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Select item 109389851.

19-base pair deletion polymorphism of the dihydrofolate reductase (DHFR) gene: maternal risk of Down syndrome and folate metabolism

Cristiani Cortez Mendes, Joice Matos Biselli, Bruna Lancia Zampieri, Eny Maria Goloni-Bertollo, Marcos Nogueira Eberlin, Renato Haddad, Maria Francesca Riccio, Hélio Vannucchi, Valdemir Melechco Carvalho, Érika Cristina Pavarino-Bertelli

Sao Paulo Med J. 2010; 128(4): 215–218. Published online 2010 Jul 1. doi: 10.1590/S1516-31802010000400008

PMCID:: PMC10938985

Abstract Article PDF–125K

Select item 86975552.

Evolution of Optimized Hydride Transfer Reaction and Overall Enzyme Turnover in Human Dihydrofolate Reductase

Jiayue Li, Jennifer Lin, Amnon Kohen, Priyanka Singh, Kevin Francis, Christopher M. Cheatum

Biochemistry. 2021 Dec 21; 60(50): 3822–3828. Published online 2021 Dec 7. doi: 10.1021/acs.biochem.1c00558

PMCID:: PMC8697555

Abstract Article PDF–1.7M

Select item 64504503.

miRNA-24 Gene Sequence, DHFR −829C-T Genotypes, and Methotrexate Response in Mexican Patients with Rheumatoid Arthritis

Martha Rocio Hernández-Preciado, María Cristina Morán-Moguel, Ingrid Patricia Dávalos-Rodríguez, Christian Michel Enríquez-Barajas, Juan Paulo Valdovinos-Maravilla, Ana Lilia Díaz-Pérez, Daniel Efraín Silva-Castro, Laura González-López, Jorge Ivan Gámez-Nava, Mario Alberto Aceves-Aceves, Mario Salazar-Páramo

Genet Test Mol Biomarkers. 2019 Mar 1; 23(3): 223–227. Published online 2019 Mar 14. doi: 10.1089/gtmb.2018.0226

PMCID:: PMC6450450

Abstract Article PDF–267K

Select item 53778024.

A-to-I RNA Editing Up-regulates Human Dihydrofolate Reductase in Breast Cancer

Masataka Nakano, Tatsuki Fukami, Saki Gotoh, Miki Nakajima

J Biol Chem. 2017 Mar 24; 292(12): 4873–4884. Published online 2017 Feb 10. doi: 10.1074/jbc.M117.775684

PMCID:: PMC5377802

Abstract Article PDF–2.4M

Select item 47660755.

The Effect of Protein Mass Modulation on Human Dihydrofolate Reductase

Kevin Francis, Paul J. Sapienza, Andrew L. Lee, Amnon Kohen

Biochemistry. Author manuscript; available in PMC 2017 Feb 23.

Published in final edited form as: Biochemistry. 2016 Feb 23; 55(7): 1100–1106. Published online 2016 Feb 9. doi: 10.1021/acs.biochem.5b00945

PMCID:: PMC4766075

Abstract Article PDF–372K

Select item 46255896.

Dihydrofolate reductase 19-bp deletion polymorphism modifies the association of folate status with memory in a cross-sectional multi-ethnic study of adults

Dana Philip, Assaf Buch, Denish Moorthy, Tammy M Scott, Laurence D Parnell, Chao-Qiang Lai, José M Ordovás, Jacob Selhub, Irwin H Rosenberg, Katherine L Tucker, Aron M Troen

Am J Clin Nutr. 2015 Nov; 102(5): 1279–1288. Published online 2015 Sep 9. doi: 10.3945/ajcn.115.111054

PMCID:: PMC4625589

Abstract Article PDF–659K

Select item 45809617.

The Dihydrofolate Reductase 19 bp Polymorphism Is Not Associated with Biomarkers of Folate Status in Healthy Young Adults, Irrespective of Folic Acid Intake

Mari Ozaki, Anne M Molloy, James L Mills, Ruzong Fan, Yifan Wang, Eileen R Gibney, Barry Shane, Lawrence C Brody, Anne Parle-McDermott

J Nutr. 2015 Oct; 145(10): 2207–2211. Published online 2015 Aug 12. doi: 10.3945/jn.115.216101

PMCID:: PMC4580961

Abstract Article PDF–497K

Select item 45106618.

The 19-bp deletion polymorphism of dihydrofolate reductase (DHFR) and nonsyndromic cleft lip with or without cleft palate: evidence for a protective role

Firoozeh RAFIGHDOOST, Amir RAFIGHDOOST, Houshang RAFIGHDOOST, Mohammad-Ayoob RIGI-LADEZ, Mohammad HASHEMI, Ebrahim ESKANDARI-NASAB

J Appl Oral Sci. 2015 May-Jun; 23(3): 272–278. doi: 10.1590/1678-775720140473

PMCID:: PMC4510661

Abstract Article PDF–267K

Select item 43064969.

