PMC Links for Gene (Select 171389) - PMC

Select item 108441551.

Decreased expression of the NLRP6 inflammasome is associated with increased intestinal permeability and inflammation in obesity with type 2 diabetes

Gema Frühbeck, Javier Gómez-Ambrosi, Beatriz Ramírez, Sara Becerril, Amaia Rodríguez, Amaia Mentxaka, Víctor Valentí, Rafael Moncada, Gabriel Reina, Jorge Baixauli, Marcos Casado, Camilo Silva, Javier Escalada, Victoria Catalán

Cell Mol Life Sci. 2024 Dec; 81(1): 77. Published online 2024 Feb 5. doi: 10.1007/s00018-024-05124-3

PMCID:: PMC10844155

Abstract Article PDF–2.5M

Select item 105393292.

NLRP6 potentiates PI3K/AKT signalling by promoting autophagic degradation of p85α to drive tumorigenesis

Feng Zhi, Bowen Li, Chuanxia Zhang, Fan Xia, Rong Wang, Weihong Xie, Sihui Cai, Dawei Zhang, Ren Kong, Yiqiao Hu, Yilin Yang, Ya Peng, Jun Cui

Nat Commun. 2023; 14: 6069. Published online 2023 Sep 28. doi: 10.1038/s41467-023-41739-z

PMCID:: PMC10539329

Abstract Article PDF–2.6M

Select item 98446073.

A novel pyroptosis risk model composed of NLRP6 effectively predicts the prognosis of hepatocellular carcinoma patients

Xin Gao, Wen‐Xin Wang, Xiao‐Lan Zhang

Cancer Med. 2023 Jan; 12(1): 808–823. Published online 2022 Jun 1. doi: 10.1002/cam4.4898

PMCID:: PMC9844607

Abstract Article PDF–15M

Select item 91600234.

Physiological and pathophysiological functions of NLRP6: pro- and anti-inflammatory roles

Diego Angosto-Bazarra, Cristina Molina-López, Pablo Pelegrín

Commun Biol. 2022; 5: 524. Published online 2022 Jun 1. doi: 10.1038/s42003-022-03491-w

PMCID:: PMC9160023

Abstract Article PDF–799K

Select item 86953585.

A detrimental role of NLRP6 in host iron metabolism during Salmonella infection

Qifeng Deng, Sidi Yang, Lanqing Sun, Kai Huang, Kedi Dong, Yuan Zhu, Yu Cao, Yuanyuan Li, Shuyan Wu, Rui Huang

Redox Biol. 2022 Feb; 49: 102217. Published online 2021 Dec 18. doi: 10.1016/j.redox.2021.102217

PMCID:: PMC8695358

Abstract Article PDF–15M

Select item 69575196.

NLRP6 self-assembles into a linear molecular platform following LPS binding and ATP stimulation

Fangwei Leng, Hang Yin, Siying Qin, Kai Zhang, Yukun Guan, Run Fang, Honglei Wang, Guohui Li, Zhengfan Jiang, Fei Sun, Da-Cheng Wang, Can Xie

Sci Rep. 2020; 10: 198. Published online 2020 Jan 13. doi: 10.1038/s41598-019-57043-0

PMCID:: PMC6957519

Abstract Article PDF–2.1M

Select item 64964247.

The protective roles of NLRP6 in intestinal epithelial cells

Jiuheng Yin, Baifa Sheng, Kunqiu Yang, Lihua Sun, Weidong Xiao, Hua Yang

Cell Prolif. 2019 Mar; 52(2): e12555. Published online 2018 Dec 4. doi: 10.1111/cpr.12555

PMCID:: PMC6496424

Abstract Article PDF–378K

Select item 38102968.

NLRP6 in Infection and Inflammation

Paras K. Anand, Thirumala-Devi Kanneganti

Microbes Infect. Author manuscript; available in PMC 2014 Sep 1.

Published in final edited form as: Microbes Infect. 2013 Sep-Oct; 15(0): 10.1016/j.micinf.2013.06.009. Published online 2013 Jun 28. doi: 10.1016/j.micinf.2013.06.009

PMCID:: PMC3810296

Abstract Article PDF–1.0M

Select item 110780159.

NLRP6 negatively regulates host defense against polymicrobial sepsis

Laxman Ghimire, Sagar Paudel, John Le, Liliang Jin, Shanshan Cai, Dinesh Bhattarai, Samithamby Jeyaseelan

Front Immunol. 2024; 15: 1248907. Published online 2024 Apr 23. doi: 10.3389/fimmu.2024.1248907

PMCID:: PMC11078015

Abstract Article PDF–4.5M

Select item 636975410.

