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Select item 80593731.

A DNA repair disorder caused by de novo monoallelic DDB1 variants is associated with a neurodevelopmental syndrome

Susan M. White, Elizabeth Bhoj, Christoffer Nellåker, Augusta M.A. Lachmeijer, Aren E. Marshall, Kym M. Boycott, Dong Li, Wendy Smith, Taila Hartley, Arran McBride, Michelle E. Ernst, Alison S. May, Dagmar Wieczorek, Rami Abou Jamra, Margarete Koch-Hogrebe, Katrin Õunap, Sander Pajusalu, K.L.I. van Gassen, Simon Sadedin, Sara Ellingwood, Tiong Yang Tan, John Christodoulou, Jaime Barea, Paul J. Lockhart, Care4Rare Canada Consortium, Marjan M. Nezarati, Kristin D. Kernohan

Am J Hum Genet. 2021 Apr 1; 108(4): 749–756. Published online 2021 Mar 19. doi: 10.1016/j.ajhg.2021.03.007

PMCID:: PMC8059373

Abstract Article PDF–953K

Select item 1549902.

Hepatitis B Virus X Protein and Simian Virus 5 V Protein Exhibit Similar UV-DDB1 Binding Properties To Mediate Distinct Activities

Olivier Leupin, Séverine Bontron, Michel Strubin

J Virol. 2003 Jun; 77(11): 6274–6283. doi: 10.1128/JVI.77.11.6274-6283.2003

PMCID:: PMC154990

Abstract Article PDF–1.1M

Select item 1367983.

The p127 Subunit (DDB1) of the UV-DNA Damage Repair Binding Protein Is Essential for the Targeted Degradation of STAT1 by the V Protein of the Paramyxovirus Simian Virus 5

J. Andrejeva, E. Poole, D. F. Young, S. Goodbourn, R. E. Randall

J Virol. 2002 Nov; 76(22): 11379–11386. doi: 10.1128/JVI.76.22.11379-11386.2002

PMCID:: PMC136798

Abstract Article PDF–621K

Select item 437214.

Correction of the DNA repair defect in xeroderma pigmentosum group E by injection of a DNA damage-binding protein.

S Keeney, A P Eker, T Brody, W Vermeulen, D Bootsma, J H Hoeijmakers, S Linn

Proc Natl Acad Sci U S A. 1994 Apr 26; 91(9): 4053–4056. doi: 10.1073/pnas.91.9.4053

PMCID:: PMC43721

Summary Page Browse PDF–985K

Select item 112135925.

Hepatocyte-specific loss of DDB1 attenuates hepatic steatosis but aggravates liver inflammation and fibrosis in MASH

Qiuxia Gu, Yushun Chang, Yan Jin, Jing Fang, Tong Ji, Jie Lin, Xi Zhu, Binzhi Dong, Hanning Ying, Xiaoxiao Fan, Zheyong Li, Zerui Gao, Yongfen Zhu, Yifan Tong, Xiujun Cai

Hepatol Commun. 2024 Jul; 8(7): e0474. Published online 2024 Jun 27. doi: 10.1097/HC9.0000000000000474

PMCID:: PMC11213592

Abstract Article PDF–2.2M

Select item 97145266.

Molecular glue CELMoD compounds are regulators of cereblon conformation

Edmond R. Watson, Scott Novick, Mary E. Matyskiela, Philip P. Chamberlain, Andres H. de la Peña, Jinyi Zhu, Eileen Tran, Patrick R. Griffin, Ingrid E. Wertz, Gabriel C. Lander

Science. Author manuscript; available in PMC 2022 Dec 1.

Published in final edited form as: Science. 2022 Nov 4; 378(6619): 549–553. Published online 2022 Nov 3. doi: 10.1126/science.add7574

PMCID:: PMC9714526

Abstract Article PDF–1.3M

Select item 87913017.

Proteomic Analysis of Nuclear Hepatitis B Virus Relaxed Circular DNA-Associated Proteins Identifies UV-Damaged DNA Binding Protein as a Host Factor Involved in Covalently Closed Circular DNA Formation

Alexander L. Marchetti, Hu Zhang, Elena S. Kim, Xiaoyang Yu, Sunbok Jang, Mu Wang, Haitao Guo

J Virol. 2022 Jan; 96(2): e01360-21. Prepublished online 2021 Oct 27. Published online 2022 Jan 26. doi: 10.1128/JVI.01360-21

PMCID:: PMC8791301

Abstract Article PDF–3.0M

Select item 83439988.

HBx represses WDR77 to enhance HBV replication by DDB1-mediated WDR77 degradation in the liver

Hongfeng Yuan, Lina Zhao, Ying Yuan, Haolin Yun, Wei Zheng, Yu Geng, Guang Yang, Yufei Wang, Man Zhao, Xiaodong Zhang

Theranostics. 2021; 11(17): 8362–8378. Published online 2021 Jul 25. doi: 10.7150/thno.57531

PMCID:: PMC8343998

Abstract Article PDF–3.1M

Select item 82182559.

G蛋白信号调节因子2在调控口腔鳞状细胞癌细胞增殖、侵袭中的作用及分子机制

林承重, 刘喆麒, 周文凯, 季彤, 曹巍

Hua Xi Kou Qiang Yi Xue Za Zhi. 2021 Jun; 39(3): 320–327. Chinese. doi: 10.7518/hxkq.2021.03.012

PMCID:: PMC8218255

Abstract Article PDF–1.4M

Select item 787365910.

