, Bin Que, Chao Chang, Wenjing Liu, Haiying Hu, Ling Liu, Ying Shi, Yuan Wang, Menglong Wang, Tao Zeng, Wang Zhen, Yao Xu, Lei Shi, Jianfang Liu, Huimin Jiang, Di Ye, Yingzhong Lin, Jun Wan, Qingwei Ji

EBioMedicine. 2018 Sep; 35: 29–39. Published online 2018 Sep 15. doi: 10.1016/j.ebiom.2018.06.009

PMCID:: PMC6154773

Abstract Article PDF–3.6M

Select item 50109526.

IL-12 signals through the TCR to support CD8 innate immune responses

Nicholas P. Goplen, Vikas Saxena, Karin M. Knudson, Adam G. Schrum, Diana Gil, Mark A. Daniels, Rose Zamoyska, Emma Teixeiro

J Immunol. Author manuscript; available in PMC 2017 Sep 15.

Published in final edited form as: J Immunol. 2016 Sep 15; 197(6): 2434–2443. Published online 2016 Aug 12. doi: 10.4049/jimmunol.1600037

PMCID:: PMC5010952

Abstract Article PDF–1.8M

Select item 45760517.

Role of Interleukin-12 in Protection against Pulmonary Infection with Methicillin-Resistant Staphylococcus aureus

Quang-Tam Nguyen, Yoichi Furuya, Sean Roberts, Dennis W. Metzger

Antimicrob Agents Chemother. 2015 Oct; 59(10): 6308–6316. Prepublished online 2015 Jul 27. Published online 2015 Sep 18. doi: 10.1128/AAC.00968-15

PMCID:: PMC4576051

Abstract Article PDF–1.3M

Select item 44524028.

Dendritic cells in irradiated mice trigger the functional plasticity and antitumor activity of adoptively transferred Tc17 cells via IL-12 signaling

Jacob S. Bowers, Michelle H. Nelson, Sreenath Kundimi, Stefanie R. Bailey, Logan W. Huff, Kristina M. Schwartz, David J. Cole, Mark P. Rubinstein, Chrystal M. Paulos

Clin Cancer Res. Author manuscript; available in PMC 2016 Jun 1.

Published in final edited form as: Clin Cancer Res. 2015 Jun 1; 21(11): 2546–2557. Published online 2015 Apr 22. doi: 10.1158/1078-0432.CCR-14-2294

PMCID:: PMC4452402

Abstract Article PDF–748K

Select item 43919919.

IL-35 mitigates murine acute graft-versus-host disease with retention of graft-versus-leukemia effects

Yuejun Liu, Yan Wu, Ying Wang, Yifeng Cai, Bo Hu, Guangming Bao, Hongying Fang, Lixiang Zhao, Shoubao Ma, Qiao Cheng, Yuan Song, Yonghao Liu, Ziling Zhu, Huirong Chang, Xiao Yu, Aining Sun, Yi Zhang, Dario A. A. Vignali, Depei Wu, Haiyan Liu

Leukemia. Author manuscript; available in PMC 2015 Oct 1.

Published in final edited form as: Leukemia. 2015 Apr; 29(4): 939–946. Published online 2014 Nov 3. doi: 10.1038/leu.2014.310

PMCID:: PMC4391991

Abstract Article PDF–1.0M

Select item 339037510.

Mycobacterium indicus pranii (Mw) Re-Establishes Host Protective Immune Response in Leishmania donovani Infected Macrophages: Critical Role of IL-12

Anupam Adhikari, Gaurav Gupta, Saikat Majumder, Sayantan Banerjee, Surajit Bhattacharjee, Parna Bhattacharya, Sangeeta Kumari, Subhadra Haldar, Suchandra Bhattacharyya Majumdar, Bhaskar Saha, Subrata Majumdar

PLoS One. 2012; 7(7): e40265. Published online 2012 Jul 5. doi: 10.1371/journal.pone.0040265

PMCID:: PMC3390375

Abstract Article PDF–2.1M

Select item 329305411.

Gene silencing of IL-12 in dendritic cells inhibits autoimmune arthritis

Rong Li, Xiufen Zheng, Igor Popov, Xusheng Zhang, Hongmei Wang, Motohiko Suzuki, Rosalia De Necochea-Campion, Peter W French, Di Chen, Leo Siu, David Koos, Robert D Inman, Wei-Ping Min

J Transl Med. 2012; 10: 19. Published online 2012 Jan 31. doi: 10.1186/1479-5876-10-19

PMCID:: PMC3293054

Abstract Article PDF–656K

Select item 326913512.

IL-35 Production by ICOS⁺ Tregs Reverses Established IL-17-dependent Allergic Airways Disease

Gregory S. Whitehead, Rhonda H. Wilson, Keiko Nakano, Lauranell H. Burch, Hideki Nakano, Donald N. Cook

J Allergy Clin Immunol. Author manuscript; available in PMC 2012 Jan 31.

Published in final edited form as: J Allergy Clin Immunol. 2012 Jan; 129(1): 207–215.e5. Published online 2011 Sep 8. doi: 10.1016/j.jaci.2011.08.009

PMCID:: PMC3269135

Abstract Article PDF–1.5M

Select item 284913113.