Molecular mechanism for NLRP6 inflammasome assembly and activation

Chen Shen, Alvin Lu, Wen Jun Xie, Jianbin Ruan, Roberto Negro, Edward H. Egelman, Tian-Min Fu, Hao Wu

Proc Natl Acad Sci U S A. 2019 Feb 5; 116(6): 2052–2057. Published online 2019 Jan 23. doi: 10.1073/pnas.1817221116

PMCID:: PMC6369754

Abstract Article PDF–1.8M

Select item 393254011.

Role of Nlrp6 and Nlrp12 in the maintenance of intestinal homeostasis

Grace Y. Chen

Eur J Immunol. Author manuscript; available in PMC 2015 Feb 1.

Published in final edited form as: Eur J Immunol. 2014 Feb; 44(2): 321–327. Published online 2014 Jan 16. doi: 10.1002/eji.201344135

PMCID:: PMC3932540

Abstract Article PDF–773K

Select item 379576412.

Sex-Specific Effects of NLRP6/AVR and ADM Loci on Susceptibility to Essential Hypertension in a Sardinian Population

Nicola Glorioso, Victoria L. Herrera, Tamara Didishvili, Maria F. Ortu, Roberta Zaninello, Giovanni Fresu, Guiseppe Argiolas, Chiara Troffa, Nelson Ruiz-Opazo

PLoS One. 2013; 8(10): e77562. Published online 2013 Oct 11. doi: 10.1371/journal.pone.0077562

PMCID:: PMC3795764

Abstract Article PDF–213K

Select item 827644213.

DHX15 is required to control RNA virus-induced intestinal inflammation

Junji Xing, Xiaojing Zhou, Mingli Fang, Evan Zhang, Laurie J. Minze, Zhiqiang Zhang

Cell Rep. Author manuscript; available in PMC 2021 Jul 13.

Published in final edited form as: Cell Rep. 2021 Jun 22; 35(12): 109205. doi: 10.1016/j.celrep.2021.109205

PMCID:: PMC8276442

Abstract Article PDF–1.2M

Select item 302634914.

AVR/NAVR deficiency lowers blood pressure and differentially affects urinary concentrating ability, cognition, and anxiety-like behavior in male and female mice

Victoria L. M. Herrera, Pia Bagamasbad, Julius L. Decano, Nelson Ruiz-Opazo

Physiol Genomics. 2011 Jan; 43(1): 32–42. Published online 2010 Oct 5. doi: 10.1152/physiolgenomics.00154.2010

PMCID:: PMC3026349

Abstract Article

Select item 284532215.

Overlapping genes in Nalp6/PYPAF5 locus encode two V2-type vasopressin isoreceptors: angiotensin-vasopressin receptor (AVR) and non-AVR

Victoria L. M. Herrera, Pia Bagamasbad, Tamara Didishvili, Julius L. Decano, Nelson Ruiz-Opazo

Physiol Genomics. Author manuscript; available in PMC 2010 Mar 25.

Published in final edited form as: Physiol Genomics. 2008 Jun 12; 34(1): 65–77. Published online 2008 Apr 15. doi: 10.1152/physiolgenomics.00199.2007

PMCID:: PMC2845322

Abstract Article PDF–2.7M

Select item 203993416.

The dual AngII/AVP receptor gene N119S/C163R variant exhibits sodium-induced dysfunction and cosegregates with salt-sensitive hypertension in the Dahl salt-sensitive hypertensive rat model.

Nelson Ruiz-Opazo, Lyle V. Lopez, Victoria L. M. Herrera

Mol Med. 2002 Jan; 8(1): 24–32.

PMCID:: PMC2039934

Summary PDF–146K

Select item 864327717.

Phase Separation Drives RNA Virus-Induced Activation of the NLRP6 Inflammasome

Chen Shen, Runzhi Li, Roberto Negro, Jiewei Cheng, Setu Vora, Tian-Min Fu, Anmin Wang, Kaixin He, Liudmila Andreeva, Pu Gao, Zhigang Tian, Richard Flavell, Shu Zhu, Hao Wu

Cell. Author manuscript; available in PMC 2022 Nov 11.

Published in final edited form as: Cell. 2021 Nov 11; 184(23): 5759–5774.e20. Published online 2021 Oct 21. doi: 10.1016/j.cell.2021.09.032

PMCID:: PMC8643277

Abstract Article PDF–3.1M

Select item 629447718.

The NLRP6 inflammasome recognizes lipoteichoic acid and regulates Gram-positive pathogen infection

Hideki Hara, Sergey S. Seregin, Dahai Yang, Koichi Fukase, Mathias Chamaillard, Emad S. Alnemri, Naohiro Inohara, Grace Y. Chen, Gabriel Núñez

Cell. Author manuscript; available in PMC 2019 Nov 29.

