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Items: 1 to 20 of 25

1.
PI5P4Kα supports prostate cancer metabolism and exposes a survival vulnerability during androgen receptor inhibition
Joanna Triscott, Matthias Reist, Lukas Küng, Francielle C. Moselle, Marika Lehner, John Gallon, Archna Ravi, Gurpreet K. Arora, Simone de Brot, Mark Lundquist, Hector Gallart-Ayala, Julijana Ivanisevic, Salvatore Piscuoglio, Lewis C. Cantley, Brooke M. Emerling, Mark A. Rubin
Sci Adv. 2023 Feb; 9(5): eade8641. Published online 2023 Feb 1. doi: 10.1126/sciadv.ade8641
PMCID:
PMC9891700
AbstractArticlePDF–2.1M
2.
Phosphatidylinositol-5-phosphate 4-kinases regulate cellular lipid metabolism by facilitating autophagy
Mark R. Lundquist, Marcus D. Goncalves, Ryan M. Loughran, Elite Possik, Tarika Vijayaraghavan, Annan Yang, Chantal Pauli, Archna Ravi, Akanksha Verma, Zhiwei Yang, Jared L. Johnson, Jenny C.Y. Wong, Yilun Ma, Katie Seo-Kyoung Hwang, David Weinkove, Nullin Divecha, John M. Asara, Olivier Elemento, Mark A. Rubin, Alec C. Kimmelman, Arnim Pause, Lewis C. Cantley, Brooke M. Emerling
Mol Cell. Author manuscript; available in PMC 2019 May 3.
Published in final edited form as: Mol Cell. 2018 May 3; 70(3): 531–544.e9. doi: 10.1016/j.molcel.2018.03.037
PMCID:
PMC5991623
AbstractArticlePDF–1.3M
3.
A targeted knockdown screen of genes coding for phosphoinositide modulators identifies PIP4K2A as required for acute myeloid leukemia cell proliferation and survival
Julian G Jude, Gary J Spencer, Xu Huang, Tim D D Somerville, David R Jones, Nullin Divecha, Tim C P Somervaille
Oncogene. Author manuscript; available in PMC 2015 Sep 5.
Published in final edited form as: Oncogene. 2015 Mar 5; 34(10): 1253–1262. Published online 2014 Mar 31. doi: 10.1038/onc.2014.77
PMCID:
PMC4130659
AbstractArticlePDF–2.2M
4.
Characterization of the megakaryocyte demarcation membrane system and its role in thrombopoiesis
Harald Schulze, Manav Korpal, Jonathan Hurov, Sang-We Kim, Jinghang Zhang, Lewis C. Cantley, Thomas Graf, Ramesh A. Shivdasani
Blood. 2006 May 15; 107(10): 3868–3875. Prepublished online 2006 Jan 24. doi: 10.1182/blood-2005-07-2755
PMCID:
PMC1895279
AbstractArticle
5.
PI5P4Ks drive metabolic homeostasis through peroxisome-mitochondria interplay
Archna Ravi, Lavinia Palamiuc, Ryan M. Loughran, Joanna Triscott, Gurpreet K. Arora, Avi Kumar, Vivian Tieu, Chantal Pauli, Matthias Reist, Rachel J. Lew, Shauna L. Houlihan, Christof Fellmann, Christian Metallo, Mark A. Rubin, Brooke M. Emerling
Dev Cell. Author manuscript; available in PMC 2022 Jun 7.
Published in final edited form as: Dev Cell. 2021 Jun 7; 56(11): 1661–1676.e10. Published online 2021 May 12. doi: 10.1016/j.devcel.2021.04.019
PMCID:
PMC9012263
AbstractArticlePDF–3.0M
6.
Distribution and localization of phosphatidylinositol 5-phosphate, 4-kinase alpha and beta in the brain
Evan K. Noch, Isaiah Yim, Teresa A. Milner, Lewis C. Cantley
J Comp Neurol. Author manuscript; available in PMC 2022 Feb 1.
Published in final edited form as: J Comp Neurol. 2021 Feb; 529(2): 434–449. Published online 2020 Jun 26. doi: 10.1002/cne.24956
PMCID:
PMC7683367
AbstractArticlePDF–4.2M
7.
Depletion of a Putatively Druggable Class of Phosphatidylinositol Kinases Inhibits Growth of p53-Null Tumors
Brooke M. Emerling, Jonathan B. Hurov, George Poulogiannis, Kazumi S. Tsukazawa, Rayman Choo-Wing, Gerburg M. Wulf, Eric L. Bell, Hye-Seok Shim, Katja A. Lamia, Lucia E. Rameh, Gary Bellinger, Atsuo T. Sasaki, John M. Asara, Xin Yuan, Andrea Bullock, Gina M. DeNicola, Jiaxi Song, Victoria Brown, Sabina Signoretti, Lewis C. Cantley
Cell. Author manuscript; available in PMC 2014 Jun 25.
