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Select item 100820141.

DUSP6 is a memory retention feedback regulator of ERK signaling for cellular resilience of human pluripotent stem cells in response to dissociation

Dae Hoon Yoo, Young Sam Im, Ji Young Oh, Dayeon Gil, Yong-Ou Kim

Sci Rep. 2023; 13: 5683. Published online 2023 Apr 7. doi: 10.1038/s41598-023-32567-8

PMCID:: PMC10082014

Abstract Article PDF–8.2M

Select item 83941672.

Single nucleotide polymorphisms in the dual specificity phosphatase genes and risk of necrotizing enterocolitis in premature infant

M.M. Talavera, Y. Jin, E.J. Zmuda, J. Frick, Y. Liu, K.L. McBride, L.D. Nelin, J.K. Trittmann

J Neonatal Perinatal Med. Author manuscript; available in PMC 2021 Aug 27.

Published in final edited form as: J Neonatal Perinatal Med. 2020; 13(3): 373–380. doi: 10.3233/NPM-190302

PMCID:: PMC8394167

Abstract Article PDF–369K

Select item 74963763.

Dual‐specificity phosphatase 6 plays a critical role in the maintenance of a cancer stem‐like cell phenotype in human endometrial cancer

Masaya Kato, Ichiro Onoyama, Sachiko Yoshida, Lin Cui, Keiko Kawamura, Keisuke Kodama, Emiko Hori, Yumiko Matsumura, Hiroshi Yagi, Kazuo Asanoma, Hideaki Yahata, Atsuo Itakura, Satoru Takeda, Kiyoko Kato

Int J Cancer. 2020 Oct 1; 147(7): 1987–1999. Published online 2020 Mar 26. doi: 10.1002/ijc.32965

PMCID:: PMC7496376

Abstract Article PDF–2.6M

Select item 74146954.

Dual-specificity phosphatase (DUSP6) in human glioblastoma: epithelial-to-mesenchymal transition (EMT) involvement

Candida Zuchegna, Erika Di Zazzo, Bruno Moncharmont, Samantha Messina

BMC Res Notes. 2020; 13: 374. Published online 2020 Aug 8. doi: 10.1186/s13104-020-05214-y

PMCID:: PMC7414695

Abstract Article PDF–1.7M

Select item 66276305.

Nuclear-Biased DUSP6 Expression is Associated with Cancer Spreading Including Brain Metastasis in Triple-Negative Breast Cancer

Fan Wu, Robert D. McCuaig, Christopher R. Sutton, Abel H. Y. Tan, Yoshni Jeelall, Elaine G. Bean, Jin Dai, Thiru Prasanna, Jacob Batham, Laeeq Malik, Desmond Yip, Jane E. Dahlstrom, Sudha Rao

Int J Mol Sci. 2019 Jun; 20(12): 3080. Published online 2019 Jun 24. doi: 10.3390/ijms20123080

PMCID:: PMC6627630

Abstract Article PDF–2.7M

Select item 65145846.

Role of Dusp6 Phosphatase as a Tumor Suppressor in Non-Small Cell Lung Cancer

Verónica Moncho-Amor, Laura Pintado-Berninches, Inmaculada Ibañez de Cáceres, Ester Martín-Villar, Miguel Quintanilla, Probir Chakravarty, María Cortes-Sempere, Beatriz Fernández-Varas, Carlos Rodriguez-Antolín, Javier de Castro, Leandro Sastre, Rosario Perona

Int J Mol Sci. 2019 Apr; 20(8): 2036. Published online 2019 Apr 25. doi: 10.3390/ijms20082036

PMCID:: PMC6514584

Abstract Article PDF–2.6M

Select item 63159167.

Dual Specificity Phosphatase 6 Protects Neural Stem Cells from β-Amyloid-Induced Cytotoxicity through ERK1/2 Inactivation

Wang Liao, Yuqiu Zheng, Wenli Fang, Shaowei Liao, Ying Xiong, Yi Li, Songhua Xiao, Xingcai Zhang, Jun Liu

Biomolecules. 2018 Dec; 8(4): 181. Published online 2018 Dec 19. doi: 10.3390/biom8040181

PMCID:: PMC6315916

Abstract Article PDF–1.6M

Select item 54103428.

