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Select item 112322841.

New mechanistic understanding of osteoclast differentiation and bone resorption mediated by P2X7 receptors and PI3K-Akt-GSK3β signaling

Jiajia Lu, Xiaojian Shi, Qiang Fu, Yaguang Han, Lei Zhu, Zhibin Zhou, Yongchuan Li, Nan Lu

Cell Mol Biol Lett. 2024; 29: 100. Published online 2024 Jul 8. doi: 10.1186/s11658-024-00614-5

PMCID:: PMC11232284

Abstract Article PDF–2.7M

Select item 110704682.

The purinergic receptor P2X7 as a modulator of viral vector-mediated antigen cross-presentation

Ylenia Longo, Sara Moreno Mascaraque, Giuseppe Andreacchio, Julia Werner, Ichiro Katahira, Elena De Marchi, Anna Pegoraro, Robert Jan Lebbink, Karl Köhrer, Patrick Petzsch, Ronny Tao, Francesco Di Virgilio, Elena Adinolfi, Ingo Drexler

Front Immunol. 2024; 15: 1360140. Published online 2024 Apr 22. doi: 10.3389/fimmu.2024.1360140

PMCID:: PMC11070468

Abstract Article PDF–3.0M

Select item 104628283.

P2X7 purinergic receptor modulates dentate gyrus excitatory neurotransmission and alleviates schizophrenia-like symptoms in mouse

Lumei Huang, Paula Mut-Arbona, Bernadett Varga, Bibiana Török, János Brunner, Antonia Arszovszki, András Iring, Máté Kisfali, E. Sylvester Vizi, Beáta Sperlágh

iScience. 2023 Sep 15; 26(9): 107560. Published online 2023 Aug 7. doi: 10.1016/j.isci.2023.107560

PMCID:: PMC10462828

Abstract Article PDF–7.4M

Select item 102456104.

P2X7 receptor inhibition ameliorates ubiquitin–proteasome system dysfunction associated with Alzheimer’s disease

Carolina Bianchi, Beatriz Alvarez-Castelao, Álvaro Sebastián-Serrano, Caterina Di Lauro, Lucia Soria-Tobar, Annette Nicke, Tobias Engel, Miguel Díaz-Hernández

Alzheimers Res Ther. 2023; 15: 105. Published online 2023 Jun 7. doi: 10.1186/s13195-023-01258-x

PMCID:: PMC10245610

Abstract Article PDF–10M

Select item 102358575.

Upregulation of P2X7 Exacerbates Myocardial Ischemia–Reperfusion Injury through Enhancing Inflammation and Apoptosis in Diabetic Mice

Fancan Wu, Hong Wei, Yingxin Hu, Jiahong Gao, Shiyuan Xu

J Immunol. 2023 Jun 15; 210(12): 1962–1973. Published online 2023 May 5. doi: 10.4049/jimmunol.2200838

PMCID:: PMC10235857

Abstract Article PDF–4.7M

Select item 101606266.

P2X7 receptor contributes to long-term neuroinflammation and cognitive impairment in sepsis-surviving mice

Vinícius Santos Alves, Joyce Pereira da Silva, Fabiana Cristina Rodrigues, Suzana Maria Bernardino Araújo, André Luiz Gouvêa, Raíssa Leite-Aguiar, Stephanie Alexia Cristina Silva Santos, Milla Souza Pessoa da Silva, Fernanda Silva Ferreira, Eduardo Peil Marques, Beatriz Amanda Barbosa Rangel dos Passos, Tatiana Maron-Gutierrez, Eleonora Kurtenbach, Robson da Costa, Cláudia Pinto Figueiredo, Angela T. S. Wyse, Robson Coutinho-Silva, Luiz Eduardo Baggio Savio

Front Pharmacol. 2023; 14: 1179723. Published online 2023 Apr 21. doi: 10.3389/fphar.2023.1179723

PMCID:: PMC10160626

Abstract Article PDF–1.8M

Select item 101080157.

Increased uptake of the P2X7 receptor radiotracer ¹⁸F‐JNJ‐64413739 in the brain and peripheral organs according to the severity of status epilepticus in male mice

James Morgan, Oscar Moreno, Mariana Alves, Zuriñe Baz, Aida Menéndez Méndez, Hanna Leister, Ciara Melia, Jonathon Smith, Alexander Visekruna, Annette Nicke, Anindya Bhattacharya, Marc Ceusters, David C. Henshall, Vanessa Gómez‐Vallejo, Jordi Llop, Tobias Engel

Epilepsia. 2023 Feb; 64(2): 511–523. Published online 2022 Dec 27. doi: 10.1111/epi.17484

PMCID:: PMC10108015

Abstract Article PDF–4.2M

Select item 99627798.

