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Select item 77359511.

A Small Molecule Inhibitor of VE-PTP Activates Tie2 in Schlemm's Canal Increasing Outflow Facility and Reducing Intraocular Pressure

Guorong Li, Astrid F. Nottebaum, Mitchell Brigell, Iris D. Navarro, Ute Ipe, Sarthak Mishra, Maria Gomez-Caraballo, Heather Schmitt, Brandi Soldo, Steve Pakola, Barbara Withers, Kevin G. Peters, Dietmar Vestweber, W. Daniel Stamer

Invest Ophthalmol Vis Sci. 2020 Dec; 61(14): 12. Published online 2020 Dec 14. doi: 10.1167/iovs.61.14.12

PMCID:: PMC7735951

Abstract Article PDF–2.9M

Select item 65049012.

VE-PTP stabilizes VE-cadherin junctions and the endothelial barrier via a phosphatase-independent mechanism

Vanessa V. Juettner, Kevin Kruse, Arkaprava Dan, Vinh H. Vu, Yousaf Khan, Jonathan Le, Deborah Leckband, Yulia Komarova, Asrar B. Malik

J Cell Biol. 2019 May 6; 218(5): 1725–1742. Published online 2019 Apr 4. doi: 10.1083/jcb.201807210

PMCID:: PMC6504901

Abstract Article PDF–3.6M

Select item 61266393.

Receptor protein tyrosine phosphatase PTPRB negatively regulates FGF2-dependent branching morphogenesis

Kelly J. Soady, Giusy Tornillo, Howard Kendrick, Valerie Meniel, Daria Olijnyk-Dallis, Joanna S. Morris, Torsten Stein, Barry A. Gusterson, Clare M. Isacke, Matthew J. Smalley

Development. Author manuscript; available in PMC 2018 Oct 15.

Published in final edited form as: Development. 2017 Oct 15; 144(20): 3777–3788. Published online 2017 Sep 4. doi: 10.1242/dev.149120

PMCID:: PMC6126639

Abstract Article PDF–2.6M

Select item 100865904.

Shear stress control of vascular leaks and atheromas through Tie2 activation by VE‐PTP sequestration

Keisuke Shirakura, Peter Baluk, Astrid F Nottebaum, Ute Ipe, Kevin G Peters, Donald M McDonald, Dietmar Vestweber

EMBO Mol Med. 2023 Apr; 15(4): e16128. Published online 2023 Feb 6. doi: 10.15252/emmm.202216128

PMCID:: PMC10086590

Abstract Article PDF–44M

Select item 86579745.

The Tyrosine Phosphatase hPTPRβ Controls the Early Signals and Dopaminergic Cells Viability via the P2X₇ Receptor

Francisco Llavero Bernal, Miriam Luque Montoro, Alazne Arrazola Sastre, Hadriano M. Lacerda, José Luis Zugaza

Int J Mol Sci. 2021 Dec; 22(23): 12936. Published online 2021 Nov 29. doi: 10.3390/ijms222312936

PMCID:: PMC8657974

Abstract Article PDF–2.4M

Select item 68744176.

Targeting the vascular-specific phosphatase PTPRB protects against retinal ganglion cell loss in a pre-clinical model of glaucoma

Benjamin R Thomson, Isabel A Carota, Tomokazu Souma, Saily Soman, Dietmar Vestweber, Susan E Quaggin

eLife. 2019; 8: e48474. Published online 2019 Oct 17. doi: 10.7554/eLife.48474

PMCID:: PMC6874417

Abstract Article PDF–1.6M

Select item 34573367.

Insulin-Like Growth Factor (IGF) Binding Protein 2 Functions Coordinately with Receptor Protein Tyrosine Phosphatase β and the IGF-I Receptor To Regulate IGF-I-Stimulated Signaling

Xinchun Shen, Gang Xi, Laura A. Maile, Christine Wai, Clifford J. Rosen, David R. Clemmons

Mol Cell Biol. 2012 Oct; 32(20): 4116–4130. doi: 10.1128/MCB.01011-12

PMCID:: PMC3457336

Abstract Article PDF–2.1M

Select item 31993928.