Published in final edited form as: Cell. 2013 Nov 7; 155(4): 844–857. doi: 10.1016/j.cell.2013.09.057
PMCID:
PMC4070383
AbstractArticlePDF–1.9M
8.
Phosphatidylinositol 5-phosphate 4-kinase (PIP4K) regulates TOR signaling and cell growth during Drosophila development
Amit Gupta, Sarah Toscano, Deepti Trivedi, David R. Jones, Swarna Mathre, Jonathan H. Clarke, Nullin Divecha, Padinjat Raghu
Proc Natl Acad Sci U S A. 2013 Apr 9; 110(15): 5963–5968. Published online 2013 Mar 25. doi: 10.1073/pnas.1219333110
PMCID:
PMC3625332
AbstractArticlePDF–679K
9.
Next-Generation Sequencing Identifies the Danforth's Short Tail Mouse Mutation as a Retrotransposon Insertion Affecting Ptf1a Expression
Christopher N. Vlangos, Amanda N. Siuniak, Dan Robinson, Arul M. Chinnaiyan, Robert H. Lyons, Jr, James D. Cavalcoli, Catherine E. Keegan
PLoS Genet. 2013 Feb; 9(2): e1003205. Published online 2013 Feb 21. doi: 10.1371/journal.pgen.1003205
PMCID:
PMC3578742
AbstractArticlePDF–492K
10.
A Retrotransposon Insertion in the 5′ Regulatory Domain of Ptf1a Results in Ectopic Gene Expression and Multiple Congenital Defects in Danforth's Short Tail Mouse
Francesca Lugani, Ripla Arora, Natalia Papeta, Ami Patel, Zongyu Zheng, Roel Sterken, Ruth A. Singer, Gianluca Caridi, Cathy Mendelsohn, Lori Sussel, Virginia E. Papaioannou, Ali G. Gharavi
PLoS Genet. 2013 Feb; 9(2): e1003206. Published online 2013 Feb 21. doi: 10.1371/journal.pgen.1003206
PMCID:
PMC3578747
AbstractArticlePDF–1.5M
11.
Phosphatidylinositol-4-Phosphate 5-Kinases and Phosphatidylinositol 4,5-Bisphosphate Synthesis in the Brain
Laura A. Volpicelli-Daley, Louise Lucast, Liang-Wei Gong, Lijuan Liu, Junko Sasaki, Takehiko Sasaki, Charles S. Abrams, Yasunori Kanaho, Pietro De Camilli
J Biol Chem. 2010 Sep 10; 285(37): 28708–28714. Published online 2010 Jul 9. doi: 10.1074/jbc.M110.132191
PMCID:
PMC2937898
AbstractArticlePDF–1.1M
12.
Insulin/IGF-1 Controls Epidermal Morphogenesis via Regulation of FoxO-Mediated p63 Inhibition
Christian Günschmann, Heike Stachelscheid, Mehmet Deniz Akyüz, Annika Schmitz, Caterina Missero, Jens C. Brüning, Carien M. Niessen
Dev Cell. 2013 Jul 29; 26(2): 176–187. doi: 10.1016/j.devcel.2013.05.017
PMCID:
PMC3730059
AbstractArticle
13.
Interaction of tau with the RNA-Binding Protein TIA1 Regulates tau Pathophysiology and Toxicity
Tara Vanderweyde, Daniel J. Apicco, Katherine Youmans-Kidder, Peter E.A. Ash, Casey Cook, Edroaldo Lummertz da Rocha, Karen Jansen-West, Alissa A. Frame, Allison Citro, John D. Leszyk, Pavel Ivanov, Jose F. Abisambra, Martin Steffen, Hu Li, Leonard Petrucelli, Benjamin Wolozin
Cell Rep. Author manuscript; available in PMC 2017 Feb 24.
Published in final edited form as: Cell Rep. 2016 May 17; 15(7): 1455–1466. Published online 2016 May 6. doi: 10.1016/j.celrep.2016.04.045
PMCID:
PMC5325702
AbstractArticlePDF–2.1M
14.
Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors
Hyeonwoo Kim, Christiane D. Wrann, Mark Jedrychowski, Sara Vidoni, Yukiko Kitase, Kenichi Nagano, Chenhe Zhou, Joshua Chou, Virginia-Jeni A. Parkman, Scott J. Novick, Timothy S. Strutzenberg, Bruce D. Pascal, Phuong T. Le, Daniel J. Brooks, Alexander M. Roche, Kaitlyn K. Gerber, Laura Mattheis, Wenjing Chen, Hua Tu, Mary L. Bouxsein, Patrick R. Griffin, Roland Baron, Clifford J. Rosen, Lynda F. Bonewald, Bruce M. Spiegelman
Cell. Author manuscript; available in PMC 2019 Dec 13.