Evolution Alters the Enzymatic Reaction Coordinate of Dihydrofolate Reductase

Jean E. Masterson, Steven D. Schwartz

J Phys Chem B. 2015 Jan 22; 119(3): 989–996. Published online 2014 Nov 4. doi: 10.1021/jp506373q

PMCID:: PMC4306496

Abstract Article PDF–2.2M

Select item 398569710.

Side Chain Conformational Averaging in Human Dihydrofolate Reductase

Lisa M. Tuttle, H. Jane Dyson, Peter E. Wright

Biochemistry. 2014 Feb 25; 53(7): 1134–1145. Published online 2014 Feb 5. doi: 10.1021/bi4015314

PMCID:: PMC3985697

Abstract Article PDF–9.0M

Select item 385530511.

Elucidating features that drive the design of selective antifolates using crystal structures of human dihydrofolate reductase

Kristen M. Lamb, Narendran G-Dayanandan, Dennis L. Wright, Amy C. Anderson

Biochemistry. Author manuscript; available in PMC 2014 Oct 15.

Published in final edited form as: Biochemistry. 2013 Oct 15; 52(41): 10.1021/bi400852h. Published online 2013 Oct 3. doi: 10.1021/bi400852h

PMCID:: PMC3855305

Abstract Article PDF–762K

Select item 383093412.

Divergent Regulation of Dihydrofolate Reductase Between Malaria Parasite and Human Host

Kai Zhang, Pradipsinh K. Rathod

Science. Author manuscript; available in PMC 2013 Nov 17.

Published in final edited form as: Science. 2002 Apr 19; 296(5567): 10.1126/science.1068274. doi: 10.1126/science.1068274

Correction in:: volume 297 on page 1278

PMCID:: PMC3830934

Abstract Article PDF–353K

Select item 382364313.

Divergent evolution of protein conformational dynamics in dihydrofolate reductase

Gira Bhabha, Damian C. Ekiert, Madeleine Jennewein, Christian M. Zmasek, Lisa M. Tuttle, Gerard Kroon, H. Jane Dyson, Adam Godzik, Ian A. Wilson, Peter E. Wright

Nat Struct Mol Biol. Author manuscript; available in PMC 2014 May 1.

Published in final edited form as: Nat Struct Mol Biol. 2013 Nov; 20(11): 1243–1249. Published online 2013 Sep 29. doi: 10.1038/nsmb.2676

PMCID:: PMC3823643

Abstract Article PDF–2.2M

Select item 355881414.

Enhanced Degradation of Dihydrofolate Reductase through Inhibition of NAD Kinase by Nicotinamide Analogs

Yi-Ching Hsieh, Philip Tedeschi, Rialnat AdeBisi Lawal, Debabrata Banerjee, Kathleen Scotto, John E. Kerrigan, Kuo-Chieh Lee, Nadine Johnson-Farley, Joseph R. Bertino, Emine Ercikan Abali

Mol Pharmacol. 2013 Feb; 83(2): 339–353. Published online 2013 Feb. doi: 10.1124/mol.112.080218

PMCID:: PMC3558814

Abstract Article PDF–1.5M

Select item 349343715.

A second target of benzamide riboside: Dihydrofolate reductase

Breton Roussel, Nadine Johnson-Farley, John E. Kerrigan, Kathleen W. Scotto, Debabrata Banerjee, Krzysztof Felczak, Krzysztof W. Pankiewicz, Murugesan Gounder, HongXia Lin, Emine Ercikan Abali, Joseph R. Bertino

Cancer Biol Ther. 2012 Nov 1; 13(13): 1290–1298. doi: 10.4161/cbt.21786

PMCID:: PMC3493437

Abstract Article PDF–1.2M

Select item 303570716.

Identification and Characterization of an Inborn Error of Metabolism Caused by Dihydrofolate Reductase Deficiency

Siddharth Banka, Henk J. Blom, John Walter, Majid Aziz, Jill Urquhart, Christopher M. Clouthier, Gillian I. Rice, Arjan P.M. de Brouwer, Emma Hilton, Grace Vassallo, Andrew Will, Desirée E.C. Smith, Yvo M. Smulders, Ron A. Wevers, Robert Steinfeld, Simon Heales, Yanick J. Crow, Joelle N. Pelletier, Simon Jones, William G. Newman

Am J Hum Genet. 2011 Feb 11; 88(2): 216–225. doi: 10.1016/j.ajhg.2011.01.004