Stabilizing the VE-cadherin–catenin complex blocks leukocyte extravasation and vascular permeability

Dörte Schulte, Verena Küppers, Nina Dartsch, Andre Broermann, Hang Li, Alexander Zarbock, Olena Kamenyeva, Friedemann Kiefer, Alexander Khandoga, Steffen Massberg, Dietmar Vestweber

EMBO J. 2011 Oct 19; 30(20): 4157–4170. Published online 2011 Aug 19. doi: 10.1038/emboj.2011.304

PMCID:: PMC3199392

Abstract Article PDF–1.5M

Select item 107742309.

Heterogeneity of endothelial VE-PTP downstream polarization, Tie2 activation, junctional claudin-5, and permeability in the aorta and vena cava

Peter Baluk, Keisuke Shirakura, Dietmar Vestweber, Donald M. McDonald

Cell Tissue Res. 2024; 395(1): 81–103. Published online 2023 Nov 30. doi: 10.1007/s00441-023-03844-9

PMCID:: PMC10774230

Abstract Article PDF–13M

Select item 644687510.

Targeting VE-PTP phosphatase protects the kidney from diabetic injury

Isabel A. Carota, Yael Kenig-Kozlovsky, Tuncer Onay, Rizaldy Scott, Benjamin R. Thomson, Tomokazu Souma, Christina S. Bartlett, Yanyang Li, Daniele Procissi, Veronica Ramirez, Shinji Yamaguchi, Antoine Tarjus, Christine E. Tanna, Chengjin Li, Vera Eremina, Dietmar Vestweber, Sunday S. Oladipupo, Matthew D. Breyer, Susan E. Quaggin

J Exp Med. 2019 Apr 1; 216(4): 936–949. Published online 2019 Mar 18. doi: 10.1084/jem.20180009

PMCID:: PMC6446875

Abstract Article PDF–3.0M

Select item 468916711.

Interfering with VE-PTP stabilizes endothelial junctions in vivo via Tie-2 in the absence of VE-cadherin

Maike Frye, Martina Dierkes, Verena Küppers, Matthias Vockel, Janina Tomm, Dagmar Zeuschner, Jan Rossaint, Alexander Zarbock, Gou Young Koh, Kevin Peters, Astrid Fee Nottebaum, Dietmar Vestweber

J Exp Med. 2015 Dec 14; 212(13): 2267–2287. doi: 10.1084/jem.20150718

PMCID:: PMC4689167

Abstract Article PDF–3.7M

Select item 258584412.

VE-PTP maintains the endothelial barrier via plakoglobin and becomes dissociated from VE-cadherin by leukocytes and by VEGF

Astrid F. Nottebaum, Giuseppe Cagna, Mark Winderlich, Alexander C. Gamp, Ruth Linnepe, Christian Polaschegg, Kristina Filippova, Ruth Lyck, Britta Engelhardt, Olena Kamenyeva, Maria Gabriele Bixel, Stefan Butz, Dietmar Vestweber

J Exp Med. 2008 Nov 24; 205(12): 2929–2945. doi: 10.1084/jem.20080406

PMCID:: PMC2585844

Abstract Article PDF–5.8M

Select item 180273013.

Vascular endothelial tyrosine phosphatase (VE-PTP)-null mice undergo vasculogenesis but die embryonically because of defects in angiogenesis

Melissa G. Dominguez, Virginia C. Hughes, Li Pan, Mary Simmons, Christopher Daly, Keith Anderson, Irene Noguera-Troise, Andrew J. Murphy, David M. Valenzuela, Samuel Davis, Gavin Thurston, George D. Yancopoulos, Nicholas W. Gale

Proc Natl Acad Sci U S A. 2007 Feb 27; 104(9): 3243–3248. Published online 2007 Feb 21. doi: 10.1073/pnas.0611510104

PMCID:: PMC1802730

Abstract Article PDF–3.3M

Select item 419101114.

Targeting VE-PTP activates TIE2 and stabilizes the ocular vasculature

Jikui Shen, Maike Frye, Bonnie L. Lee, Jessica L. Reinardy, Joseph M. McClung, Kun Ding, Masashi Kojima, Huiming Xia, Christopher Seidel, Raquel Lima e Silva, Aling Dong, Sean F. Hackett, Jiangxia Wang, Brian W. Howard, Dietmar Vestweber, Christopher D. Kontos, Kevin G. Peters, Peter A. Campochiaro

J Clin Invest. 2014 Oct 1; 124(10): 4564–4576. Published online 2014 Sep 2. doi: 10.1172/JCI74527

PMCID:: PMC4191011

Abstract Article PDF–6.2M

Select item 852366415.