Published in final edited form as: Cell. 2018 Dec 13; 175(7): 1756–1768.e17. doi: 10.1016/j.cell.2018.10.025
Correction in:
Cell. 2019 Jul 11; 178(2): 507–508.
PMCID:
PMC6298040
AbstractArticlePDF–1.2M
15.
BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING)
Kou Motani, Hidetaka Kosako
J Biol Chem. 2020 Aug 7; 295(32): 11174–11183. Published online 2020 Jun 17. doi: 10.1074/jbc.RA120.014323
PMCID:
PMC7415991
AbstractArticlePDF–2.0M
16.
GenePaint.org: an atlas of gene expression patterns in the mouse embryo
Axel Visel, Christina Thaller, Gregor Eichele
Nucleic Acids Res. 2004 Jan 1; 32(Database issue): D552–D556. doi: 10.1093/nar/gkh029
PMCID:
PMC308763
AbstractArticlePDF–253K
17.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
18.
A conditional knockout resource for the genome–wide study of mouse gene function
William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley
Nature. Author manuscript; available in PMC 2013 Feb 14.
Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163
PMCID:
PMC3572410
AbstractArticlePDF–1.1M
19.
Wnk1 kinase deficiency lowers blood pressure in mice: A gene-trap screen to identify potential targets for therapeutic intervention
Brian P. Zambrowicz, Alejandro Abuin, Ramiro Ramirez-Solis, Lizabeth J. Richter, James Piggott, Hector BeltrandelRio, Eric C. Buxton, Joel Edwards, Rick A. Finch, Carl J. Friddle, Anupma Gupta, Gwenn Hansen, Yi Hu, Wenhu Huang, Crystal Jaing, Billie Wayne Key, Jr., Peter Kipp, Buckley Kohlhauff, Zhi-Qing Ma, Diane Markesich, Robert Payne, David G. Potter, Ny Qian, Joseph Shaw, Jeff Schrick, Zheng-Zheng Shi, Mary Jean Sparks, Isaac Van Sligtenhorst, Peter Vogel, Wade Walke, Nianhua Xu, Qichao Zhu, Christophe Person, Arthur T. Sands
Proc Natl Acad Sci U S A. 2003 Nov 25; 100(24): 14109–14114. Published online 2003 Nov 10. doi: 10.1073/pnas.2336103100
Correction in:
Proc Natl Acad Sci U S A. 2004 Mar 23; 101(12): 4332.
PMCID:
PMC283554
AbstractArticlePDF–481K
20.
A High-Resolution Anatomical Atlas of the Transcriptome in the Mouse Embryo
Graciana Diez-Roux, Sandro Banfi, Marc Sultan, Lars Geffers, Santosh Anand, David Rozado, Alon Magen, Elena Canidio, Massimiliano Pagani, Ivana Peluso, Nathalie Lin-Marq, Muriel Koch, Marchesa Bilio, Immacolata Cantiello, Roberta Verde, Cristian De Masi, Salvatore A. Bianchi, Juliette Cicchini, Elodie Perroud, Shprese Mehmeti, Emilie Dagand, Sabine Schrinner, Asja Nürnberger, Katja Schmidt, Katja Metz, Christina Zwingmann, Norbert Brieske, Cindy Springer, Ana Martinez Hernandez, Sarah Herzog, Frauke Grabbe, Cornelia Sieverding, Barbara Fischer, Kathrin Schrader, Maren Brockmeyer, Sarah Dettmer, Christin Helbig, Violaine Alunni, Marie-Annick Battaini, Carole Mura, Charlotte N. Henrichsen, Raquel Garcia-Lopez, Diego Echevarria, Eduardo Puelles, Elena Garcia-Calero, Stefan Kruse, Markus Uhr, Christine Kauck, Guangjie Feng, Nestor Milyaev, Chuang Kee Ong, Lalit Kumar, MeiSze Lam, Colin A. Semple, Attila Gyenesei, Stefan Mundlos, Uwe Radelof, Hans Lehrach, Paolo Sarmientos, Alexandre Reymond, Duncan R. Davidson, Pascal Dollé, Stylianos E. Antonarakis, Marie-Laure Yaspo, Salvador Martinez, Richard A. Baldock, Gregor Eichele, Andrea Ballabio
PLoS Biol. 2011 Jan; 9(1): e1000582. Published online 2011 Jan 18. doi: 10.1371/journal.pbio.1000582
PMCID:
PMC3022534
AbstractArticlePDF–3.8M

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