IL-12 induces salivary gland dysfunction, providing a new mouse model of Sjögren's syndrome

Jelle L. Vosters, Melissa A. Landek-Salgado, Hongen Yin, William D. Swaim, Hiroaki Kimura, Paul P. Tak, Patrizio Caturegli, John A. Chiorini

Arthritis Rheum. Author manuscript; available in PMC 2010 Dec 1.

Published in final edited form as: Arthritis Rheum. 2009 Dec; 60(12): 3633–3641. doi: 10.1002/art.24980

PMCID:: PMC2849131

Abstract Article PDF–674K

Select item 284161914.

Differential Regulation of Effector- and Central-Memory Responses to Toxoplasma gondii Infection by IL-12 Revealed by Tracking of Tgd057-Specific CD8+ T Cells

Douglas C. Wilson, Gijsbert M. Grotenbreg, Kenian Liu, Yanlin Zhao, Eva-Maria Frickel, Marc-Jan Gubbels, Hidde L. Ploegh, George S. Yap

PLoS Pathog. 2010 Mar; 6(3): e1000815. Published online 2010 Mar 19. doi: 10.1371/journal.ppat.1000815

PMCID:: PMC2841619

Abstract Article PDF–1.5M

Select item 282741415.

Docosahexaenoic acid prevents dendritic cell maturation and in vitro and in vivo expression of the IL-12 cytokine family

Weimin Kong, Jui-Hung Yen, Evros Vassiliou, Sabina Adhikary, Miguel G Toscano, Doina Ganea

Lipids Health Dis. 2010; 9: 12. Published online 2010 Feb 1. doi: 10.1186/1476-511X-9-12

PMCID:: PMC2827414

Abstract Article PDF–590K

Select item 219186716.

Interleukin 12 administration induces T helper type 1 cells and accelerates autoimmune diabetes in NOD mice

J Exp Med. 1995 Feb 1; 181(2): 817–821. doi: 10.1084/jem.181.2.817

PMCID:: PMC2191867

Summary PDF–2.7M

Select item 182843417.

Respiratory Tract Infection with Mycoplasma pneumoniae in Interleukin-12 Knockout Mice Results in Improved Bacterial Clearance and Reduced Pulmonary Inflammation

C. M. Salvatore, M. Fonseca-Aten, K. Katz-Gaynor, A. M. Gomez, A. Mejias, C. Somers, S. Chavez-Bueno, G. H. McCracken, R. D. Hardy

Infect Immun. 2007 Jan; 75(1): 236–242. Published online 2006 Oct 30. doi: 10.1128/IAI.01249-06

PMCID:: PMC1828434

Abstract Article PDF–502K

Select item 1004236818.

IL-12p40 is essential but not sufficient for Francisella tularensis LVS clearance in chronically infected mice

Lara R. Mittereder, Jonathan Swoboda, Roberto De Pascalis, Karen L. Elkins

PLoS One. 2023; 18(3): e0283161. Published online 2023 Mar 27. doi: 10.1371/journal.pone.0283161

PMCID:: PMC10042368

Abstract Article PDF–1.1M

Select item 856963719.

The subunits of IL-12, originating from two distinct cells, can functionally synergize to protect against pathogen dissemination in vivo

Allison N. Gerber, Kaveh Abdi, Nevil J. Singh

Cell Rep. Author manuscript; available in PMC 2021 Nov 5.

Published in final edited form as: Cell Rep. 2021 Oct 12; 37(2): 109816. doi: 10.1016/j.celrep.2021.109816

PMCID:: PMC8569637

Abstract Article PDF–1.6M

Select item 810255020.

Nanoparticle-mediated tumor cell expression of mIL-12 via systemic gene delivery treats syngeneic models of murine lung cancers

Hye-Hyun Ahn, Christine Carrington, Yizong Hu, Heng-wen Liu, Christy Ng, Hwanhee Nam, Andrew Park, Catherine Stace, Will West, Hai-Quan Mao, Martin G. Pomper, Christopher G. Ullman, Il Minn

Sci Rep. 2021; 11: 9733. Published online 2021 May 6. doi: 10.1038/s41598-021-89124-4

PMCID:: PMC8102550

Abstract Article PDF–1.3M

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PMC Links for Gene (Select 16159) (243)
PMC
TPA: Spr6p [Saccharomyces cerevisiae S288C]
TPA: Spr6p [Saccharomyces cerevisiae S288C]
gi|285811747|tpg|DAA07775.1|

Protein
Uncultured bacterium clone cafs1166 16S ribosomal RNA gene, partial sequence
Uncultured bacterium clone cafs1166 16S ribosomal RNA gene, partial sequence
gi|1214631685|gb|MF440291.1|

Nucleotide
1294636[uid] (1)
Taxonomy
Acinetobacter baumannii strain NCTC7364 genome assembly, chromosome: 1
Acinetobacter baumannii strain NCTC7364 genome assembly, chromosome: 1
gi|1050996618|emb|LT605059.1|

Nucleotide

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