Dual Role of the P2X7 Receptor in Dendritic Outgrowth during Physiological and Pathological Brain Development

Paula Mut-Arbona, Lumei Huang, Mária Baranyi, Pál Tod, András Iring, Francesco Calzaferri, Cristobal de los Ríos, Beáta Sperlágh

J Neurosci. 2023 Feb 15; 43(7): 1125–1142. doi: 10.1523/JNEUROSCI.0805-22.2022

PMCID:: PMC9962779

Abstract Article PDF–4.0M

Select item 98321819.

P2X7 receptor activation mediates superoxide dismutase 1 (SOD1) release from murine NSC-34 motor neurons

Rachael Bartlett, Diane Ly, Neil R. Cashman, Ronald Sluyter, Justin J. Yerbury

Purinergic Signal. 2022 Dec; 18(4): 451–467. Published online 2022 Apr 28. doi: 10.1007/s11302-022-09863-5

PMCID:: PMC9832181

Abstract Article PDF–4.4M

Select item 935548010.

ATP indirectly stimulates hippocampal CA1 and CA3 pyramidal neurons via the activation of neighboring P2X7 receptor-bearing astrocytes and NG2 glial cells, respectively

Ying Zhang, Hai-Yan Yin, Patrizia Rubini, Peter Illes, Yong Tang

Front Pharmacol. 2022; 13: 944541. Published online 2022 Jul 22. doi: 10.3389/fphar.2022.944541

PMCID:: PMC9355480

Abstract Article PDF–3.1M

Select item 925064111.

P2RX7 enhances tumor control by CD8⁺ T cells in adoptive cell therapy

Kelsey M. Wanhainen, Changwei Peng, Maggie H. Zhou, Bruna de Gois Macedo, Stephen O’Flanagan, Tingyuan Yang, Ameeta Kelekar, Brandon J. Burbach, Henrique Borges da Silva, Stephen C. Jameson

Cancer Immunol Res. Author manuscript; available in PMC 2023 Jan 1.

Published in final edited form as: Cancer Immunol Res. 2022 Jul 1; 10(7): 871–884. doi: 10.1158/2326-6066.CIR-21-0691

PMCID:: PMC9250641

Abstract Article PDF–2.2M

Select item 909955112.

The P2X7 Receptor Promotes Colorectal Inflammation and Tumorigenesis by Modulating Gut Microbiota and the Inflammasome

Claudio Bernardazzi, Morgana Teixeira Lima Castelo-Branco, Beatriz Pêgo, Beatriz Elias Ribeiro, Siane Lopes Bittencourt Rosas, Patrícia Teixeira Santana, João Carlos Machado, Camille Leal, Fabiano Thompson, Robson Coutinho-Silva, Heitor Siffert Pereira de Souza

Int J Mol Sci. 2022 May; 23(9): 4616. Published online 2022 Apr 21. doi: 10.3390/ijms23094616

PMCID:: PMC9099551

Abstract Article PDF–4.5M

Select item 909763213.

Medullary astrocytes mediate irregular breathing patterns generation in chronic heart failure through purinergic P2X7 receptor signalling

Camilo Toledo, Esteban Díaz-Jara, Hugo S. Diaz, Karla G. Schwarz, Katherin V. Pereyra, Alexandra Las Heras, Angélica Rios-Gallardo, David C. Andrade, Thiago Moreira, Ana Takakura, Noah J. Marcus, Rodrigo Del Rio

eBioMedicine. 2022 Jun; 80: 104044. Published online 2022 May 9. doi: 10.1016/j.ebiom.2022.104044

PMCID:: PMC9097632

Abstract Article PDF–4.1M

Select item 901800914.

Parental obesity alters offspring blood pressure regulation and cardiovascular responses to stress: role of P2X7R and sex differences

Alexandre A. da Silva, Sydney P. Moak, Xuemei Dai, Gisele C. Borges, Ana C. M. Omoto, Zhen Wang, Xuan Li, Alan J. Mouton, John E. Hall, Jussara M. do Carmo

Am J Physiol Regul Integr Comp Physiol. 2022 May 1; 322(5): R421–R433. Published online 2022 Mar 23. doi: 10.1152/ajpregu.00300.2021

PMCID:: PMC9018009

Abstract Article

Select item 897673915.