Expanding molecular roles of UV-DDB: shining light on genome stability and cancer

Maria Beecher, Namrata Kumar, Sunbok Jang, Vesna Rapić-Otrin, Bennett Van Houten

DNA Repair (Amst) Author manuscript; available in PMC 2021 Oct 1.

Published in final edited form as: DNA Repair (Amst). 2020 Oct; 94: 102860. Published online 2020 Apr 27. doi: 10.1016/j.dnarep.2020.102860

PMCID:: PMC7873659

Abstract Article PDF–1.7M

Select item 668437211.

Damage sensor role of UV-DDB during base excision repair

Sunbok Jang, Namrata Kumar, Emily C. Beckwitt, Muwen Kong, Elise Fouquerel, Vesna Rapić-Otrin, Rajendra Prasad, Simon C. Watkins, Cindy Khuu, Chandrima Majumdar, Sheila S. David, Samuel H. Wilson, Marcel P. Bruchez, Patricia L. Opresko, Bennett Van Houten

Nat Struct Mol Biol. Author manuscript; available in PMC 2020 Jan 22.

Published in final edited form as: Nat Struct Mol Biol. 2019 Aug; 26(8): 695–703. Published online 2019 Jul 22. doi: 10.1038/s41594-019-0261-7

PMCID:: PMC6684372

Abstract Article PDF–1.0M

Select item 661826012.

The Antiresection Activity of the X Protein Encoded by Hepatitis Virus B

Laifeng Ren, Ming Zeng, Zizhi Tang, Mingyuan Li, Xiaojun Wang, Yang Xu, Yuding Weng, Xiaobo Wang, Huan Wang, Liandi Guo, Bing Zuo, Xin Wang, Si Wang, Jiangyan Lou, Yaxiong Tang, Dezhi Mu, Ning Zheng, Xianhui Wu, Junhong Han, Antony M. Carr, Penelope Jeggo, Cong Liu

Hepatology. 2019 Jun; 69(6): 2546–2561. Published online 2019 Apr 11. doi: 10.1002/hep.30571

PMCID:: PMC6618260

Abstract Article PDF–1.7M

Select item 628812613.

Structural insights into DDA1 function as a core component of the CRL4-DDB1 ubiquitin ligase

Nitzan Shabek, James Ruble, Claire J. Waston, Kenneth C. Garbutt, Thomas R. Hinds, Ti Li, Ning Zheng

Cell Discov. 2018; 4: 67. Published online 2018 Dec 11. doi: 10.1038/s41421-018-0064-8

PMCID:: PMC6288126

Article PDF–810K

Select item 620224614.

Plasticity in binding confers selectivity in ligand induced protein degradation

Radosław P. Nowak, Stephen L. DeAngelo, Dennis Buckley, Zhixiang He, Katherine A. Donovan, Jian An, Nozhat Safaee, Mark P. Jedrychowski, Charles M. Ponthier, Mette Ishoey, Tinghu Zhang, Joseph D. Mancias, Nathanael S. Gray, James E. Bradner, Eric S. Fischer

Nat Chem Biol. Author manuscript; available in PMC 2018 Dec 11.

Published in final edited form as: Nat Chem Biol. 2018 Jul; 14(7): 706–714. Published online 2018 Jun 11. doi: 10.1038/s41589-018-0055-y

PMCID:: PMC6202246

Abstract Article PDF–947K

Select item 542870415.

Integrative analysis of multi-omics data reveals distinct impacts of DDB1-CUL4 associated factors in human lung adenocarcinomas

Hong Yan, Lei Bi, Yunshan Wang, Xia Zhang, Zhibo Hou, Qian Wang, Antoine M. Snijders, Jian-Hua Mao

Sci Rep. 2017; 7: 333. Published online 2017 Mar 23. doi: 10.1038/s41598-017-00512-1

PMCID:: PMC5428704

Abstract Article PDF–2.7M

Select item 402004816.

Single-molecule analysis reveals human UV-damaged DNA-binding protein (UV-DDB) dimerizes on DNA via multiple kinetic intermediates

Harshad Ghodke, Hong Wang, Ching L. Hsieh, Selamawit Woldemeskel, Simon C. Watkins, Vesna Rapić-Otrin, Bennett Van Houten

Proc Natl Acad Sci U S A. 2014 May 6; 111(18): E1862–E1871. Published online 2014 Apr 23. doi: 10.1073/pnas.1323856111

PMCID:: PMC4020048

Abstract Article PDF–1.6M

Select item 401725317.

Absence of mutations in cereblon (CRBN) and DNA damage-binding protein 1 (DDB1) genes and significance for IMiD therapy

A Thakurta, A K Gandhi, M F Waldman, C Bjorklund, Y Ning, D Mendy, P Schafer, A Lopez-Girona, S Lentzsch, S A Schey, Y Calle, R Chelliah, R Z Orlowski, A Madan, H Avet-Loiseau, R Chopra

Leukemia. 2014 May; 28(5): 1129–1131. Prepublished online 2013 Oct 29. Published online 2013 Nov 29. doi: 10.1038/leu.2013.315

PMCID:: PMC4017253

Article PDF–199K

Select item 395975618.

Ubiquitin ligase defect by DCAF8 mutation causes HMSN2 with giant axons

Christopher J. Klein, Yanhong Wu, Peter Vogel, Hans H. Goebel, Carsten Bönnemann, Kristen Zukosky, Maria-Victoria Botuyan, Xiaohui Duan, Sumit Middha, Elizabeth J. Atkinson, Georges Mer, Peter J. Dyck

Neurology. 2014 Mar 11; 82(10): 873–878. doi: 10.1212/WNL.0000000000000206