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Select item 63824621.

Application of hepatic cytochrome b₅/P450 reductase null (HBRN) mice to study the role of cytochrome b₅ in the cytochrome P450-mediated bioactivation of the anticancer drug ellipticine

Lindsay Reed, Radek Indra, Iveta Mrizova, Michaela Moserova, Heinz H. Schmeiser, C. Roland Wolf, Colin J. Henderson, Marie Stiborova, David H. Phillips, Volker M. Arlt

Toxicol Appl Pharmacol. 2019 Mar 1; 366: 64–74. doi: 10.1016/j.taap.2019.01.020

PMCID:: PMC6382462

Abstract Article

Select item 41439082.

Significance of Neuronal Cytochrome P450 Activity in Opioid-Mediated Stress-Induced Analgesia

Lindsay B. Hough, Julia W. Nalwalk, Weizhu Yang, Xinxin Ding

Brain Res. Author manuscript; available in PMC 2015 Aug 26.

Published in final edited form as: Brain Res. 2014 Aug 26; 1578: 30–37. Published online 2014 Jul 11. doi: 10.1016/j.brainres.2014.07.007

PMCID:: PMC4143908

Abstract Article PDF–320K

Select item 40804313.

Mice Deficient in Intestinal Epithelium Cytochrome P450 Reductase are Prone to Acute Toxin-induced Mucosal Damage

Sarita Ahlawat, Fang Xie, Yi Zhu, Rebecca D'Hondt, Xinxin Ding, Qing-Yu Zhang, Nicholas J. Mantis

Sci Rep. 2014; 4: 5551. Published online 2014 Jul 3. doi: 10.1038/srep05551

PMCID:: PMC4080431

Abstract Article PDF–1.2M

Select item 37758824.

The role of renal proximal tubule P450 enzymes in chloroform-induced nephrotoxicity: utility of renal specific P450 reductase knockout mouse models

Senyan Liu, Yunyi Yao, Shijun Lu, Kenneth Aldous, Xinxin Ding, Changlin Mei, Jun Gu

Toxicol Appl Pharmacol. Author manuscript; available in PMC 2014 Oct 1.

Published in final edited form as: Toxicol Appl Pharmacol. 2013 Oct 1; 272(1): 230–237. Published online 2013 Jun 1. doi: 10.1016/j.taap.2013.05.022

PMCID:: PMC3775882

Abstract Article PDF–2.7M

Select item 37310425.

Suppression of cytochrome P450 reductase expression promotes astrocytosis in subventricular zone of adult mice

Yunyi Yao, Senyan Liu, Yue Wang, Weiping Yuan, Xinxin Ding, Tao Cheng, Qin Shen, Jun Gu

Neurosci Lett. Author manuscript; available in PMC 2014 Aug 26.

Published in final edited form as: Neurosci Lett. 2013 Aug 26; 548: 84–89. Published online 2013 May 30. doi: 10.1016/j.neulet.2013.05.043

PMCID:: PMC3731042

Abstract Article PDF–2.1M

Select item 37247806.

Suppression of Cytochrome P450 Reductase Enhances Long-Term Hematopoietic Stem Cell Repopulation Efficiency in Mice

Yan Zhang, Fang Dong, Na Zhang, Hui Cheng, Yakun Pang, Xiaomin Wang, Jing Xu, Xinxin Ding, Tao Cheng, Jun Gu, Weiping Yuan

PLoS One. 2013; 8(7): e69913. Published online 2013 Jul 26. doi: 10.1371/journal.pone.0069913

PMCID:: PMC3724780

Abstract Article PDF–2.5M

Select item 33938387.

Neurobehavioral abnormalities in a brain-specific NADPH-cytochrome P450 reductase knockout mouse model

Cheng Fang, Valerie J. Bolivar, Jun Gu, Weizhu Yang, Scott O. Zeitlin, Xinxin Ding

Neuroscience. Author manuscript; available in PMC 2013 Aug 30.

Published in final edited form as: Neuroscience. 2012 Aug 30; 218: 170–180. Published online 2012 May 22. doi: 10.1016/j.neuroscience.2012.05.027

PMCID:: PMC3393838

Abstract Article PDF–1.0M

Select item 32437448.