Systematic screening of isogenic cancer cells identifies DUSP6 as context-specific synthetic lethal target in melanoma

Stephanie Wittig-Blaich, Rainer Wittig, Steffen Schmidt, Stefan Lyer, Melanie Bewerunge-Hudler, Sabine Gronert-Sum, Olga Strobel-Freidekind, Carolin Müller, Markus List, Aleksandra Jaskot, Helle Christiansen, Mathias Hafner, Dirk Schadendorf, Ines Block, Jan Mollenhauer

Oncotarget. 2017 Apr 4; 8(14): 23760–23774. Published online 2017 Mar 2. doi: 10.18632/oncotarget.15863

PMCID:: PMC5410342

Abstract Article PDF–8.0M

Select item 29393039.

Infrequent methylation of the DUSP6 phosphatase in endometrial cancer

Katherine B. Chiappinelli, B. J. Rimel, L. Stewart Massad, Paul J. Goodfellow

Gynecol Oncol. Author manuscript; available in PMC 2011 Oct 1.

Published in final edited form as: Gynecol Oncol. 2010 Oct; 119(1): 146–150. Published online 2010 Jul 16. doi: 10.1016/j.ygyno.2010.06.015

PMCID:: PMC2939303

Abstract Article PDF–576K

Select item 271698110.

Down-Regulation of DUSP6 Expression in Lung Cancer —Its Mechanism and Potential Role in Carcinogenesis

Koji Okudela, Takuya Yazawa, Tetsukan Woo, Masashi Sakaeda, Jun Ishii, Hideaki Mitsui, Hiroaki Shimoyamada, Hanako Sato, Michihiko Tajiri, Nobuo Ogawa, Munetaka Masuda, Takashi Takahashi, Haruhiko Sugimura, Hitoshi Kitamura

Am J Pathol. 2009 Aug; 175(2): 867–881. doi: 10.2353/ajpath.2009.080489

PMCID:: PMC2716981

Abstract Article PDF–1.7M

Select item 266140911.

Inhibition of Mitogen-activated Protein Kinase Phosphatase 3 Activity by Interdomain Binding

John K. Mark, Rémy A. Aubin, Sophie Smith, Mary Alice Hefford

J Biol Chem. 2008 Oct 17; 283(42): 28574–28583. doi: 10.1074/jbc.M801747200

PMCID:: PMC2661409

Abstract Article PDF–719K

Select item 186813112.

Potential Tumor Suppressive Pathway Involving DUSP6/MKP-3 in Pancreatic Cancer

Toru Furukawa, Makoto Sunamura, Fuyuhiko Motoi, Seiki Matsuno, Akira Horii

Am J Pathol. 2003 Jun; 162(6): 1807–1815. doi: 10.1016/S0002-9440(10)64315-5

PMCID:: PMC1868131

Abstract Article PDF–924K

Select item 900459213.

MicroRNA-211 modulates the DUSP6-ERK5 signaling axis to promote BRAF^V600E-driven melanoma growth in vivo and BRAF/MEK inhibitor resistance

Bongyong Lee, Anupama Sahoo, Junko Sawada, John Marchica, Sanjay Sahoo, Fabiana I. A. L. Layng, Darren Finlay, Joseph Mazar, Piyush Joshi, Masanobu Komatsu, Kristiina Vuori, Petrus R. de Jong, Animesh Ray, Ranjan J. Perera

J Invest Dermatol. Author manuscript; available in PMC 2022 Apr 12.

Published in final edited form as: J Invest Dermatol. 2021 Feb; 141(2): 385–394. Published online 2020 Sep 2. doi: 10.1016/j.jid.2020.06.038

PMCID:: PMC9004592

Abstract Article PDF–1.8M

Select item 897377114.

microRNA-211-5p predicts the progression of postmenopausal osteoporosis and attenuates osteogenesis by targeting dual specific phosphatase 6

Huan Wang, Xiaoyan Shi, Zhenye Guo, Feng Zhao, Weifu He, Mingming Kang, Zhi Lv

Bioengineered. 2022; 13(3): 5709–5723. Published online 2022 Feb 21. doi: 10.1080/21655979.2021.2017626

PMCID:: PMC8973771

Abstract Article PDF–3.3M

Select item 857722415.

