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Select item 68888431.

E3 ubiquitin ligase Nedd4 is a key negative regulator for non-canonical inflammasome activation

Qingjun Liu, Shihui Zhang, Zhongjie Sun, Xiao Guo, Hong Zhou

Cell Death Differ. 2019 Nov; 26(11): 2386–2399. Published online 2019 Feb 28. doi: 10.1038/s41418-019-0308-7

PMCID:: PMC6888843

Abstract Article PDF–2.8M

Select item 34822202.

The Ubiquitin Ligase Nedd4-1 Participates in Denervation-Induced Skeletal Muscle Atrophy in Mice

Preena Nagpal, Pamela J. Plant, Judy Correa, Alexandra Bain, Michiko Takeda, Hiroshi Kawabe, Daniela Rotin, James R. Bain, Jane A. E. Batt

PLoS One. 2012; 7(10): e46427. Published online 2012 Oct 26. doi: 10.1371/journal.pone.0046427

PMCID:: PMC3482220

Abstract Article PDF–1.3M

Select item 12232513.

Regulation of the epithelial sodium channel by accessory proteins.

Kelly Gormley, Yanbin Dong, Giuseppe A Sagnella

Biochem J. 2003 Apr 1; 371(Pt 1): 1–14. doi: 10.1042/BJ20021375

PMCID:: PMC1223251

Summary PDF–383K

Select item 111865774.

The Role of Ubiquitination and the E3 Ligase Nedd4 in Regulating Corneal Epithelial Wound Healing

Xuemei Ling, Weiwei Xu, Jingjing Tang, Qiongjie Cao, Guangying Luo, Xiaoyan Chen, Shuai Yang, Peter Sol Reinach, Dongsheng Yan

Invest Ophthalmol Vis Sci. 2024 Jun; 65(6): 29. Published online 2024 Jun 18. doi: 10.1167/iovs.65.6.29

PMCID:: PMC11186577

Abstract Article PDF–9.4M

Select item 72445635.

Dietary sodium modulates nephropathy in Nedd4-2-deficient mice

Jantina A. Manning, Sonia S. Shah, Tanya L. Henshall, Andrej Nikolic, John Finnie, Sharad Kumar

Cell Death Differ. 2020 Jun; 27(6): 1832–1843. Published online 2019 Dec 4. doi: 10.1038/s41418-019-0468-5

PMCID:: PMC7244563

Abstract Article PDF–3.9M

Select item 33878156.

E3 Ubiquitin Ligase Cbl-b Regulates Pten via Nedd4 in T Cells Independently of Its Ubiquitin Ligase Activity

Hui Guo, Guilin Qiao, Haiyan Ying, Zhenping Li, Yixia Zhao, Yanran Liang, Lifen Yang, Stanley Lipkowitz, Josef M. Penninger, Wallace Y. Langdon, Jian Zhang

Cell Rep. Author manuscript; available in PMC 2012 Jul 2.

Published in final edited form as: Cell Rep. 2012 May 17; 1(5): 472–482. doi: 10.1016/j.celrep.2012.04.008

PMCID:: PMC3387815

Abstract Article PDF–4.4M

Select item 30590387.

Neuronal Precursor Cell-expressed Developmentally Down-regulated 4-1 (NEDD4-1) Controls the Sorting of Newly Synthesized Ca_V1.2 Calcium Channels

Jean-Sebastien Rougier, Maxime Albesa, Hugues Abriel, Patricia Viard

J Biol Chem. 2011 Mar 18; 286(11): 8829–8838. Published online 2011 Jan 10. doi: 10.1074/jbc.M110.166520

PMCID:: PMC3059038

Abstract Article PDF–1.6M

Select item 100532658.

MicroRNA‐155‐5p in serum derived‐exosomes promotes ischaemia–reperfusion injury by reducing CypD ubiquitination by NEDD4

Chenkai Hu, Junyu Liao, Ruiyan Huang, Qiang Su, Lei He

ESC Heart Fail. 2023 Apr; 10(2): 1144–1157. Published online 2023 Jan 11. doi: 10.1002/ehf2.14279

PMCID:: PMC10053265

Abstract Article PDF–2.3M

Select item 99993029.

Celastrol targeting Nedd4 reduces Nrf2-mediated oxidative stress in astrocytes after ischemic stroke

Zexuan Hong, Jun Cao, Dandan Liu, Maozhu Liu, Mengyuan Chen, Fanning Zeng, Zaisheng Qin, Jigang Wang, Tao Tao

J Pharm Anal. 2023 Feb; 13(2): 156–169. Published online 2023 Jan 7. doi: 10.1016/j.jpha.2022.12.002

PMCID:: PMC9999302

Abstract Article PDF–5.5M

Select item 812406610.