PAH Particles Perturb Prenatal Processes and Phenotypes: Protection from Deficits in Object Discrimination Afforded by Dampening of Brain Oxidoreductase Following In Utero Exposure to Inhaled Benzo(a)pyrene

Zhu Li, Gayathri Chadalapaka, Aramandla Ramesh, Habibeh Khoshbouei, Mark Maguire, Stephen Safe, Raina E. Rhoades, Ryan Clark, George Jules, Monique McCallister, Michael Aschner, Darryl B. Hood

Toxicol Sci. 2012 Jan; 125(1): 233–247. Published online 2011 Oct 10. doi: 10.1093/toxsci/kfr261

PMCID:: PMC3243744

Abstract Article PDF–979K

Select item 28283259.

Opioids Activate Brain Analgesic Circuits Through Cytochrome P450/Epoxygenase Signaling

Jennie L. Conroy, Cheng Fang, Jun Gu, Scott O. Zeitlin, Weizhu Yang, Jun Yang, Melissa A. VanAlstine, Julia W. Nalwalk, Phillip J. Albrecht, Joseph E. Mazurkiewicz, Abigail Snyder-Keller, Zhixing Shan, Shao-Zhong Zhang, Mark P. Wentland, Melissa Behr, Brian I. Knapp, Jean M. Bidlack, Obbe P. Zuiderveld, Rob Leurs, Xinxin Ding, Lindsay B. Hough

Nat Neurosci. Author manuscript; available in PMC 2010 Sep 1.

Published in final edited form as: Nat Neurosci. 2010 Mar; 13(3): 284–286. Published online 2010 Feb 7. doi: 10.1038/nn.2497

PMCID:: PMC2828325

Article PDF–874K

Select item 264547710.

An Intestinal Epithelium-Specific Cytochrome P450 (P450) Reductase-Knockout Mouse Model: Direct Evidence for a Role of Intestinal P450s in First-Pass Clearance of Oral Nifedipine

Qing-Yu Zhang, Cheng Fang, Jin Zhang, Deborah Dunbar, Laurence Kaminsky, Xinxin Ding

Drug Metab Dispos. 2009 Mar; 37(3): 651–657. Published online 2008 Dec 4. doi: 10.1124/dmd.108.025429

PMCID:: PMC2645477

Abstract Article PDF–266K

Select item 943703911.

Humanized liver TK-NOG mice with functional deletion of hepatic murine cytochrome P450s as a model for studying human drug metabolism

Shotaro Uehara, Yuichi Iida, Miyuki Ida-Tanaka, Motohito Goto, Kenji Kawai, Masafumi Yamamoto, Yuichiro Higuchi, Satoshi Ito, Riichi Takahashi, Hidetaka Kamimura, Mamoru Ito, Hiroshi Yamazaki, Mitsuo Oshimura, Yasuhiro Kazuki, Hiroshi Suemizu

Sci Rep. 2022; 12: 14907. Published online 2022 Sep 1. doi: 10.1038/s41598-022-19242-0

PMCID:: PMC9437039

Abstract Article PDF–2.0M

Select item 694913312.

Application of a novel regulatable Cre recombinase system to define the role of liver and gut metabolism in drug oral bioavailability

Colin J. Henderson, Lesley A. McLaughlin, Maria Osuna-Cabello, Malcolm Taylor, Ian Gilbert, Aileen W. McLaren, C. Roland Wolf

Biochem J. Author manuscript; available in PMC 2020 Jan 8.

Published in final edited form as: Biochem J. 2015 Feb 1; 465(3): 479–488. doi: 10.1042/BJ20140582

PMCID:: PMC6949133

Abstract Article PDF–1.5M

Select item 548948113.

A novel humanized mouse lacking murine P450 oxidoreductase for studying human drug metabolism

Mercedes Barzi, Francis P. Pankowicz, Barry Zorman, Xing Liu, Xavier Legras, Diane Yang, Malgorzata Borowiak, Beatrice Bissig-Choisat, Pavel Sumazin, Feng Li, Karl-Dimiter Bissig

Nat Commun. 2017; 8: 39. Published online 2017 Jun 28. doi: 10.1038/s41467-017-00049-x

Correction in:: Nat Commun. 2017; 8: 984.

PMCID:: PMC5489481

Abstract Article PDF–2.3M

Select item 385677614.

Pyrethroid activity-based probes for profiling cytochrome P450 activities associated with insecticide interactions

Hanafy M. Ismail, Paul M. O’Neill, David W. Hong, Robert D. Finn, Colin J. Henderson, Aaron T. Wright, Benjamin F. Cravatt, Janet Hemingway, Mark J. I. Paine

Proc Natl Acad Sci U S A. 2013 Dec 3; 110(49): 19766–19771. Published online 2013 Nov 18. doi: 10.1073/pnas.1320185110

PMCID:: PMC3856776

Abstract Article PDF–841K

Select item 378349715.