The Extracellular ATP Receptor P2RX7 Imprints a Promemory Transcriptional Signature in Effector CD8⁺ T Cells

Trupti Vardam-Kaur, Sarah van Dijk, Changwei Peng, Kelsey M. Wanhainen, Stephen C. Jameson, Henrique Borges da Silva

J Immunol. 2022 Apr 1; 208(7): 1686–1699. Published online 2022 Apr 1. doi: 10.4049/jimmunol.2100555

PMCID:: PMC8976739

Abstract Article PDF–2.9M

Select item 878877816.

Mitochondrial P2X7 Receptor Localization Modulates Energy Metabolism Enhancing Physical Performance

Alba Clara Sarti, Valentina Vultaggio-Poma, Simonetta Falzoni, Sonia Missiroli, Anna Lisa Giuliani, Paola Boldrini, Massimo Bonora, Francesco Faita, Nicole Di Lascio, Claudia Kusmic, Anna Solini, Salvatore Novello, Michele Morari, Marco Rossato, Mariusz R Wieckowski, Carlotta Giorgi, Paolo Pinton, Francesco Di Virgilio

Function (Oxf) 2021; 2(2): zqab005. Published online 2021 Jan 28. doi: 10.1093/function/zqab005

Correction in:: Function (Oxf). 2021; 2(4): zqab025.

PMCID:: PMC8788778

Abstract Article PDF–1.1M

Select item 869542117.

Contingent intramuscular boosting of P2XR7 axis improves motor function in transgenic ALS mice

Paola Fabbrizio, Jessica D’Agostino, Cassandra Margotta, Giulia Mella, Nicolò Panini, Laura Pasetto, Eliana Sammali, Flavia Raggi, Gianni Sorarù, Valentina Bonetto, Caterina Bendotti, Giovanni Nardo

Cell Mol Life Sci. 2022 Jan; 79(1): 7. Published online 2021 Dec 22. doi: 10.1007/s00018-021-04070-8

PMCID:: PMC8695421

Abstract Article PDF–13M

Select item 867194718.

P2X7 receptor is essential for cross-dressing of bone marrow-derived dendritic cells

Carlos Barrera-Avalos, Pedro Briceño, Daniel Valdés, Mónica Imarai, Elías Leiva-Salcedo, Leonel E. Rojo, Luis A. Milla, Juan Pablo Huidobro-Toro, Claudia Robles-Planells, Alejandro Escobar, Francesco Di Virgilio, Gabriel Morón, Daniela Sauma, Claudio Acuña-Castillo

iScience. 2021 Dec 17; 24(12): 103520. Published online 2021 Nov 26. doi: 10.1016/j.isci.2021.103520

PMCID:: PMC8671947

Abstract Article PDF–4.1M

Select item 809110119.

Purinergic P2X7 Receptor Mediates the Elimination of Trichinella spiralis by Activating NF-κB/NLRP3/IL-1β Pathway in Macrophages

Fei Guan, Wangfang Jiang, Yang Bai, Xiao Hou, Chunjie Jiang, Chongyang Zhang, Muziazia Lupemba Jacques, Wenqi Liu, Jiahui Lei

Infect Immun. 2021 May; 89(5): e00683-20. Prepublished online 2021 Feb 8. Published online 2021 Apr 16. doi: 10.1128/IAI.00683-20

PMCID:: PMC8091101

Abstract Article PDF–1.7M

Select item 801873620.

Functional P2X₇ Receptors in the Auditory Nerve of Hearing Rodents Localize Exclusively to Peripheral Glia

Silvia Prades, Gregory Heard, Jonathan E. Gale, Tobias Engel, Robin Kopp, Annette Nicke, Katie E. Smith, Daniel J. Jagger

J Neurosci. 2021 Mar 24; 41(12): 2615–2629. doi: 10.1523/JNEUROSCI.2240-20.2021

PMCID:: PMC8018736

Abstract Article PDF–6.5M

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PMC Links for Gene (Select 18439) (357)
PMC
CUGBP Elav-like family member 4 isoform 24 [Homo sapiens]
CUGBP Elav-like family member 4 isoform 24 [Homo sapiens]
gi|1219184946|ref|NP_001340673.1|

Protein
Mus musculus purinergic receptor P2X, ligand-gated ion channel, 7 (P2rx7), trans...
Mus musculus purinergic receptor P2X, ligand-gated ion channel, 7 (P2rx7), transcript variant 3, mRNA
gi|1686254412|ref|NM_001038839.3|

Nucleotide
Austraeolis stearnsi
Austraeolis stearnsi
Austraeolis stearnsi Transcriptome or Gene expression

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