Cellular crosstalk regulates the aqueous humor outflow pathway and provides new targets for glaucoma therapies

Benjamin R. Thomson, Pan Liu, Tuncer Onay, Jing Du, Stuart W. Tompson, Sol Misener, Raj R. Purohit, Terri L. Young, Jing Jin, Susan E. Quaggin

Nat Commun. 2021; 12: 6072. Published online 2021 Oct 18. doi: 10.1038/s41467-021-26346-0

PMCID:: PMC8523664

Abstract Article PDF–7.1M

Select item 544463116.

Expression of receptor-type protein tyrosine phosphatase in developing and adult renal vasculature

Keiko Takahashi, Rachel Kim, Colette Lauhan, Yuna Park, Nghiep G. Nguyen, Dietmar Vestweber, Melissa G. Dominguez, David M. Valenzuela, Andrew J. Murphy, George D. Yancopoulos, Nicholas W. Gale, Takamune Takahashi

PLoS One. 2017; 12(5): e0177192. Published online 2017 May 25. doi: 10.1371/journal.pone.0177192

PMCID:: PMC5444631

Abstract Article PDF–61M

Select item 549594317.

Pyk2 phosphorylation of VE-PTP downstream of STIM1-induced Ca²⁺ entry regulates disassembly of adherens junctions

Dheeraj Soni, Sushil C. Regmi, Dong-Mei Wang, Auditi DebRoy, You-Yang Zhao, Stephen M. Vogel, Asrar B. Malik, Chinnaswamy Tiruppathi

Am J Physiol Lung Cell Mol Physiol. 2017 Jun 1; 312(6): L1003–L1017. Published online 2017 Apr 6. doi: 10.1152/ajplung.00008.2017

PMCID:: PMC5495943

Abstract Article

Select item 271157518.

VE-PTP controls blood vessel development by balancing Tie-2 activity

Mark Winderlich, Linda Keller, Giuseppe Cagna, Andre Broermann, Olena Kamenyeva, Friedemann Kiefer, Urban Deutsch, Astrid F. Nottebaum, Dietmar Vestweber

J Cell Biol. 2009 May 18; 185(4): 657–671. doi: 10.1083/jcb.200811159

PMCID:: PMC2711575

Abstract Article PDF–8.2M

Select item 12629319.

VE-PTP and VE-cadherin ectodomains interact to facilitate regulation of phosphorylation and cell contacts

Roman Nawroth, Gregor Poell, Alexander Ranft, Stephan Kloep, Ulrike Samulowitz, Gregor Fachinger, Matthew Golding, David T. Shima, Urban Deutsch, Dietmar Vestweber

EMBO J. 2002 Sep 16; 21(18): 4885–4895. doi: 10.1093/emboj/cdf497

Correction in:: EMBO J. 2005 Sep 7; 24(17): 3158.

PMCID:: PMC126293

Abstract Article PDF–412K

Select item 522859020.

IRS-1 Functions as a Molecular Scaffold to Coordinate IGF-I/IGFBP-2 Signaling During Osteoblast Differentiation

Gang Xi, Xinchun Shen, Clifford J Rosen, David R Clemmons

J Bone Miner Res. Author manuscript; available in PMC 2017 Jun 1.

Published in final edited form as: J Bone Miner Res. 2016 Jun; 31(6): 1300–1314. Published online 2016 Feb 20. doi: 10.1002/jbmr.2791

Correction in:: J Bone Miner Res. 2019 Dec; 34(12): 2331.

PMCID:: PMC5228590

Abstract Article PDF–3.5M

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PMC Links for Gene (Select 19263) (34)
PMC
PREDICTED: Homo sapiens ring finger protein 32 (RNF32), transcript variant X16, ...
PREDICTED: Homo sapiens ring finger protein 32 (RNF32), transcript variant X16, mRNA
gi|2217365649|ref|XM_047419900.1|

Nucleotide
hypothetical protein FDH53_gp112 [Escherichia phage ECD7]
hypothetical protein FDH53_gp112 [Escherichia phage ECD7]
gi|1631924224|ref|YP_009602077.1|

Protein
polyprotein [Banana streak OL virus]
polyprotein [Banana streak OL virus]
gi|2371068726|gb|WAB21420.1|

Protein
virion-associated protein [Banana streak OL virus]
virion-associated protein [Banana streak OL virus]
gi|2513020926|gb|WIF19183.1|

Protein

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