Conditional Deletion of Cytochrome P450 Reductase in Osteoprogenitor Cells Affects Long Bone and Skull Development in Mice Recapitulating Antley-Bixler Syndrome: Role of a Redox Enzyme in Development

Satya P. Panda, Anyonya R. Guntur, Srikanth R. Polusani, Roberto J. Fajardo, Peter T. Gakunga, Linda J. Roman, Bettie Sue Masters

PLoS One. 2013; 8(9): e75638. Published online 2013 Sep 25. doi: 10.1371/journal.pone.0075638

PMCID:: PMC3783497

Abstract Article PDF–3.4M

Select item 336685216.

Potential Biological Functions of Cytochrome P450 Reductase-dependent Enzymes in Small Intestine: NOVEL LINK TO EXPRESSION OF MAJOR HISTOCOMPATIBILITY COMPLEX CLASS II GENES

Jaime D'Agostino, Xinxin Ding, Peng Zhang, Kunzhi Jia, Cheng Fang, Yi Zhu, David C. Spink, Qing-Yu Zhang

J Biol Chem. 2012 May 18; 287(21): 17777–17788. Published online 2012 Mar 27. doi: 10.1074/jbc.M112.354274

PMCID:: PMC3366852

Abstract Article PDF–948K

Select item 292237717.

The PPCD1 Mouse: Characterization of a Mouse Model for Posterior Polymorphous Corneal Dystrophy and Identification of a Candidate Gene

Anna L. Shen, Kathleen A. O'Leary, Richard R. Dubielzig, Norman Drinkwater, Christopher J. Murphy, Charles B. Kasper, Christopher A. Bradfield

PLoS One. 2010; 5(8): e12213. Published online 2010 Aug 16. doi: 10.1371/journal.pone.0012213

PMCID:: PMC2922377

Abstract Article PDF–754K

Select item 291204618.

Generation of a Mouse Model with a Reversible Hypomorphic Cytochrome P450 Reductase Gene: Utility for Tissue-Specific Rescue of the Reductase Expression, and Insights from a Resultant Mouse Model with Global Suppression of P450 Reductase Expression in Extrahepatic Tissues

Yuan Wei, Xin Zhou, Cheng Fang, Lei Li, Kerri Kluetzman, Weizhu Yang, Qing-Yu Zhang, Xinxin Ding

J Pharmacol Exp Ther. 2010 Jul; 334(1): 69–77. doi: 10.1124/jpet.110.167411

PMCID:: PMC2912046

Abstract Article PDF–703K

Select item 118346619.

Relationship between hepatic phenotype and changes in gene expression in cytochrome P450 reductase (POR) null mice

Xiu Jun Wang, Mark Chamberlain, Olga Vassieva, Colin J. Henderson, C. Roland Wolf

Biochem J. 2005 Jun 15; 388(Pt 3): 857–867. Prepublished online 2005 Feb 17. Published online 2005 Jun 7. doi: 10.1042/BJ20042087

PMCID:: PMC1183466

Abstract Article PDF–320K

Select item 476192120.

Oscillating primary transcripts harbor miRNAs with circadian functions

Haifang Wang, Zenghua Fan, Meng Zhao, Juan Li, Minghua Lu, Wei Liu, Hao Ying, Mofang Liu, Jun Yan

Sci Rep. 2016; 6: 21598. Published online 2016 Feb 22. doi: 10.1038/srep21598

PMCID:: PMC4761921

Abstract Article PDF–1.7M

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PMC Links for Gene (Select 18984) (44)
PMC
Escherichia coli strain RHB06-C06 chromosome, complete genome
Escherichia coli strain RHB06-C06 chromosome, complete genome
gi|1886781902|gb|CP057994.1|

Nucleotide
SH3 domain-containing protein [Caenorhabditis elegans]
SH3 domain-containing protein [Caenorhabditis elegans]
gi|115533056|ref|NP_001041048.1|

Protein
AV177483 Yuji Kohara unpublished cDNA:Strain N2 hermaphrodite embryo Caenorhabdi...
AV177483 Yuji Kohara unpublished cDNA:Strain N2 hermaphrodite embryo Caenorhabditis elegans cDNA clone yk529d12 3', mRNA sequence
gi|5557384|gnl|dbEST|2971882|dbj|AV 3.1|

Nucleotide
M.musculus mitochondrial malate dehydrogenase gene 5'flank and exon 1 (and joine...
M.musculus mitochondrial malate dehydrogenase gene 5'flank and exon 1 (and joined CDS)
gi|50679|emb|X07295.1|

Nucleotide

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