Beraprost ameliorates postmenopausal osteoporosis by regulating Nedd4-induced Runx2 ubiquitination

Huo-Liang Zheng, Wen-Ning Xu, Wen-Sheng Zhou, Run-Ze Yang, Peng-Bo Chen, Tao Liu, Lei-Sheng Jiang, Sheng-Dan Jiang

Cell Death Dis. 2021 May; 12(5): 497. Published online 2021 May 15. doi: 10.1038/s41419-021-03784-8

PMCID:: PMC8124066

Abstract Article PDF–4.3M

Select item 746205711.

The Daam2–VHL–Nedd4 axis governs developmental and regenerative oligodendrocyte differentiation

Xiaoyun Ding, Juyeon Jo, Chih-Yen Wang, Carlo D. Cristobal, Zhongyuan Zuo, Qi Ye, Marvin Wirianto, Aaron Lindeke-Myers, Jong Min Choi, Carrie A. Mohila, Hiroshi Kawabe, Sung Yun Jung, Hugo J. Bellen, Seung-Hee Yoo, Hyun Kyoung Lee

Genes Dev. 2020 Sep 1; 34(17-18): 1177–1189. doi: 10.1101/gad.338046.120

PMCID:: PMC7462057

Abstract Article PDF–49M

Select item 549418312.

NEDD4 controls spermatogonial stem cell homeostasis and stress response by regulating messenger ribonucleoprotein complexes

Zhi Zhou, Hiroshi Kawabe, Atsushi Suzuki, Kaori Shinmyozu, Yumiko Saga

Nat Commun. 2017; 8: 15662. Published online 2017 Jun 6. doi: 10.1038/ncomms15662

PMCID:: PMC5494183

Abstract Article PDF–4.3M

Select item 426109213.

Synaptic Strength Is Bidirectionally Controlled by Opposing Activity-Dependent Regulation of Nedd4-1 and USP8

Samantha L. Scudder, Marisa S. Goo, Anna E. Cartier, Alice Molteni, Lindsay A. Schwarz, Rebecca Wright, Gentry N. Patrick

J Neurosci. 2014 Dec 10; 34(50): 16637–16649. doi: 10.1523/JNEUROSCI.2452-14.2014

PMCID:: PMC4261092

Abstract Article PDF–3.6M

Select item 368129014.

Upregulation of the E3 ligase NEDD4-1 by Oxidative Stress Degrades IGF-1 Receptor Protein in Neurodegeneration

Young-Don Kwak, Bin Wang, Jing Jing Li, Ruishan Wang, Qiyue Deng, Shiyong Diao, Yaomin Chen, Raymond Xu, Eliezer Masliah, Huaxi Xu, Jung-Joon Sung, Francesca-Fang Liao

J Neurosci. 2012 Aug 8; 32(32): 10971–10981. doi: 10.1523/JNEUROSCI.1836-12.2012

PMCID:: PMC3681290

Abstract Article PDF–1.7M

Select item 300993815.

Structural Basis for the Interaction between the Growth Factor-binding Protein GRB10 and the E3 Ubiquitin Ligase NEDD4

Qingqiu Huang, Doletha M. E. Szebenyi

J Biol Chem. 2010 Dec 31; 285(53): 42130–42139. Published online 2010 Oct 26. doi: 10.1074/jbc.M110.143412

PMCID:: PMC3009938

Abstract Article PDF–2.6M

Select item 283336216.

Nedd4 Controls Animal Growth by Regulating IGF-1 Signaling

Xiao R. Cao, Nancy L. Lill, Natasha Boase, Peijun P. Shi, David R. Croucher, Hongbo Shan, Jing Qu, Eileen M. Sweezer, Trenton Place, Patricia A. Kirby, Roger J. Daly, Sharad Kumar, Baoli Yang

Sci Signal. Author manuscript; available in PMC 2010 Mar 8.

Published in final edited form as: Sci Signal. 2008 Sep 23; 1(38): ra5. Published online 2008 Sep 23. doi: 10.1126/scisignal.1160940

PMCID:: PMC2833362

Abstract Article PDF–4.4M

Select item 282298017.

Nedd4-2–Mediated Ubiquitination Facilitates Processing of Surfactant Protein–C

Juliana J. Conkright, Karen S. Apsley, Emily P. Martin, Ross Ridsdale, Ward R. Rice, Cheng-Lun Na, Baoli Yang, Timothy E. Weaver

Am J Respir Cell Mol Biol. 2010 Feb; 42(2): 181–189. Published online 2009 May 7. doi: 10.1165/rcmb.2009-0058OC

PMCID:: PMC2822980

Abstract Article PDF–915K

Select item 279791718.

Tetracycline Treatment Retards the Onset and Slows the Progression of Diabetes in Human Amylin/Islet Amyloid Polypeptide Transgenic Mice

Jacqueline F. Aitken, Kerry M. Loomes, David W. Scott, Shivanand Reddy, Anthony R.J. Phillips, Gordana Prijic, Chathurini Fernando, Shaoping Zhang, Ric Broadhurst, Phil L'Huillier, Garth J.S. Cooper

Diabetes. 2010 Jan; 59(1): 161–171. Published online 2009 Sep 30. doi: 10.2337/db09-0548