Loss of FBXO31-mediated degradation of DUSP6 dysregulates ERK and PI3K-AKT signaling and promotes prostate tumorigenesis

Shanshan Duan, Loredana Moro, Rui Qu, Daniele Simoneschi, Hyunwoo Cho, Shaowen Jiang, Huiyong Zhao, Qing Chang, Elisa de Stanchina, Arnaldo A. Arbini, Michele Pagano

Cell Rep. Author manuscript; available in PMC 2021 Nov 9.

Published in final edited form as: Cell Rep. 2021 Oct 19; 37(3): 109870. doi: 10.1016/j.celrep.2021.109870

PMCID:: PMC8577224

Abstract Article PDF–1.3M

Select item 818350916.

Tripartite motif protein 11 (TRIM11), an oncogene for human lung cancer via the DUSP6-mediated ERK1/2 signaling pathway

Xiao-Lin Wang, Shi-Chun Lu, Chao Sun, Wei-Guo Jin, Yi-Wei Fan, Yu-Sheng Shu, Hong-Can Shi, Ling-Feng Min

Cancer Biol Ther. 2021; 22(4): 324–332. Published online 2021 May 10. doi: 10.1080/15384047.2021.1902912

PMCID:: PMC8183509

Abstract Article PDF–3.1M

Select item 729745517.

Knockdown of TRIM37 Promotes Apoptosis and Suppresses Tumor Growth in Gastric Cancer by Inactivation of the ERK1/2 Pathway

Hongyi Zhu, Yuanwen Chen, Jie Zhang, Changlin Qian, Weiqing Qiu, Huojian Shen, Zhiyong Shen

Onco Targets Ther. 2020; 13: 5479–5491. Published online 2020 Jun 12. doi: 10.2147/OTT.S233906

PMCID:: PMC7297455

Abstract Article PDF–7.6M

Select item 694833118.

Tripartite Motif Containing 11 Interacts with DUSP6 to Promote the Growth of Human Osteosarcoma Cells through Regulating ERK1/2 Pathway

Zhaofeng Wang, Xiaobo Xu, Wenxiao Tang, Youcai Zhu, Jichao Hu, Xingen Zhang

Biomed Res Int. 2019; 2019: 9612125. Published online 2019 Dec 25. doi: 10.1155/2019/9612125

PMCID:: PMC6948331

Abstract Article PDF–2.3M

Select item 650397019.

A Two-Gene Prognostic Classifier for Early-Stage Lung Squamous Cell Carcinoma in Multiple Large-Scale and Geographically Diverse Cohorts

Rintaro Noro, Teruhide Ishigame, Naomi Walsh, Kouya Shiraishi, Ana I. Robles, Bríd M. Ryan, Aaron J. Schetter, Elise D. Bowman, Judith A. Welsh, Masahiro Seike, Akihiko Gemma, Vidar Skaug, Steen Mollerup, Aage Haugen, Jun Yokota, Takashi Kohno, Curtis C. Harris

J Thorac Oncol. Author manuscript; available in PMC 2019 May 7.

Published in final edited form as: J Thorac Oncol. 2017 Jan; 12(1): 65–76. Published online 2016 Sep 6. doi: 10.1016/j.jtho.2016.08.141

PMCID:: PMC6503970

Abstract Article PDF–489K

Select item 564193920.

Dual specificity phosphatase 5 and 6 are oppositely regulated in human skeletal muscle by acute exercise

Shirin Pourteymour, Marit Hjorth, Sindre Lee, Torgeir Holen, Torgrim M. Langleite, Jørgen Jensen, Kåre I. Birkeland, Christian A. Drevon, Kristin Eckardt

Physiol Rep. 2017 Oct; 5(19): e13459. Published online 2017 Oct 9. doi: 10.14814/phy2.13459

PMCID:: PMC5641939

Abstract Article PDF–899K

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