Published in final edited form as: Cell. 2018 Nov 29; 175(6): 1651–1664.e14. Published online 2018 Nov 1. doi: 10.1016/j.cell.2018.09.047

PMCID:: PMC6294477

Abstract Article PDF–2.8M

Select item 333529619.

New gene functions in megakaryopoiesis and platelet formation

Christian Gieger, Aparna Radhakrishnan, Ana Cvejic, Weihong Tang, Eleonora Porcu, Giorgio Pistis, Jovana Serbanovic-Canic, Ulrich Elling, Alison H. Goodall, Yann Labrune, Lorna M. Lopez, Reedik Mägi, Stuart Meacham, Yukinori Okada, Nicola Pirastu, Rossella Sorice, Alexander Teumer, Katrin Voss, Weihua Zhang, Ramiro Ramirez-Solis, Joshua C. Bis, David Ellinghaus, Martin Gögele, Jouke-Jan Hottenga, Claudia Langenberg, Peter Kovacs, Paul F. O’Reilly, So-Youn Shin, Tõnu Esko, Jaana Hartiala, Stavroula Kanoni, Federico Murgia, Afshin Parsa, Jonathan Stephens, Pim van der Harst, C. Ellen van der Schoot, Hooman Allayee, Antony Attwood, Beverley Balkau, François Bastardot, Saonli Basu, Sebastian E. Baumeister, Ginevra Biino, Lorenzo Bomba, Amélie Bonnefond, François Cambien, John C. Chambers, Francesco Cucca, Pio D’Adamo, Gail Davies, Rudolf A. de Boer, Eco J. C. de Geus, Angela Döring, Paul Elliott, Jeanette Erdmann, David M. Evans, Mario Falchi, Wei Feng, Aaron R. Folsom, Ian H. Frazer, Quince D. Gibson, Nicole L. Glazer, Chris Hammond, Anna-Liisa Hartikainen, Susan R. Heckbert, Christian Hengstenberg, Micha Hersch, Thomas Illig, Ruth J. F. Loos, Jennifer Jolley, Kay Tee Khaw, Brigitte Kühnel, Marie-Christine Kyrtsonis, Vasiliki Lagou, Heather Lloyd-Jones, Thomas Lumley, Massimo Mangino, Andrea Maschio, Irene Mateo Leach, Barbara McKnight, Yasin Memari, Braxton D. Mitchell, Grant W. Montgomery, Yusuke Nakamura, Matthias Nauck, Gerjan Navis, Ute Nöthlings, Ilja M. Nolte, David J. Porteous, Anneli Pouta, Peter P. Pramstaller, Janne Pullat, Susan M. Ring, Jerome I. Rotter, Daniela Ruggiero, Aimo Ruokonen, Cinzia Sala, Nilesh J. Samani, Jennifer Sambrook, David Schlessinger, Stefan Schreiber, Heribert Schunkert, James Scott, Nicholas L. Smith, Harold Snieder, John M. Starr, Michael Stumvoll, Atsushi Takahashi, W. H. Wilson Tang, Kent Taylor, Albert Tenesa, Swee Lay Thein, Anke Tönjes, Manuela Uda, Sheila Ulivi, Dirk J. van Veldhuisen, Peter M. Visscher, Uwe Völker, H.-Erich Wichmann, Kerri L. Wiggins, Gonneke Willemsen, Tsun-Po Yang, Jing Hua Zhao, Paavo Zitting, John R. Bradley, George V. Dedoussis, Paolo Gasparini, Stanley L. Hazen, Andres Metspalu, Mario Pirastu, Alan R. Shuldiner, L. Joost van Pelt, Jaap-Jan Zwaginga, Dorret I. Boomsma, Ian J. Deary, Andre Franke, Philippe Froguel, Santhi K. Ganesh, Marjo-Riitta Jarvelin, Nicholas G. Martin, Christa Meisinger, Bruce M. Psaty, Timothy D. Spector, Nicholas J. Wareham, Jan-Willem N. Akkerman, Marina Ciullo, Panos Deloukas, Andreas Greinacher, Steve Jupe, Naoyuki Kamatani, Jyoti Khadake, Jaspal S. Kooner, Josef Penninger, Inga Prokopenko, Derek Stemple, Daniela Toniolo, Lorenz Wernisch, Serena Sanna, Andrew A. Hicks, Augusto Rendon, Manuel A. Ferreira, Willem H. Ouwehand, Nicole Soranzo

Nature. Author manuscript; available in PMC 2012 Apr 24.

Published in final edited form as: Nature. 2011 Nov 30; 480(7376): 201–208. Published online 2011 Nov 30. doi: 10.1038/nature10659

PMCID:: PMC3335296

Abstract Article PDF–862K

Select item 317805920.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

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